oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2020 ( 74 )

2019 ( 442 )

2018 ( 566 )

2017 ( 596 )

Custom range...

Search Results: 1 - 10 of 414289 matches for " José G. Díaz Almeida "
All listed articles are free for downloading (OA Articles)
Page 1 /414289
Display every page Item
Pitiriasis rubra pilaris asociada a artritis reumatoidea: Presentación de 1 caso
Moreira Preciado,Marisela; Díaz Almeida,José G.; Pérez López,Aylet; Colomé Escobar,Magaly;
Revista Cubana de Medicina , 2000,
Abstract: the case of a 74-year-old patient with pityriasis rubra pilaris of 10 years of evolution was presented. it was observed that the skin disease was associated with rheumatoid arthritis, which made the authors think about the possible etiologic role played by the immunological factors in pityriasis rubra pilaris. a bladder papillary carcinoma, mutiple seborrheic keratosis, a laryngeal bening tumor, basal carcinomas and a keratoacanthoma appeared during its evolution. the patient received treatment with methotrexate, but it was not successful for its prp. a good response was observed with etretinate
Liquen escleroso y atrófico extragenital
Moreira Preciado,Marisela; Díaz Almeida,José G.; Moredo Romo,Edelisa;
Revista Cubana de Medicina , 2003,
Abstract: some aspects on lichen sclerosus et atrophicus (lsa) were updated and the results of the clinicoepidemiological study conducted among 12 patients with extragenital lichen sclerosus et atrophicus were presented. al l the reviewed cases corresponded to white individuals and the highest incidence was observed in women over 40. the most frequent localization of the injuries was the thorax.
Pioderma gangrenoso vegetante asociado con insuficiencia renal
Moreira Preciado,Marisela; Díaz Almeida,José G.; Pérez López,Aylet;
Revista Cubana de Medicina Tropical , 2001,
Abstract: a case report was presented in which a patient developed vegetative pyoderma gangrenosum that was concomitant with acute renal failure; this led to the critical condition of the patient. he was initially treated with systemic antibiotics because his clinical picture was considered to be pyodermitis, but the response was unsatisfactory. after being treated with levamizol and alfa interferon, an improvement in his general condition and skin lesions was observed. then surgical exeresis was successfully performed, with skin self-grafting in the face and penis lesions. pyoderma gangrenosum lesions relapsed but they were treated with prednisone, and then there was a rapid elimination of lesions every time they came up.
Pitiriasis rubra pilaris asociada a artritis reumatoidea: Presentación de 1 caso
Marisela Moreira Preciado,José G. Díaz Almeida,Aylet Pérez López,Magaly Colomé Escobar
Revista Cubana de Medicina , 2000,
Abstract: Se presentó 1 caso de pitiriasis rubra pilaris eritrodérmica de 10 a os de evolución en 1 paciente de 74 a os de edad. Se observó que la enfermedad cutánea se asoció con artritis reumatoidea lo que hizo pensar a los autores en el posible papel etiológico de los factores inmunológicos en la pitiriasis rubra pilaris. Durante su evolución también se presentó un carcinoma papilar de vejiga, queratosis seborreicas múltiples, nódulo laríngeo benigno, carcinomas basales y un queratoacantoma. Se impuso tratamiento con methotrexate, pero no resultó satisfactorio para su PRP. Se obtuvo una buena respuesta con el etretinato The case of a 74-year-old patient with pityriasis rubra pilaris of 10 years of evolution was presented. It was observed that the skin disease was associated with rheumatoid arthritis, which made the authors think about the possible etiologic role played by the immunological factors in pityriasis rubra pilaris. A bladder papillary carcinoma, mutiple seborrheic keratosis, a laryngeal bening tumor, basal carcinomas and a keratoacanthoma appeared during its evolution. The patient received treatment with methotrexate, but it was not successful for its PRP. A good response was observed with etretinate
Acné vulgar e inmunidad celular
Addis Abad Machado,Victoria Fundora Guerra,José G. Díaz Almeida,Isabel Molinet Duarte
Revista Cubana de Medicina , 1996,
