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Search Results: 1 - 10 of 114301 matches for " José Fernández-Britto Rodríguez "
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La lesión aterosclerótica: estado del arte a las puertas del siglo XXI
Fernández-Britto Rodríguez,José E;
Revista Cubana de Investigaciones Biom??dicas , 1998,
Abstract: medical literature, particularly the research works carried out by the center for investigations and reference of atherosclerosis of havana are reviewed. the most relevant historical events related to the first atherosclerotic lesions studied in egyptian mummies are stated. reference is made to the most usual classifications for this type of lesions since 1957 (world health organization): fatty streak, fibrous plaque, complicated plaque and calcified plaque. the concept of calcified and complicated plaques unified into equally severe plaque concept are analyzed. reference is also made to the methods for studying the lesions and to the stary’s classification into six kinds of atherosclerotic lesions. the factors affecting the development of lesions making special emphasis on the role of lipids, the endothelium, smooth muscle cells (contractile and synthetic), macrophages, various growth factores, free radicals and the response of the connective tissue of the arterial wall are chronologically described. the connective tissue of the arterial wall which includes the inflammatory and immunity mechanisms in its defense actions, causes and develops the atherosclerotic plaque. the mechanisms by which the plaque rupture occurs leading to the thrombosis (atherothrombosis) and infarcts in the affected areas are explained.
La lesión aterosclerótica: estado del arte a las puertas del siglo XXI
José E Fernández-Britto Rodríguez
Revista Cubana de Investigaciones Biom??dicas , 1998,
Abstract: Se revisa la literatura médica y principalmente las investigaciones terminadas en el Centro de Investigaciones y Referencia de Aterosclerosis de La Habana. Se mencionan los hechos históricos más relevantes de las primeras lesiones ateroscleróticas estudiadas en momias egipcias. Se hace referencia a las clasificaciones más usadas de este tipo de lesiones desde 1957 (Organización Mundial de la Salud): estría adiposa, placa fibrosa, placa complicada y placa calcificada. Se analiza el concepto de unificación de las placas complicadas y calcificadas como lesiones de igual valor de gravedad y la introducción del concepto de placa grave. Se hace referencia a los métodos de estudiar las lesiones y a la clasificación de Stary, en 6 variedades de lesiones ateroscleróticas. Se describen en forma cronológica los fenómenos que influyen en el desarrollo de la lesión, con especial énfasis en el papel de los lípidos, el endotelio, las células musculares lisas (contráctiles y sintéticas), los macrófagos, los diferentes factores de crecimiento, los radicales libres y la respuesta del tejido conectivo de la pared arterial, que englobando en sus acciones de defensa los mecanismos de inflamación e inmunidad crea y desarrolla la placa aterosclerótica. Se mencionan los mecanismos por los cuales la placa se rompe produciendo la trombosis (aterotrombosis) que lleva a los infartos de los territorios afectados. Medical literature, particularly the research works carried out by the Center for Investigations and Reference of Atherosclerosis of Havana are reviewed. The most relevant historical events related to the first atherosclerotic lesions studied in Egyptian mummies are stated. Reference is made to the most usual classifications for this type of lesions since 1957 (World Health Organization): fatty streak, fibrous plaque, complicated plaque and calcified plaque. The concept of calcified and complicated plaques unified into equally severe plaque concept are analyzed. Reference is also made to the methods for studying the lesions and to the Stary’s classification into six kinds of atherosclerotic lesions. The factors affecting the development of lesions making special emphasis on the role of lipids, the endothelium, smooth muscle cells (contractile and synthetic), macrophages, various growth factores, free radicals and the response of the connective tissue of the arterial wall are chronologically described. The connective tissue of the arterial wall which includes the inflammatory and immunity mechanisms in its defense actions, causes and develops the atherosclerotic plaque. The
EDITORIAL
José Emilio Fernández-Britto Rodríguez
Revista Habanera de Ciencias M??dicas , 2012,
Abstract:
Metabolismo de la homocisteína y su relación con la aterosclerosis
Menéndez Cabezas,Arturo; Fernández-Britto Rodríguez,José E;
Revista Cubana de Investigaciones Biom??dicas , 1999,
Abstract: a review on the details of the metabolism of homocysteine, a sulfur-containing amino acid that is normally obtained from methionine during the accomplishment of its function as a donor of methyl groups was made. its possible metabolic destinations are analyzed, particularly the remethylation and the transsulfuration, in which the coenzymatic forms of vitamins b6, b12 and folate are involved, as well as its oxidation with which homocystine and mixed disulphides including the so-called homocystein attached to protcin, which is the main form circulating in plasma and in other destinations described in literature, are originated. the methods for stimating its plasmatic concentration and its reference values are related. the possible cause of hyperhomocysteinemia and the physiopathological mechanisms that link this status to atherogenesis and that try to explain the proposed hyperhomocysteinemia- atherosclerosis relation established by the results of epidemiological and clinical studies during the last 30 years are analyzed.
