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Search Results: 1 - 10 of 155285 matches for " Jorge Sanchez V "
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Romero P,Marlyn; Sanchez V,Jorge;
Revista MVZ Córdoba , 2009,
Abstract: objective. to determe leptospirosis seroprevalence and dominant serovars in canine population of three municipalities of tolima department of colombia. materials and methods. a cross-sectional study was carried out (subjects being selected by sampling in 62 districts). samples from 900 dogs during june, july and august 2007 were collected and processed using microscopic agglutination test (mat). five serovars: hardjo, pomona, grippotyphosa, canicola, icterohaemorrhagiae and bratislava were tested. the mat was considered positive when 50% or more leptospiras were agglutinated with one or more serovars in a serum dilution of 1:100. results. at least one serovar showed evidence of infection in 21.4 % of the canines. the most dominant serovars were grippotyphosa (82.4%) and pomona (8.2%). it was evident the decrease in the frequency of reactivity of canicola and icterohaemorrhagiae serovars (0.5 and 2.2% respectively). co-agglutinations were presented in 4.3% canine sera samples. the sera-reactivity showed statistically significant differences when was compared for sex and age (p=0.038). conclusions. these findings suggested that dogs are potential reservoirs of leptospira in the three municipalities evaluated. it is necessary to conduct studies that permit the isolation and characterization of the serovars prevalent in endemic areas to guide preventive measures to avoid the risk of disease transmission to human.
Marlyn Romero P,Jorge Sanchez V
Revista MVZ Córdoba , 2009,
Abstract: Objetivo. Determinar la seroprevalencia de Leptospira spp. y los serovares dominantes, en caninos de tres municipios del departamento del Tolima, Colombia. Materiales y métodos. Se realizó un estudio epidemiológico trasversal con 900 caninos localizados en 62 barrios de los tres municipios, de los cuales se obtuvieron muestras de sangre durante los meses de junio, julio y agosto de 2007, que fueron procesadas utilizando la prueba de microaglutinación (MAT). En la prueba se incluyeron 5 serovares: hardjo, pomona, grippotyphosa, canicola, icterohaemorrhagiae y bratislava. La prueba se interpretó como positiva por la presencia de una aglutinación 350 % de las leptospiras con uno o más serovares, en una dilución del suero 3100. Resultados. La seroprevalencia de leptospirosis en la población canina fue del 20.2%. La mayor dominancia fue para los serovares grippotyphosa (82.4%) y pomona (8.2%), observándose una baja reactividad ante canicola e icterohaemorrhagiae, 0.5 y 2.2% respectivamente. Se presentaron coaglutinaciones en el 4.3% de los sueros. La seropositividad presentó diferencias estadísticamente significativas cuando se compararon los resultados por sexo y edad (p=0.038). Conclusiones. Los resultados sugieren que los caninos pueden ser posibles reservorios de la leptospirosis en los tres municipios evaluados, siendo necesario realizar estudios que permitan el aislamiento y tipificación de los serovares prevalentes en las zonas endémicas para orientar las medidas de prevención que eviten el riesgo de transmisión de la enfermedad a la población humana.
Evaluación de la persistencia de una formulación comercial de Bacillus sphaericus en criaderos naturales de anofelinos vectores de malaria en estado Bolívar, Venezuela
Moreno,Jorge E; Acevedo,Porfirio; Martínez,ángela; Sanchez,Víctor; Petterson,Luis;
Boletín de Malariología y Salud Ambiental , 2010,
Abstract: sifontes municipality in bolivar state is the main malaria endemic area in venezuela. during the last five years an annual average of 14,000 cases has been reported, reaching 13,450 during 2008, resulting in an epidemic situation. a commercial formulation of bacillus sphaericus neide (vectolex cg 7.5%), was evaluated in larval habitats of anopheles marajoara, an. triannulatus and an. braziliensis. two experiments were carried out in a lagoon and a pasture inundated area, 2 and 3 gr/m2 doses were evaluated during 60 and 90 days. the results point out that there are differences in the persistence depending on the type of larval habitat and anopheline species. the general trend indicated that for all the species the persistence of the vectolex, therefore the reduction of the larval population was 100% during the first week. however, it felt under 40% after day 28, then recovered by day 45, and remaining around 40% for 90 days with both doses. a similar pattern was observed for an. marajoara, whereas for an. triannulatus the efficacy remained around 80% during 90 days only at 3 gr/m2. with an. braziliensis there was 100% persistence until day 14 with both doses, for then felt abruptly without recovering. this is the first time that b. sphaericus was evaluated for these anopheline species in venezuela, considering these results promissory for the malaria control program.
Jorge Vázquez Valcuende,José María Eiros Bouza,Antonio Sanchez Porto
Electronic Journal of Biomedicine , 2009,
Abstract: The present paper represents a conceptual review on both theoretical approximations for the anti-influenza vaccination. Globally considered the influenza vaccines are based on the utilization of virus inactivated or attenuated viruses. The firsts ones can be categorized in turn in five modalities: those who shelter complete virus, elaborated with fragmented virus, the constituted ones based on subunits, which they contain adyuvants and the virosomics. In a complementary way one presents the steps in the manufacturing processes with individual reference to the vaccines produced in eggs embrionated.
