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Search Results: 1 - 10 of 115650 matches for " José Eugenio; Fernández-Britto Rodríguez "
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Prevalencia y formas de insuficiencia cardíaca en mayores de 65 a os Prevalence and heart failure in over 65 years-old elders
José Eugenio Negrín Expósito,José Emilio Fernández-Britto Rodríguez,José A. Castillo Herrera,Gerardo Senra Armas
Revista Cubana de Investigaciones Biom??dicas , 2007,
Abstract: Se realizó un estudio poblacional en 10 consultorios de médicos de familia seleccionados al azar, con el objetivo de conocer la prevalencia y formas de insuficiencia cardíaca en pacientes mayores de 65 a os, del policlínico "Marcio Manduley" de Centro Habana. Fueron entrevistados y examinados 805 casos, de los cuales se recogieron síntomas y signos de insuficiencia cardíaca. A los que tenían 2 síntomas y signos o más, se les realizó ecocardiograma y si existía disfunción sistólica o diastólica, o ambas, se consideraron casos positivos de insuficiencia cardíaca. Se obtuvieron 2 síntomas y signos o más, en 111 casos, el ecocardiograma fue positivo de insuficiencia cardíaca en 87 de estos, o sea, la prevalencia total cardíaca fue 10,8 %. Presentaron disfunción sistólica 18,4 %, diastólica 42,5 % y mixta 39,0 %. Se concluyó que la prevalencia de insuficiencia cardíaca fue elevada. La presencia de insuficiencia cardíaca diastólica aislada debe ser buscada activamente. A population-based study was carried out in 10 randomly selected family physician’s offices, with the objective of determining the prevalence and forms of heart failure in patients aged over 65 years seen at "Marcio Manduley" polyclinics in Centro Habana municipality. Eight hundred and five cases were interviewed and tested to collect heart failure symptoms and signs. Echocardiogram was performed in those who presented with two or more symptoms and signs; if there was systolic or diastolic dysfunction or both, these cases were considered positive to heart failure. One hundred and eleven cases showed two or more symptoms and signs, echocardiogram showed heart failure in 87 cases, that is, the total heart failure prevalence was 10.8 %. 18.4 % had systolic dysfunction, 42.5 % diastolic and 39 % both. It was concluded that heart failure prevalence was high. Isolated diastolic heart failure should be actively traced.
Factores de riesgo, manifestaciones clínicas y tratamiento de la insuficiencia cardiaca en mayores de 65 a os Risk factors, clinical manifestations and treatment of heart failure in over 65 years-old patients
José Eugenio Negrín Expósito,José Emilio Fernández-Britto Rodríguez,José A. Castillo Herrera,Gerardo Senra Armas
Revista Cubana de Investigaciones Biom??dicas , 2007,
Abstract: Se realizó un estudio poblacional en 10 consultorios de médicos de familia seleccionados al azar para conocer la etiología, los síntomas, signos y el tratamiento de la insuficiencia cardiaca en pacientes mayores de 65 a os. Se entrevistaron y examinaron 805 casos, se recogieron enfermedades previas, síntomas y signos, y tratamientos utilizados en ese momento. A los que tenían 2 síntomas y signos o más, se les realizó ecocardiograma y si existía disfunción sistólica y/o diastólica se consideraron casos positivos de insuficiencia cardiaca. Los principales factores etiológicos (solos o asociados) fueron hipertensión arterial 75,7 % y cardiopatía isquémica 61,3 %; la combinación de disnea de esfuerzo y edemas de miembros inferiores fue la más frecuente (54 %). Usaban diuréticos 55,1 %, inhibidores de la enzima convertidora de angiotensina 42,5 %, betabloqueadores 18,3 % y digoxina 43,6 %. La hipertensión arterial fue el principal factor etiológico. Hubo casos con insuficiencia cardiaca que estando ambulatorios, presentaron pocos síntomas. La mayoría no estaba recibiendo tratamiento adecuado. A population-based study was carried out in ten randomly selected family physician` offices in order to find out the etiology, symptoms, signs and treatment of heart failure in over 65 years-old patients. Eight hundred and five cases were surveyed and examined, data on previous diseases, symptoms, signs and therapies at that moment were collected. Those patients with two or more symptoms and signs underwent echocardiogram and in case of systolic and/or diastolic dysfunction, they were classified as heart failure cases. The main etiological factors (single or associated) were blood hypertension in 75,7 % of cases and ischemic cardiopathy in 61,3 %; the combination of effort dyspnea and swollen low limbers was the most common (54 %). Of the total number of patients, 55,1 % used diuretics; 42,5 % took angiotensin- converting enzyme inhibitors; 18,3 % used beta blockers whereas 43,6 % was prescribed Digoxin. Hypertension was the main etiological factor. There were cases of heart failure seen at outpatient service, but with few symptoms. Most of patients were not being properly treated.
