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Search Results: 1 - 10 of 23065 matches for " Jorge Galvez "
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A Graph-Theoretical Approach to Calculate Vibrational Energies of Atomic and Subatomic Systems  [PDF]
Jorge Galvez
Open Journal of Physical Chemistry (OJPC) , 2012, DOI: 10.4236/ojpc.2012.24028
Abstract: One of the challenges still pending in string theory and other particle physics related fields is the accurate prediction of the masses of the elementary particles defined in the standard model. In this paper an original algorithm to assign graphs to each of these particles is proposed. Based on this mapping, we demonstrate that certain indices associated with the topology of the graph (graph theoretical indices) are very effective in predicting the masses of the particles. Specifically, the spectral moments of the graph adjacency matrix weighted by edge degrees play a key role in the excellent correlations found. Moreover, the same topological pattern is found in other well known quantum systems such as the particle in a box and the vibrational frequencies of diatomic molecules, such as hydrogen. The results shown here open a suggestive pathway for the use of graph-theoretical approaches in predicting properties of elementary particles and other physical systems, which seem to match similar topological patterns.
A Graph Theoretical Interpretation of Different Types of Energies of Elementary Particles, Atoms and Molecules  [PDF]
Jorge Galvez
Open Journal of Physical Chemistry (OJPC) , 2019, DOI: 10.4236/ojpc.2019.92003
Abstract: The present work illustrates a predictive method, based on graph theory, for different types of energy of subatomic particles, atoms and molecules, to be specific, the mass defect of the first thirteen elements of the periodic table, the rotational and vibrational energies of simple molecules (such as \"\", H2, FH and CO) as well as the electronic energy of both atoms and molecules (conjugated alkenes). It is shown that such a diverse group of energies can be expressed as a function of few simple graph-theoretical descriptors, resulting from assigning graphs to every wave function. Since these descriptors are closely related to the topology of the graph, it makes sense to wonder about the meaning of such relation between energy and topology and suggests points of view helping to formulate novel hypotheses about this relation.
The Challenge of Targeting Notch in Hematologic Malignancies
Jorge R. Galvez Silva,Patrick A. Zweidler-McKay
Frontiers in Pediatrics , 2014, DOI: 10.3389/fped.2014.00054
Abstract: Notch signaling can play oncogenic and tumor suppressor roles depending on cell type. Hematologic malignancies encompass a wide range of transformed cells, and consequently the roles of Notch are diverse in these diseases. For example Notch is a potent T-cell oncogene, with >50% of T-cell acute lymphoblastic leukemia (T-ALL) cases carry activating mutations in the Notch1 receptor. Targeting Notch signaling in T-ALL with gamma-secretase inhibitors, which prevent Notch receptor activation, has shown pre-clinical activity, and is under evaluation clinically. In contrast, Notch signaling inhibits acute myeloblastic leukemia growth and survival, and although targeting Notch signaling in AML with Notch activators appears to have pre-clinical activity, no Notch agonists are clinically available at this time. As such, despite accumulating evidence about the biology of Notch signaling in different hematologic cancers, which provide compelling clinical promise, we are only beginning to target this pathway clinically, either on or off. In this review, we will summarize the evidence for oncogenic and tumor suppressor roles of Notch in a wide range of leukemias and lymphomas, and describe therapeutic opportunities for now and the future.
