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Search Results: 1 - 10 of 458547 matches for " José M. Grima "
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Gerencia de empresas recuperadas por los trabajadores en Argentina
Bialakowsky,Alberto L; Grima,José M; Costa,María Ignacia; López,Néstor;
Revista Venezolana de Gerencia , 2005,
Abstract: in this paper we discuss the traditional sense of the term management in order to construct a more appropriate concept in relation to recent experience in the emerging social movements to recover businesses on the part of their workers in argentina after the crisis of the 1970s. in these movements a new type of management is emerging on the part of their work force within the context of a movement to recover businesses based on a sampling of the same. this is ethnographic, sociological and co-productive research that is articulated along three tangents: power, knowledge and cooperation. the conclusion is that the recovered businesses discovered hidden dimensions in traditional management, which makes it more plastic and creative based on the collective aspect, when it assumes its identity as an anti-taylorist collective
Gerencia de empresas recuperadas por los trabajadores en Argentina
Alberto L. Bialakowsky,José M. Grima,María Ignacia Costa,Néstor López
Revista Venezolana de Gerencia , 2005,
Abstract: En este trabajo se discute sobre el sentido tradicional del término gerencia con la finalidad de construir un concepto más próximo a la experiencia reciente de lo que acontece con el movimiento social emergente de empresas recuperadas por parte de los trabajadores en Argentina después de la crisis de los a os 70 en adelante. En ellas está naciendo un nuevo tipo de gerencia desarrollada por los propios trabajadores en el contexto del movimiento de empresas recuperadas sobre la base de una muestra de dichas empresas. Se trata de una investigación etnográfica, sociológica y coproductiva que vertebra tres ejes analíticos: poder, saber y cooperación. Se concluye que las empresas recuperadas redescubren dimensiones ocultas de la gerencia tradicional lo que hace que adquieran mayor plasticidad y creatividad a partir del colectivo, cuando éste asume su identidad como colectivo antitaylorista.
Uma sociologia do trabalho contrastada
Bialakowsky, Alberto L.;Franco, Delia E.;Patrouilleau, M. Mercedes;Bardi, Nora;Lusnich, Cecilia;Zelaschi, Constanza;Grima, José M.;,;
Tempo Social , 2006, DOI: 10.1590/S0103-20702006000100013
Abstract: the article proposes a systematic reading of work and the institutional work processes involved in patterns of social exclusion. it specifically centres on the institutional work process in a mental health hospital, proposing an analogy with the process of factory work. as a paradigmatic model, nursing work and its history enable a re-reading of the history of workers in general, since in this area workers are dealing first-hand with comrades who find themselves in a process of social degradation. the dimensions approached from this angle include: institutional intervention and work processes; the macro-processes of social exclusion/extinction; the epistemology and co-production of research for the analysis of the social processes of work. our gnosological approach is based on co-produced research, formed by transdisciplinary intervention devices, semi-structured interviews, focused life histories, field observations, accounts from co-researcher workers and intertexts.
Empresas recuperadas: cooperación y conflicto en las nuevas formas de autogestión de los trabajadores
Alberto L. Bialakowsky,Guillermo Robledo,José Manuel Grima,Ernestina Rosendo
Revista Venezolana de Gerencia , 2004,
Abstract: El presente trabajo es el resultado de una investigación coproducida entre el equipo de la Universidad de Buenos Aires y los trabajadores de IMPA (Industria Metalúrgica Plástica Argentina), empresa recuperada por los trabajadores en el a o 1998, después de ser llevada a una situación de quiebra por sus administradores. A fines de la década de los noventa, la crisis salarial, la crisis de legitimidad acerca de la propiedad privada conmovida por la crisis financiera, la flexibilización laboral y los procesos de desalojo social, han desencadenado y van gestando distintas formas de resistencia, entre las cuales se destaca un nuevo hecho socio-productivo, con antecedentes históricos escasamente homologables. El estudio se focaliza en el contexto del Movimiento Nacional de Empresas Recuperadas. Estas experiencias interrogan a los desarrollos de la sociología del trabajo al cuestionar la lógica de los procesos taylorista-fordistas-toyotistas y al enfrentar al desafío de construir teoría crítica y propositiva en acción coproductiva. En este sentido el artículo se dirige a analizar tres aspectos vinculados con las mutaciones en el mundo del trabajo:en primer lugar, el proceso social de trabajo a la luz de estas nuevas formas de gestión y autogestión que nacen de la resistencia de la clase trabajadora por preservar su reproducción como colectivo;en segundo lugar, la mutación interna del proceso social de trabajo en fábricas recuperadas y su encadenamiento con la producción de un proceso de trabajo social de creación institucional y cultural asentado en una lógica de cooperación interinstitucional solidaria de carácter movimientista y, en tercer lugar, la emergencia de un cambio en la subjetividad de los trabajadores como resultado de la lucha frente a la dinámica de exclusión- extinción propia de las lógicas y materialidades neoliberales imperantes en la región a partir de las últimas tres décadas. El análisis de la temática propuesta implicará la utilización de una metodología investigativa cualitativa en el marco del paradigma de la complejidad y será abordado a partir de historias de vida, entrevistas, observaciones participantes y talleres coproductivos que darán cuenta, a través de las dimensiones de cooperación, poder y subjetividad, de las formas en que se recrean las identidades, la cultura y la conciencia colectiva-subjetiva en las empresas sociales .
