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Search Results: 1 - 10 of 48663 matches for " Jorge Pereira Pinto "
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Hepcidina: A Molécula-Chave na Regula??o do Metabolismo do Ferro
Porto,Gra?a; Oliveira,Susana; Pinto,Jorge Pereira;
Jornal Português de Gastrenterologia , 2012,
Abstract: the discovery of hepcidin constitutes one of the greatest revolutions in the present knowledge of iron homeostasis. the demonstration that this small peptide, synthesized mostly in the liver, functions as a central regulator of iron metabolism, and the subsequent elucidation of its mechanisms of action and regulation, all lead to a better understanding of a vast number of disorders of iron metabolismo and offer a new perspective in the diagnosis and treatment in the clinical practice. in this paper we review basic aspects of the regulation and action of hepcidin, and also address some novel concepts which enlarge the spectrum of interest around hepcidin and its clinical application
Hepcidina: A Molécula-Chave na Regula o do Metabolismo do Ferro Hepcidin: the key-molecule in the regulation of iron metabolismo
Gra?a Porto,Susana Oliveira,Jorge Pereira Pinto
Jornal Português de Gastrenterologia , 2012,
Abstract: A descoberta da hepcidina constitui uma das grandes revolu es do conhecimento na área da homeostasia do ferro. A demonstra o de que este pequeno péptido de síntese maioritariamente hepática funciona como um controlador central do metabolismo do ferro e a subsequente elucida o dos seus mecanismos de ac o e regula o, abriram novas portas na compreens o de um vasto leque de doen as do metabolismo do ferro e oferecem hoje novas perspectivas na prática clínica de diagnóstico e tratamento. Neste artigo s o revistos alguns aspectos básicos da regula o e ac o da hepcidina, e s o também abordados novos conceitos que alargam o espectro de interesse à volta da hepcidina e da sua aplica o clínica The discovery of hepcidin constitutes one of the greatest revolutions in the present knowledge of iron homeostasis. The demonstration that this small peptide, synthesized mostly in the liver, functions as a central regulator of iron metabolism, and the subsequent elucidation of its mechanisms of action and regulation, all lead to a better understanding of a vast number of disorders of iron metabolismo and offer a new perspective in the diagnosis and treatment in the clinical practice. In this paper we review basic aspects of the regulation and action of hepcidin, and also address some novel concepts which enlarge the spectrum of interest around hepcidin and its clinical application
Características de carca?a e qualidade de carne de novilhos superprecoces de três grupos genéticos
Pereira, Patrícia Maria Ribeiro Campos;Pinto, Marcos Franke;Abreu, Urbano Gomes Pinto de;Lara, Jorge Antonio Ferreira de;
Pesquisa Agropecuária Brasileira , 2009, DOI: 10.1590/S0100-204X2009001100021
Abstract: the objective of this work was to evaluate carcass parameters, physicochemical characteristics and quality of meat of young bulls. three genetic groups with 8 nelore (n), 18 ? abeerden angus ? nelore (an), and 18 ? limousin ? abeerden angus ? nelore (lan) animals, with ages varying between 7.5 and 11.5 months at the beginning of the experiment, slaughtered after 143 days of confinement, were evaluated. an animals were heavier at slaughter and showed higher average daily weight gain, higher hot carcass weight and carcass length; lan animals had higher carcass yield and rib-eye area. lan animals showed 72% convex carcasses, while 83% of an and 100% of n carcasses were classified as subconvex. lan and an meat showed no significant difference (p>5%) in shear force values, which indicates the possibility of use of 50% of bos indicus genotypes without loss of meat tenderness. the carcass and meat characteristics of the an, lan and n genetic groups comply with market specifications and are adequate for slaughter at 15 months of age, which makes the system for production of young bulls viable.
An Efficient Method for Genomic DNA Extraction from Different Molluscs Species
Jorge C. Pereira,Raquel Chaves,Estela Bastos,Alexandra Leit?o,Henrique Guedes-Pinto
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12118086
Abstract: The selection of a DNA extraction method is a critical step when subsequent analysis depends on the DNA quality and quantity. Unlike mammals, for which several capable DNA extraction methods have been developed, for molluscs the availability of optimized genomic DNA extraction protocols is clearly insufficient. Several aspects such as animal physiology, the type (e.g., adductor muscle or gills) or quantity of tissue, can explain the lack of efficiency (quality and yield) in molluscs genomic DNA extraction procedure. In an attempt to overcome these aspects, this work describes an efficient method for molluscs genomic DNA extraction that was tested in several species from different orders: Veneridae, Ostreidae, Anomiidae, Cardiidae (Bivalvia) and Muricidae (Gastropoda) , with different weight sample tissues. The isolated DNA was of high molecular weight with high yield and purity, even with reduced quantities of tissue. Moreover, the genomic DNA isolated, demonstrated to be suitable for several downstream molecular techniques, such as PCR sequencing among others.
Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer
Sandra Costa, Daniela Pinto, Deolinda Pereira, Helena Rodrigues, Jorge Cameselle-Teijeiro, Rui Medeiros, Fernando Schmitt
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-32
Abstract: We analysed DNA samples from 264 breast cancer patients and 440 controls, for TP53 Arg72Pro and PIN3 Ins16bp polymorphisms using PCR-RFLP.We observed that women with A2A2 genotype have increased risk for developing breast cancer, either in women with or without familial history (FH) of the disease (OR = 4.40, 95% CI 1.60–12.0; p = 0.004; OR = 3.88, 95% CI 1.18–12.8; p = 0.026, respectively). In haplotype analysis, statistically significant differences were found between TP53 Arg-A2 haplotype frequencies and familial breast cancer cases and the respective control group (OR = 2.10, 95% CI 1.08–4.06; p = 0.028). Furthermore, both TP53 polymorphisms are associated with higher incidence of lymph node metastases.Our findings suggest TP53 PIN3 Ins16bp polymorphism as a real risk modifier in breast cancer disease, either in sporadic and familial breast cancer. Furthermore, both TP53 polymorphisms are associated with higher incidence of lymph node metastases.Breast cancer have been associated with well-established risk factors, such as high estrogen exposure, environmental factors (e. g. diet and ionizing radiation) and family history [1,2]. Family history of breast cancer is a particularly important high risk factor for this disease. Two genes were identified as the major susceptibility genes in high risk families, namely BRCA1 and BRCA2. However, these genes account for only a minority of the overall family risk of breast cancer [3]. Furthermore, approximately only 10% of all breast cancer cases exhibit a familial pattern of incidence [4,5]. In this way, the remaining familial and sporadic risk may be due to common low to moderate penetrance genetic variants, which are also referred as genetic polymorphisms. One strong candidate for genetic susceptibility factor to familial and/or sporadic breast cancer is the TP53 gene. This gene is frequently somatically mutated in breast cancer [6,7] and TP53 germline mutations are associated with increased risk for developing diverse m
Produ??o de mudas de hortel?-japonesa em fun??o da idade e de diferentes tipos de estaca
Chagas, Jorge Henrique;Pereira Pinto, José Eduardo Brasil;Bertolucci, Suzan Kelly Vilela;Nalon, Felipe Hébia;
Ciência Rural , 2008, DOI: 10.1590/S0103-84782008000800011
Abstract: the objective of this research was to verify the influence of different age and types of cuttings in the production of scion of mentha arvensis l. four different types of cuttings were evaluated: apical and medium cuttings (from aerial part); tip and medium cuttings (from rhizome part). the different types of cuttings were evaluated at 25 and 40 days of age. the cuttings used had 4-5cm long and covered with plantmax? substrate to a depth of 2/3. two rooting periods (25 and 40 days) from the different types of cuttings were evaluated: height, shoots number, aerial and roots dry biomass and percentage of mortality. the cuttings after the rooting period were transplanted to bed and pots. the mortality and the aerial part, roots and rhizome dry biomass were determined 30 days after being cultivated. the results showed that apical cuttings from aerial part at 25 and 40 days after being planted in trays had higher rooting, aerial part development and low mortality. at 25 days the aerial part developed and the scion was ready to be transplanted to field. thirty days after transplanted apical cuttings from aerial part showed a higher growth, except for rhizome dry biomass.
Crescimento vegetativo e produ??o de óleo essencial de hortel??pimenta cultivada sob malhas
Costa, Andressa Giovannini;Chagas, Jorge Henrique;Pinto, José Eduardo Brasil Pereira;Bertolucci, Suzan Kelly Vilela;
Pesquisa Agropecuária Brasileira , 2012, DOI: 10.1590/S0100-204X2012000400009
Abstract: the objective of this work was to evaluate the growth and the content, yield, and chemical composition of the essential oil of peppermint (mentha piperita) grown under different nets in lavras, mg, brazil. peppermint plants were grown in five environments: full sun, black net, aluminet net, blue net, and red net, all with 50% of irradiance. the experimental design was a completely randomized block with four replicates and five plants per plot. the evaluated parameters were: vegetative growth, content, yield, and chemical analysis of the essential oil. peppermint plants grown under full sun and black and red nets produced higher dry leaf biomass and higher essential oil content and yield. however, in full sun, the essential oil of the plants had higher contents of menthol and, under black and blue nets, of menthophurane. therefore, it is possible to manipulate plant growth and yield and chemical composition of the essential oil of peppermint with cultivation under nets or full sun.
