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Search Results: 1 - 10 of 1750 matches for " Josep Corominas "
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Josep Corominas
Revista Eureka sobre Ense?anza y Divulgación de las Ciencias , 2010,
Abstract: Para ilustrar el fenómeno de la ósmosis se presentan dos experiencias sencillas que pueden realizarse con materiales cotidianos (patatas, huevos, agua, sal, vinagre...), tanto a nivel cualitativo como cuantitativo.
Chemical party: spirits that are not so, drinks for no drinking and something to eat
Corominas, Josep
Revista Eureka sobre Ense?anza y Divulgación de las Ciencias , 2011,
Abstract: Se describen cuatro experimentos de reacciones químicas y propiedades de las soluciones presentados en forma lúdica, con la finalidad primero de atraer la atención para inmediatamente después provocar la reflexión acerca del fenómeno observado.
Polysomy of chromosome 17 in breast cancer tumors showing an overexpression of ERBB2: a study of 175 cases using fluorescence in situ hybridization and immunohistochemistry
Marta Salido, Ignasi Tusquets, Josep M Corominas, Marta Suarez, Blanca Espinet, Cristina Corzo, Meritxell Bellet, Xavier Fabregat, Sergi Serrano, Francesc Solé
Breast Cancer Research , 2005, DOI: 10.1186/bcr996
Abstract: We used FISH on a series of 175 formalin-fixed paraffin-embedded breast carcinomas to detect ERBB2 amplification, using a dual-probe system for the simultaneous enumeration of the ERBB2 gene and the centromeric region of chromosome 17, as well as using IHC to detect overexpression. We analyzed clinical and pathological variables in a subgroup of patients with 2+ and 3+ IHC scores (147 patients), to describe any differences in clinicopathological characteristics between polysomic and non-polysomic cases with the use of the χ2 test.We found 13% of cases presenting polysomy, and three cases presented monosomy 17 (2%). According to the status of the ERBB2 gene, instances of polysomy 17 were more frequently observed in non-amplified cases than in FISH-amplified cases, suggesting that the mechanism for ERBB2 amplification is independent of polysomy 17. Polysomy 17 was detected in patients with 2+ and 3+ IHC scores. We found that nodal involvement was more frequent in polysomic than in non-polysomic cases (P = 0.046).The determination of the copy number of chromosome 17 should be incorporated into the assesment of ERBB2 status. It might also be helpful to differentiate a subgroup of breast cancer patients with polysomy of chromosome 17 and overexpression of ERBB2 protein that probably have genetic and clinical differences.Proto-oncogenes and tumor suppressor genes are two classes of genes with central roles in the regulation of cell growth. One of the most common genetic alterations associated with human breast cancer is the amplification of the ERBB2 proto-oncogene [1]. The ERBB2 gene located on 17q12-q21 encodes a 185 kDa transmembrane tyrosine kinase receptor [2,3]. This protein is a member of the epidermal growth factor receptor family [4] that comprises four homologous receptors: HER1 (ERBB1), ERBB2 (ERBB2), HER3 and HER4. These receptors are involved in the activation of complex signaling pathways, essential for cell survival and for the regulation of normal breast g
Polymorphism in the ELOVL6 Gene Is Associated with a Major QTL Effect on Fatty Acid Composition in Pigs
Jordi Corominas, Yuliaxis Ramayo-Caldas, Anna Puig-Oliveras, Dafne Pérez-Montarelo, Jose L. Noguera, Josep M. Folch, Maria Ballester
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053687
Abstract: Background The ELOVL fatty acid elongase 6 (ELOVL6), the only elongase related to de novo lipogenesis, catalyzes the rate-limiting step in the elongation cycle by controlling the fatty acid balance in mammals. It is located on pig chromosome 8 (SSC8) in a region where a QTL affecting palmitic, and palmitoleic acid composition was previously detected, using an Iberian x Landrace intercross. The main goal of this work was to fine-map the QTL and to evaluate the ELOVL6 gene as a positional candidate gene affecting the percentages of palmitic and palmitoleic fatty acids in pigs. Methodology and Principal Findings The combination of a haplotype-based approach and single-marker analysis allowed us to identify the main, associated interval for the QTL, in which the ELOVL6 gene was identified and selected as a positional candidate gene. A polymorphism in the promoter region of ELOVL6, ELOVL6:c.-533C>T, was highly associated with the percentage of palmitic and palmitoleic acids in muscle and backfat. Significant differences in ELOVL6 gene expression were observed in backfat when animals were classified by the ELOVL6:c.-533C>T genotype. Accordingly, animals carrying the allele associated with a decrease in ELOVL6 gene expression presented an increase in C16:0 and C16:1(n-7) fatty acid content and a decrease of elongation activity ratios in muscle and backfat. Furthermore, a SNP genome-wide association study with ELOVL6 relative expression levels in backfat showed the strongest effect on the SSC8 region in which the ELOVL6 gene is located. Finally, different potential genomic regions associated with ELOVL6 gene expression were also identified by GWAS in liver and muscle, suggesting a differential tissue regulation of the ELOVL6 gene. Conclusions and Significance Our results suggest ELOVL6 as a potential causal gene for the QTL analyzed and, subsequently, for controlling the overall balance of fatty acid composition in pigs.
