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Search Results: 1 - 10 of 580779 matches for " Jorge E; García-Nieto "
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Exposición infantil al plomo en sitios contaminados
Flores-Ramírez,Rogelio; Rico-Escobar,Edna; Nú?ez-Monreal,Jorge E; García-Nieto,Edelmira; Carrizales,Leticia; Ilizaliturri-Hernández,César; Díaz-Barriga,Fernando;
Salud Pública de México , 2012, DOI: 10.1590/S0036-36342012000400008
Abstract: objective: to assess the exposure to lead in children living in various types of contaminated sites. materials and methods: the study was conducted from june 2008 to december 2009 at four sites in mexico: avalos metallurgical, chihuahua; morales metallurgical, san luis potosí (slp); trinidad pottery area, tlaxcala and cedral mine site, slp. these sites contain different sources of lead. the metal levels were quantified in outdoor dust and in peripheral blood of children. results: lead dust concentrations exceed the national guidelines for residential soils (400 mg/kg) in a range of values for the four sites from 62 to 5 187 mg/kg. regarding biological monitoring, the studied children showed maximum lead blood levels of 22 μg/dl in cedral, 31 μg/dl in morales, 32 μg/dl in avalos, and 52 μg/dl in trinidad. it is important to mention that in all the studied sites, a significative positive correlation was found between blood lead levels and the lead concentrations in dust. conclusion: these sites are an example of the health risks related to lead exposure in mexico; therefore, there is an urgent need for a national public health program aimed at reducing lead exposure in vulnerable populations.
Déficit de memoria en una muestra de pacientes con dolor crónico
García-Nieto,R.; Ortega-Ladrón de Cegama,E.; Ruiz de Santos,E.; Lorenzo,J. Ma;
Revista de la Sociedad Espa?ola del Dolor , 2008,
Abstract: background: it is relatively common that patients suffering from chronic pain complain about memory loss and concentration problems. traditionally, this fact has been connected with the medication aimed at the management of pain, with the depressed mood and with pain itself. aims: to know whether the subjective complaints of memory loss about which these patients complain can be found in their performance in neuropsychological tasks. secondly, to study whether there is any difference in such tasks between patients suffering from chronic pain with depressed mood and those without depressive symptomatology. finally, to analyze if there is a relationship between the severity of the depressive symptomatology and the performance in neuropsychological tasks that assess memory and attention. method: in order to fulfil the previous aims, we have carried out a transversal observational study. in this study, 21 patients with chronic pain and subjective complaints of memory loss referred by the pain unit of the "río hortega" university hospital took part. results: only those patients suffering from chronic pain and depressed mood performed badly in neuropsychological tasks, especifically in the ones that assess memory in which attention plays a major role. finally, the data obtained in our study revealed that the more severe the depressive disorder was, the more the performance of the patients in the neuropsychological tasks got worse. discussion: subjective complaints of memory loss that these patients state seem to be related to the depressed mood from which many of them suffer. memory impairment can be explained, at least partially, by the attentional déficit they suffer from.
