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Search Results: 1 - 10 of 281445 matches for " José C Espinoza-Hicks "
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Experimental and quantum chemical studies of a novel synthetic prenylated chalcone
José C Espinoza-Hicks, Alejandro A Camacho-Dávila, Norma R Flores-Holguín, Guadalupe V Nevárez-Moorillón, Daniel Glossman-Mitnik, Luz M Rodríguez-Valdez
Chemistry Central Journal , 2013, DOI: 10.1186/1752-153x-7-17
Abstract: A novel substituted chalcone has been synthetized. In order to identify the functional groups present in the new synthesized compound and confirm its chemical structure, experimental and theoretical 1H-NMR and 13C-NMR spectra were analyzed. The theoretical molecular structure and NMR spectra were calculated at both the Hartree-Fock and Density Functional (meta: TPSS; hybrid: B3LYP and PBE1PBE; hybrid meta GGA: M05-2X and M06-2X) levels of theory in combination with a 6-311++G(d,p) basis set. The structural parameters showed that the best method for geometry optimization was DFT:M06-2X/6-311++G(d,p), whereas the calculated bond angles and bond distances match experimental values of similar chalcone derivatives. The NMR calculations were carried out using the Gauge-Independent Atomic Orbital (GIAO) formalism in a DFT:M06-2X/6-311++G(d,p) optimized geometry.Considering all HF and DFT methods with GIAO calculations, TPSS and PBE1PBE were the most accurate methods used for calculation of 1H-NMR and 13C-NMR chemical shifts, which was almost similar to the B3LYP functional, followed in order by HF, M05-2X and M06-2X methods. All calculations were done using the Gaussian 09 software package. Theoretical calculations can be used to predict and confirm the structure of substituted chalcones with good correlation with the experimental data.Chalcones are ubiquitous substances found in a diversity of plants. They are precursors to other natural products, such as flavonoids, which have reported a wide range of biological activities such as antioxidant, antibacterial, antitumoral among others [1]. Due to the importance of these compounds, diverse studies on synthesis and biological activities of molecules containing the chalcone ring system, have been reported recently [2]. The prenyloxychalcones are important derivatives of chalcones, which contain a prenyl-type side chain with different length, including 2,2-dimethylallyl, geranyl or farnesyl chains; these compounds have shown i
La incorporación de la mujer en la cirugía chilena The incorporation of women in Chilean surgery
Ricardo Espinoza G,Camila Onetto C,Juan José Lombardi A,Juan Pablo Espinoza G
Revista Chilena de Cirugía , 2012,
Abstract: Se ha observado un aumento del número de mujeres que estudia medicina. No obstante, la incorporación de la mujer a la cirugía sigue siendo baja. En Chile no conocemos de información sobre este tema. Nuestro objetivo fue recopilar información que proporcionara cifras y tendencias en este sentido. Se obtuvo información de la Sociedad de Cirujanos de Chile (SCCh), del Capítulo Chileno del Colegio Americano de Cirujanos (CCh CAC), de la Comisión Nacional Autónoma de Especialidades Médicas (CONACEM) y de la Superintendencia de Salud de Chile (SS), hasta junio de 2011. La SCCh tiene 854 socios y 64 corresponden a mujeres (7,5%). El Capítulo Chileno del CAC tiene 162 miembros y 4 son mujeres (2,5%). Ante CONACEM se han certificado 1.070 cirujanos, de los cuales 80 son mujeres (7,5%). En el registro de la SS hay 1.177 cirujanos, 8,4% de sexo femenino. El a o 1959 se incorporó la primera mujer a la SCCh. Desde ahí, el número ha sido progresivo, aumentando principalmente en las dos décadas recientes hasta alcanzar el 7,5% actual. No obstante este aumento, en todas las fuentes consultadas el porcentaje de mujeres en práctica quirúrgica es inferior al 10%. Pareciera ser que la mujer intenta realmente una mayor participación en el campo quirúrgico. Sin embargo, el "estilo de vida del cirujano", choca con una compatibilización mayor entre vida laboral y familiar. Creemos que hay espacio para investigaciones cualitativas en este campo, que reflejen mejor las motivaciones y dificultades de la mujer por acceder al mundo quirúrgico en nuestro medio. It has been observed an increasing number of women studying medicine. However, the incorporation of women to surgery remains low. In Chile we do not have information on this topic. Our goal was to collect information to provide the figures and trends in