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Search Results: 1 - 10 of 182019 matches for " Jose Macario de Siqueira "
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Experimentación de las soluciones tecnológicas del proyecto PAULEX para optimizar la prueba de inglés del examen de acceso a la universidad en Espa a / Experimenting the technological solutions within the PAULEX project to...
Jesús Garcia Laborda,Ana Gimeno,Jose Macario de Siqueira
ETD : Educa??o Temática Digital , 2011,
Abstract: Este trabajo gira en torno a la experimentación inicial de las soluciones propuestas por la Plataforma PAUER-PAULEX para la realización de las Pruebas de de Acceso a la Universidad (PAU) en Espa a a través de Internet. PAUER es una plataforma dedicada a la evaluación de lenguas extranjeras que integra las tecnologías de la información y de las comunicaciones (TIC) en la ense anza y en la evaluación de conocimientos. La plataforma es uno de los principales resultados del proyecto de investigación Paulex-Universitas, cuyo objetivo es analizar las diversas posibilidades que ofrecen las TIC para la creación, realización y corrección del examen de lengua extranjera de las PAU. En este artículo, se presentan los resultados de la experimentación de campo en la que se han utilizado técnicas de observación cualitativa. En este proceso han participado cerca de 280 estudiantes de segundo de bachillerato, profesores e investigadores. Esta experimentación ha concluido que las pruebas informatizadas pueden ser una alternativa válida al examen actual en papel y bolígrafo, pese a las dificultades que se han encontrado. Abstract This paper deals with the initial experimentation in search of technological solutions for the PAUER-PAULEX platform for the delivery of the University Entrance Examination (PAU) in Spain through Internet. PAUER is a computer platform used for foreign language assessment that integrates the information and communication technologies (ICT) in the teaching and knowledge assessment. The platform is one of the main outcomes of the Paulex-Universitas research project of which the main goal is to analyze the feasibility of ICT in the creation, development and rating of the foreign language test in the PAU. This paper presents the results of the field experimentation for which a qualitative approach has been used. 280 students in their last high school year, as well as teachers and researchers, have taken par in this process. The experimentation concludes that the computer based tests can be a valid alternative to the current pen and paper test despite the constraints hereby presented.
Saúde coletiva na perspectiva ecossistêmica: uma possibilidade de a??es do enfermeiro
Santos, Mateus Casanova dos;Siqueira, Hedi Crecencia Heckler de;Silva, Jose Richard de Sosa;
Revista Gaúcha de Enfermagem , 2009, DOI: 10.1590/S1983-14472009000400023
Abstract: the understructure of the collective health as looking for strategies of protection to the environment also develops a practice of ecosystemic conscience. the ecological practices recognize the right of the human being of living in a healthy and appropriate environment, and being informed about the risks of the environment regarding the health and his welfare. the aim of this present work is stimulate a discussion reflexive-theoretically on the adoption of the ecological urbane practices in communities and the relation with the collective health and to glimpse insertion possibilities of the actions of the nurse in this space. the conversations actions, a stimulative discussion and approximation of the nurse with the habitat of the human, are able to find reciprocity in the collective health and to the ecosystemic approach. the respect his beliefs and to his to know in relation his necessities in health, can come across, objectively, in the promotion of the ecological conscience and of the collective spirit turned to the citizenship.
Contribution to the study of pteridophytes of the Serra do Urubú, Maraial municipality, Pernambuco state, Northeastern Brazil (Marattiaceae-Vittariaceae)
Matos Moura, Alfredo,Gomes dos Santos, Vaneicia,Alves de Siqueira, Jose,Baracho, George Sydney
Anales del Jardín Botánico de Madrid , 2000,
Abstract: This paper presents a study of the pteridophytes of six families collected in one of the few remaining fragments of atlantic forest in Pernambuco, NE Brazil. 22 species of 13 genera are recorded most of which live on the ground in shady hollows. The specimens are deposited in the EAN, IPA, UFP and PEUFR herbaria. En el presente trabajo se estudian los pteridófitos de las familias Marattiaceae, Schizaeaceae, Gleicheniaceae, Cyatheaceae, Pteridaceae y Vittariaceae, colectados en uno de los pocos testimonios de selva fragmentada montana, llamada "floresta atlántica", en la Serra do Urubú, Mata do Ageró, municipio de Maraial, estado de Pernambuco, en el NE de Brasil. Se citan, para las seis familias mencionadas, 22 especies incluidas en 13 géneros, las que preferentemente viven como terrícolas en taludes y barrancos sombríos. Los pliegos están depositados en los herbarios EAN, IPA, UFP y PEUFR.