Abstract: Se realizó un estudio prospectivo de la inmunidad celular de 44 pacientes con acné que acudieron a la Consulta Externa del Hospital "General Calixto García" durante el a o 1992, mediante el test de roseta espontánea y de roseta activa, para aportar nuevos elementos que ayuden a esclarecer uno de los aspectos más controvertidos de la patogenia del acné, el inmunológico. La formación de roseta espontánea estuvo por debajo de los valores normales en el 64 % de los enfermos, en el de roseta activa tuvieron respuesta normal el 55 % de los casos. Hubo disminución significativa de la formación de roseta espontánea y activa en relación con los grados de intensidad del acné. En los pacientes con acné vulgar estudiados, la inmunidad celular parece estar comprometida y relacionada con los grados de intensidad del acné, hecho muy importante que abriría nuevas perspectivas en la inmunoterapia para el tratamiento de esta afección. A prospective study of cell-mediated immunity was carried out in 44 patients presenting with acne who were attended at the out patient service of "Calixto García" Hospital during 1992, by the spontaneous rosetting assay and the active roselting formation test with the aim of providing with new elements for elucidating one of the most controversial aspects of the pathogenesis of acne, i.e. the immunological aspect. The spontaneous rosetting formation was found to be below normal values in 64 % of patients, while the active rosething formation showed a normal response in 55 % of cases. There was a significant reduction in the formation of spontaneous and active rosettes related to the severity degree of acne. In patients presenting with acne vulgaris, the cell-mediated immunity seems to be compromized and related to the degrees of severity of the disease, fact that appears to be very important and may lead to new perspectives for the immunologic therapy of this condition.
Pioderma gangrenoso vegetante asociado con insuficiencia renal
Marisela Moreira Preciado,José G. Díaz Almeida,Aylet Pérez López
Revista Cubana de Medicina Tropical , 2001,
Abstract: Se presentó el caso de un paciente que desarrolló un pioderma gangrenoso vegetante que concomitaba con una insuficiencia renal aguda, esto lo llevó a un estado de gravedad extrema. El paciente recibió tratamiento inicialmente con antibióticos sistémicos por considerarse el cuadro como una piodermitis, pero no se obtuvo una respuesta satisfactoria. Después fue tratado con Levamizol y alfa interferón, y se logró con este tratamiento mejoría de su estado general y de sus lesiones cutáneas. Se realizó entonces exéresis quirúrgica, con autoinjerto de las lesiones de la cara y el pene, con buenos resultados. Las lesiones pioderma gangrenoso fueron recidivantes, se trataron con prednisona y se obtuvo una rápida resolución de las lesiones en cada ocasión que se presentaron. A case report was presented in which a patient developed vegetative pyoderma gangrenosum that was concomitant with acute renal failure; this led to the critical condition of the patient. He was initially treated with systemic antibiotics because his clinical picture was considered to be pyodermitis, but the response was unsatisfactory. After being treated with levamizol and alfa interferon, an improvement in his general condition and skin lesions was observed. Then surgical exeresis was successfully performed, with skin self-grafting in the face and penis lesions. Pyoderma gangrenosum lesions relapsed but they were treated with prednisone, and then there was a rapid elimination of lesions every time they came up.
Liquen escleroso y atrófico extragenital
Marisela Moreira Preciado,José G. Díaz Almeida,Edelisa Moredo Romo
Revista Cubana de Medicina , 2003,
Abstract: Se actualizaron algunos aspectos del liquen escleroso y atrófico (LEA) y se presentaron los resultados del estudio clínico-epidemiológico de 12 pacientes con LEA extragenital. Todos los casos revisados pertenecían a la raza blanca y la mayor incidencia se encontró en mujeres mayores de 40 a os. La localización de las lesiones fue más frecuente en el tórax. Some aspects on lichen sclerosus et atrophicus (LSA) were updated and the results of the clinicoepidemiological study conducted among 12 patients with extragenital lichen sclerosus et atrophicus were presented. Al l the reviewed cases corresponded to white individuals and the highest incidence was observed in women over 40. The most frequent localization of the injuries was the thorax.
Acné vulgar e inmunidad celular
Abad Machado,Addis; Fundora Guerra,Victoria; Díaz Almeida,José G.; Molinet Duarte,Isabel; Manrique,Juan René;
Revista Cubana de Medicina , 1996,