this regard. Information was obtained from the Society of Surgeons of Chile (SCCH), the Chilean Chapter of the American College of Surgeons (CCh CAC), the Autonomous National Commission of Medical Specialties (CONACEM) and the Superintendent of Health of Chile (SS), until June 2011. The SCCH has 854 partners and 64 were women (7.5%). The Chilean Chapter of the CCh CAC has 162 members and 4 women (2.5%). At CONACEM, 1.070 persons have been certified as surgeons, 80 are women (7.5%). In the register of SS there are 1.177 surgeons, 8.4% female. In 1959 the first women joined SCCH. Since then, the number has been progressive, growing mainly in the last two decades to reach the 7.5% now. Nevertheless, in all consulted sources, the percentage of women in surgical practice, still les
ESTADO NUTRITIVO MATERNO INICIAL Y PESO PROMEDIO DE SUS RECIéN NACIDOS A TéRMINO
Lagos S.,Rudecindo; Espinoza G.,Rodolfo; Orellana C,Juan José;
Revista chilena de nutrición , 2004, DOI: 10.4067/S0717-75182004000100007
Abstract: the association between maternal nutrition during the first trimester of pregnancy (bmi at 8-12th weeks) and foetal growth at term (mean birth weight) is shown in 9.735 pregnant women who gave birth in the maternity ward at the hospital regional de temuco (from 1994 to 2002). gestational age was well established and deliveries occurred at term (38 to 42 weeks). the centiles 10 and 90 of bmi observed at the beginning of pregnancy were 20.7 and 30.6 respectively. average birth weight at term (38-42 weeks) was 3560±442 g. a positive correlation was observed between bmi at the beginning of pregnancy and mean birth weight (r = 0.0611) for each unit of change of bmi (kg/m2) an increase of 27.9 g was founded in birth weight. a multiple regression analysis was performed using birth weight as depending variable and four independent variables (gestational age at delivery, sex of newborn, parity ,a and to a lesser degree, maternal age), indicating that bmi continued to be positively associated to birth weight (p<0.00). in this case, for every additional unit of maternal bmi at the beginning of pregnancy, an increase of 23.9 g in birth weight was observed. maternal body mass index at the beginning of pregnancy continues to be a predictive factor of birth weight, after correcting for intervening variables such as gestational age at delivery, newborn gender, parity and maternal age
ESTADO NUTRITIVO MATERNO INICIAL Y PESO PROMEDIO DE SUS RECIéN NACIDOS A TéRMINO MATERNAL NUTRITIONAL STATUS AT THE BEGINNING OF PREGNANCY AND AVERAGE WEIGHT OF THEIR NEWBORNS AT TERM
Rudecindo Lagos S.,Rodolfo Espinoza G.,Juan José Orellana C
Revista Chilena de Nutricíon , 2004,
Abstract: Se estudió la relación existente entre la nutrición materna de primer trimestre, el índice de Masa Corporal (IMC), que presentaban en un control prenatal inicial a las 8-12 semanas, con el crecimiento fetal expresado como peso promedio de nacimiento a término, en 9.735 mujeres que tuvieron parto en la Maternidad del Hospital Regional de Temuco (1994-2002) con embarazos seleccionados, edad gestacional conocida precozmente y partos de término (38 a 42 semanas), Los percentiles 10 y 90 de índice de masa corporal materna observados al control prenatal inicial fueron: 20.7, y 30.6 respectivamente. El peso neonatal promedio a término para el momento del estudio (38 - 42 semanas) fue 3560 ± 442 g (1DE). Se observó una correlación positiva entre el IMC materno inicial y el peso promedio de nacimiento (r = 0.0611). El análisis de tendencia mostró que por unidad de cambio de IMC materno (Kg / Mt2) se producen 27.9 g de cambio en el peso de nacimiento. Un modelo de asociación obtenido por regresión lineal múltiple entre el IMC materno y el peso neonatal ajustado por cuatro variables (edad de gestación al parto, sexo del recién nacido, paridad y en menor grado edad materna), mostró que el IMC materno sigue en asociación significativa con el peso de nacimiento (p < 0.00). Por cada unidad de cambio de IMC materno, se producen 23.3 de cambio en el peso neonatal. El IMC materno al comienzo del embarazo es un factor predictivo altamente asociado al peso de nacimiento, aún cuando sea corregido por variables intervinientes como edad gestacional al parto, sexo del recién nacido, y paridad edad materna The association between maternal nutrition during the first trimester of pregnancy (BMI at 8-12th weeks) and foetal growth at term (mean birth weight) is shown in 9.735 pregnant women who gave birth in the