Radionuclide Transport in Fractured Rock: Numerical Assessment for High Level Waste Repository
Claudia Siqueira da Silveira,Antonio Carlos Marques Alvim,Jose de Jesus Rivero Oliva
Science and Technology of Nuclear Installations , 2013, DOI: 10.1155/2013/827961
Abstract: Deep and stable geological formations with low permeability have been considered for high level waste definitive repository. A common problem is the modeling of radionuclide migration in a fractured medium. Initially, we considered a system consisting of a rock matrix with a single planar fracture in water saturated porous rock. Transport in the fracture is assumed to obey an advection-diffusion equation, while molecular diffusion is considered the dominant mechanism of transport in porous matrix. The partial differential equations describing the movement of radionuclides were discretized by finite difference methods, namely, fully explicit, fully implicit, and Crank-Nicolson schemes. The convective term was discretized by the following numerical schemes: backward differences, centered differences, and forward differences. The model was validated using an analytical solution found in the literature. Finally, we carried out a simulation with relevant spent fuel nuclide data with a system consisting of a horizontal fracture and a vertical fracture for assessing the performance of a hypothetical repository inserted into the host rock. We have analysed the bentonite expanded performance at the beginning of fracture, the quantified radionuclide released from a borehole, and an estimated effective dose to an adult, obtained from ingestion of well water during one year. 1. Introduction With the advent of nuclear technology, countries that employ it received many benefits from the energy production increase, but, as occurs to any activity related to industrialization, there is inevitably a waste production, but the volume of radioactive waste produced is very small, when compared with other industrial residues. The relatively long half-lives of some radionuclides present in this material, as well as their high activity and toxicity, pose a burden for the present and future generation. Part of this waste, the high level waste resulting from reprocessing and spent fuel disposal (HLW—high level waste), remains hazardous for thousands of years and therefore should be carefully stored, using barriers that delay the migration of radioisotopes to the biosphere. Thus, the greatest challenge involves the management of high level radioactive waste, which must be isolated from the environment, and a disposal site for this waste, chosen to ensure safety for many thousands of years, OECD [1]. Although it is impossible to establish a safe depth, for which the biosphere could be effectively isolated from the buried radioactive wastes, it is recognized that a deep repository
hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions
Luciano Brocchieri, Everly Conway de Macario, Alberto JL Macario
BMC Evolutionary Biology , 2008, DOI: 10.1186/1471-2148-8-19
Abstract: We identified 47 hsp70 sequences, 17 genes and 30 pseudogenes. The genes distributed into seven evolutionarily distinct groups with distinguishable subgroups according to phylogenetic and other data, such as exon-intron and protein features. The N-terminal ATP-binding domain (ABD) was conserved at least partially in the majority of the proteins but the C-terminal substrate-binding domain (SBD) was not. Nine proteins were typical Hsp70s (65–80 kDa) with ABD and SBD, two were lighter lacking partly or totally the SBD, and six were heavier (>80 kDa) with divergent C-terminal domains. We also analyzed exon-intron features, transcriptional variants and protein structure and isoforms, and modality and patterns of expression in various tissues and developmental stages. Evolutionary analyses, including human hsp70 genes and pseudogenes, and other eukaryotic hsp70 genes, showed that six human genes encoding cytosolic Hsp70s and 27 pseudogenes originated from retro-transposition of HSPA8, a gene highly expressed in most tissues and developmental stages.The human hsp70-gene family is characterized by a remarkable evolutionary diversity that mainly resulted from multiple duplications and retrotranspositions of a highly expressed gene, HSPA8. Human Hsp70 proteins are clustered into seven evolutionary Groups, with divergent C-terminal domains likely defining their distinctive functions. These functions may also be further defined by the observed differences in the N-terminal domain.Molecular chaperones encompass several families, play important physiological roles, some of which essential for life, and are key components of anti-stress mechanisms in all organisms, tissues and cells [1]. The Hsp70 family is thought to be required for various cellular processes and for the response to environmental changes and survival [2,3]. Although there is no doubt about the biological and medical importance to the human Hsp70 chaperone family, a coherent, unifying informational framework encom
