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Search Results: 1 - 10 of 111232 matches for " José Jiun-Shian Wu "
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Network dynamics in nociceptive pathways assessed by the neuronal avalanche model
José Jiun-Shian Wu, Hsi-Chien Shih, Chen-Tung Yen, Bai-Chuang Shyu
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-33
Abstract: Neuronal activity was recorded with a 4 × 8 multichannel electrode array in the primary somatosensory cortex (S1) and anterior cingulate cortex (ACC). Under light anesthesia, peripheral pinch stimulation increased the slope of the α value in both the ACC and S1, whereas brush stimulation increased the α value only in the S1. The increase in α values was blocked in both regions under deep anesthesia. The increase in α values in the ACC induced by peripheral pinch stimulation was blocked by medial thalamic lesion, but the increase in α values in the S1 induced by brush and pinch stimulation was not affected.The neuronal avalanche model shows a critical state in the cortical network for noxious-related signal processing. The α value may provide an index of brain network activity that distinguishes the responses to somatic stimuli from the control state. These network dynamics may be valuable for the evaluation of acute nociceptive processes and may be applied to chronic pathological pain conditions.
Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis
Tsung-Chieh Chen, Jiun-Shian Wu, Wei-Pang Chang, Ping-Ning Hsu, Sung-Tsang Hsieh, Bai-Chuang Shyu
Journal of Biomedical Science , 2012, DOI: 10.1186/1423-0127-19-55
Abstract: We investigated abnormal sensory processing, neuronal peptides, and behavioral responses after the induction of autoinflammatory disease. Single-nucleotide polymorphism (SNP) markers and polymerase chain reaction product sequencing were used to identify the mutation site.All affected mice developed paw inflammation at 4–8?weeks. Histological examinations revealed hyperplasia of the epidermis in the inflamed paws and increased macrophage expression in the spleen and paw tissues. Mechanical and thermal nociceptive response thresholds were reduced in the affected mice. Locomotor activity was decreased in affected mice with inflamed hindpaws, and this reduction was attributable to the avoidance of contact of the affected paw with the floor. Motor strength and daily activity in the home cage in the affected mice did not show any significant changes. Although Fos immunoreactivity was normal in the dorsal horn of affected mice, calcitonin gene-related peptide immunoreactivity significantly increased in the deep layer of the dorsal horn. The number of microglia increased in the spinal cord, hippocampus, and cerebral cortex in affected mice, and the proliferation of microglia was maintained for a couple of months. Two hundred eighty-five SNP markers were used to reveal the affected gene locus, which was found on the distal part of chromosome 18. A point mutation was detected at A to G in exon 8 of the pstpip2 gene, resulting in a conserved tyrosine residue at amino acid 180 replaced by cysteine (Y180 C).The data provide definitive evidence that a mutation in pstpip2 causes autoinflammatory disease in an N-ethyl-N-nitrosourea mutagenesis mouse model. Thus, our pstpip2 mutant mice provide a new model for investigating the potential mechanisms of inflammatory pain.
Jiun-Shiung Wu
Taiwan Journal of Linguistics , 2008,
Abstract: Jingran indicates that the (non)occurrence of a situation that it presents contradicts the expectation, while guoran indicates that the (non)occurrence of a situation presented by it converges with the expectation. Arguing against Hsieh's (2005, 2006a, 2006b) proposal that evaluative modals in Mandarin do not have a model-theoretic semantics, I propose that, given that the expectation serves as a modal base B which an evaluative conversational background forms, jingran presents a proposition which represents a simple necessity of negation in a possible world w with respect to B, whereas guoran presents a proposition which is equivalent to a simple necessity in a possible world w with respect to B. Contrary to Hsieh's claim that modality in Mandarin has a language-specific property, i.e., that the semantics of certain modals in Mandarin cannot be defined in terms of possibility and necessity, I seek to fit modality in Mandarin into a bigger picture of modality in general and show that it is possible to achieve a universally valid notional category of modality, similar to the works of Kratzer (1981), though different languages may have language-specific choices for modal bases, which result in different types of modality in languages.
Jiun-Shiung Wu
Taiwan Journal of Linguistics , 2009,
Abstract: This paper examines how the temporal relation between a clause containing the experiential guo and an adjacent clause is determined. Mandarin is a language not morphologically marked for tenses (e.g., Lin 2006), and therefore, tenses cannot help in determining temporal relations in Mandarin. However, Mandarin has a rich aspectual system. This paper argues that the experiential guo indirectly influences temporal relations via rhetorical relations by either specifying a default rhetorical relation, or by constraining the circumstances under which a certain rhetorical relation can connect a clause with guo to an adjacent clause. This paper also argues that the default rhetorical relation and the constraints are determined by the aspectual properties of the experiential marker. Other information, such as discourse connectors, lexical information, etc., can override the default rhetorical relation indicated by guo and specifies a rhetorical relation. Therefore, this paper concludes that in Mandarin aspect markers can indirectly affect temporal relations by means of rhetorical relations, a result consistent with Wu’s (2005b) paper on the perfective marker le in Mandarin, and Wu’s (2007b, 2004) work on the progressive marker zai and the durative marker zhe.
