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Search Results: 1 - 10 of 470760 matches for " Joseph A. Kovacs "
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Discordant antibody and cellular responses to Pneumocystis major surface glycoprotein variants in mice
Lisa R Bishop, Daniel Helman, Joseph A Kovacs
BMC Immunology , 2012, DOI: 10.1186/1471-2172-13-39
Abstract: Proliferative responses to each of two recombinant Msg variant proteins were seen in mice immunized with either recombinant protein, but no proliferation to these antigens was seen in mice immunized with crude Pneumocystis antigens or in mice that had cleared infection, although the latter animals demonstrated proliferative responses to crude Pneumocystis antigens and native Msg. IL-17 and MCP-3 were produced in previously infected animals in response to the same antigens, but not to recombinant antigens. Antibody responses to the recombinant P. murina Msg variant proteins were seen in all groups of animals, demonstrating that all groups were exposed to and mounted immune responses to Msg. No human PBMC samples proliferated following stimulation with P. jirovecii Msg, while antibody responses were detected in sera from 4 of 5 samples.Cross-reactive antibody responses to Msg variants are common, while cross-reactive T cell responses are uncommon; these results support the hypothesis that Pneumocystis utilizes switching of Msg variant expression to avoid host T cell responses.
Occurence of 1/29 translocation in "Hungarian Grey" cattle
A Kovacs
Genetics Selection Evolution , 1978, DOI: 10.1186/1297-9686-10-4-594a
Abstract:
The Cancer-Associated Virus Landscape in HIV Patients with Oral Hairy Leukoplakia, Kaposi's Sarcoma, and Non-Hodgkin Lymphoma
Peter D. Burbelo,Joseph A. Kovacs,Jason Wagner,Ahmad Bayat,Craig S. Rhodes,Yvonne De Souza,John S. Greenspan,Michael J. Iadarola
AIDS Research and Treatment , 2012, DOI: 10.1155/2012/634523
Abstract: Although HIV-positive patients are at higher risk for developing a variety of infection-related cancers, the prevalence of infections with the seven known cancer-associated viruses has not been studied. Luciferase immunoprecipitation systems were used to evaluate antiviral antibodies in four 23-person groups: healthy blood donors and HIV-infected patients with oral hairy leukoplakia (OLP), Kaposi's sarcoma (KS), or non-Hodgkin lymphoma (NHL). Antibody profiling revealed that all HIV-positive individuals were strongly seropositive for anti-gp41 and antireverse transcriptase antibodies. However, anti-p24 HIV antibody levels were highly variable and some OLP and KS patients demonstrated weak or negative responses. Profiling two EBV antigens revealed no statistical difference in antibody levels among the three HIV-infected groups. A high frequency of KSHV infection was detected in HIV patients including 100% of KS, 78% of OLP, and 57% of NHL patients. Most HIV-infected subjects (84%) showed anti-HBV core antibodies, but only a few showed antibodies against HCV. MCV seropositivity was also common (94%) in the HIV-infected individuals and KS patients showed statistically higher antibody levels compared to the OLP and NHL patients. Overall, 68% of the HIV-infected patients showed seropositivity with at least four cancer-associated viruses. Antibody profiles against these and other infectious agents could be useful for enhancing the clinical management of HIV patients. 1. Introduction It is estimated that approximately 18% of all human cancers are caused by infectious agents [1]. A bulk of these cancers are caused by the seven known cancer-associated viruses including Epstein-Barr virus (EBV), hepatitis B virus (HBV), human T-lymphotropic virus-I (HTLV-I), human papilloma virus (HPV), hepatitis C virus (HCV), Kaposi’s sarcoma herpesvirus (KSHV; also known as HHV-8), and Merkel cell polyomavirus (MCV) [2]. Although HIV is not a cancer-causing virus, HIV-infected individuals are particularly vulnerable for developing several infection-related malignancies compared to the general population [3–6]. Mechanistically, the increase in malignancy seen in AIDS patients is due to HIV-associated immune suppression and the higher rates of infection by several cancer-associated viruses. In particular, HIV-infected individuals show a high incidence of three AIDS-defining malignancies including KSHV-associated Kaposi sarcoma (KS), HPV-driven invasive cervical cancer, and EBV-associated and nonassociated non-Hodgkin lymphoma (NHL). For KS and NHL, there is a 310-fold and
Nucleic Acid Amplification Tests for Diagnosis of Smear-Negative TB in a High HIV-Prevalence Setting: A Prospective Cohort Study
J. Lucian Davis,Laurence Huang,William Worodria,Henry Masur,Adithya Cattamanchi,Charles Huber,Cecily Miller,Patricia S. Conville,Patrick Murray,Joseph A. Kovacs
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016321
Abstract: Nucleic acid amplification tests are sensitive for identifying Mycobacterium tuberculosis in populations with positive sputum smears for acid-fast bacilli, but less sensitive in sputum-smear-negative populations. Few studies have evaluated the clinical impact of these tests in low-income countries with high burdens of TB and HIV.
