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Search Results: 1 - 10 of 3531 matches for " Jordan Morgan "
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Quantitative genomics of locomotor behavior in Drosophila melanogaster
Katherine W Jordan, Mary Carbone, Akihiko Yamamoto, Theodore J Morgan, Trudy FC Mackay
Genome Biology , 2007, DOI: 10.1186/gb-2007-8-8-r172
Abstract: We quantified locomotor behavior of Drosophila melanogaster in a large population of inbred lines derived from a single natural population, and derived replicated selection lines with different levels of locomotion. Estimates of broad-sense and narrow-sense heritabilities were 0.52 and 0.16, respectively, indicating substantial non-additive genetic variance for locomotor behavior. We used whole genome expression analysis to identify 1,790 probe sets with different expression levels between the selection lines when pooled across replicates, at a false discovery rate of 0.001. The transcriptional responses to selection for locomotor, aggressive and mating behavior from the same base population were highly overlapping, but the magnitude of the expression differences between selection lines for increased and decreased levels of behavior was uncorrelated. We assessed the locomotor behavior of ten mutations in candidate genes with altered transcript abundance between selection lines, and identified seven novel genes affecting this trait.Expression profiling of genetically divergent lines is an effective strategy for identifying genes affecting complex behaviors, and reveals that a large number of pleiotropic genes exhibit correlated transcriptional responses to multiple behaviors.Locomotion is required for localization of food and mates, escape from predators, defense of territory, and response to stress, and is, therefore, an integral component of most animal behaviors. In humans, Parkinson's disease, Huntington's disease, activity disorders and depression are associated with deficits in locomotion. Thus, understanding the genetic architecture of locomotor behavior is important from the dual perspectives of evolutionary biology and human health.Locomotion is a complex behavior, with variation in nature attributable to multiple interacting quantitative trait loci (QTL) with individually small effects, whose expression is sensitive to the environment [1]. Dissecting the ge
Development and Implementation of a Smartphone Application to Promote Physical Activity and Reduce Screen-Time in Adolescent Boys
David R. Lubans,Jordan J. Smith,Geoff Skinner,Philip J. Morgan
Frontiers in Public Health , 2014, DOI: 10.3389/fpubh.2014.00042
Abstract: Purpose: To describe the development and implementation of a smartphone application (app) designed to promote physical activity and reduce screen-time in adolescent boys considered “at-risk” of obesity.
Further Properties of Reproducing Graphs  [PDF]
Jonathan Jordan, Richard Southwell
Applied Mathematics (AM) , 2010, DOI: 10.4236/am.2010.15045
Abstract: Many real world networks grow because their elements get replicated. Previously Southwell and Cannings introduced a class of models within which networks change because the vertices within them reproduce. This happens deterministically so each vertex simultaneously produces an offspring every update. These offspring could represent individuals, companies, proteins or websites. The connections given to these offspring depend upon their parent’s connectivity much as a child is likely to interact with their parent’s friends or a new website may copy the links of pre-existing one. In this paper we further investigate one particular model, ‘model 3’, where offspring connect to their parent and parent’s neighbours. This model has some particularly interesting features, including a degree distribution with an interesting fractal-like form, and was introduced independently under the name Iterated Local Transitivity by Bonato et al. In particular we show connections between this degree distribution and the theory of integer partitions and show that this can be used to explain some of the features of the degree distribution; we give exact formulae for the number of complete subgraphs and the global clustering coefficient and we show how to calculate the minimal cycle basis.
A Comparative Analysis of MMPI and Rorschach Findings Assessing Combat-Related PTSD in Vietnam Veterans—Analysis of MMPI and Rorschach Findings Assessing PTSD  [PDF]
Ioanna Katsounari, Jordan Jacobowitz
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.24053
Abstract: There has been a proliferation of assessment research on Post-traumatic Stress Disorder (PTSD) over the past twenty years. In spite of recent advances in the PTSD assessment research, there continues to be a controversy as to whether the MMPI or Rorschach is more useful in determining the presence of PTSD. The present comparative analysis of the research literature will carefully evaluate controlled empirical studies, which utilized psychometric measures such as the MMPI/2 and Rorschach to identify PTSD in Vietnam Veterans. This analysis is guided by the paucity of comparative data for standardized objective and projective instruments to assess combat-related PTSD. The analysis indicated that the MMPI as an assessment instrument focuses on symptom recognition of PTSD while the Rorschach seems to be more likely to identify chronic adaptations to trauma. The significance of pre-combat factors, such as preexisting personality, and their impact on the way individuals make meaning and express traumatic experiences needs to be further addressed in future research. The need for reliable and valid measures to assess combat-related PTSD is urgent as an increasing number of soldiers return from war zones.