Single-tablet regimen is associated with reduced efavirenz withdrawal in antiretroviral na ve or switching for simplification HIV-infected patients
M Fabbiani,P Grima,M Prosperi,I Fanti
Journal of the International AIDS Society , 2012, DOI: 10.7448/ias.15.6.18094
Abstract: Purpose of the study: Efavirenz (EFV) is still discussed for its high rate of interruption due to adverse event, in particular central nervous system side effects (CNS-SE). Aim of the study was to define if better drug formulations up to single tablet regimen (STR), including (EFV) plus NRTI backbone (tenofovir-emtricitabine), reduced the risk of interruption. Methods: From the database of two reference centers, patients starting any cART regimen including EFV+2 NRTI or switching to EFV+2 NRTI for simplification after virological suppression were selected. Probability of interruption by virological failure, side effects, CNS-SE and any cause were assessed with survival analysis and Cox proportional hazard model. Summary of results: Overall, 533 patients, starting EFV-containing regimen from May 1998 to March 2012, were included (51.2% na ve, 48.8% switched). Patients characteristics: males 70.7%, median age 39 years, injecting drug use (IDU) 11.2%, median nadir CD4 194/mmc, median CD4 at EFV start 305/mmc: 38.7% started BID regimen, 43.9% OD regimen and 17.4% STR. At survival analysis, the overall proportion of EFV interruption was 19.1% at 1 year and 33.0% at 3 years; interruption for virological failure were 2.8% and 7.4% and for toxicity 10.2% and 15.9%, respectively. CNS-SE accounted for about half of interruptions for toxicity (5.7% and 8.0% at 1 and 3 years, respectively). Na ve patients had a higher risk of interruption as compared to switched patients: 37.7% vs. 28.0% at 3 years (p=0.06). While no significant difference was observed comparing OD vs. B ID regimens, starting with STR was associated with significant lower proportion of overall interruption at 3 years (17.1% vs. 36.6%, p<0.01). No virological failure was observed with STR up to 3 years (0.0% vs. 8.9%, p=0.05); no difference of interruption by overall toxicity and higher, though non-significant, frequency of interruption by CNS-SE (12.8% vs. 6.8%) were also observed. STR also accounted for lower proportion of interruption by patient wish, including low adherence (1.5% vs. 12.3%, p=0.01). At adjusted Cox model, STR (HR: 0.44; 95% CI: 0.26–0.77) and male gender (HR: 0.71; 95% CI: 0.53–0.97) were associated with lower risk of EFV interruption and IDU with higher risk (HR: 1.64; 95% CI: 1.11–2.42). Conclusions: In our experience, EFV co-formulated in STR was associated with lower virological failure and higher adherence, despite keeping CNS toxicity, thus reducing the risk of treatment interruption.
Investigating the robustness of the classical enzyme kinetic equations in small intracellular compartments
Ramon Grima
BMC Systems Biology , 2009, DOI: 10.1186/1752-0509-3-101
Abstract: Starting from a master equation description of enzyme reaction kinetics and assuming metabolic steady-state conditions, we derive novel mesoscopic rate equations which take into account (i) the intrinsic molecular noise due to the low copy number of molecules in intracellular compartments (ii) the physical nature of the substrate transport process, i.e. diffusion or vesicle-mediated transport. These equations replace the conventional macroscopic and deterministic equations in the context of intracellular kinetics. The latter are recovered in the limit of infinite compartment volumes. We find that deviations from the predictions of classical kinetics are pronounced (hundreds of percent in the estimate for the reaction velocity) for enzyme reactions occurring in compartments which are smaller than approximately 200 nm, for the case of substrate transport to the compartment being mediated principally by vesicle or granule transport and in the presence of competitive enzyme inhibitors.The derived mesoscopic rate equations describe subcellular enzyme reaction kinetics, taking into account, for the first time, the simultaneous influence of both intrinsic noise and the mode of transport. They clearly show the range of applicability of the conventional deterministic equation models, namely intracellular conditions compatible with diffusive transport and simple enzyme mechanisms in several hundred nanometre-sized compartments. An active transport mechanism coupled with large intrinsic noise in enzyme concentrations is shown to lead to huge deviations from the predictions of deterministic models. This has implications for the common approach of modeling large intracellular reaction networks using ordinary differential equations and also for the calculation of the effective dosage of competitive inhibitor drugs.The inside of a cell is a highly complex environment. In the past two decades, detailed measurements of the chemical and biophysical properties of the cytoplasm have es
Directed cell migration in the presence of obstacles
Ramon Grima
Theoretical Biology and Medical Modelling , 2007, DOI: 10.1186/1742-4682-4-2