Whole Slide Imaging and telepathology
J Galvez
Breast Cancer Research , 2003, DOI: 10.1186/bcr669
Abstract: The immediate need has been for publication quality images that are connected to a robust database. This has been accomplished using a shareware program that is connected to our SQL Mutant Mouse Pathology Archive database. This program develops Image Galleries 'on the fly' that can display still images with demographic, genetic, and diagnostic information stored in the database. The application includes a dialog box that permits the viewer and the pathologist to exchange information and comments. However, the images are limited to adynamic jpeg and tiff files that illustrate limited fields selected by the photographer and do not display or annotate the image in full context.To provide the digital view of the complete slide in context, several new technologies have been merged to the Image Archive using Whole Slide Imaging. Whole Slide images are digital images of the entire block face or slide. These digitized images are captured, compressed and viewed on any browser over the internet. The digital image allows users to view entire microscopic images at any magnification on their monitor. The images are captured with the ScanScope (AperioTech Inc., Vista, CA, USA) in approximately 3–5 min at a resolution of 50,000 dpi, producing 8–20 Gb of raw data. To make the images accessible to the community, the images are processed with the Zoomify compression algorithm which results in a 200–300 Mb image that can be viewed with a standard web browser using a Flash6 plug-in. The plug-in only downloads the pixels required to render the view requested by the user (approximately 75 kb/view).The images can be annotated with layers that point to specific features in the image allowing users to easily navigate to selected points of interest within a slide while still being able to maneuver the entire slide. Examples of these images can be viewed online http://imagearchive.compmed.ucdavis.edu webcite.The full capabilities of the Zoomify system, have been exploited by combining the Who
Aplicación de transductores de estado-finito a los procesos de unificación de términos
Galvez, Carmen;
Ciência da Informa??o , 2006, DOI: 10.1590/S0100-19652006000300007
Abstract: an approach based on techniques of state-finite has applied to the processes of unification of terms in spanish. the algorithms of conflation are computational procedures utilized in some information retrieval (ri) systems for the unification of term variants, semantically equivalent, to a normalized form. the programs that carry out habitually this process are called: stemmers and lematizadores. the objective of this work is to evaluate the deficiencies and errors of the lematizadores in the conflation of terms. the method utilized for the construction of the lematizador has been based on the implementation of a linguistic tool that permits to build electronic dictionaries represented internally in finite-state transducers (fst). the lexical resources developed have applied to a corpus of verification to evaluate the performance of these lexical parsers. the metric of evaluation utilized has been an adaptation of coverage and precision measures. the results show that the main limitation of unification processes of tem variants through technology of state-finite is the under-analysis.
La capacidad de dirección y la formación de los ingenieros agrónomos
Cuellar Galvez David
Agronomía Colombiana , 1992,
Abstract: This paper analyzes the scenery for the academic reform in the Schooll of Agriculture of the Universidad Nacional de Colombia. It emphasizes the need for developing leadership as a main trait for the students. It is stressed the importance of, first, distinguishing between "summing up knowlegde" and "rational thinking", and second, assuming that the whole is more than the addition of its parts. Structural changes and practical ways of dealing with the leadership education, underlying the relevance of the student autonomous work as a learning approach, are, suggested. El documento expone diversas circunstancias que motivan la reforma académica en Agronomía, de las que infiere la importancia de formar Ingenieros Agrónomos con capacidad de dirigencia. A continuación sustenta que al abordar el proceso de formación se debe diferenciar la suma de conocimientos, del proceso de raciocinio, y además considerar que el todo es más (o menos) que la suma de las partes. El documento sugiere cambios en la estructura curricular, cambios metodológicos y el estímulo de un ambiente extra curricular, para avanzaren la formación de dirigentes, subrayando la importancia del "trabajo autónomo" de los estudiantes.
Los planes de estudio de agronomía y el componente ambiental
Cuellar Galvez David
Agronomía Colombiana , 1995,
Abstract: Este articulo tiene como propósito mostrar la relación estrecha entre los planes de estudio de la carrera de agronomía con los modelos de desarrollo de la agricultura, as! como con una creciente elevación del nivel académico, elevación representada por transformaciones en los métodos de ense anza, redefiniciones de contenidos en los cursos y transformaciones en la estructura curricular, buscando opciones para acercar los conocimientos científicos en la interpretación y transformación del proceso productivo en las condiciones que se dan en nuestro país. Para desarrollar esta punta se hará un análisis histórico de la formación del ingeniero Agrónomo en Colombia, subrayando algunos elementos que permiten enfocar el como integrar la cuestión ambiental en el curriculum, de manera tal que coadyuven un proceso de transformación de la agricultura. Para facilitar este análisis se definen cuatro etapas, iniciando con una primera que cubre desde la creación da los primaros programas curriculares hasta 1945, época en la que aun predomina en el país una agricultura extensiva; se sigue con una segunda etapa (1945-1960) en la cual emerge con fuerza, en algunas regiones del país, una agricultura empresarial de tipo capitalista: una tercera etapa (1960-1975) se define con el ''boom'' en la agricultura de las variedades de altos rendimientos, y con el desarrollo de programas del Estado para el campesinado: por último, se define una etapa en la cual la agricultura colombiana se enmarca en la búsqueda de nuevas formas de relacionarse con el Estado, con los ciudadanos y con la naturaleza, dentro de contextos de globalización de la economía.
