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Search Results: 1 - 10 of 9763 matches for " Joo-Hee Park "
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A case of successful survival from ventricular free wall micro-rupture without surgery  [PDF]
Jae-Bin Seo, Ki-Hyun Jeon, Jin-Hyun Park, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim, Woo-Young Chung
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.32029

We report a case of successful survival from ventricular free wall rupture without surgery, which was not overt rupture but micro-rupture. The patient was diagnosed with acute myocardial infarction (AMI) and underwent primary percutaneous coronary intervention (PCI). Myocardial blood leakage could be detected on transthoracic echocardiography with intravenous infusion of contrast dye 3 days after PCI. This examination revealed that there was not overt perforation but diffuse fissure. Because of his critical condition, he was treated conservatively without surgery. Nevertheless, he survived eventually.

The prevention of contrast induced nephropathy by sarpogrelate in patients with chronic kidney disease: a study protocol for a prospective randomized controlled clinical trial
Kyungil Park, Woo-Young Chung, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim, Young-Bae Park
Trials , 2010, DOI: 10.1186/1745-6215-11-122
Abstract: The present study aims to investigate differences in occurrence of CIN after sarpogrelate premedication in patients with chronic kidney disease (CKD). 268 participants, aged 20-85 years with a clinical diagnosis of CKD will be recruited. They will be randomly allocated to one of two conditions: (i) routine treatment without sarpogrelate, and (ii) routine treatment with sarpogrelate (a fixed-flexible dose of 300 mg/day). The primary outcome is the occurrence of CIN during 4 weeks after receiving contrast agent.As of May 2010, there were no registered trials evaluating the therapeutic potentials of sarpogrelate in preventing for CIN. If sarpogrelate decreases the worsening of renal function and occurrence of CIN, it will provide a safe, easy and inexpensive treatment option.NCT01165567Contrast-induced nephropathy (CIN) is a common form of hospital-acquired acute renal failure (ARF) after coronary angiography (CAG) and percutaneous coronary intervention (PCI) and is associated with prolonged hospitalization and adverse clinical outcomes [1,2]. Patients undergoing PCI have a higher mortality rate if the nephropathy develops [3]. Although its incidence is low in patients with normal renal function, it can be much higher in those with renal insufficiency at baseline [4,5]. Adequate prophylaxis is needed to reduce the higher morbidity and mortality associated with CIN in high-risk patients. A variety of therapeutic interventions, including saline hydration, diuretics, mannitol, calcium channel antagonists, theophylline, endothelin receptor antagonists, and dopamine, have been used in an attempt to prevent CIN [6-9]. Hydration with normal saline solution is the most widely accepted preventive intervention [9,10]. But the nephropathy occurred in 20~30% who received the recommend treatment [11,12], it means current treatments are not enough and the optimal strategy to prevent CIN has not been established.Although the pathogenesis of this condition is not fully understood, it
Age-hardening by grain interior and grain boundary precipitation in an Au-Ag-Pt-Zn-In alloy for multipurpose dental use
Joo-Hee Park,Mi-Hyang Cho,Mi-Gyoung Park,Yong Hoon Kwon,Hyung-Il Kim,Hyo-Joung Seol
Gold Bulletin , 2010, DOI: 10.1007/BF03215001
Abstract: The complex precipitation mechanisms related to the age-hardening of Cu-free Au-Ag-Pt-Zn-In alloy for multipurpose dental use was studied by means of hardness test, X-ray diffraction (XRD) studies, field emission scanning electron microscopic (FE-SEM) observations, energy dispersive spectrometer (EDS) analysis, and electron probe microanalysis (EPMA). The early diffusion and then clustering of the In-concentrated phase in the grain interior, together with the early diffusion and then ordering of the PtZn phase in the grain boundary, introduced the internal strains in the Au-Ag-rich α1 matrix, resulting in the hardening process. As the Au-Ag-rich α 1 ’ and PtZn β lamellarforming grain boundary reaction progressed, the phase boundaries between the solute-depleted face-centered cubic (FCC) α 1 ’ matrix and the face-centered tetragonal (FCT) PtZn β precipitate reduced, resulting in softening. In the particlelike structures composed of the major Pt-Au-rich α2 phase and the minor Pt-Zn-rich α3 phase, the separation of In and Zn progressed producing the In-increased Pt-Au-rich α 2 ’ phase and the Zn-increased PtZn α3′ phase with aging time without restraining the softening. The miscibility limit by complex systems of Au-Pt, Ag-Pt, Au-In and In-Zn resulted in the phase transformation and related microstructural changes.