Report on chromosomal examination of A.I. bulls in Hungary
A Kovacs, M Papp
Genetics Selection Evolution , 1977, DOI: 10.1186/1297-9686-9-4-528b
Abstract:
Routine chromosomal examination of ai bulls in hungary
M Papp, A Kovacs
Genetics Selection Evolution , 1978, DOI: 10.1186/1297-9686-10-4-593b
Abstract:
The translocation 1/29 in Swedish Red-White cows imported from Sweden to Hungary
I Gustavsson, A Kovacs
Genetics Selection Evolution , 1977, DOI: 10.1186/1297-9686-9-4-535a
Abstract:
Thermo-photovoltaic spacecraft electricity generation
A. Kovacs,P. Janhunen
Astrophysics and Space Sciences Transactions (ASTRA) , 2010, DOI: 10.5194/astra-6-19-2010
Abstract: We describe a solution for powering a spacecraft in the 5 kW – 0.5 MW power range. The introduced thermo-photovoltaic electricity generation works without magnets or external cooling; it combines operational simplicity with a good power per mass ratio. Once in orbit, the system shall be capable of powering numerous successive missions within the solar system or a long range exploratory mission.
COENOLOGICAL DIFFERENTIATION OF PEUCEDANUM SPECIES (SECT. PEUCEDANUM) STANDS IN THE CARPATHIAN BASIN
J.A. KOVACS
Annali di Botanica , 2011,
Abstract: Species of Peucedanum (sect. Peucedanum) with closer botanical relationships were source of taxonomic, ecologic and coenologic incertitudes. Coenological studies of grassland vegetation in the Carpathian basin completed with the ecological indicators contributed to the foundation some coeno-ecological species groups, which can express and characterize the coenological differentiation of the Peucedanum-species and stands. Thus, various stands of P. officinale are characterized by distinctive group of species for dry, humid and semi-dry salt meadows, P. longifolium by groups for rupicolous submediterranean habitats, P. rochelianum by a group of fen and wet meadows, P. tauricum by a group of xerothermic fringe vegetation and an other for stepic grasslands. It is presented the vegetation structure, local diagnostics, constant and dominant species of recently described plant community: Inulo ensifoliae-Peucedanetum tauricae.
Altered Antibody Profiles against Common Infectious Agents in Chronic Disease
Peter D. Burbelo, Kathryn H. Ching, Caryn G. Morse, Ilias Alevizos, Ahmad Bayat, Jeffrey I. Cohen, Mir A. Ali, Amit Kapoor, Sarah K. Browne, Steven M. Holland, Joseph A. Kovacs, Michael J. Iadarola
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081635
Abstract: Despite the important diagnostic value of evaluating antibody responses to individual human pathogens, antibody profiles against multiple infectious agents have not been used to explore health and disease mainly for technical reasons.??We hypothesized that the interplay between infection and chronic disease might be revealed by profiling antibodies against multiple agents. Here, the levels of antibodies against a panel of 13 common infectious agents were evaluated with the quantitative Luciferase Immunoprecipitation Systems (LIPS) in patients from three disease cohorts including those with pathogenic anti-interferon-γ autoantibodies (IFN-γ AAB), HIV and Sj?gren’s syndrome (SjS) to determine if their antibody profiles differed from control subjects.? The IFN-γ AAB patients compared to controls demonstrated statistically higher levels of antibodies against VZV (p=0.0003), EBV (p=0.002), CMV (p=0.003), and C. albicans (p=0.03), but lower antibody levels against poliovirus (p=0.04). Comparison of HIV patients with blood donor controls revealed that the patients had higher levels of antibodies against CMV (p=0.0008), HSV-2 (p=0.0008), EBV (p=0.001), and C. albicans (p=0.01), but showed decreased levels of antibodies against coxsackievirus B4 (p=0.0008), poliovirus (p=0.0005),?? and HHV-6B (p=0.002). Lastly, SjS patients had higher levels of anti-EBV antibodies (p=0.03), but lower antibody levels against several enteroviruses including a newly identified picornavirus, HCoSV-A (p=0.004), coxsackievirus B4 (p=0.04), and poliovirus (p=0.02). For the IFN-γ AAB and HIV cohorts, principal component analysis revealed unique antibody clusters that showed the potential to discriminate patients from controls.? The results suggest that antibody profiles against these and likely other common infectious agents may yield insight into the interplay between exposure to infectious agents, dysbiosis, adaptive immunity and disease activity.
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