In Silico Analysis of Cross Reactivity between Lipocalin of Domestic Animals*  [PDF]
Múnera Marlon, Sanchez Andres, Sanchez Jorge, Emiliani Yuliana
Open Journal of Immunology (OJI) , 2018, DOI: 10.4236/oji.2018.84006
Abstract: Lipocalins are one of the groups of allergens derived from domestic animals with clinical importance for the development of allergic responses. They have been characterized in different animals. With allergenic capacity characterized, little is known about the epitopes involved in allergic responses. Here, potential antigenic regions involved in cross-reactivity among lipocalins were explored through bioinformatics tools. The amino acid sequences of several lipocalins from different domestic animals (mouse, dog, cat, bull, hamster, horse and pig) were used to determine the degree of kinship by phylogenetic studies. Groups with highest phylogenetic relation were obtained by using MEGA software. 3D models of lipocalins not reported in the protein data bank were modeled by homology to identify potential antigenic regions compromised in the cross-reactivity of this group of allergens. The alignment of the entire database of allergenic lipocalins and the inferred maximum likelihood tree segregate lipocalins into five monophyletic clades (referenced here as A, B, C, D and E). According to the multiple pairing analyzes, group C (Fel d 4, Rat n 1 and Equ c 1) showed the highest degree of identity among their amino acid sequences (58%). The analysis of conserved and exposed residues showed that group C shares three antigenic regions that could potentially contribute to its cross-reactivity. Potential antigenic sites were identified for the generation of cross-reactivity between the different lipocalins analyzed in this study. These studies support the need to carry out directed mutagenesis tests to confirm their relevance in the allergenic capacity of lipocalins.
CIGB-247 vaccine breaks immunological tolerance to the vascular endothelial growth factor in mice, rats, rabbits and non-human primates, without disturbing physiologic angiogenic processes
Morera,Yanelys; Bequet,Mónica; Ayala,Marta; Gavilondo,Jorge V; Castro,Jorge; Puente,Pedro; Ancízar,Julio; Suarez,José; Sanchez,Javier; Cosme,Karelia; Bacardí,Dania; Acevedo,Boris E;
Biotecnolog?-a Aplicada , 2012,
Abstract: cigb-247 is a novel cancer therapeutic vaccine that uses a mutated form of human vascular endothelial growth factor (vegf) as antigen in combination with the oil-free adjuvant vssp (very small sized proteoliposomes of neisseria meningitidis outer membrane). the vaccine was designed to affect tumor neo-vascularization and tumor cell viability by eliciting antibodies that block the interaction of vegf and its receptors in activated endothelial cells, as well as specific cytotoxic t cells that can directly destroy tumor and tumor stroma cells producing vegf. our previous experimental studies with cigb-247 in mice, in which vegf shares an 87% homology to the human molecule, have shown that the vaccine has anti-tumoral and anti-metastatic activity, and produces anti-vegf antibodies and a specific t cell cytotoxic response against tumor cells. herein we extend the immunogenicity and safety studies of cigb-247 in mice, rats, rabbits and non-human primates. all the species develop antigen-specific igg antibodies able to block the interaction of vegf and vegf receptor 2 in an elisa assay. purified igg from cigb-247 immunized monkey sera effectively impair human microvascular endothelial cells' proliferation and capillary-like structures formation in matrigeltm. in monkeys and mice, dth and direct cell cytotoxicity experiments suggest that specific t cell responses are elicited after vaccination. immunization with cigb-247 does not affect animal behavior, hematology counts, blood biochemistry or histology of critical organs. skin deep wound healing was not affected in vaccinated rats and monkeys. altogether, these results support further clinical development of cigb-247 therapeutic cancer vaccine, and shed light on the potential mechanisms underlying its effects.
Jorge Luis Reales Sanchez
ENGI : Revista Electrónica de la Facultad de Ingenieria , 2012,
Abstract: Presentación de ENGI Revista Electronica de la Facultad de Ingenieria de la Universidad de Cundinamarca
Jorge Luis Reales Sanchez
ENGI : Revista Electrónica de la Facultad de Ingenieria , 2013,
Abstract: Editorial Vol. 1 No. 2
Jorge Luis Reales Sanchez
ENGI : Revista Electrónica de la Facultad de Ingenieria , 2013,
Abstract: .
Generic extensions and generic Polynomials for multiplicative groups
Jorge Morales,Anthony Sanchez
Mathematics , 2014,
Abstract: Let $\mathcal{A}$ be a finite-dimensional algebra over a finite field $\mathbf{F}_q$ and let $G=\mathcal{A}^\times$ be the multiplicative group of $\mathcal{A}$. In this paper, we construct explicitly a generic Galois $G$-extension $S/R$, where $R$ is a localized polynomial ring over $\mathbf{F}_q$, and an explicit generic polynomial for $G$ in $\dim_{\mathbf{F}_q}(\mathcal{A})$ parameters.
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