Factores de riesgo, manifestaciones clínicas y tratamiento de la insuficiencia cardiaca en mayores de 65 a?os
Negrín Expósito,José Eugenio; Fernández-Britto Rodríguez,José Emilio; Castillo Herrera,José A.; Senra Armas,Gerardo; Gutiérrez Rojas,ángela; Pérez Yn,Mercedes; Rodríguez de Armas,Lissette; Rodríguez,Luis Reinaldo;
Revista Cubana de Investigaciones Biom??dicas , 2007,
Abstract: a population-based study was carried out in ten randomly selected family physician` offices in order to find out the etiology, symptoms, signs and treatment of heart failure in over 65 years-old patients. eight hundred and five cases were surveyed and examined, data on previous diseases, symptoms, signs and therapies at that moment were collected. those patients with two or more symptoms and signs underwent echocardiogram and in case of systolic and/or diastolic dysfunction, they were classified as heart failure cases. the main etiological factors (single or associated) were blood hypertension in 75,7 % of cases and ischemic cardiopathy in 61,3 %; the combination of effort dyspnea and swollen low limbers was the most common (54 %). of the total number of patients, 55,1 % used diuretics; 42,5 % took angiotensin- converting enzyme inhibitors; 18,3 % used beta blockers whereas 43,6 % was prescribed digoxin. hypertension was the main etiological factor. there were cases of heart failure seen at outpatient service, but with few symptoms. most of patients were not being properly treated.
Prevalencia y formas de insuficiencia cardíaca en mayores de 65 a?os
Negrín Expósito,José Eugenio; Fernández-Britto Rodríguez,José Emilio; Castillo Herrera,José A.; Senra Armas,Gerardo; Gutiérrez Rojas,Angela; Pérez Yn,Mercedes; Rodríguez de Armas,Lissette; Rodríguez,Luis Reinaldo;
Revista Cubana de Investigaciones Biom??dicas , 2007,
Abstract: a population-based study was carried out in 10 randomly selected family physician?s offices, with the objective of determining the prevalence and forms of heart failure in patients aged over 65 years seen at "marcio manduley" polyclinics in centro habana municipality. eight hundred and five cases were interviewed and tested to collect heart failure symptoms and signs. echocardiogram was performed in those who presented with two or more symptoms and signs; if there was systolic or diastolic dysfunction or both, these cases were considered positive to heart failure. one hundred and eleven cases showed two or more symptoms and signs, echocardiogram showed heart failure in 87 cases, that is, the total heart failure prevalence was 10.8 %. 18.4 % had systolic dysfunction, 42.5 % diastolic and 39 % both. it was concluded that heart failure prevalence was high. isolated diastolic heart failure should be actively traced.
