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Search Results: 1 - 10 of 472204 matches for " José Galberto M. Costa "
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Antibacterial activity of Momordica charantia
José Galberto M. Costa,Eidla M. M. Nascimento,Fabiola F. G. Rodrigues,Adriana R. Campos
Journal of Basic and Clinical Pharmacy , 2011,
Abstract: Momordica charantia L. belongs to the family Curcubitaceae and it isvery common in many Brazilian regions. The plant is a liana with flowers and yellow fruits that present red seeds when are ripe. Popularly known as “mel o-de-s ocaetano”,“mel o amargo” or “caba o-amargo”, it possesses many uses: antidiabetic,antihelmintic, antmicrobial, anticancerigenous and antioxidant. The phytochemicalprospection of the fresh and dried leaves extracts showed the presence of different classes of secondary metabolites, asflavonoids, alkaloids and tannins, that have demonstratedantimicrobial action. Fresh and dried leaves presented significantly antimicrobial activity against all bacterial strains tested, specially Escherichia coli. Ethyl acetate fractions were effective against Escherichia coli and Bacillus cereus. The modulatory activity was significative too.
Benzoquinonas, hidroquinonas e sesquiterpenos de Auxemma glazioviana
Costa, Jose Galberto M.;Pessoa, Otília Deusdênia L.;Monte, Francisco José Q.;Menezes, Eveline A.;Lemos, Telma Leda G.;Braz-Filho, Raimundo;
Química Nova , 2005, DOI: 10.1590/S0100-40422005000400007
Abstract: two new compounds, 5 and 8, and an epimeric mixture 4a/4b were isolated from hardwood of auxemma glazioviana. their structures and relative configurations were determined by modern spectroscopic analysis to be rel-10a,11a-epoxy-11b-ethoxy-8a- hydroxy-2-methoxy -8ab-methyl-5,6,7,8,8a,9,10,10ab-octahydro-1,4-anthracenedione (or rel-2r,2ar,5r,5as ,10bs,10cs-2-ethoxy-5-hydroxy-8-methoxy-5a-methyl- 2a,3,4,5,5a,6,10b,10c-octahydro-2h-anthra[9,1-bc]furan-7,10-dione, 4a), rel-10a,11a- epoxy-11a-ethoxy-8a-hydroxy-2-methoxy-8ab-methyl-5,6,7,8,8a,9,10,10ab-octahydro- 1,4-anthracenedione (or rel-2s,2ar,5r,5as ,10bs,10cs-2-ethoxy-5-hydroxy-8-methoxy- 5a-methyl-2a,3,4,5,5a,6,10b10c-octahydro-2h-anthra[9,1-bc]furan-7,10-dione, 4b), rel-10a,11a-epoxy-8a,11-dihydroxy-2-methoxy-8ab-methyl-5,6,7,8,8a,9,10,10ab- octahydro-1,4-anthracenedione (or rel-2s,2ar,5r,5as ,10bs,10cs-2,5-dihydroxy-8- methoxy-5a-methyl-2a,3,4,5,5a,6,10b,10c-octahydro-2h-anthra[9,1-bc]furan-7,10 -dione, 5) and rel-10,11-epoxy-8ab-methyl-1,4,5a,9a-tetrahydroxy-5,6,7,8,8a,9,10,10a- octahydro-8-anthracenone (or rel-2as,5as,6r,10br ,10c5-2a,6,7,10-tetrahydroxy-5a-methyl-2a,3,4,5,5a,6,10b,10c-octahydro-2h-anthra [9,1-bc]-furan-5-one, 8). in addition, known compounds were also isolated.
Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives
Patrícia G.G. do Nascimento,Telma L.G. Lemos,Ayla M.C. Bizerra,?ngela M.C. Arriaga,Daniele A. Ferreira,Gilvandete M.P. Santiago,Raimundo Braz-Filho,José Galberto M. Costa
Molecules , 2014, DOI: 10.3390/molecules19011317
Abstract: Ursolic acid, an important bioactive compound, was isolated from ethanol extract of aerial parts of Sambucus australis. In order to develop bioactive ursolic acid derivatives, two semi-synthetic compounds were obtained through modification at C-3. The antibacterial activity of the ursolic acid and its derivatives was investigated. The microdilution method was used for determination of the minimal inhibitory concentration (MIC), against twelve bacterial strains. The influence of ursolic acid and its derivatives on the susceptibility of some bacterial pathogens to the aminoglycosides antibiotics neomycin, amikacin, kanamycin and gentamicin was evaluated. The most representative synergistic effect was observed by 3β-formyloxy-urs-12-en-28-oic acid at the concentration of 64 μg/mL in combination with kanamycin against Escherichia coli (27), a multidrug-resistant clinical isolate from sputum, with reduction of MIC value from 128 μg/mL to 8 μg/mL. Ursolic acid and its derivatives were examined for their radical scavenger activity using the DPPH assay, and showed significant activity.
Biological screening of araripe basin medicinal plants using Artemia salina Leach and pathogenic bacteria
da Costa José Galberto,Campos Adriana,Brito Samara,Pereira Carla Karine
Pharmacognosy Magazine , 2010,
Abstract: Background: Many medicinal plant species from the Araripe Basin are widely known and used in folk medicine and for commercial manufacturing of phytotherapeutic products. Few ethnobotanical and pharmacological studies have been undertaken in this region, however, in spite of the great cultural and biological diversity found there. Materials and Methods : Extracts of 11 plant species collected from Cearα state, Brazil, were subjected to the brine shrimp lethality test in order to detect potential sources of novel cytotoxic, antitumor compounds. The larvicidal activity, based on the percentage of larval mortality, was evaluated after 24 h exposure to the treatments. Results: All species tested showed good larvicidal activity as compared to a reference compound and literature data. The extract from Vanillosmopsis arborea was the most active with an LC 50 of 3.9 μg/ml. Best results were shown by Lantana montevidensis against Pseudomonas aeruginosa [minimum inhibitory concentration (MIC) 8μg/ml] and Escherichia coli (MIC 32 μg/ml), Zanthoxylum rhoifolium against E. coli (MIC, 256 μg/ml) and Staphylococcus aureus (MIC 64 μg/ml) and Croton zenhtneri against S. aureus (MIC 64 μg/ml). Conclusion: Chemical tests indicated that a wide variety of natural product classes was present in those extracts that showed significant activities in the bioassays.
Abordagem fitoquímica, composi o bromatológica e atividade antibacteriana de Mimosa tenuiflora (Wild) Poiret E Piptadenia stipulacea (Benth) Ducke =Phytochemical approach, bromatologic composition and antibacterial activity of Mimosa tenuiflora (Wild) Poiret and Piptadenia stipulacea (Benth) Ducke
Denise Aline Casimiro Bezerra,Fabíola Fernandes Galv?o Rodrigues,José Galberto Martins da Costa,Andréia Vieira Pereira
Acta Scientiarum : Biological Sciences , 2011,
Abstract: A necessidade de encontrar novas drogas eficazes no combate microbiano tem aumentado a cada dia e estimulado a busca de novos compostos naturais com atividades biológicas. Neste trabalho, realizaram-se estudo fitoquímico e análises microbiológicas com os extratos etanólicos das espécies (jurema-preta) Mimosa tenuiflora (Wild) Poiret e (juremabranca) Piptadenia stipulacea (Benth) Ducke, frente a linhagens de bactérias patogênicas. O pó da casca do caule de ambas as espécies foi submetido à avalia o bromatológica e determinados os teores de Matéria Seca, Matéria Mineral, Proteína Bruta, Fibra em Detergente Neutro e Energia Bruta. Os resultados para a prospec o química indicaram a presen a de taninos e outros compostos fenólicos, bem como a presen a de saponinas em ambos os extratos. Os extratos das duas espécies demonstraram que mais de uma parte das plantas possui atividade antimicrobiana. A composi o bromatológica da casca do caule de jurema-preta e jurema-branca apresentou teores diferenciados para as variáveis avaliadas. The need to find new efficient drugs to combat microbes has increasedthe search for new natural compounds with biological activities. In this work, phytochemical studies and microbiological analysis were carried out with the ethanol extracts of Mimosa tenuiflora (Wild) Poiret and Piptadenia stipulacea (Benth) Ducke on pathogenic bacteria strains. The bark powders of both species were submitted to bromatologic evaluation and the levels of dry matter, mineral matter, crude protein, neutral detergent fiber (NDF) and crude energy were determined. The results of the chemical search chemical showed the presence of tannins and other phenolic compounds as well as the presence of saponins in both extracts. The microbiologic evaluation of the extracts of both species showed that more than one part of the plants had antimicrobial activity. The bromatologic composition of the bark powder of Mimosa tenuiflora (Wild) Poiret and Piptadenia stipulacea (Benth) Ducke showed different contents for analyzed variables.
