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Search Results: 1 - 10 of 515708 matches for " José A Lopez-Escamez "
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Polymorphisms of CD16A and CD32 Fcγ receptors and circulating immune complexes in Ménière's disease: a case-control study
José A Lopez-Escamez, Pablo Saenz-Lopez, Irene Gazquez, Antonia Moreno, Carlos Gonzalez-Oller, Andrés Soto-Varela, Sofía Santos, Ismael Aran, Herminio Perez-Garrigues, águeda Iba?ez, Miguel A Lopez-Nevot
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-2
Abstract: The functional CD16A (FcγRIIIa*559A > C, rs396991) and CD32A (FcγRIIa*519A > G, rs1801274) SNPs were analyzed using PCR-based TaqMan Genotyping Assay in two cohorts of 156 mediterranean and 112 Galicia patients in a case-control study. Data were analyzed by χ2 with Fisher's exact test and Cochran-Armitage trend test (CATT). CIC were measured by ELISA for C1q-binding CIC.Elevated CIC were found in 7% of patients with MD during the intercrisis period. No differences were found in the allelic frequency for rs396991 or rs1801274 in controls subjects when they were compared with patients with MD from the same geographic area. However, the frequency of AA and AC genotypes of CD16A (rs396991) differed among mediterranean and Galicia controls (Fisher's test, corrected p = 6.9 × 10-4 for AA; corrected p = 0.02 for AC). Although genotype AC of the CD16A receptor was significantly more frequent in mediterranean controls than in patients, [Fisher's test corrected p = 0.02; OR = 0.63 (0.44-0.91)], a genetic additive effect for the allele C was not observed (CATT, p = 0.23). Moreover, no differences were found in genotype frequencies for rs396991 between patients with MD and controls from Galicia (CATT, p = 0.14). The allelic frequency of CD32 (rs1801274) was not different between patients and controls either in mediterranean (p = 0.51) or Galicia population (p = 0.11).Elevated CIC are not found in most of patients with MD. Functional polymorphisms of CD16A and CD32 genes are not associated with onset of MD.Ménière's disease (MD) is a chronic disease defined by recurrent spells of vertigo associated with sensorineural hearing loss and tinnitus or aural fullness. Different autoimmune diseases share susceptibility loci, but consistent associations with multiple autoimmune disorders have been restricted to three genes: the human leukocyte antigen (HLA) DRB1 gene, the PTPN22 gene encoding lymphoid tyrosine phosphatase LYP and the gene encoding cytotoxic T lymphocyte-associated 4 (CTL
A variant of PTPN22 gene conferring risk to autoimmune diseases may protect against tuberculosis
Lopez-Escamez J
Journal of Postgraduate Medicine , 2010,
Abstract:
Accompanying symptoms overlap during attacks in Menière’s Disease and Vestibular Migraine
Jose A. Lopez-Escamez,Julia Dlugaiczyk,Julien Jacobs,Thomas Lempert,Roberto Teggi,Michael von Brevern,Alexandre Bisdorff
Frontiers in Neurology , 2014, DOI: 10.3389/fneur.2014.00265
Abstract: Meniere’s disease and vestibular migraine are the most common causes of spontaneous recurrent vertigo. The current diagnostic criteria for the two disorders are mainly based on patients’ symptoms and no biological marker is available. When applying these criteria, an overlap of the two disorders is occasionally observed in clinical practice. Therefore, the present prospective multi-center study aimed to identify accompanying symptoms that may help to differentiate between Meniere’s disease (MD), vestibular migraine (VM) and probable vestibular migraine (pVM). Two hundred and sixty-eight patients were included in the study (MD: n = 119, VM: n = 84, pVM: n = 65). Patients with MD suffered mainly from accompanying auditory symptoms (tinnitus, fullness of ear and hearing loss), while accompanying migraine symptoms (migraine-type headache, photo-/phonophobia, visual aura), anxiety and palpitations were more common during attacks of VM. However, it has to be noted that a subset of MD patients also experienced (migraine-type) headache during the attacks. On the other hand, some VM/pVM patients reported accompanying auditory symptoms. The female/male ratio was statistically higher in VM/pVM as compared to MD, while the age of onset was significantly lower in the former two. The frequency of migraine-type headache was significantly higher in VM as compared to both pVM and MD. Accompanying headache of any type was observed in declining order in VM, pVM and MD. In conclusion, the present study confirms a considerable overlap of symptoms in MD, VM and pVM. In particular, we could not identify any highly specific symptom for one of the three entities. It is rather the combination of symptoms that should guide diagnostic reasoning. The identification of common symptom patterns in VM and MD may help to refine future diagnostic criteria for the two disorders.