Tromboelastografía: nuevos conceptos en la fisiología de la hemostasia y su correlación con la coagulopatía asociada al trauma Thromboelastography: New concepts in haemostasis physiology and correlation with trauma associated coagulopathy
Kenny Galvez,Claudia Cortes
Revista Colombiana de Anestesiología , 2012,
Abstract: La interpretación inicial del proceso de coagulación mencionaba la presencia de 2 vías: la extrínseca, formada por el factor tisular (FT) y el factor VII, y la intrínseca, en la que participan los factores XII, XI, IX, VIII y V. Hoy en día este concepto ha cambiado y se acepta de forma categórica que el evento iniciador principal de la coagulación sanguínea es la exposición del FT. En este artículo revisamos los nuevos conceptos de la cascada de coagulación con los hallazgos de la tromboelastografía y los diferentes mecanismos que precipitan la coagulopatía asociada al trauma. Para tal fin se realizó una búsqueda sistemática en las principales bases de datos, como Medline, Embase y Lilacs, en el periodo comprendido entre 2000 y 2011. Se encontraron 114 artículos, de los cuales se tomaron 50 para realizar la revisión. Como hallazgo relevante se encontró que la tromboelastografía permite detectar con precisión el defecto subyacente en la cascada de coagulación, y de esta manera se ha convertido en una herramienta útil e indispensable para guiar el manejo de la coagulopatía asociada al trauma. Initial interpretation of the process of coagulation refers to two pathways: (1) the extrinsic pathway, consisting of tissue factor (TF) and factor VII, and (2) the intrinsic pathway, in which factors XII, XI, IX, VIII and V are involved. Currently, this concept has changed and it is accepted that the main initiating event in blood coagulation is TF exposure. In this article, we review the new concepts of the coagulation cascade based on thromboelastography findings and the different mechanisms involved in trauma-associated coagulopathy. For this purpose, a systematic research was carried out using the main databases, including Medline, Embase and Lilacs between 2000 and 2011. One hundred and fourteen articles were found, and 50 were selected for the review. A relevant finding was that thromboelastography allows a precise detection of the underlying flaw in the coagulation cascade. Therefore, this procedure has become an essential tool and a guide for the management of trauma-associated coagulopathy.
Infinite sums of Adams operations and cobordism
Imma Galvez,Sarah Whitehouse
Mathematics , 2004,
Abstract: In recent work by Clarke, Crossley and the second author, various algebras of stable degree zero operations in p-local K-theory were described explicitly. The elements are certain infinite sums of Adams operations. Here we show how to make sense of the same expressions for p-local cobordism and for BP, thus identifying the "Adams subalgebra" of the algebras of operations. We prove that the Adams subalgebra is the centre of the ring of degree zero operations.
Molecular Topology as Novel Strategy for Discovery of Drugs with Aβ Lowering and Anti-Aggregation Dual Activities for Alzheimer’s Disease
Jun Wang, David Land, Kenjiro Ono, Jorge Galvez, Wei Zhao, Prashant Vempati, John W. Steele, Alice Cheng, Masahito Yamada, Samara Levine, Paolo Mazzola, Giulio M. Pasinetti
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0092750
Abstract: Background and Purpose In this study, we demonstrate the use of Molecular topology (MT) in an Alzheimer’s disease (AD) drug discovery program. MT uses and expands upon the principles governing the molecular connectivity theory of numerically characterizing molecular structures, in the present case, active anti-AD drugs/agents, using topological descriptors to build models. Topological characterization has been shown to embody sufficient molecular information to provide strong correlation to therapeutic efficacy. Experimental Approach We used MT to include multiple bioactive properties that allows for the identification of multi-functional single agent compounds, in this case, the dual functions of β-amyloid (Aβ) -lowering and anti-oligomerization. Using this technology, we identified and designed novel compounds in chemical classes unrelated to current anti-AD agents that exert dual Aβ lowering and anti-Aβ oligomerization activities in animal models of AD. AD is a multifaceted disease with different pathological features. Conclusion and Implications Our study, for the first time, demonstrated that MT can provide novel strategy for discovering drugs with Aβ lowering and anti-aggregation dual activities for AD.
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