Abstract: We propose that cells can sense the presence of obstacles and avoid them because obstacles interfere with the chemical field. We build a model to test this hypothesis and find that this naturally enables efficient at-a-distance sensing to be achieved with no need for a specific and active obstacle-sensing mechanism. We find that (i) the efficiency of obstacle avoidance depends strongly on whether the chemotactic chemical reacts or remains unabsorbed at the obstacle surface. In particular, it is found that chemotactic cells generally avoid absorbing barriers much more easily than non-absorbing ones. (ii) The typically low noise in a cell's motion hinders the ability to avoid obstacles. We also derive an expression estimating the typical distance traveled by chemotactic cells in a 3D random distribution of obstacles before capture; this is a measure of the distance over which chemotaxis is viable as a means of directing cells from one point to another in vivo.Chemotactic cells, in many cases, can avoid obstacles by simply following the spatially perturbed chemical gradients around obstacles. It is thus unlikely that they have developed specialized mechanisms to cope with environments having low to moderate concentrations of obstacles.Directed cell motion is a common feature of many cells and micro-organisms; this movement can be induced by a number of factors including light (phototaxis), gravity (gravitotaxis) and various chemicals (chemotaxis). The last of these is the most pervasive natural form of taxis. The bacteria Escherichia coli and Salmonella typhimurium, the slime mould Dictyostelium discoideum, and neutrophils [1] are a few of the many well studied examples of chemotactic life-forms. Chemotaxis involves the detection of a local chemical gradient and the subsequent movement of the organism up (positive chemotaxis) or down (negative chemotaxis) the gradient. For example, Dictyostelium discoideum follows trails of folic acid secreted by its food source, bacte
An Iconography of Insularity: A Cosmological Interpretation of some Images and Spaces in the Late Neolithic Temples of Malta
Reuben Grima
Papers from the Institute of Archaeology , 2001, DOI: 10.5334/pia.164
Abstract: This paper proposes a fresh model for interpreting some of the iconography and megalithic architectural forms that emerged in Malta during the Late Neolithic. Recent studies of the relationship between the Maltese archipelago and the world beyond, and between the monumental megalithic sites and their landscape setting, will inform an interpretation of some of the iconography and architectural forms that characterize these sites. Patterns in their use of spatial order, architectural devices and carved reliefs are interpreted as elements in a programmatic recreation of an island cosmology. It is suggested that the prehistoric islanders used these images and spaces to express and mediate concerns with cosmological order.
Cultivating complexity: Maltese/Australian women in Lou Drofenik = Cultivando complexidades: mulheres maltesas-australianas nos romances de Lou Drof
Adrian Grima
Acta Scientiarum : Language and Culture , 2010,
Abstract: Most Maltese literature both before and after Independence has depicted women in stereotypical ways as weaklings who live in the shadows of their men or as mothers who are exclusively committed to their families and pass on the values and norms of the patriarchy from one generation to the next. Maltese-Australian novelist Lou Drofenik breaks with this narrative by giving a voice to the many women characters in her novels and explores the complexities of individual persons. She consistently refuses to repeat the commonplaces about womanhood and manhood and problematizes both the dominant sexual dualism itself and the positioning of woman as the privileged figure of otherness. Femininity is seen as constantly in process, and the subjectivity that most discourses seek to fix is open to dispersal. Like the young contemporary Maltese short story writer Clare Azzopardi, Drofenik tries to narrate the constantly evolving nature of becoming-woman, and sometimes becoming-man, and inevitably defies the stereotypes and the dualistic reduction of difference. A maioria da literatura oriunda de Malta pré- e pós- Independência tem continuado estereotipando as mulheres como sujeitos fracos que vivem na sombra de seus maridos ou como m es que vivem exclusivamente dedicadas às suas famílias e que transmitem estes valores e normas patriarcais às gera es futuras. A escritora maltesa-australiana, Lou Drofenik, solapa este esquema narrativo dando voz às personagensfemininas em seus romances e explora as complexidades de cada pessoa. A escritora recusa repetir os estereótipos referentes ao masculino e ao feminino e problematiza n o apenas o dualismo sexual dominante, mas também a condi o das mulheres como figura privilegiada da alteridade. A feminilidade é analisada como em processo constante e implode-se a subjetividade que a maioria dos discursos procura fixar. Semelhante à escritora maltesa contemporanea de contos, Clare Azzopardi, Drofenik narra a constante evolu o de ‘tornar-se-mulher’ e, às vezes, ‘tornar-se-homem.’ Esse esquema desafia os estereótipos e a redu o dualística da diferen a.
Monuments and landscapes in Late Neolithic Malta
Reuben Grima
Archaeology International , 2002, DOI: 10.5334/ai.0608
Abstract: The imposing prehistoric buildings of the Maltese islands have long fascinated Mediterranean travellers. They have also been the subject of much archaeological study and speculation, most of which has focused on their architectural development and the technology used to construct them. Now investigation of the relationship between these impressive sites and the islands’ landscapes is yielding new insights into how the Neolithic islanders organized their world.
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