Age-hardening by miscibility limit in a multi-purpose dental gold alloy containing platinum
Hyo-Joung Seol,Joo-Hee Park,Ri-Mo Ku,Mi-Gyoung Park,Yong Hoon Kwon,Hyung-Il Kim
Gold Bulletin , 2010, DOI: 10.1007/BF03214965
Abstract: This study examined the age-hardening by miscibility limit in a multi-purpose dental gold alloy containing platinum. The hardness increased rapidly in the initial stage of the aging process, reached the maximum value, then decreased continuously with aging time. The significant hardness increase resulted from the heterogeneous precipitation of the Pt-rich β phase from the grain boundary of the Au-rich α1 matrix due to the miscibility limit of Au-Pt system. With increasing aging time, the fine Pt-rich β precipitates covered almost the whole matrix, and by further aging, the precipitates grew coarse. The microstructural coarsening reduced the interface between the Au-rich α1 matrix and the Pt-rich β precipitates, which released the lattice strains between the two phases, resulting in a softening effect. In the later stage of aging process, the Au-containing Pt3In particle-like structure was transformed into the Au-depleted particle-like structure containing relatively large amounts of Cu resulting from the overlapping miscibility limit of both Au-Pt and Ag-Cu systems, which was responsible for the slow decreasing rate in hardness in the later stage of aging.
Immediate impact of exercise on arterial stiffness in humans  [PDF]
Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.31009

Background and objectives: Increased arterial stiffness is an accepted cardiovascular risk factor. Several studies have shown that regular exercise is associated with reduced arterial stiffness. However, the acute effect is not well known. The aim of this study was to evaluate the immediate impact of exercise on arterial stiffness measured by pulse wave velocity (PWV). Subjects and Methods: Data from 100 consecutive patients who underwent graded maximal aerobic exercise test and pulse wave velocity study due to chest pain were analyzed. Results: With respect to brachial-ankle pulse wave velocity (baPWV), it decreased after the exercise test (before vs. after; 1420 ± 260 vs. 1358 ± 245, 1428 ± 255, vs. 1360 ±239 cm/sec; left and right, respectively). Upper extremity systolic blood pressure did not change from baseline. However, upper extremity diastolic blood pressure increased slightly. In addition, lower extremity blood pressure decreased in both systolic and diastolic phases. In both normotensives and hypertensives, baPWV decreased after exercise test. Conclusion: Exercise immediately decreases arterial stiffness.