Study of the Interference between Plectranthus Species Essential Oils from Brazil and Aminoglycosides
Fabíola Fernandes Galv?o Rodrigues,José Galberto Martins Costa,Fábio Fernandes Galvao Rodrigues,Adriana Rolim Campos
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/724161
Attenuation of visceral pain in mice by the essential oil from Vanillosmopsis arborea bark
Leite, Gerlania de Oliveira;Sampaio, Renata Souza;Leite, Laura Hévila Inocêncio;Menezes, Irwin Rose Alencar de;Costa, José Galberto Martins da;Campos, Adriana Rolim;
Revista Dor , 2011, DOI: 10.1590/S1806-00132011000100010
Abstract: background and objectives: vanillosmopsis arborea baker (asteraceae) has high economic value and anti-inflammatory properties due the presence of alpha-bisabolol in its bark essential oil. keeping in view the high content of α-bisabolol in vanillosmopsis arborea (eova) bark essential oil, the aim of our study was to determine whether eova mitigates viscer method: mice (n = 8) were pretreated orally with eova (100, 200 e 400 mg/kg) or vehicle, and pain-related behavioral responses to intraperitoneal cyclophosphamide (cpm 400 mg/kg), intracolonic mustard oil (mo 0.75%) or capsaicin (cap 0.3%) were analyzed. results: animals that received cfm, om or cap presented spontaneous nociceptive behaviors that were significantly suppressed by eova. conclusion: these findings point to visceral antinociceptive properties of eova suggesting the potential use of vanillosmopsis arborea to treat pain associated to gastrointestinal disorders.
Estudo fitoquímico de Auxemma glazioviana Taub.
Costa, J. Galberto M.;Magalh?es, Hemerson I. F.;Lemos, Telma L. G.;Pessoa, Otília D. L.;Pinheiro, Gilvandete M.;
Revista Brasileira de Farmacognosia , 2002, DOI: 10.1590/S0102-695X2002000300033
Abstract: phytochemical investigation of heartwood of auxemma glazioviana (boraginaceae) has led to the isolation of three benzoquinones, one hydroquinone identified as: oncocalyxone a (1), oncocalyxone c (2), glazioviana a (3), glaziovianol (4) besides allantoin (5) α-bisabolol (6) and α-cadinol (7). their structures were determined based on spectral analysis, including 2d nmr experiments. essential oil obtained from heartwood by hydrodistillation was analyzed by gc/ms. the major constituents were identified as α-bisabolol and α-cadinol. the oil was active against larvae of dengue (aedes aegypti ) with dl50 2.98 ppm.