Abstract: a prospective study of cell-mediated immunity was carried out in 44 patients presenting with acne who were attended at the out patient service of "calixto garcía" hospital during 1992, by the spontaneous rosetting assay and the active roselting formation test with the aim of providing with new elements for elucidating one of the most controversial aspects of the pathogenesis of acne, i.e. the immunological aspect. the spontaneous rosetting formation was found to be below normal values in 64 % of patients, while the active rosething formation showed a normal response in 55 % of cases. there was a significant reduction in the formation of spontaneous and active rosettes related to the severity degree of acne. in patients presenting with acne vulgaris, the cell-mediated immunity seems to be compromized and related to the degrees of severity of the disease, fact that appears to be very important and may lead to new perspectives for the immunologic therapy of this condition.
Strategies in secondary biliary fibrosis  [PDF]
José M. Hermosillo-Sandoval, Adolfo D. Rodríguez-Carrizález, Alejandra G. Miranda-Díaz
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.68A2002
Abstract: The cellular and molecular mechanisms that mediate hepatic fibrosis have provided a framework of different therapeutic foci to prevent, delay or in such case revert fibrosis and cirrhosis. The fundamental event in development of hepatic fibrosis caused by secondary biliary cholestasis is based on activation of the hepatic stellar cells (HSC) which the primary function is forming fibrosis. The activated HSC cells transform into myofibroblasts with capacity to produce alpha smooth muscle actin (α-SMA). As a result, the HSC activates proliferation of the cholangiocytes and epithelial cells whose functions represent important anti-fibrotic objectives. Some strategies are described as targeting against molecule involved in fibrosis production; and some medications with anti-fibrotic functions that are actually available in the medical arsenal have been tested in experimental animal models and in few clinical studies, and their components act in relation to the fibrotic cascade. In the end, the treatment strategies for hepatic fibrosis can vary on an individual basis depending on the etiology, the risk of fibrosis progression and the predominant pathogenic medium, which indicates that a multi-factorial approach could be necessary. Orthotopic liver transplant continues being the last final alternative for hepatic insufficiency from any cause; however, in no way does it supersede healthy natural liver in survival and adequate function. The investigative arsenal continues to develop rapidly, giving rise to other possible objectives in pre-clinical studies of conceptual trials, such as the utilization of molecular, cellular, drugs therapy and Chinese herbs. Despite being aforementioned, there are no existing ideal alternatives that completely reverse fibrosis in humans. Future usefulness of the majority of management alternatives seems probable and could be feasible.
Evaluation of the effect of compound aqueous solubility in cytochrome P450 inhibition assays  [PDF]
José Pérez, Caridad Díaz, Irene G. Salado, Daniel I. Pérez, Fernando Peláez, Olga Genilloud, Francisca Vicente
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.45083
Abstract:

It is a common practice in drug discovery organizations to screen new chemical entities in order to predict future drug-drug interactions. For this purpose, there are two main assay strategies, one based on recombinant cytochrome P450 (rCYP) enzymes and fluorescent detection, and other on human liver microsomes (HLM) and liquid chromatography coupled to mass spectrometry. Many authors have reported a poor correlation between both technologies, giving rise to concerns about the usefulness of fluorometric methods for predicting drug-drug interactions. In this study, we investigated the role that compound aqueous kinetic solubility may play in this lack of correlation. We found that drug discovery compounds with unacceptable kinetic solubility, measured by a turbidimetric solutibility assay, tended to yield higher IC50 values in in vitro models based on human liver microsomes, whereas compounds with kinetic solubility values higher than 50 μM showed very similar IC50 values in both in vitro models. Our results show that the turbidimetric solubility assay is a useful tool to identify those discovery compounds that may require further investigation in order to avoid overlooking future drug-drug interactions.

Page 1 /414289
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.