Correlation between the Digital Cervicography and Pathological Diagnosis Performed at Private Clinics in Korea
Seog-Nyeon Bae, Jin-Hwi Kim, Chung-Won Lee, Min-Jong Song, Eun-Kyung Park, Yong-Seok Lee, Keun-Ho Lee, Soo-Young Hur, Joo-Hee Yoon, Sung-Jong Lee
International Journal of Medical Sciences , 2012,
Abstract: Objective: To evaluate the correlation tendency between abnormal findings of digital cervicography and cervical pathology at private clinics in Korea. Methods: Abnormal finding of digital cervicography performed at private clinics in Korea between January 1, 2010 and May 31, 2012 were analysed retrospectively. The patient's age, abnormal findings of digital cervicography, cervical cytology, human papillomaviru (HPV) test and cervical pathology were investigated and the rate of agreement between abnormal finding of digital cervicography and cervical pathology results was calculated. Abnormal findings of digital cervicography were divided into 4 categories: atypical, compatible with CIN1, compatible with CIN2/3 and compatible with cancer. Results: The study group was composed of 1547 women with a mean (range) age of 37.4 (14-91 years). The agreement rate between abnormal findings of digital cervicography and cervical pathology was 52.0% in “compatible with CIN1”, 78.9% in “compatible with CIN2/3”, and 90.2% in “compatible with cancer”. Conclusions: Abnormal findings of digital cervicography were highly concordant with cervical intraepithelial neoplasia (CIN) and cancer examined at outpatient clinics in Korea. Therefore, abnormal interpretations of digital cervicography can be used as an excellent auxiliary technique with cervical cytology for CIN and cancer.
Visible Light Irradiation-Mediated Drug Elution Activity of Nitrogen-Doped TiO2 Nanotubes
Seunghan Oh,Kyung-Suk Moon,Joo-Hee Moon,Ji-Myung Bae
Journal of Nanomaterials , 2013, DOI: 10.1155/2013/802318
The association between arterial stiffness and left ventricular filling pressure in an apparently healthy Korean population
Hack-Lyoung Kim, Moon-Sun Im, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
Cardiovascular Ultrasound , 2013, DOI: 10.1186/1476-7120-11-2
Abstract: A total of 115 healthy subjects without known cardiovascular risk factors or overt heart disease who underwent both transthoracic echocardiography and brachial-ankle pulse wave velocity (baPWV) measurement at the same day during their routine check-ups were analyzed.The mean age of study subjects was 52.8 ± 8.4 years, and 78 (67.8%) were men. The mean baPWV value was 1,325 ± 185 cm/s. Study subjects were divided into 3 groups according to E/E’ value: subjects with E/E’ < 8, 8–12.9 and E/E’ ≥ 13. As E/E’ increased, baPWV value increased gradually: baPWV in subjects with E/E’ < 8, E/E’ 8–12.9 and E/E’ ≥ 13, were 1,261 ± 163, 1,345 ± 169, 1,569 ± 232 cm/s, respectively (p < 0.001). In multiple linear regression analyses, baPWV was significantly associated with E/E’ (β = 0.371, p < 0.001) after controlling confounders including age, sex and body mass index. In receiver-operating characteristic (ROC) curve analysis, the sensitivity and specificity for detection of E/E’ ≥ 10 were 78.6% and 59.8%, respectively with mean baPWV of 1,282 cm/s as the cut off value. The discriminatory capacity for predicting E/E’ ≥ 10 was improved from an area under the ROC curve of 0.646 with age alone to 0.734 when baPWV was added (p < 0.001).There is a significant association between baPWV and E/E’ in an apparently healthy Korean population. BaPWV is useful as a simple and non-invasive method for early detection of increased LV filling pressure among these people.Stiffened artery increases pulse pressure leading to left ventricular hypertrophy and coronary artery disease [1]. Arterial stiffness has been reported to be associated with cardiovascular morbidity and mortality [2,3].There are several methods to estimate arterial stiffness. Among them, pulse wave velocity (PWV) is generally accepted as the most simple, non-invasive and validated indicator of arterial stiffness [4,5]. Recently, the brachial-ankle PWV (baPWV) measurement, which is easy to perform, has become available in clinical pr
HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis
Goang-Won Cho, Seung Shin, Hyun Kim, Seon-Ah Ha, Sanghee Kim, Joo-Hee Yoon, Soo Hur, Tae Kim, Jin Kim
BMC Cell Biology , 2007, DOI: 10.1186/1471-2121-8-50