Differences in Muscle Transcriptome among Pigs Phenotypically Extreme for Fatty Acid Composition
Anna Puig-Oliveras, Yuliaxis Ramayo-Caldas, Jordi Corominas, Jordi Estellé, Dafne Pérez-Montarelo, Nicholas J. Hudson, Joaquim Casellas, Josep M. Folch Maria Ballester
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099720
Abstract: Background Besides having an impact on human health, the porcine muscle fatty acid profile determines meat quality and taste. The RNA-Seq technologies allowed us to explore the pig muscle transcriptome with an unprecedented detail. The aim of this study was to identify differentially-expressed genes between two groups of 6 sows belonging to an Iberian × Landrace backcross with extreme phenotypes according to FA profile. Results We sequenced the muscle transcriptome acquiring 787.5 M of 75 bp paired-end reads. About 85.1% of reads were mapped to the reference genome. Of the total reads, 79.1% were located in exons, 6.0% in introns and 14.9% in intergenic regions, indicating expressed regions not annotated in the reference genome. We identified a 34.5% of the intergenic regions as interspersed repetitive regions. We predicted a total of 2,372 putative proteins. Pathway analysis with 131 differentially-expressed genes revealed that the most statistically-significant metabolic pathways were related with lipid metabolism. Moreover, 18 of the differentially-expressed genes were located in genomic regions associated with IMF composition in an independent GWAS study in the same genetic background. Thus, our results indicate that the lipid metabolism of FAs is differently modulated when the FA composition in muscle differs. For instance, a high content of PUFA may reduce FA and glucose uptake resulting in an inhibition of the lipogenesis. These results are consistent with previous studies of our group analysing the liver and the adipose tissue transcriptomes providing a view of each of the main organs involved in lipid metabolism. Conclusions The results obtained in the muscle transcriptome analysis increase the knowledge of the gene regulation of IMF deposition, FA profile and meat quality, in terms of taste and nutritional value. Besides, our results may be important in terms of human health.
PSI Deformation Map Retrieval by Means of Temporal Sublook Coherence on Reduced Sets of SAR Images
Rubén Iglesias,Jordi J. Mallorqui,Dani Monells,Carlos López-Martínez,Xavier Fabregas,Albert Aguasca,Josep A. Gili,Jordi Corominas
Remote Sensing , 2015, DOI: 10.3390/rs70100530
Abstract: Prior to the application of any persistent scatterer interferometry (PSI) technique for the monitoring of terrain displacement phenomena, an adequate pixel selection must be carried out in order to prevent the inclusion of noisy pixels in the processing. The rationale is to detect the so-called persistent scatterers, which are characterized by preserving their phase quality along the multi-temporal set of synthetic aperture radar (SAR) images available. Two criteria are mainly available for the estimation of pixels’ phase quality, i.e., the coherence stability and the amplitude dispersion or permanent scatterers (PS) approach. The coherence stability method allows an accurate estimation of the phase statistics, even when a reduced number of SAR acquisitions is available. Unfortunately, it requires the multi-looking of data during the coherence estimation, leading to a spatial resolution loss in the final results. In contrast, the PS approach works at full-resolution, but it demands a larger number of SAR images to be reliable, typically more than 20. There is hence a clear limitation when a full-resolution PSI processing is to be carried out and the number of acquisitions available is small. In this context, a novel pixel selection method based on exploiting the spectral properties of point-like scatterers, referred to as temporal sublook coherence (TSC), has been recently proposed. This paper seeks to demonstrate the advantages of employing PSI techniques by means of TSC on both orbital and ground-based SAR (GB-SAR) data when the number of images available is small (10 images in the work presented). The displacement maps retrieved through the proposed technique are compared, in terms of pixel density and phase quality, with traditional criteria. Two X-band datasets composed of 10 sliding spotlight TerraSAR-X images and 10 GB-SAR images, respectively, over the landslide of El Forn de Canillo (Andorran Pyrenees), are employed for this study. For both datasets, the TSC technique has showed an excellent performance compared with traditional techniques, achieving up to a four-fold increase in the number of persistent scatters detected, compared with the coherence stability approach, and a similar density compared with the PS approach, but free of outliers.
The Hidden Risk Factor  [PDF]
J. H. Witte, D. Ples, J. Corominas
Journal of Mathematical Finance (JMF) , 2013, DOI: 10.4236/jmf.2013.33A003

To achieve maximum returns consistent with an investor’s appetite for risk, the correct identification and estimation of all relevant risk factors in a portfolio are necessary. In this paper, we identify the role of foreign currency as an important risk factor from an international investor’s point of view.

The Tekhne-Logic Revolution. Rethinking the “Interobjective” Dimension of the Integral Theory. Consequences and Relevance to Education  [PDF]
Josep Gallifa
Creative Education (CE) , 2018, DOI: 10.4236/ce.2018.97081
Abstract: Wilber’s Integral Theory is a framework, widely used in different fields, aimed at unifying the premodern, modern and postmodern legacies and worldviews in one system. The subjective, objective and intersubjective dimensions of the Integral Theory correspond respectively to each one of the mentioned worldviews. This article reviews and explores in depth the interobjective dimension, necessary for a really quaternary integral approach, which has to include appropriately the human work and creativity. This is achieved trough understanding the interobjective character of the tekhne logic. Tekhne is the Aristotelian word to designate “productive science”. The study discusses the foundation of the interobjective at different levels (ontological, anthropological, cultural and psychological) and describes the evolutionary character of the tekhne logic. Finally the article explores the relevance of this characterization to the Integral Theory; but also to Metaphysics, Epistemology and especially to Education.
“Diálogo de las empresas militares y amorosas”
Libros de la Corte.es , 2012,
“Jorde de Montemayor: Vida y obra de un advenedizo portugués en la corte castellana”
Libros de la Corte.es , 2012,
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