A 3D Model of the Membrane Protein Complex Formed by the White Spot Syndrome Virus Structural Proteins
Yun-Shiang Chang,Wang-Jing Liu,Cheng-Chung Lee,Tsung-Lu Chou,Yuan-Ting Lee,Tz-Shian Wu,Jiun-Yan Huang,Wei-Tung Huang,Tai-Lin Lee,Guang-Hsiung Kou,Andrew H.-J. Wang,Chu-Fang Lo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010718
Abstract: Outbreaks of white spot disease have had a large negative economic impact on cultured shrimp worldwide. However, the pathogenesis of the causative virus, WSSV (whit spot syndrome virus), is not yet well understood. WSSV is a large enveloped virus. The WSSV virion has three structural layers surrounding its core DNA: an outer envelope, a tegument and a nucleocapsid. In this study, we investigated the protein-protein interactions of the major WSSV structural proteins, including several envelope and tegument proteins that are known to be involved in the infection process.
Cosmological matter perturbations
Jiun-Huei Proty Wu
Physics , 2000,
Abstract: We investigate matter density perturbations in models of structure formation with or without causal/acausal source. Under the fluid approximation in the linear theory, we first derive full perturbation equations in flat space with a cosmological constant $\Lambda$. We then use Green-function technique to obtain analytic solutions for matter perturbations in a flat $\Lambda=0$ model. Some incorrect solutions in the literature are corrected here. A simple yet accurate extrapolation scheme is then proposed to obtain solutions in curved or $\Lambda\neq 0$ cosmologies. Some general features of these solutions are revealed. In particular, we analytically prove that the resulting matter density perturbations are independent of the way the causal source was compensated into the background contents of the universe when it was first formed. We also use our Green-function solutions to investigate the compensation mechanism for perturbations with causal seeds, and yield a mathematically and physically explicit formin interpreting it. We found that the compensation scale depends not only on the dynamics of the universe, but also on the properties of the seeds near the horizon scale. It can be accurately located by employing our Green functions.
Cluster abundance and large scale structure
Jiun-Huei Proty Wu
Physics , 2000, DOI: 10.1046/j.1365-8711.2001.04807.x
Abstract: We use the presently observed number density of large X-ray clusters and the linear mass power spectra to constrain $\sigma_8$ and the redshift distortion parameter $\beta$, in both OCDM and $\Lambda$CDM models. The best fit to the observed mass power spectra gives $n=0.84\pm 0.67$ and $\Gamma=0.27^{+0.42}_{-0.16}$, with the theoretically expected degeneracy $\Gamma'=0.247\Gamma\exp(1.4n)=0.220^{+0.036}_{-0.031}$ (all at 95% confidence level). Based on this, we then calculate the cluster-abundance-normalized $\sigma_8$, using different models of mass function: Press & Schechter (1974), Sheth & Tormen (1999), and Lee & Shandarin (1999). The $\sigma_8$ based on the non-spherical-collapse models (ST & LS) are significantly lower, mainly due to the larger mass function within the scale range of our interest. In particular, we found $\sigma_{8{\rm (ST+LS)}}=0.477\Omega_{\rm m0}^\alpha$, where $\alpha=-0.3-0.17\Omega_{\rm m0}^{0.34}-0.13\Omega_{\Lambda 0}$. We also derive the probability distribution function of cluster formation redshift using the Lacey-Cole formalism (1993), but with modifications to incorporate non-spherical collapse. The uncertainties in our $\sigma_8$ are mainly contributed from the normalization in the virial mass-temperature relation. We also obtain for the IRAS galaxies $\sigma_{8\rm (I)}=0.78\pm 0.06$ (at 95% confidence level), and found $\beta_{\rm I(ST+LS)}=0.613\Omega_{\rm m0}^{0.24-0.16(\Omega_{\rm m0}+\Omega_{\Lambda 0})}$. This is more consistent with the recent observations than the result based on the PS formalism.
New method of extracting non-Gaussian signals
Jiun-Huei Proty Wu
Physics , 2000,
Abstract: We propose a new general method of extracting non-Gaussian features in a given field. It sets the mean of the field to zero and renormalizes its Fourier (or multipole) power to white noise, while keeping the phase information unchanged. Using simulated cosmic microwave background (CMB) as an example, we demonstrate the power of this method under many challenging circumstances. In particular, we show its capability of detecting cosmic strings in the CMB.
Cluster abundance and large-scale structure
Jiun-Huei Proty Wu
Physics , 2001, DOI: 10.1063/1.1419566
Abstract: We use the presently observed number density of large X-ray clusters and linear mass power spectra to constrain the shape parameter ($\Gamma$), the spectral index ($n$), the amplitude of matter density perturbations on the scale of $8 h^{-1}$Mpc ($\sigma_8$), and the redshift distortion parameter ($\beta$). The non-spherical-collapse model as an improvement to the Press-Schechter formula is used and yields significantly lower $\sigma_8$ and $\beta$. An analytical formalism for the formation redshift of halos is also derived.
New method of extracting non-Gaussian signals in the CMB
Jiun-Huei Proty Wu
Physics , 2001,
Abstract: Searching for and charactering the non-Gaussianity (NG) of a given field has been a vital task in many fields of science, because we expect the consequences of different physical processes to carry different statistical properties. Here we propose a new general method of extracting non-Gaussian features in a given field, and then use simulated cosmic microwave background (CMB) as an example to demonstrate its power. In particular, we show its capability of detecting cosmic strings.
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