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Search Results: 1 - 10 of 26166 matches for " Jorge Erdely Graham "
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Ministros de culto y abuso sexual. Existen cifras en México?: un acercamiento estadístico
Jorge Erdely Graham
Ciencia Ergo Sum , 2003,
Abstract: Se presenta una panorámica global que abarca distintas regiones, posteriormente se hace referencia al caso de México. Usando un metaanálisis, estudios de campo, datos empíricos y estadísticas, se presenta una aproximación cuantitativa preliminar y datos cualitativos sobre los casos de abuso sexual por parte de los ministros de culto de diferentes afiliaciones.
Suicidios colectivos rituales: un análisis interdisciplinario
Jorge Erdely Graham
Ciencia Ergo Sum , 2000,
Abstract: A partir de estudiar la manipulación psicofisiológica que inhibe el juicio crítico en comunidades con pretensiones mesiánicas que han conducido a suicidios colectivos rituales, el autor propone intensificar las investigaciones que conduzcan a evitar estas patologías.
Backtesting forecast accuracy
Arturo Erdely
Statistics , 2015,
Abstract: A statistical test based on the geometric mean is proposed to determine if a predictive model should be rejected or not, when the quantity of interest is a strictly positive continuous random variable. A simulation study is performed to compare test power performance against an alternative procedure, and an application to insurance claims reserving is illustrated.
New Approaches to Vaccine Adjuvants: Inhibiting the Inhibitor.
PLOS Medicine , 2006,
Sex differences in slow-wave electroencephalographic activity (SWA) in adolescent depression
Jorge Lopez,Robert Hoffmann,Graham Emslie,Roseanne Armitage
Mental Illness , 2012, DOI: 10.4081/mi.2012.e4
Abstract: Sleep disturbance, present in more than 90% of major depressive disorder (MDD) patients, are moderated by sex in adult MDD. In particular, slow-wave electroencephalographic activity (SWA; 0.5-4 Hz) accumulation is low and dissipation impaired. This SWA abnormality in depressed adult males does not change with age, suggesting that SWA abnormality appears at early ages. The present study evaluated sex differences in SWA in adolescents with MDD compared to healthy controls. We evaluated regularized sleep-wake schedules at home for 5-7 days, followed by two consecutive nights of sleep EEG recording. The study included 104 participants, 52 symptomatic and depressed subjects (MDD: 20 males and 32 females) and 52 healthy controls (HC: 20 males and 32 females), aged 13-18 years. SWA power and dissipation, and duration and latencies to each Non-Rapid Eye Movement (NREM) sleep period were calculated for each group. Results showed that SWA accumulation in the first NREM period was lower and its dissipation across the night more irregular in MDD males compared to HC males (P<0.009). By contrast, SWA was equivalent in MDD and HC females. In conclusion, as reported in adult MDD, the accumulation and dissipation of SWA was abnormal in depressed adolescents, but only in males. SWA abnormalities in adolescent MDD may relate to different depressive symptoms in females and males. These results underscore the need to develop sex-specific therapies to enhance and restore SWA in depressed adolescents
A Neurological Perspective upon Diabetes and Obesity, What They Are, and How They Can Be Measured  [PDF]
Graham Ewing
Case Reports in Clinical Medicine (CRCM) , 2018, DOI: 10.4236/crcm.2018.74025
Abstract: New technologies bring new insights. The existence of the first mathematical model of how the brain regulates the autonomic nervous system and physiological systems, and knowledge of how this can be applied to screen or treat the diabetic, enables the author to take a comprehensive view of the etiology of diabetes and obesity. This paper illustrates the dynamic relationship between the brain, physiological systems and visceral organs. It highlights that 1) blood glucose is a neurally regulated physiological system, and/or network of organs, which function coherently in order to maintain blood glucose within normal physiological limits; and 2) that dysregulation of this physiological system (regulation of blood glucose levels), by genetic or phenotypic pathologies in the organs in this system, influences the prevailing levels of insulin, directly influences brain function and hence the coherent function of this and other physiological systems and organs e.g. blood pressure, sleep, pH, digestion, sexual function, etc. In addition 3) the observation that proteins may be coiled and reactive, or uncoiled and resist reacting with their reactive substrates, leads to a greater level of understanding of the mechanisms responsible for type 2 diabetes and obesity and how such conditions could be screened and treated.
Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume
Patti C Zeidler-Erdely, Michael L Kashon, Lori A Battelli, Shih-Houng Young, Aaron Erdely, Jenny R Roberts, Steven H Reynolds, James M Antonini
Particle and Fibre Toxicology , 2008, DOI: 10.1186/1743-8977-5-12
Abstract: BAL revealed notable strain-dependent differences with regards to the degree and resolution of the inflammatory response after exposure to the fumes. At 48 weeks, carcinogenic metal-containing GMA-SS fume caused the greatest increase in tumor multiplicity and incidence, but this was not different from sham. By 78 weeks, tumor incidence in the GMA-SS group versus sham approached significance (p = 0.057). A significant increase in perivascular/peribronchial lymphoid infiltrates for the GMA-SS group versus sham and an increased persistence of this fume in lung cells compared to the other welding fumes was found.The increased persistence of GMA-SS fume in combination with its metal composition may trigger a chronic, but mild, inflammatory state in the lung possibly enhancing tumorigenesis in this susceptible mouse strain.For decades researchers have tried to determine whether exposure to welding fumes poses an increased risk of lung cancer. Indeed, this health concern is one of the most important questions in welding fume-related toxicological research. The International Agency for Research on Cancer has deemed welding fume a group 2B agent, defined as a mixture "possibly carcinogenic" to humans [1]. This categorization of welding fume carcinogenicity, however, was based on limited evidence in humans and a lack of animal data.The harmful health effects of welding are well documented and epidemiological evidence generally supports the hypothesis that exposure to welding fume increases lung cancer risk, but confounders such as asbestos exposure and smoking obscure these findings [2-5]. Debate also exists over which type of welding may pose the greater risk. Interestingly, fumes from both non-carcinogenic metal-containing mild steel (MS) and carcinogenic metal-containing stainless steel (SS) welding wire have been shown to increase lung cancer risk in welders [6,7]. For these reasons, we initiated a multipart study to ultimately determine the carcinogenic potential of SS a
Case Study: The Determination of a Complex Multi-Systemic Medical Condition by a Cognitive, Virtual Scanning Technique  [PDF]
Graham Wilfred Ewing
Case Reports in Clinical Medicine (CRCM) , 2015, DOI: 10.4236/crcm.2015.46042
The study of various medical conditions is limited by the current state of knowledge. New tech-nologies enable researchers to advance their understanding of various medical conditions and to advance their understanding of particular pathologies. Strannik Virtual Scanning (SVS) is such a technology. SVS is able to determine the genetic and non-genetic components of every pathology in each of the 30 main organs, and it is able to determine the onset of pathologies at a much earlier stage than any other technologies or techniques. This makes it an ideal tool to screen for the onset and progression of pathologies which are implicated in multi-systemic conditions and to determine the spectrum of pathologies i.e. comorbidities which are involved in diabetes, cardiovascular disease, migraine, chronic fatigue syndrome, fibromyalgia, depression, chronic kidney disease, etc. This case study illustrates how the technology can be usefully and cost-effectively deployed to determine the spectrum of pathologies which characterise Reynaud’s phenomenon. This includes pathologies in the liver and kidneys e.g. portal hypertension, renal insufficiency, nephritis, liver insufficiency, pre-symptomatic onset of heart attack, presymptomatic indications of dementia, pancreatic cancer, and ovarian cancer, which are difficult to diagnose and/or for which there is currently an unmet clinical need.
The Successful Treatment of Dysarthria Using Strannik Light Therapy (Biofeedback): A Case Study  [PDF]
Graham Wilfred Ewing
Case Reports in Clinical Medicine (CRCM) , 2015, DOI: 10.4236/crcm.2015.47053
Abstract: This article reports a case of dysarthria which was successfully treated by Strannik Light Therapy (SLT). It briefly discusses the known etiology for the condition and illustrates that dysarthria must be a problem of autonomic dysfunction in which pathological changes can influence the structure and/or subsequent function of the dynamic interplay between the brain and the organs involving the autonomic nervous system and physiological systems. The author reports a particular case in which a patient undertaking SLT fully recovered the ability to speak within 6 days.
Comparison of RANS and LES in the Prediction of Airflow Field over Steep Complex Terrain  [PDF]
Takanori Uchida, Graham Li
Open Journal of Fluid Dynamics (OJFD) , 2018, DOI: 10.4236/ojfd.2018.83018
Abstract: The present study compared the prediction accuracy of the three CFD software packages for simulating airflow around a three-dimensional, isolated hill with a steep slope: 1) WindSim (turbulence model: RNG k-ε RANS), 2) Meteodyn WT (turbulence model: k-L RANS), which are the leading commercially available CFD software packages in the wind power industry and 3) RIAM-COMPACT (turbulence model: standard Smagorinsky LES), which has been developed by the lead author of the present paper. Distinct differences in the airflow patterns were identified in the vicinity of the isolated hill (especially downstream of the hill) between the RANS results and the LES results. No reverse flow region (vortex region) characterized by negative wind velocities was identified downstream of the isolated hill in the result from the simulation with WindSim (RNG k-ε RANS) and Meteodyn WT (k-L RANS). In the case of the simulation with RIAM-COMPACT natural terrain version (standard Smagorinsky LES), a reverse flow region (vortex region) characterized by negative wind velocities clearly forms. Next, an example of wind risk (terrain-induced turbulence) diagnostics was presented for a large-scale wind farm in China. The vertical profiles of the streamwise (x) wind velocity do not follow the so-called power law wind profile; a large velocity deficit can be seen between the hub center and the lower end of the swept area in the case of the LES calculation (RIAM-COMPACT).
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