Metabolismo de la homocisteína y su relación con la aterosclerosis
Arturo Menéndez Cabezas,José E Fernández-Britto Rodríguez
Revista Cubana de Investigaciones Biom??dicas , 1999,
Abstract: Se realizó una revisión sobre los detalles del metabolismo de la homocisteína, aminoácido azufrado que se forma normalmente a partir de la metionina durante el cumplimiento de su función de donante de grupos metilos. Se analizaron sus posibles destinos metabólicos, en particular la remetilación y la transulfuración, en las que están implicadas las formas coenzimáticas de las vitaminas folacina, B12 y B6; así como su oxidación con lo que se origina la homocistina y disulfuros mixtos que incluyen a la llamada homocisteína ligada a proteína, forma principal que circula en el plasma, y otros destinos descritos en la literatura. Se relacionan los métodos de estimación de su concentración plasmática y sus valores de referencia. Se analizaron las posibles causas de hiperhomocisteinemia y los mecanismos fisiopatológicos que vinculan a este estado con la aterogénesis y que tratan de explicar la relación hiperhomocisteinemia-aterosclerosis, propuesta fundamentada por los resultados de estudios epidemiológicos y clínicos de los últimos 30 a os. A review on the details of the metabolism of homocysteine, a sulfur-containing amino acid that is normally obtained from methionine during the accomplishment of its function as a donor of methyl groups was made. Its possible metabolic destinations are analyzed, particularly the remethylation and the transsulfuration, in which the coenzymatic forms of vitamins B6, B12 and folate are involved, as well as its oxidation with which homocystine and mixed disulphides including the so-called homocystein attached to protcin, which is the main form circulating in plasma and in other destinations described in literature, are originated. The methods for stimating its plasmatic concentration and its reference values are related. The possible cause of hyperhomocysteinemia and the physiopathological mechanisms that link this status to atherogenesis and that try to explain the proposed hyperhomocysteinemia- atherosclerosis relation established by the results of epidemiological and clinical studies during the last 30 years are analyzed.
La lesión aterosclerótica coronaria en la muerte súbita: aplicación del sistema aterométrico
Falcón Vilaú,Leonel; Fernández-Britto Rodríguez,José E; Castillo Herrera,José A;
Revista Cubana de Investigaciones Biom??dicas , 2000,
Abstract: the main branches of the right, anterior descending and left circumflex coronary epicardial arteries of 237 patients that died from sudden death according to the selection criteria established by the world health organization and of 113 patients who died from non cardiovascular causes and without history of atherosclerotic risk factor, a group of low atherosclerotic level used as control, were studied. both populations were the result of consecutive necropsies performed in persons over 15. the atherometric system was used for the morphological and morphometric characterization of the atherosclerotic lesion. the injured intimal surface was larger in the group of sudden death and its atherosclerotic profile was characterized by the strong predominance of the elevated lesions represented by the fibrous and severe plaques, which account for a higher index of obstruction and stenosis and a greater severity of the atherosclerotic process in this group. fibrous and severe plaques showed a high signification, both isolated and as a whole, when the one-way variance analysis (anova) and the multivariate analysis (manova) were applied, respectively. this explained the quantitative differences found on comparing the mean values of the atherosclerotic lesions in the coronary arteries of the studied groups
La lesión aterosclerótica coronaria en la muerte súbita: aplicación del sistema aterométrico
Leonel Falcón Vilaú,José E Fernández-Britto Rodríguez,José A Castillo Herrera
Revista Cubana de Investigaciones Biom??dicas , 2000,
Abstract: Se estudiaron las ramas principales de las arterias coronarias epicárdicas derecha, descendente anterior y circunfleja izquierda de 237 fallecidos súbitamente, mediante los criterios de selección establecidos por la Organización Mundial de la Salud, y 113 fallecidos por causas no cardiovasculares y sin antecedentes de factores de riesgo aterosclerótico, grupo de bajo nivel aterosclerótico utilizado como control. Ambas poblaciones eran el resultado de necropsias consecutivas y en personas mayores de 15 a os. Para la caracterización morfológica y morfométrica de la lesión aterosclerótica se utilizó el sistema aterométrico. La superficie intimal lesionada resultó mayor en el grupo de muerte súbita y se caracterizó su perfil aterosclerótico por el fuerte predominio de las lesiones elevadas representadas por las placas fibrosas y las placas graves, las que conforman un índice de obstrucción y estenosis superior y una mayor severidad del proceso aterosclerótico en este grupo. Las placas fibrosas y graves mostraron alta significación, tanto de forma aislada, como en su conjunto, cuando se aplicaron los análisis de varianza de una vía (ANOVA) y multivariado (MANOVA), respectivamente. Esto explicó las diferencias cuantitativas encontradas en la comparación de los valores medios de las lesiones ateroscleróticas en las coronarias de los grupos estudiados The main branches of the right, anterior descending and left circumflex coronary epicardial arteries of 237 patients that died from sudden death according to the selection criteria established