Análise dos padr?es histopatológicos do colesteatoma adquirido da orelha média
Alves, Adriana Leal;Pereira, Celina Siqueira Barbosa;Ribeiro, Fernando de Andrade Quintanilha;Fregnani, Jose Humberto Tavares Guerreiro;
Revista Brasileira de Otorrinolaringologia , 2008, DOI: 10.1590/S0034-72992008000600005
Abstract: middle ear cholesteatomas are characterized by the presence of stratified squamous epithelium in this cavity with highly invasive properties causing bone destruction and it may lead to complications. aim: to study the histopathological features in acquired cholesteatomas of the middle ear, correlating this data with patient age. study design:clinical and experimental cross-sectional study. material and methods: samples were obtained from 50 patients submitted to otologic surgery for the removal of middle ear cholesteatomas from 2006 to 2007. thirty four patients were adults and 16 were children. samples were studied by histological analysis. results: we found the presence of epithelial atrophy (78%), epithelial acanthosis (88%), hyperplasia of the basal layer (88%) and formation of epithelial cones (62%). there was a positive and significant correlation between histopathological variables (such as epithelial acanthosis, hyperplasia of the basal layer and formation of epithelial cones). histopathological variables presented no statistical significant difference in both age groups (p>0,05). conclusion: cholesteatomas have hyperproliferating characteristics with epithelial acanthosis, hyperplasia of the basal layer and the presence of epithelial cones in the matrix.
Development of a New Approach to Aid in Visual Identification of Murine iPS Colonies Using a Fuzzy Logic Decision Support System
Vinicius Bassaneze, Chester Bittencourt Sacramento, Rodolfo Freire, Patrícia Fernandes De Alencar, Neli Regina Siqueira Ortega, Jose Eduardo Krieger
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070605
Abstract: The a priori identification of induced pluripotent stem cells remains a challenge. Being able to quickly identify the most embryonic stem cell-similar induced pluripotent stem cells when validating results could help to reduce costs and save time. In this context, tools based on non-classic logic can be useful in creating aid-systems based on visual criteria. True colonies when viewed at 100x magnification have been found to have the following 3 characteristics: a high degree of border delineation, a more uniform texture, and the absence of a cracked texture. These visual criteria were used for fuzzy logic modeling. We investigated the possibility of predicting the presence of alkaline phosphatase activity, typical of true induced pluripotent stem cell colonies, after 25 individuals, with varying degrees of experience in working with murine iPS cells, categorized the images of 136 colonies based on visual criteria. Intriguingly, the performance evaluation by area under the ROC curve (16 individuals with satisfactory performance), Spearman correlation (all statistically significant), and Cohen's Kappa agreement analysis (all statistically significant) demonstrates that the discriminatory capacity of different evaluators are similar, even those who have never cultivated cells. Thus, we report on a new system to facilitate visual identification of murine- induced pluripotent stem cell colonies that can be useful for staff training and opens the possibility of exploring visual characteristics of induced pluripotent stem cell colonies with their functional peculiarities. The fuzzy model has been integrated as a web-based tool named “2see-iPS” which is freely accessed at http://genetica.incor.usp.br/2seeips/.
HyperPro An integrated documentation environment for CLP
AbdelAli Ed-Dbali,Pierre Deransart,Mariza A. S. Bigonha,Jose de Siqueira,Roberto da S. Bigonha
Computer Science , 2001,
Abstract: The purpose of this paper is to present some functionalities of the HyperPro System. HyperPro is a hypertext tool which allows to develop Constraint Logic Programming (CLP) together with their documentation. The text editing part is not new and is based on the free software Thot. A HyperPro program is a Thot document written in a report style. The tool is designed for CLP but it can be adapted to other programming paradigms as well. Thot offers navigation and editing facilities and synchronized static document views. HyperPro has new functionalities such as document exportations, dynamic views (projections), indexes and version management. Projection is a mechanism for extracting and exporting relevant pieces of code program or of document according to specific criteria. Indexes are useful to find the references and occurrences of a relation in a document, i.e., where its predicate definition is found and where a relation is used in other programs or document versions and, to translate hyper-texts links into paper references. It still lack importation facilities.