maternity ward at the Hospital Regional de Temuco (from 1994 to 2002). Gestational age was well established and deliveries occurred at term (38 to 42 weeks). The centiles 10 and 90 of BMI observed at the beginning of pregnancy were 20.7 and 30.6 respectively. Average birth weight at term (38-42 weeks) was 3560±442 g. A positive correlation was observed between BMI at the beginning of pregnancy and mean birth weight (r = 0.0611) For each unit of change of BMI (kg/m2) an increase of 27.9 g was founded in birth weight. A multiple regression analysis was performed using birth weight as depending variable and four independent variables (gestational age at delivery, sex of newborn, parity ,a and to a lesser degree, maternal age), indicating that BMI continued to be positively ass
CALCINOSIS TUMORAL EN PEDIATRíA: REPORTE DE UN CASO CLíNICO Y REVISIóN DE LA LITERATURA
Espinoza G,Aníbal; Céspedes V,María José; Kakarieka,Elena;
Revista chilena de radiología , 2008, DOI: 10.4067/S0717-93082008000200010
Abstract: we repon a case oftumoral calcinosis in young girl, a quite infrecuent condition, causee! by a herditary dysfunción of phosphfate regulation. ouraims are to review imaging signs (plain radiography ultrasound, computed tomography and nuclear medicine) and clinical and labortory findigs as well. finally we made a literature search, oriented to help in diagnosing this disease, specially regarding images.
Uso del forraje de maíz (Zea mays) hidropónico en la alimentación de toretes mestizos
Espinoza,Freddy; Argenti,Patricia; Urdaneta,Giovanni; Araque,César; Fuentes,Armando; Palma,José; Bello,Carlos;
Zootecnia Tropical , 2004,
Abstract: to evaluate the nutritive value of hydroponics forage corn (hfc) and the effects on bovine weight change, it was carried out an experiment in experimental farm located in maracay, aragua state, venezuela at 463 masl, 10o17?n and 67o37?w. the total annual rainfall was 1,013 mm with a mean temperature of 26oc. the soils were loam texture with 12 ppm of phosphorous and ph 8.5. ten growing bovines crossbreed 5/8 holstein x brahman were used, separated in different corrals (five animals/corral), under a stalled system. two treatments were evaluated: control, animals fed with grass only, and animals fed with 70% grass plus 30% of hydroponics forage corn. the animals were previously fed with the experimental diets for a period of 7 days and then for seven continuous weeks. the variables were: nutritive value of the grass and the hfc, nitrogen content in blood and semen, and weight change. the design was a complete randomize, where each animal was a repetition. the results showed that the nutritive value of the hfc was higher than the grass with a high protein content in the leaves and the whole plant (33.5 and 19.4%, respectively) (p<0.01). also, higher mineral content was observed in the hfc. significant differences were observed (p<0.05) between treatments for the consumption and use of the hfc. the nitrogen content in blood and semen of the animals showed no significant differences (1.3 and 0.7%, respectively) from the control. the weight gain was higher in the animals that consumed grass plus hfc (1.123 g/animal/d). it is concluded that the hfc could be a feeding alternative for the growing bovines in stalled conditions as a supplement in the base diet.
CALCINOSIS TUMORAL EN PEDIATRíA: REPORTE DE UN CASO CLíNICO Y REVISIóN DE LA LITERATURA TUMORAL CALCINOSIS IN YOUNG CHILDREN: REPORT OF A CASE AND LITERATURE REVIEW
Aníbal Espinoza G,María José Céspedes V,Elena Kakarieka
Revista Chilena de Radiología , 2008,
Abstract: Presentamos el caso de una ni a preescolar portadora de calcinosis tumoral, entidad infrecuente, causada por una disfunción hereditaria en la regulación de la excreción de fosfatos. Damos a conocer los hallazgos radiológicos (radiografía simple, ultra-sonografía, tomografia computada y cintigrafía ósea), así como también hallazgos clínicos y laboratorio del caso, además de revisar la literatura para una breve actualización de esta condición, especialmente en lo que respecta al diagnóstico y las imágenes. We repon a case oftumoral calcinosis in young girl, a quite infrecuent condition, causee! by a herditary dysfunción of phosphfate regulation. Ouraims are to review imaging signs (plain radiography ultrasound, Computed Tomography and nuclear medicine) and clinical and labortory findigs as well. Finally we made a literature search, oriented to help in diagnosing this disease, specially regarding images.