Maximizing Sampling Efficiency  [PDF]
Harmon S. Jordan
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.411209
Abstract: Background and Goals: Although health care quality improvement has traditionally involved extensive work with paper records, the adoption of health information technology has increased the use of electronic record and administrative systems. Despite these advances, quality improvement practitioners now and for the foreseeable future need guidance in defining populations of individuals for study and in selecting and analyzing sample data from such populations. Statistical data analysis in health care research often involves using samples to make inferences about populations. The investigator needs to consider the goals of the study, whether sampling is to be used, and the type of population being studied. While there are numerous sampling strategies designed to conserve resources and yield accurate results, one of these techniques—use of the finite population correction (FPC)—has received relatively little attention in health care sampling contexts. It is important for health care quality practitioners to be aware of sampling options that may increase accuracy and conserve resources. This article describes common sampling situations in which the issue of the finite population correction decision often arises. Methods: This article describes 3 relevant sampling situations that influence the design and analysis phases of a study and offers guidance for choosing the most effective and efficient design. Situation 1: The study or activity involves taking a sample from a large finite target population for which enumerative inferences are needed. Situation 2: The population is finite and the study is enumerative. A complete enumerative count of “defects” in the process is needed so that remediation can occur. Here, statistical inference is unnecessary. Situation 3: The target population is viewed as infinite; such populations are “conceptual populations” [1] or “processes”. Results: The article shows how savings in resources can be achieved by choosing the correct analytic framework at the conceptualization phase of study design. Choosing the right sampling approach can produce accurate results at lower costs. Several examples are presented and the implications for health services research are discussed. Conclusion: By clearly specifying the objectives of a
Automated electronic medical record sepsis detection in the emergency department
Su Q. Nguyen,Edwin Mwakalindile,James S. Booth,Vicki Hogan,Jordan Morgan,Charles T. Prickett,John P. Donnelly,Henry E. Wang
PeerJ , 2015, DOI: 10.7717/peerj.343
Abstract: Background. While often first treated in the emergency department (ED), identification of sepsis is difficult. Electronic medical record (EMR) clinical decision tools offer a novel strategy for identifying patients with sepsis. The objective of this study was to test the accuracy of an EMR-based, automated sepsis identification system.
The Value of Beauty in Theory Pursuit: Kuhn, Duhem, and Decision Theory  [PDF]
Gregory J. Morgan
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.31003
Abstract:

Should judgments of beauty play a guiding role in theoretical science even if beauty is not a sign of truth? In this paper I argue that they should in certain cases. If we analyze the rationality of theoretical pursuit using decision theory, a theory’s beauty can influence the utilities of the various options confronting the researcher. After considering the views of Pierre Duhem and Thomas Kuhn on aesthetics in science, I suggest that because we value freedom of inquiry we rightly allow scientists some choice in how they value aesthetic properties of theories and thus some freedom to use beauty to guide their research program.

Student Experience and Ubiquitous Learning in Higher Education: Impact of Wireless and Cloud Applications  [PDF]
Vladlena Benson, Stephanie Morgan
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.48A001
Abstract:

Mobile learning apps for smartphones and tablet computer devices have entered Higher Education (HE) market. While universities are investing in new technologies, they also look into cost reduction strategies, including cloud computing. We draw upon a case study of a successful migration to mobile virtual environment and effective use of cloud computing at a UK university. Success factors and challenges of these emerging technologies in HE are discussed. The paper concludes with the consideration of student experience implications and research questions which need addressing in the area of ubiquitous learning.