Déficit de memoria en una muestra de pacientes con dolor crónico Memory impairment in a sample of patients with chronic pain
R. García-Nieto,E. Ortega-Ladrón de Cegama,E. Ruiz de Santos,J. Ma Lorenzo
Revista de la Sociedad Espa?ola del Dolor , 2008,
Abstract: Introducción: Es relativamente frecuente que los pacientes con dolor crónico se quejen de problemas de memoria y concentración. Históricamente, este hecho se ha relacionado con la medicación dirigida al control del dolor, con el estado de ánimo y con el hecho de padecer dolor crónico. Objetivos: Conocer si las quejas subjetivas de pérdida de memoria que refieren los pacientes se objetivan en su ejecución en pruebas neuropsicológicas. En segundo lugar, estudiar si hay alguna diferencia en el rendimiento en dichas pruebas entre pacientes con dolor crónico que presentan sintomatología depresiva asociada y aquellos que no presentan dicha sintomatología. Por último, analizar si existe alguna relación entre la intensidad del episodio depresivo que padece el paciente con dolor crónico y el rendimiento en pruebas neuropsicológicas que evalúan atención y memoria. Método: Se trata de un estudio observacional transversal en el que participaron pacientes derivados por la Unidad de Dolor del Hospital Universitario "Del Río Hortega" con problemas de dolor crónico y queja subjetiva de pérdida de memoria. Conclusiones: únicamente los pacientes con dolor crónico y depresión asociada tuvieron un rendimiento deficitario en pruebas neuropsicológicas, especialmente en tareas que evalúan memoria en las que la atención juega un papel importante. Por último, los datos de nuestro estudio revelan que a medida que la intensidad del episodio depresivo que padece el paciente aumenta, el rendimiento del paciente en dichas pruebas empeora. Discusión: Las quejas subjetivas de pérdida de memoria que refieren estos pacientes parecen guardar relación con el estado de ánimo depresivo que muchos de ellos presentan. Las alteraciones mnésicas parecen explicarse, al menos en parte, por el déficit atencional que padecen. Background: It is relatively common that patients suffering from chronic pain complain about memory loss and concentration problems. Traditionally, this fact has been connected with the medication aimed at the management of pain, with the depressed mood and with pain itself. Aims: To know whether the subjective complaints of memory loss about which these patients complain can be found in their performance in neuropsychological tasks. Secondly, to study whether there is any difference in such tasks between patients suffering from chronic pain with depressed mood and those without depressive symptomatology. Finally, to analyze if there is a relationship between the severity of the depressive symptomatology and the performance in neuropsychological tasks that assess memory and att
índices de calidad y eficiencia diagnóstica de varios marcadores de función renal para detectar la pérdida de parénquima en la edad pediátrica
García-Nieto,Víctor M.; Afonso-Coderch,María; García-Rodríguez,Victoria E.; Monge-Zamorano,Margarita; Hernández-González,M. José; Luis-Yanes,M. Isabel;
Nefrología (Madrid) , 2012, DOI: 10.3265/Nefrologia.pre2012.Jan.11168
Abstract: introduction: we analysed a large sample of children diagnosed with urinary tract malformations and/or infections and calculated diagnostic efficiency and quality indexes for five different functional markers, with the goal of testing which is the most sensitive for detecting a loss of renal parenchyma. patients and method: ours was a cross-sectional retrospective study in which the clinical histories of 179 paediatric patients (91 male and 88 female) were evaluated. in 102 of these patients (57%), a scintigraphy revealed loss of parenchyma. the most commonly observed morphological type of damage was renal scarring. all patients had undergone at least one desmopressin urine concentration test. we also analysed albumin/creatinine and n-acetyl-glucosaminidase (nag)/creatinine ratios, glomerular filtration rate (gfr), and urine volume. results: by distributing patients according to normal/abnormal scintigraphy, we observed statistically significant differences between the two groups in maximum urine osmolality and gfr. urine volume was elevated in 31.3% of cases (sensitivity: 37.9%; specificity: 81.8%) and 24% had a defect in renal concentrating ability (sensitivity: 30.4%; specificity: 84.8%). urinary albumin excretion was high in 12.2% of patients, and 7.2% had a high nag/creatinine ratio. gfr was low in only 5.7% of patients. these last two markers were the least sensitive but most specific for detecting a loss of renal parenchyma (100%). conclusions: in our study, the most sensitive functional tests for detecting the loss of renal parenchyma were the two that take into account the ability of the kidney to manage water, i.e. urine volume and maximum urine osmolality. these two tests had specificity >80%. however, the maximum specificity was obtained by the nag/creatinine ratio and gfr, which were, conversely, the least sensitive tests. a normal gfr does not necessarily show normal renal function.
Estrategias de Ense?anza a Distancia sobre Control No-Lineal Aplicada al Péndulo Invertido
García-Nieto,Sergio; Martínez,Miguel; Llosá,ángel; Sanchis,Javier;
Información tecnológica , 2007, DOI: 10.4067/S0718-07642007000500011
Abstract: this paper presents a software/hardware tool to study, at university level, distributed control systems in real time. this platform is applied to control nonlinear processes. the system has three different parts which students can evaluate and modify; i) a virtual model represents the physic model of the inverted pendulum; the controller is implemented by a real time distributed control system; and iii) the whole system is managed with a java application. therefore, students have all the necessary elements to practice with complex nonlinear systems, such as the inverted pendulum discussed in this work. the tests done show that the plattform represents a fast and reliable method for experimentation by the students.