Chlamydia trachomatis Infection and Anti-Hsp60 Immunity: The Two Sides of the Coin
Francesco Cappello ,Everly Conway de Macario,Valentina Di Felice,Giovanni Zummo,Alberto J. L. Macario
PLOS Pathogens , 2009, DOI: 10.1371/journal.ppat.1000552
Abstract: Chlamydia trachomatis (CT) infection is one of the most common causes of reproductive tract diseases and infertility. CT-Hsp60 is synthesized during infection and is released in the bloodstream. As a consequence, immune cells will produce anti-CT-Hsp60 antibodies. Hsp60, a ubiquitous and evolutionarily conserved chaperonin, is normally sequestered inside the cell, particularly into mitochondria. However, upon cell stress, as well as during carcinogenesis, the chaperonin becomes exposed on the cell surface (sf-Hsp60) and/or is secreted from cells into the extracellular space and circulation. Reports in the literature on circulating Hsp and anti-Hsp antibodies are in many cases short on details about Hsp60 concentrations, and about the specificity spectra of the antibodies, their titers, and their true, direct, pathogenetic effects. Thus, more studies are still needed to obtain a definitive picture on these matters. Nevertheless, the information already available indicates that the concurrence of persistent CT infection and appearance of sf-Hsp60 can promote an autoimmune aggression towards stressed cells and the development of diseases such as autoimmune arthritis, multiple sclerosis, atherosclerosis, vasculitis, diabetes, and thyroiditis, among others. At the same time, immunocomplexes composed of anti-CT-Hsp60 antibodies and circulating Hsp60 (both CT and human) may form deposits in several anatomical locations, e.g., at the glomerular basal membrane. The opposite side of the coin is that pre-tumor and tumor cells with sf-Hsp60 can be destroyed with participation of the anti-Hsp60 antibody, thus stopping cancer progression before it is even noticed by the patient or physician.
Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes
Krishanu Mukherjee, Everly Conway de Macario, Alberto JL Macario, Luciano Brocchieri
BMC Evolutionary Biology , 2010, DOI: 10.1186/1471-2148-10-64
Abstract: We identified fifty-four chaperonin-like sequences in the human genome and similar numbers in the genomes of the model organisms mouse and rat. In mammal genomes we identified, besides the well-known CCT chaperonin genes and the three genes associated with the MKKS and BBS pathological conditions, a newly-defined class of chaperonin genes named CCT8L, represented in human by the two sequences CCT8L1 and CCT8L2. Comparative analyses from several vertebrate genomes established the monophyletic origin of chaperonin-like MKKS and BBS genes from the CCT8 lineage. The CCT8L gene originated from a later duplication also in the CCT8 lineage at the onset of mammal evolution and duplicated in primate genomes. The functionality of CCT8L genes in different species was confirmed by evolutionary analyses and in human by expression data. Detailed sequence analysis and structural predictions of MKKS, BBS and CCT8L proteins strongly suggested that they conserve a typical chaperonin-like core structure but that they are unlikely to form a CCT-like oligomeric complex. The characterization of many newly-discovered chaperonin pseudogenes uncovered the intense duplication activity of eukaryotic chaperonin genes.In vertebrates, chaperonin genes, driven by intense duplication processes, have diversified into multiple classes and functionalities that extend beyond their well-known protein-folding role as part of the typical oligomeric chaperonin complex, emphasizing previous observations on the involvement of individual CCT monomers in microtubule elongation. The functional characterization of newly identified chaperonin genes will be a challenge for future experimental analyses.Hsp60-like chaperonin proteins are well known for their role in assisting protein folding and in protecting cells from the deleterious effects of stress [1-5]. The eukaryotic cell expresses representatives of two distinct groups of chaperonin genes that are otherwise typical of bacteria (Group I) or archaea (Group I
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