Role of raltegravir in the management of HIV-1 infection
Okeke NL, Hicks C
HIV/AIDS - Research and Palliative Care , 2011, DOI: http://dx.doi.org/10.2147/HIV.S13985
Abstract: le of raltegravir in the management of HIV-1 infection Review (4103) Total Article Views Authors: Okeke NL, Hicks C Published Date July 2011 Volume 2011:3 Pages 81 - 92 DOI: http://dx.doi.org/10.2147/HIV.S13985 N Lance Okeke1, Charles Hicks2 1Duke University Medical Center, Department of Hospital Medicine, Durham Regional Hospital, Durham, North Carolina, USA; 2Duke University School of Medicine, Durham, NC, USA Abstract: The development of multiple agents with potent antiretroviral activity against HIV has ushered in a new age of optimism in the management of patients infected with the virus. However, the viruses’ dynamic ability to develop resistance against these agents necessitates the investigation of novel targets for viral suppression. Raltegravir represents a first-in-class agent targeting the HIV integrase enzyme, which is responsible for integration of virally encoded DNA into the host genome. Over the last 5 years, clinical trials data has demonstrated an increasing role for raltegravir in the management of both treatment-experienced and treatment-na ve HIV-1-infected patients. This review focuses on the evidence supporting raltegravir’s efficacy in an array of clinical settings. Other HIV-1 integrase inhibitors in development are also briefly discussed.
Role of raltegravir in the management of HIV-1 infection
Okeke NL,Hicks C
HIV/AIDS - Research and Palliative Care , 2011,
Abstract: N Lance Okeke1, Charles Hicks21Duke University Medical Center, Department of Hospital Medicine, Durham Regional Hospital, Durham, North Carolina, USA; 2Duke University School of Medicine, Durham, NC, USAAbstract: The development of multiple agents with potent antiretroviral activity against HIV has ushered in a new age of optimism in the management of patients infected with the virus. However, the viruses’ dynamic ability to develop resistance against these agents necessitates the investigation of novel targets for viral suppression. Raltegravir represents a first-in-class agent targeting the HIV integrase enzyme, which is responsible for integration of virally encoded DNA into the host genome. Over the last 5 years, clinical trials data has demonstrated an increasing role for raltegravir in the management of both treatment-experienced and treatment-na ve HIV-1-infected patients. This review focuses on the evidence supporting raltegravir’s efficacy in an array of clinical settings. Other HIV-1 integrase inhibitors in development are also briefly discussed.Keywords: HIV, antiretroviral therapy, raltegravir
Hábitos de amamantamiento del ganado bovino Chinampo (Bos taurus) de México
Espinoza V,José; Rigoberto,López A; Ortega P,Ricardo; Palacios E,Alejandro; Guillén T,Ariel; Hernandez C,Hugo;
Revista MVZ Córdoba , 2011,
Abstract: objective. to determine the nursing habits of chinampo calves (bos taurus) during different stages of lactation. materials and methods. twenty cows with their calves were used. the animals were observed from day 30 to 180 of lactation during 24 continuous hours each month, recording the frequency with which the calves nursed and the duration of each nursing. a linear model was used and correlations between age, weight of calves and milk production of cows, with the frequency and duration of nursing have been established. the means were compared by tukey test. results. the calves nursed with higher frequency between 06:00 and 07:00; other peaks were observed at 10:00 and at 19:00 hours. the average frequency of nursing in 24 hours was 4.9±0.21 using a total of 66.9±3.1 minutes. the calves of 180 days of age nursed fewer times with respect to those of ages below 150 days; the duration of nursing decreased at 180 days of age (p<0.05). the females nursed with more frequency than the males (p<0.05), but the time they occupied for this activity was similar between males and females (p>0.05). conclusions. the frequency of nursing is higher during the first morning and late afternoon hours. up until 5 months of age the frequency and time of nursing did not vary, but were reduced at 180 days. the females nursed with more periodicity than the males.
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