High Prevalence of Systemic Autoimmune Diseases in Patients with Menière's Disease
Irene Gazquez, Andres Soto-Varela, Ismael Aran, Sofia Santos, Angel Batuecas, Gabriel Trinidad, Herminio Perez-Garrigues, Carlos Gonzalez-Oller, Lourdes Acosta, Jose A. Lopez-Escamez
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026759
Abstract: Background Autoimmunity appears to be associated with the pathophysiology of Meniere's disease (MD), an inner ear disorder characterized by episodes of vertigo associated with hearing loss and tinnitus. However, the prevalence of autoimmune diseases (AD) in patients with MD has not been studied in individuals with uni or bilateral sensorineural hearing loss (SNHL). Methods and Findings We estimated the prevalence of AD in 690 outpatients with MD with uni or bilateral SNHL from otoneurology clinics at six tertiary referral hospitals by using clinica criteria and an immune panel (lymphocyte populations, antinuclear antibodies, C3, C4 and proinflammatory cytokines TNFα, INFγ). The observed prevalence of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS) was higher than expected for the general population (1.39 for RA, 0.87 for SLE and 0.70 for AS, respectively). Systemic AD were more frequently observed in patients with MD and diagnostic criteria for migraine than cases with MD and tension-type headache (p = 0.007). There were clinical differences between patients with uni or bilateral SNHL, but no differences were found in the immune profile. Multiple linear regression showed that changes in lymphocytes subpopulations were associated with hearing loss and persistence of vertigo, suggesting a role for the immune response in MD. Conclusions Despite some limitations, MD displays an elevated prevalence of systemic AD such as RA, SLE and AS. This finding, which suggests an autoimmune background in a subset of patients with MD, has important implications for the treatment of MD.
Evolución urológica de pacientes con agenesia de sacro: 20 a?os de seguimiento
Abascal Junquera,José María; Conejero Sugra?es,Joan; Martos Calvo,Raul; Celma Doménech,Ana; Salvador Lacambra,Carlos; Zamora Escamez,Pascual;
Archivos Espa?oles de Urología (Ed. impresa) , 2006, DOI: 10.4321/S0004-06142006000600005
Abstract: objectives: complete or partial sacral agenesis is a rare malformation consisting in the absence of one or more sacral vertebrae. it is part of a caudal regression syndrome and it may be associated with other congenital anomalies (currarino syndrome). it does not have an established etiology but is associated with insulin-dependent diabetes mellitus in the mother (1%). the objective of this is study was to retrospectively analyze the urological outcome of patients with sacral agenesis in our case series. methods: retrospective analysis of 14 patients between 1975 and 2005. we evaluated reason for consultation, urological status, continence outcome, urological complications, hospital admissions and number of office visits. results: no patient had history of diabetic mother. the number of male/female patients were similar. mean age at first visit was 13.2 years and main reason for consultation was urinary incontinence. 60% of the patients presented associated myelomeningocele. 70% had a normal upper urinary tract at the beginning of follow-up; 10 patients presented some degree of incontinence (70%). mean follow-up was 19.7 years (7-30): 50% of the patients keep a normal upper urinary tract. all of them have presented symptomatic urinary tract infection. the main urological reason for hospital admission was programmed surgery (7). the mean number of visits per year was 1.9. conclusions: sacral agenesis is a rare congenital malformation requiring an early diagnosis to avoid mid-term urological complications. these patients need life-long urological follow-up. the mean reason for consultation is urinary incontinence secondary to neurogenic bladder which may be satisfactorily treated in most cases
Angiotensin II type 1 receptor A1166C GENE polymorphism and essential hypertension in San Luis
Lapierre,Alicia Viviana; Arce,María Elena; Lopez,José Raúl; Ciuffo,Gladys María;
Biocell , 2006,