Physico-Chemical Quality of Selected Drinking Water Sources in Mbarara Municipality, Uganda  [PDF]
Ben Lukubye, Morgan Andama
Journal of Water Resource and Protection (JWARP) , 2017, DOI: 10.4236/jwarp.2017.97047
Abstract: The study assessed the physico-chemical quality of selected drinking water sources (springs, boreholes, shallow wells and rainfall) in Mbarara municipality with respect to World Health Organization (WHO) drinking water guidelines and other guidelines in light of the increased anthropogenic activities in the municipality. A total of 70 water samples were collected from purposively selected boreholes, springs, wells and rainwater in Nyamitanga, Kamukuzi and Kakoba divisions of Mbarara municipality with various human activities. The samples were analysed for physico-chemical parameters: Temperature, pH, Dissolved Oxygen (DO), Biological Oxygen Demand (BOD), Total Dissolved Solids (TDS), Electrical Conductivity (EC) and Total hardness using American Public Health Association (APHA) standard methods. The mean temperature and pH ranged between 18.07 °C - 23.45 °C and 5.74 - 7.54, respectively. The mean DO values were found to be between 4.84 and 12.86 mg/l; whereas mean BOD was within the range of 1.83 - 7.71 mg/l. The mean TDS and EC of the water samples ranged, between 33.40 - 569.20 mg/l and 29.30 - 1139.90 μS/cm respectively. Furthermore, the lowest and highest mean total hardness were 70.00 and 264.00 mg/l, respectively. The recorded mean water temperatures for each of the water sources were above the WHO threshold temperature (15 °C) which makes drinking water palatable. Boreholes in Nyamitanga and Shuhaddea Secondary Schools, spring in Kiswahili, well in Kisenyi and rainwater in Mbarara University of Science and Technology (MUST) had mean pH below the WHO minimum guideline value (6.5) hence acidic. Borehole in Nyamitanga secondary school, spring in Kisenyi, shallow well in Nyamitanga and the rainwater in MUST had mean DO values below the WHO range (10 - 12 mg/l). Borehole in Shuhaddea Secondary School and the well in Kisenyi had average BOD values above the range of European Union guideline values (3 - 6 mg/l). TDS and EC of all the water sources were below the WHO maximum guideline limits of 1000 mg/l and 1500 μs/cm respectively. Total hardness was also below the WHO harmless limit of 1000 mg/l. However rainwater in MUST was moderately soft while the other drinking water sources exhibited moderate to full total hardness. The physicochemical parameters of some of the selected water sources in Mbarara municipality have been compromised mainly by the increased human activities especially croplands, latrines, landfills, transportation, animal and municipal wastes at the vicinity of the water sources. Mbarara municipal council should therefore ensure
Bacterial Analysis of Selected Drinking Water Sources in Mbarara Municipality, Uganda  [PDF]
Ben Lukubye, Morgan Andama
Journal of Water Resource and Protection (JWARP) , 2017, DOI: 10.4236/jwarp.2017.98066
Abstract: Surveillance of water quality to ensure microbiological safety is a vital public health function to prevent water borne diseases. Bacterial total coliform and Escherichia coli (E. coli) examination provide indication of the hygienic condition of drinking water and are major tools in the assessment of the health risk borne by pathogen in water. Unfortunately, there is insufficient information on the total coliform and E. coli amounts in the common drinking water sources in Mbarara Municipality, Uganda despite the eminent anthropogenic sources of contamination. Hence the study established the sanitary risk and quantified the total coliform and E. coli load in selected drinking water sources in Mbarara Municipality, Uganda. A total of 70 water samples were collected from selected boreholes, springs, wells and rainwater in Nyamitanga, Kamukuzi and Kakoba divisions of Mbarara municipality. The water samples were analysed for total coliform and E. coli abundance using the American Public Health Association (APHA) standard method. The total coliform and Escherichia coli counts were compared with the World Health Organization (WHO) drinking water standard guidelines. The findings indicate that all the studied groundwater sources (boreholes, springs and wells) in Mbarara Municipality were not compliant to either both or one of the WHO total coliform (<10 CFU/100 ml) and E. coli (0 CFU/100 ml) criteria for drinking water hence they are unsuitable for drinking without treatment e.g. boiling etc. Only rainwater collected from Mbarara University of Science and Technology met the WHO total coliform and E. coli criteria for drinking water thus is suitable for drinking without any treatment. There is a strong linkage between bacterial (total coliforms and E. coli) water quality and water source sanitation, as well as the proximity of latrines, animal farms and landfills around the water sources. Mbarara municipal council should therefore ensure effective and regular operation and maintenance of the drinking water sources through the adoption and promotion of appropriate water safety plans.
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