by the World Health Organization and of 113 patients who died from non cardiovascular causes and without history of atherosclerotic risk factor, a group of low atherosclerotic level used as control, were studied. Both populations were the result of consecutive necropsies performed in persons over 15. The atherometric system was used for the morphological and morphometric characterization of the atherosclerotic lesion. The injured intimal surface was larger in the group of sudden death and its atherosclerotic profile was characterized by the strong predominance of the elevated lesions represented by the fibrous and severe plaques, which account for a higher index of obstruction and stenosis and a greater severity of the atherosclerotic process in this group. Fibrous and severe plaques showed a high signification, both isolated and as a whole, when the one-way variance analysis (ANOVA) and the multivariate analysis (MANOVA) were applied, respectively. This explained the quantitative differences found on comparing the mean valu
Asociación patomorfológica y morfométrica de la lesión aterosclerótica en siete diferentes sectores arteriales
Serra Ortega,Alain; Fernández-Britto Rodríguez,José; Campos,R;
Revista Cubana de Investigaciones Biom??dicas , 2008,
Abstract: four hundred and sixty necropsies of patients from "carlos j. finlay" hospital performed between 1999 and 2003 were investigated. eighteen arteries from the following seven vascular arteries were analyzed: willis circle, considered as only one artery, the three epicardial coronaries (right, anterior descending and left circumflex) , the aorta (thoracic and abdominal); the two renal, the iliac and the phemoral. an atherometric system was used for the pathomorphological and morphometric study. the arteries were dissected, fixed and coloured. a qualitative and quantitative analysis was made for the statistical study by canonical correlation. among the most important results there were observed very strong correlations between the adipose stria, the fibrous plaque and the severe plaque in the analyses of all among all the investigated arteries, with a few exceptions. all these results strongly suggest that atherosclerosis is a process of systemic distribution
Adherencia terapéutica farmacológica antihipertensiva en adultos de atención primaria y factores relacionados con su incumplimiento
Quintana Setién,Carlos; Fernández-Britto Rodríguez,José Emilio;
Revista Cubana de Investigaciones Biom??dicas , 2009,
Abstract: the control of blood pressure and the drug therapy compliance are related. the objective of this research study is to find out the prevalence of this compliance, the factors that propitiate it and to assess the usefulness of this procedure to measure such compliance. this procedure resulted from the combination of indirect methods of measuring drug therapy compliance. a population-based study was performed in six doctor′s offices from "vedado", "dr. diego tamayo" and "heroes de girón" teaching polyclinics located in plaza de la revolución, habana vieja and cerro municipalities, respectively. three hundred and twenty nine patients were interviewed and examined through a data model that allows relating lifestyles and compliance with the therapy. adherence was determined in 37.4 % of cases and favorably correlated with age, sex, educational level, exercising, living with another person, balanced diet and regular visits to the doctor's. the study suggested that the procedure can be used and that the variables for definition of therapy compliance profile should be taken into account.
Nuevos modelos conceptual y matemático para el contorno de la onda de volumen de pulso arterial
Pascau Simón,Alexander; Fernández-Britto Rodríguez,José E; Allen,John;
Revista Cubana de Investigaciones Biom??dicas , 2011,
Abstract: introduction: the analysis of volume wave contour of arterial pulse has been useful for non-invasive diagnosis of cardiovascular diseases, but the pathophysiological origins contributing to this contour are not totally explained. the objective of present paper was to find the coincidence level of a new simple conceptual form, based on the hemodynamic strengths regarding a new mathematical form applied to different classes of volume waves of arterial pulse in toe fingers. methods: the proposal of conceptual form was based on that this contour is the addition of pairs of action hemodynamic strengths gradients from the heart, aorta and the peripheral arterial zone and of the reactions coming from study musculoelastic arterial wall. the mathematical form was designed as a non-lineal programming problem to find the six numeral unknown quantities of each pair of gradients, under non-lineal restriction based on its temporary relations. the contours from toe fingers were registered in patients with four potential classes of volume wave known contours of arterial pulse. the fitting quality of 4 403 experimental above mentioned contours was analyzed versus the arterial pulse volume resulting from mathematical form of 123 registries of 14 patients (7 women). results: there was predominance of iii class, the i and ii ones were frequent in patients with less cardiovascular risk and the iv class in those of great risk. the 64% of the wave volume of arterial pulse had a quality fitting > 95% and the 36% had the presence of oscillating waves from skeletal muscle. conclusions: the coincidence of both forms is accepted to characterize in a morphologic way the contour of any class of wave volume of arterial pulse.
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