La lesión aterosclerótica: estado del arte a las puertas del siglo XXI
Fernández-Britto Rodríguez,José E;
Revista Cubana de Investigaciones Biom??dicas , 1998,
Abstract: medical literature, particularly the research works carried out by the center for investigations and reference of atherosclerosis of havana are reviewed. the most relevant historical events related to the first atherosclerotic lesions studied in egyptian mummies are stated. reference is made to the most usual classifications for this type of lesions since 1957 (world health organization): fatty streak, fibrous plaque, complicated plaque and calcified plaque. the concept of calcified and complicated plaques unified into equally severe plaque concept are analyzed. reference is also made to the methods for studying the lesions and to the stary’s classification into six kinds of atherosclerotic lesions. the factors affecting the development of lesions making special emphasis on the role of lipids, the endothelium, smooth muscle cells (contractile and synthetic), macrophages, various growth factores, free radicals and the response of the connective tissue of the arterial wall are chronologically described. the connective tissue of the arterial wall which includes the inflammatory and immunity mechanisms in its defense actions, causes and develops the atherosclerotic plaque. the mechanisms by which the plaque rupture occurs leading to the thrombosis (atherothrombosis) and infarcts in the affected areas are explained.
La lesión aterosclerótica: estado del arte a las puertas del siglo XXI
José E Fernández-Britto Rodríguez
Revista Cubana de Investigaciones Biom??dicas , 1998,
Abstract: Se revisa la literatura médica y principalmente las investigaciones terminadas en el Centro de Investigaciones y Referencia de Aterosclerosis de La Habana. Se mencionan los hechos históricos más relevantes de las primeras lesiones ateroscleróticas estudiadas en momias egipcias. Se hace referencia a las clasificaciones más usadas de este tipo de lesiones desde 1957 (Organización Mundial de la Salud): estría adiposa, placa fibrosa, placa complicada y placa calcificada. Se analiza el concepto de unificación de las placas complicadas y calcificadas como lesiones de igual valor de gravedad y la introducción del concepto de placa grave. Se hace referencia a los métodos de estudiar las lesiones y a la clasificación de Stary, en 6 variedades de lesiones ateroscleróticas. Se describen en forma cronológica los fenómenos que influyen en el desarrollo de la lesión, con especial énfasis en el papel de los lípidos, el endotelio, las células musculares lisas (contráctiles y sintéticas), los macrófagos, los diferentes factores de crecimiento, los radicales libres y la respuesta del tejido conectivo de la pared arterial, que englobando en sus acciones de defensa los mecanismos de inflamación e inmunidad crea y desarrolla la placa aterosclerótica. Se mencionan los mecanismos por los cuales la placa se rompe produciendo la trombosis (aterotrombosis) que lleva a los infartos de los territorios afectados. Medical literature, particularly the research works carried out by the Center for Investigations and Reference of Atherosclerosis of Havana are reviewed. The most relevant historical events related to the first atherosclerotic lesions studied in Egyptian mummies are stated. Reference is made to the most usual classifications for this type of lesions since 1957 (World Health Organization): fatty streak, fibrous plaque, complicated plaque and calcified plaque. The concept of calcified and complicated plaques unified into equally severe plaque concept are analyzed. Reference is also made to the methods for studying the lesions and to the Stary’s classification into six kinds of atherosclerotic lesions. The factors affecting the development of lesions making special emphasis on the role of lipids, the endothelium, smooth muscle cells (contractile and synthetic), macrophages, various growth factores, free radicals and the response of the connective tissue of the arterial wall are chronologically described. The connective tissue of the arterial wall which includes the inflammatory and immunity mechanisms in its defense actions, causes and develops the atherosclerotic plaque. The
EDITORIAL
José Emilio Fernández-Britto Rodríguez
Revista Habanera de Ciencias M??dicas , 2012,
Abstract:
Metabolismo de la homocisteína y su relación con la aterosclerosis
Menéndez Cabezas,Arturo; Fernández-Britto Rodríguez,José E;
Revista Cubana de Investigaciones Biom??dicas , 1999,
Abstract: a review on the details of the metabolism of homocysteine, a sulfur-containing amino acid that is normally obtained from methionine during the accomplishment of its function as a donor of methyl groups was made. its possible metabolic destinations are analyzed, particularly the remethylation and the transsulfuration, in which the coenzymatic forms of vitamins b6, b12 and folate are involved, as well as its oxidation with which homocystine and mixed disulphides including the so-called homocystein attached to protcin, which is the main form circulating in plasma and in other destinations described in literature, are originated. the methods for stimating its plasmatic concentration and its reference values are related. the possible cause of hyperhomocysteinemia and the physiopathological mechanisms that link this status to atherogenesis and that try to explain the proposed hyperhomocysteinemia- atherosclerosis relation established by the results of epidemiological and clinical studies during the last 30 years are analyzed.