Antioxidant Effect of Stryphnodendron rotundifolium Martius Extracts from Cariri-Ceará State (Brazil): Potential Involvement in Its Therapeutic Use
José Galberto Martins da Costa,Gerlania de Oliveira Leite,Albys Ferrer Dubois,Rodrigo Lopes Seeger,Aline Augusti Boligon,Margareth Linde Athayde,Adriana Rolim Campos,Jo?o Batista Teixeira da Rocha
Molecules , 2012, DOI: 10.3390/molecules17010934
Abstract: Stryphnodendron rotundifolium is a phytotherapic used in the northeast of Brazil for the treatment of inflammatory processes which normally are associated with oxidative stress. Consequently, we have tested the antioxidant properties of hydroalcoholic (HAB) and aqueous extracts (AB) from the bark and aqueous extract (AL) from the leaves of Stryphnodendron rotundifolium to determine a possible association between antioxidant activity and the popular use of this plant. Free radical scavenger properties were assessed by the quenching of 1′,1′-diphenil-2-picrylhydrazyl (DPPH) and the calculated IC50 were: HAB = 5.4 ± 0.7, AB = 12.0 ± 2.6, and AL = 46.3 ± 12.3 μg/mL. Total phenolic contents were: HAB = 102.7 ± 2.8, AB = 114.4 ± 14.6, and AL = 93.8 ± 9.1 μg/mg plant). HPLC/DAD analyses indicated that gallic acid, catechin, rutin and caffeic acid were the major components of the crude extracts of S. rotundifolium. Plant extracts inhibited Fe(II)-induced lipid peroxidation in brain homogenates. Iron chelation was also investigated and only HBA exhibited a weak activity. Taken together, the results suggest that S. rotundifolium could be considered an effective agent in the prevention of diseases associated with oxidative stress.
Gastroprotective and Ulcer Healing Effects of Essential Oil of Hyptis martiusii Benth. (Lamiaceae)
Germana Freire Rocha Caldas, Alisson Rodrigo da Silva Oliveira, Alice Valen?a Araújo, Dafne Carolina Alves Quixabeira, Jacinto da Costa Silva-Neto, Jo?o Henrique Costa-Silva, Irwin Rose Alencar de Menezes, Fabiano Ferreira, Ana Cristina Lima Leite, José Galberto Martins da Costa, Almir Gon?alves Wanderley
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0084400
Abstract: Hyptis martiusii Benth. is an aromatic plant found in abundance in northeastern Brazil that is used in ethnomedicine to treat gastric disorders. The aim of this study was to elucidate the mechanisms of action involved in the gastroprotection of the essential oil of Hyptis martiusii (EOHM) and to evaluate its healing capacity. Wistar rats were exposed to different protocols and subsequently were treated with 1% Tween-80 aqueous solution (negative control), pantoprazole, carbenoxolone, N-acetylcysteine (depending on the specificity of each model) or EOHM. The antisecretory activity (basal or stimulated) was determined using the pyloric ligature method. The gastroprotective action of nitric oxide and sulphydryl groups (–SH groups), as well as the quantification of adherent mucus and the levels of malondialdehyde and –SH groups in gastric mucosa, were evaluated using ethanol-induced gastric ulcer model. The healing ability was evaluated using the acetic acid-induced gastric ulcer model and histological and immunohistochemical analysis (HE, PAS and PCNA). EOHM (400 mg/kg) reduced the volume and acidity of gastric secretion stimulated by histamine and pentagastrin. The gastroprotective effect of EOHM involves the participation of endogenous sulfhydryl groups. EOHM increased mucus production (54.8%), reduced levels of MDA (72.5%) and prevented the depletion of –SH groups (73.8%) in the gastric mucosa. The treatment with EOHM reduced in 70.3% the gastric lesion area, promoting significant regeneration of the gastric mucosa, as confirmed by histological analysis and analysis of proliferating cell nuclear antigen. The results show that gastroprotective effect of EOHM is mediated by cytoprotective and antioxidant mechanisms and by their antisecretory activity, and suggest that the essential oil of Hyptis martiusii is a promising candidate for the treatment of gastric ulcers.
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