Estrategias de Ense anza a Distancia sobre Control No-Lineal Aplicada al Péndulo Invertido Strategies for Distance Learning Courses on Nonlinear Control Applied to the Inverted Pendulum
Sergio García-Nieto,Miguel Martínez,ángel Llosá,Javier Sanchis
Información Tecnológica , 2007,
Abstract: Este artículo describe el desarrollo de una herramienta software/hardware destinada al estudio, en el ámbito de la ense anza universitaria, de sistemas de control distribuidos en tiempo real. El sistema se empleará en el control de procesos no lineales. Esta herramienta presenta tres partes claramente diferenciadas, las cuales pueden ser analizadas y modificadas por los estudiantes: i) se introduce el modelo físico del péndulo invertido; ii) el controlador es implementado en un sistema distribuido de tiempo real; y iii) todo el sistema es manejado mediante una aplicación desarrollada en JAVA. Por lo tanto, los estudiantes tienen todos los elementos necesarios para trabajar con sistemas complejos no lineales, como el problema del péndulo invertido que se discute en este trabajo. Las pruebas realizadas muestran que la plataforma proporciona un método rápido y seguro de experimentación para los estudiantes. This paper presents a software/hardware tool to study, at university level, distributed control systems in real time. This platform is applied to control nonlinear processes. The system has three different parts which students can evaluate and modify; i) a virtual model represents the physic model of the inverted pendulum; the controller is implemented by a real time distributed control system; and iii) the whole system is managed with a JAVA application. Therefore, students have all the necessary elements to practice with complex nonlinear systems, such as the inverted pendulum discussed in this work. The tests done show that the plattform represents a fast and reliable method for experimentation by the students.
Contenido y traslocación de plomo en avena ( Avena sativa , L.) y haba ( Vicia faba , L.) de un suelo contaminado
García-Gallegos, Elizabeth;Hernández-Acosta, Elizabeth;García-Nieto, Edelmira;Acevedo-Sandoval, Otilio A.;
Revista Chapingo. Serie ciencias forestales y del ambiente , 2011, DOI: 10.5154/r.rchscfa.2010.02.002
Abstract: a greenhouse experiment was established to determine the concentration of lead (pb) in soil, root and aerial part of broad bean and oats. the bioconcentration and translocation factors in the two species were calculated, and 50, 100 and 150 mg·pb·kg-1 of soil, including a control, were tested. plants were collected 60 days after sowing and plant height (ph), root volume (rv) and total dry biomass (tdb) were measured, as well as pb content in soil, root and aerial part. the quantification of pb was performed by atomic absorption spectrophotometry. the soil cultivated with broad bean presented 28.48 % pbedta. the ph, rv and tdb variables were not drastically affected by the pb concentrations tested. the broad bean and oat plants absorbed a total of 55 mg·kg-1 and 45.3 mg·kg-1, respectively, which are considered toxic concentrations for cultivated plants. the results can serve as a base to expand knowledge of pb content absorbed and translocated in broad bean and oat plants, as the ability to tolerate and absorb pb is specific to the species, including the variety of plant.
Laminin and Fibronectin Treatment Leads to Generation of Dendritic Cells with Superior Endocytic Capacity
Samuel García-Nieto,Ramneek K. Johal,Kevin M. Shakesheff,Mohamed Emara,Pierre-Joseph Royer,David Y. S. Chau,Farouk Shakib,Amir M. Ghaemmaghami
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010123
Abstract: Sampling the microenvironment at sites of microbial exposure by dendritic cells (DC) and their subsequent interaction with T cells in the paracortical area of lymph nodes are key events for initiating immune responses. Most of our knowledge of such events in human is based on in vitro studies performed in the absence of extracellular matrix (ECM) proteins. ECM in basement membranes and interstitial spaces of different tissues, including lymphoid organs, plays an important role in controlling specific cellular functions such as migration, intracellular signalling and differentiation. The aim of this study was, therefore, to investigate the impact of two abundant ECM components, fibronectin and laminin, on the phenotypical and functional properties of DC and how that might influence DC induced T-cell differentiation.