Abstract: essential hypertension is considered a multifactorial trait resulting from a combination of environmental and genetic factors. the angiotensin ii type 1 receptor mediates the vasoconstrictor and growthpromoting effects of ang ii. the a1166c polymorphism of the at1 receptor gene may be associated with cardiovascular phenotypes, such as high arterial blood pressure, aortic stiffness, and increased cardiovascular risk. we investigated the association between this a1166c polymorphism and hypertension in hypertense and normotense subjects from san luis (argentina) by mismatch pcr-rflp analysis. hypertense patients exhibited significant increases in lipid related values and body mass index. the frequency of occurrence of the c1166 allele was higher among patients with hypertension (0.19) than in the control group (0.06). no significant association was found between this polymorphism and essential hypertension in the study population, although the ac genotype prevalence was higher in patients with hypertension and positive family history of hypertension (32%) than in control subjects (12%). patients with the a1166c polymorphism exhibited higher levels of serum total cholesterol, ldl-cholesterol and bmi than in control subjects. taken together the genotype and biochemical parameters and considering the restrictive selection criteria used, the present results suggest a correlation between at1 a1166c gene polymorphism and risk of cardiovascular disease.
Angiotensin II type 1 receptor A1166C GENE polymorphism and essential hypertension in San Luis
Alicia Viviana Lapierre,María Elena Arce,José Raúl Lopez,Gladys María Ciuffo
Biocell , 2006,
Abstract: Essential hypertension is considered a multifactorial trait resulting from a combination of environmental and genetic factors. The angiotensin II type 1 receptor mediates the vasoconstrictor and growthpromoting effects of Ang II. The A1166C polymorphism of the AT1 receptor gene may be associated with cardiovascular phenotypes, such as high arterial blood pressure, aortic stiffness, and increased cardiovascular risk. We investigated the association between this A1166C polymorphism and hypertension in hypertense and normotense subjects from San Luis (Argentina) by mismatch PCR-RFLP analysis. Hypertense patients exhibited significant increases in lipid related values and body mass index. The frequency of occurrence of the C1166 allele was higher among patients with hypertension (0.19) than in the control group (0.06). No significant association was found between this polymorphism and essential hypertension in the study population, although the AC genotype prevalence was higher in patients with hypertension and positive family history of hypertension (32%) than in control subjects (12%). Patients with the A1166C polymorphism exhibited higher levels of serum total cholesterol, LDL-cholesterol and BMI than in control subjects. Taken together the genotype and biochemical parameters and considering the restrictive selection criteria used, the present results suggest a correlation between AT1 A1166C gene polymorphism and risk of cardiovascular disease.
Xenobiotic-Metabolizing Enzymes in Skeletal Muscle of Children and Adolescents  [PDF]
Dora Molina-Ortiz, José Francisco González-Zamora, Rafael Camacho-Carranza, Ocarol Lopez-Acosta, Oscar Colin-Martinez, Adriana Miriam Domínguez-Ramírez, Araceli Vences-Mejía
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.42032
Abstract:

Cytochrome P450 (CYP) enzymes metabolize endogenous compounds such as steroid hormones, fatty acids, and xenobiotics, including drugs and carcinogens. The skeletal muscle is highly exposed to circulating xenobiotics; nevertheless the knowledge on the expression of these enzymes not only in adult skeletal muscle but also in younger individuals has been very little. Therefore, the aim of the present study was to investigate the expression of CYP enzymes in healthy skeletal muscles of children and adolescents. This was investigated in a total of 18 biopsies taken from the quadriceps skeletal muscle of younger patients: 9 boys and 9 girls (≤18 years) by using specific antibodies in immunoblots and by RT-PCR mRNA analysis. The mRNA transcripts for CYP1B1 and CYP2E1 were consistently detected in all samples, but in the immunoblot only was identified CYP1B1 protein in four samples. Regarding CYP1A1, CYP3A4 and CYP3A5 enzymes in skeletal muscle, there were found in some samples in both techniques, although with significant inter-individual variations. Finally CYP2W1 only was detected in one sample belonging to the youngest patient. These data show that a range of CYP enzymes are expressed in the skeletal muscle of children and adolescents, suggesting that the metabolism of several xenobiotic chemicals to which humans are exposed takes place in muscle cells. Moreover, since the potential participation of muscles is a fact in pharmacokinetics of many therapeutic drugs, expression of CYPs in skeletal muscle may play an important role in drug-dependent toxicity.