EFEITO HIPOLIDêMICO E SINéRGICO DA NARINGINA, CLOROFILA E MONASCUS EM RATOS (RATUS NOVERGICUS)
Tania Toledo de OLIVEIRA,Tanus Jorge NAGEM,Wander Lopes PEREIRA,Aloísio Silva PINTO
Alimentos e Nutri??o , 2009,
Abstract: O objetivo do presente trabalho é avaliar a redu o dos níveis de colesterol e outros lipídeos administrando substancias naturais a ratos com hiperlipidemia induzida por Triton, visando conhecer novas substancias para o tratamento das hiperlipidemias e, dessa forma, aumentar as alternativas de preven o e/ou controle das doen as cardiovasculares. Para induzir a hiperlipidemia, foi administrado, por via intraperitoneal, Triton, na dose de 300 mg/kg de peso corporal. Imediatamente após a administra o do Triton, os animais receberam de cada substancia 2 doses de 5 mg/kg de peso corporal, por via intraperitoneal, sendo a primeira imediatamente após a administra o do Triton e a segunda 20 horas depois. Decorridas 23 horas desta última administra o, as dosagens sorológicas de colesterol, colesterol-HDL e triacilgliceróis foram efetuadas. Os resultados indicaram que o grupo que recebeu Naringina + Monascus foi o que apresentou a maior porcentagem de varia o (66,70%) para colesterol e o maior aumento nos níveis de colesterol-HDL (16,14%). Observa-se ainda que os animais que receberam Naringina e os que receberam Naringina + Monascus foram os mais eficientes na redu o de triacilgliceróis.
Diagnóstico molecular da taxa de infec??o natural de flebotomíneos (Psychodidae, Lutzomyia) por Leishmania sp na Amaz?nia maranhense
Oliveira-Pereira, Yrla Nívea;Rebêlo, José Manuel Macário;Moraes, Jorge Luiz Pinto;Pereira, Silma Regina Ferreira;
Revista da Sociedade Brasileira de Medicina Tropical , 2006, DOI: 10.1590/S0037-86822006000600005
Abstract: the natural infection rate due to leishmania was studied in three different sandfly species using the polymerase chain reaction technique. leishmania specific primers were designed to examine whether sandfly pools were infected. in total 1,100 female sandflies separated into pools of 10 individuals, consisting of 50 pools of lutzomyia whitmani, 43 of lutzomyia triacantha and 17 of lutzomyia choti, were analyzed. among all the pools examined, four pools of lutzomyia whitmani were positive, but none of the pools of the other two species were infected. thus, a total infection rate of 0.4% was established in this study. a similar infection rate was found in previous studies, suggesting that lutzomyia whitmani transmits leishmania to mammals in buriticupu, maranh?o.
Análisis multifactorial de los factores de riesgo de bajo peso al nacer en Salvador, Bahia
Solla,Jorge José Santos Pereira; Pereira,Rosana Aquino Guimar?es; Medina,María Guadalupe; Pinto,Lorene Louise S.; Mota,Eduardo;
Revista Panamericana de Salud Pública , 1997, DOI: 10.1590/S1020-49891997000700001
Abstract: this study is a multifactorial analysis of the risk factors for low birthweight in a group of newborns in an urban area of brazil. a total of 1 023 infants born in four maternity units in salvador, bahia, between july 1987 and february 1988 were included in the study. the sources of information were clinical histories and interviews with the mothers in the maternity units. the analysis was by means of logistic regression. in the final model the risk factors were the following: maternal age less than 21 years or more than 35; gestational age less than 38 weeks; unfavorable outcome of an earlier pregnancy; interval of 12 months or less since prior birth; tobacco smoking; and hypertension. the population attributable risk values for the risk factors included in the final model are presented. these factors should be used to identify pregnant women at high risk of giving birth to a low-birthweight baby, in order to provide them with more prenatal care.
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