Metabolismo de la homocisteína y su relación con la aterosclerosis
Arturo Menéndez Cabezas,José E Fernández-Britto Rodríguez
Revista Cubana de Investigaciones Biom??dicas , 1999,
Abstract: Se realizó una revisión sobre los detalles del metabolismo de la homocisteína, aminoácido azufrado que se forma normalmente a partir de la metionina durante el cumplimiento de su función de donante de grupos metilos. Se analizaron sus posibles destinos metabólicos, en particular la remetilación y la transulfuración, en las que están implicadas las formas coenzimáticas de las vitaminas folacina, B12 y B6; así como su oxidación con lo que se origina la homocistina y disulfuros mixtos que incluyen a la llamada homocisteína ligada a proteína, forma principal que circula en el plasma, y otros destinos descritos en la literatura. Se relacionan los métodos de estimación de su concentración plasmática y sus valores de referencia. Se analizaron las posibles causas de hiperhomocisteinemia y los mecanismos fisiopatológicos que vinculan a este estado con la aterogénesis y que tratan de explicar la relación hiperhomocisteinemia-aterosclerosis, propuesta fundamentada por los resultados de estudios epidemiológicos y clínicos de los últimos 30 a os. A review on the details of the metabolism of homocysteine, a sulfur-containing amino acid that is normally obtained from methionine during the accomplishment of its function as a donor of methyl groups was made. Its possible metabolic destinations are analyzed, particularly the remethylation and the transsulfuration, in which the coenzymatic forms of vitamins B6, B12 and folate are involved, as well as its oxidation with which homocystine and mixed disulphides including the so-called homocystein attached to protcin, which is the main form circulating in plasma and in other destinations described in literature, are originated. The methods for stimating its plasmatic concentration and its reference values are related. The possible cause of hyperhomocysteinemia and the physiopathological mechanisms that link this status to atherogenesis and that try to explain the proposed hyperhomocysteinemia- atherosclerosis relation established by the results of epidemiological and clinical studies during the last 30 years are analyzed.
La lesión aterosclerótica coronaria en la muerte súbita: aplicación del sistema aterométrico
Falcón Vilaú,Leonel; Fernández-Britto Rodríguez,José E; Castillo Herrera,José A;
Revista Cubana de Investigaciones Biom??dicas , 2000,
Abstract: the main branches of the right, anterior descending and left circumflex coronary epicardial arteries of 237 patients that died from sudden death according to the selection criteria established by the world health organization and of 113 patients who died from non cardiovascular causes and without history of atherosclerotic risk factor, a group of low atherosclerotic level used as control, were studied. both populations were the result of consecutive necropsies performed in persons over 15. the atherometric system was used for the morphological and morphometric characterization of the atherosclerotic lesion. the injured intimal surface was larger in the group of sudden death and its atherosclerotic profile was characterized by the strong predominance of the elevated lesions represented by the fibrous and severe plaques, which account for a higher index of obstruction and stenosis and a greater severity of the atherosclerotic process in this group. fibrous and severe plaques showed a high signification, both isolated and as a whole, when the one-way variance analysis (anova) and the multivariate analysis (manova) were applied, respectively. this explained the quantitative differences found on comparing the mean values of the atherosclerotic lesions in the coronary arteries of the studied groups
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