Fatores de risco associados ao desmame precoce e ao período de desmame em lactentes matriculados em creches
Barbosa, Marina Borelli;Palma, Domingos;Domene, Semíramis Martins A.;Taddei, José Augusto A. C.;Lopez, Fábio Ancona;
Revista Paulista de Pediatria , 2009, DOI: 10.1590/S0103-05822009000300007
Abstract: objective: to evaluate risk factors associated with weaning of infants enrolled in daycare centers. methods: analytical cross-sectional study comprising 56 children aged nine to 18 months in five daycare centers of s?o paulo. a pre-tested questionnaire was applied to their mother, including questions on demographics and socioeconomic issues, gestation and birth, illness, breastfeeding, complementary feeding (when and how new foods were introduced) and children activities in daycare centers. factors associated with early weaning and short weaning period (defined as the difference between exclusive breastfeeding period and total breastfeeding period) were determined by bivariate analyses. conceptual hierarchical multivariate analysis (logistic regression) was applied. results: in the multivariate analysis, the independent risk factors for early weaning were: family income <3 minimum wage (or 3.73; 95%ci 1.23-11.34); mother's age >25 years (or 4.91; 95%ci 1.35-17.95); mother living without a partner (or 6.42; 95%ci 1.28-32.20); use of pacifier before 30 days of life (or 8.75; 95%ci 1.90-40.23). risk factors for insufficient weaning period were: attending public daycare centers (or 3.20; 95%ci 0.77-14.29) and late start of prenatal care (or 4.13; 95%ci 0.70-31.29). conclusions: characteristics related to family and to daycare centers are risk factors for breastfeeding weaning among institutionalized infants. such factors approach is strategic to define nutrition and health actions for favoring breastfeeding practice and to qualify daycare centers as infant health and nutrition promoters.
Odanacatib, a New Drug for the Treatment of Osteoporosis: Review of the Results in Postmenopausal Women
José Luis Pérez-Castrillón,Florentino Pinacho,Daniel De Luis,María Lopez-Menendez,Antonio Due as Laita
Journal of Osteoporosis , 2010, DOI: 10.4061/2010/401581
Abstract: Osteoclasts are specialized cells that initiate the process of bone resorption, which has two phases, dissolution of the mineral component and degradation of the organic matrix, in which cathepsin K plays a key role. Cathepsin K inhibitors, which block the activity of cathepsin on bone resorption lacunae, may be a new therapeutic option in osteoporosis. Odanacatib is a nonpeptidic biaryl inhibitor of cathepsin K. Two studies have evaluated the efficacy and safety of odanacatib, a phase I study to determine the dose and a phase II study of safety and efficacy. Due to the long half-life of odanacatib and the similar effects of different doses on bone remodeling markers, a weekly dosage was chosen for the phase II trail, with the best results being obtained with a dose of 50 mg. At 36 months, increases in bone mineral density similar to those produced by other powerful antiresorptive drugs (zoledronate and denosumab) were observed but there were differences in the behaviour of bone remodeling markers. Data on fractures from the phase III trial currently in development are required to confirm these possible advantages.
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