Abstract: To investigate the biological function of HCCR-1 in the cell, we predicted biological features using bioinformatic tools, and have identified a LETM1 homologous domain at position 75 to 346 of HCCR-1. This domain contains proteins identified from diverse species predicted to be mitochondrial proteins. Fluorescence microscopy and fractionation experiments showed that HCCR-1 is located in mitochondria in the COS-7, MCF-7 and HEK/293 cell lines, and subcompartamentally at the outer membrane in the HEK/293 cell line. The topological structure was revealed as the NH2-terminus of HCCR-1 oriented toward the cytoplasm. We also observed that the D1-2 region, at position 1 to 110 of HCCR-1, was required and sufficient for posttranslational mitochondrial import. The function of HCCR-1 on mitochondrial membrane is to retard the intrinsic apoptosis induced by UVC and staurosporine, respectively.Our experiments show the biological features of HCCR-1 in the cell, and suggest that uncontrolled expression of HCCR-1 may cause mitochondrial dysfunction that can result in resisting the UVC or staurosporine-induced apoptosis and progressing in the tumor formation.Mitochondria are responsible for a number of metabolic tasks in eukaryotic cells. Their primary function is to generate energy through oxidative phosphorylation in organelles. Mitochondria also play an important role in other biological activities such as programmed cell death [1], calcium signaling and generation of detoxification of reactive oxygen species [2].Mitochondria consist of four subcompartments – an outer membrane, an inner membrane, an inter-membrane space and matrix. The chaperone proteins, and the translocase components, help mitochondrial transport into the subcompartments through their membranes [3]. During the cytoplasmic translation of mitochondrial proteins, they are recognized by chaperone proteins which interfere with the folding of the protein. A positively charged signal sequence, on the mitochondrial pr
Impact of acute exercise on brachial artery flow-mediated dilatation in young healthy people
In-Chang Hwang, Kyung-Hee Kim, Won-Suk Choi, Hyun-Jin Kim, Moon-Sun Im, Yong-Jin Kim, Sang-Hyun Kim, Myung-A Kim, Dae-Won Sohn, Joo-Hee Zo
Cardiovascular Ultrasound , 2012, DOI: 10.1186/1476-7120-10-39
Abstract: Eighty-six young healthy volunteers were prospectively enrolled from January 2011 to December 2011. The subjects completed FMD tests at rest and immediately after treadmill exercise test. Primary outcome was the impact of acute exercise on FMD, measured by the difference of FMD before and after exercise. Secondary outcomes were the relationship of gender and exercise habit with FMD.Seventy-four subjects who met the eligibility criteria were included for analysis. Thirty-five (47.3%) were male, and the mean age was 22.7±2.7 years. FMD was reduced after exercise (8.98±4.69 to 7.51±4.03%; P=0.017) and the reduction was found in female group (10.36±5.26 to 7.62±3.71%; P=0.002) but not in male group. Post-exercise FMD was significantly impaired in subjects who did not exercise regularly (6.92±3.13% versus 8.95±5.33%; P=0.003). The decrease of FMD after exercise was greater in female group (?2.75±5.28% versus 0.27±3.24%; P=0.003) and was associated with exercise habit (β=2.532; P=0.027).In healthy young subjects, FMD was reduced after a bout of acute exercise. The impact of acute exercise showed significant differences according to gender and exercise habit. FMD impairment after acute exercise was observed in females and subjects without regular exercise.Endothelial dysfunction is an important factor in the development of atherosclerosis, hypertension, and coronary artery disease (CAD) [1-4]. Impaired endothelial function is observed in subjects with risk factors for atherosclerosis and in patients with essential hypertension [2,5,6]. Also it is an important predictor of long-term cardiovascular events [7,8].There are several methods to assess endothelial dysfunction and flow-mediated dilatation (FMD) is the most widely used non-invasive method to assess the endothelial function, reflecting the endothelial nitric oxide (NO) dependent vasodilation in response to occlusion-induced reactive hyperemia [5,9]. As FMD is non-invasive and reliable, allows repeated measurements [1
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