Plomo y arsénico en la subcuenca del Alto Atoyac en Tlaxcala, México
García-Nieto, Edelmira;Carrizales-Ya?ez, Leticia;Juárez-Santacruz, Libertad;García-Gallegos, Elizabeth;Hernández-Acosta, Elizabeth;Briones-Corona, Elia;Vázquez-Cuecuecha, Oscar G.;
Revista Chapingo. Serie ciencias forestales y del ambiente , 2011, DOI: 10.5154/r.rchscfa.2010.06.040
Abstract: environmental indicators in the zahuapan-atoyac hydrological system (za:hs) in tlaxcala, mexico, a region impacted by wastewater discharges from urban, agricultural and industrial sources, were assessed. samples were collected in the spring 2008 dry season. sixteen sampling stations were selected, stretching from the source of the zahuapan river, including three samples from the atoyac river, to its exit point from the state of tlaxcala. arsenic, lead, ph and temperature were measured in the water samples; in the sediments, the following were measured: arsenic, lead, texture, organic matter content, total organic carbon, ph and electrical conductivity according to nmx-aa-051-scfi-2001, goyberg-rein and vázquez, 2003 and nom-021-semarnat-2000. the results showed that the arsenic concentrations ranged from 0.06 to 0.87 mgl-1 in water and from 1.3 to 127 mg·kg-1 in sediment, whereas lead levels reached up to 1.05 mgl-1 in water from a place called el ojito and 89.5 mgl-1 in sediment from the apizaco station. these levels exceeded the national and international levels set for drinking water and protection of aquatic life. the results suggest an anthropogenic contribution at some stations that adds to natural pollution.
Claudin-19 Mutations and Clinical Phenotype in Spanish Patients with Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis
Félix Claverie-Martín, Víctor García-Nieto, Cesar Loris, Gema Ariceta, Inmaculada Nadal, Laura Espinosa, ángeles Fernández-Maseda, Montserrat Antón-Gamero, áfrica Avila, álvaro Madrid, Hilaria González-Acosta, Elizabeth Córdoba-Lanus, Fernando Santos, Marta Gil-Calvo, Mar Espino, Elena García-Martinez, Ana Sanchez, Rafael Muley, RenalTube Group
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053151
Abstract: Familial hypomagnesemia with hypercalciuria and nephrocalcinosis is an autosomal recessive tubular disorder characterized by excessive renal magnesium and calcium excretion and chronic kidney failure. This rare disease is caused by mutations in the CLDN16 and CLDN19 genes. These genes encode the tight junction proteins claudin-16 and claudin-19, respectively, which regulate the paracellular ion reabsortion in the kidney. Patients with mutations in the CLDN19 gene also present severe visual impairment. Our goals in this study were to examine the clinical characteristics of a large cohort of Spanish patients with this disorder and to identify the disease causing mutations. We included a total of 31 patients belonging to 27 unrelated families and studied renal and ocular manifestations. We then analyzed by direct DNA sequencing the coding regions of CLDN16 and CLDN19 genes in these patients. Bioinformatic tools were used to predict the consequences of mutations. Clinical evaluation showed ocular defects in 87% of patients, including mainly myopia, nystagmus and macular colobomata. Twenty two percent of patients underwent renal transplantation and impaired renal function was observed in another 61% of patients. Results of the genetic analysis revealed CLDN19 mutations in all patients confirming the clinical diagnosis. The majority of patients exhibited the previously described p.G20D mutation. Haplotype analysis using three microsatellite markers showed a founder effect for this recurrent mutation in our cohort. We also identified four new pathogenic mutations in CLDN19, p.G122R, p.I41T, p.G75C and p.G75S. A strategy based on microsequencing was designed to facilitate the genetic diagnosis of this disease. Our data indicate that patients with CLDN19 mutations have a high risk of progression to chronic renal disease.
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