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Search Results: 1 - 10 of 25976 matches for " Joo Youl Lee "
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Vortex Solutions of Four-fermion Theory coupled to a Yang-Mills-Chern-Simons Gauge Field
Hyuk-jae Lee,Joo Youl Lee,Jae Hyung Yee
Physics , 1998, DOI: 10.1103/PhysRevD.58.087701
Abstract: We have constructed a four-fermion theory coupled to a Yang-Mills-Chern-Simons gauge field which admits static multi-vortex solutions. This is achieved through the introduction of an anomalous magnetic interation term in addition to the usual minimal coupling, and the appropriate choice of the fermion quartic coupling constant.
Regulatory Effect of Cinnamaldehyde on Monocyte/Macrophage-Mediated Inflammatory Responses
Byung Hun Kim,Yong Gyu Lee,Jaehwi Lee,Joo Young Lee,Jae Youl Cho
Mediators of Inflammation , 2010, DOI: 10.1155/2010/529359
Abstract: Cinnamaldehyde (CA) has been known to exhibit anti-inflammatory and anticancer effects. Although numerous pharmacological effects have been demonstrated, regulatory effect of CA on the functional activation of monocytes and macrophages has not been fully elucidated yet. To evaluate its monocyte/macrophage-mediated immune responses, macrophages activated by lipopolysaccharide (LPS), and monocytes treated with proaggregative antibodies, and extracellular matrix protein fibronectin were employed. CA was able to suppress both the production of nitric oxide (NO) and upregulation of surface levels of costimulatory molecules (CD80 and CD69) and pattern recognition receptors (toll-like receptor 2 (TLR2) and complement receptor (CR3)). In addition, CA also blocked cell-cell adhesion induced by the activation of CD29 and CD43 but not cell-fibronectin adhesion. Immunoblotting analysis suggested that CA inhibition was due to the inhibition of phosphoinositide-3-kinase (PI3K) and phosphoinositide-dependent kinase (PDK)1 as well as nuclear factor-(NF-) B activation. In particular, thiol compounds with sulphydryl group, L-cysteine and dithiothreitol (DTT), strongly abrogated CA-mediated NO production and NF-B activation. Therefore, our results suggest that CA can act as a strong regulator of monocyte/macrophage-mediated immune responses by thiolation of target cysteine residues in PI3K or PDK1.
Hormonal responses upon return of spontaneous circulation after cardiac arrest: a retrospective cohort study
Jin Joo Kim, Sung Youl Hyun, Seong Youn Hwang, Young Bo Jung, Jong Hwan Shin, Yong Su Lim, Jin Seong Cho, Hyuk Jun Yang, Gun Lee
Critical Care , 2011, DOI: 10.1186/cc10019
Abstract: This is a retrospective review of the chart and laboratory findings in a single medical facility. The patients admitted to the intensive care unit after successful resuscitation after out-of-hospital cardiac arrest were retrospectively identified and evaluated. Patients with hormonal diseases, patients who received cortisol treatment, those experiencing trauma, and pregnant women were excluded. Serum cortisol, adrenocorticotropic hormone (ACTH), and anti-diuretic hormone (ADH (vasopressin)) were analyzed and a corticotropin-stimulation test was performed. Mortality at one week and one month after admission, and neurologic outcome (cerebral performance category (CPC)) one month after admission were evaluated.A total of 117 patients, including 84 males (71.8%), were evaluated in this study. One week and one month after admission, 87 (74.4%) and 65 patients (55.6%) survived, respectively. Relative adrenal insufficiency, and higher plasma ACTH and ADH levels were associated with shock-related mortality (P = 0.046, 0.005, and 0.037, respectively), and ACTH and ADH levels were also associated with late mortality (P = 0.002 and 0.004, respectively). Patients with relative adrenal insufficiency, ACTH ≧5 pg/mL, and ADH ≧30 pg/mL, had a two-fold increased risk of a poor outcome (shock-related mortality): (odds ratio (OR), 2.601 and 95% confidence interval (CI), 1.015 to 6.664; OR, 2.759 and 95% CI, 1.060 to 7.185; OR, 2.576 and 95% CI, 1.051 to 6.313, respectively). Thirty-five patients (29.9%) had a good CPC (1 to 2), and 82 patients (70.1%) had a bad CPC (3 to 5). Age ≧50 years and an ADH ≧30 pg/mL were associated with a bad CPC (OR, 4.564 and 95% CI, 1.794 to 11.612; OR, 6.568 and 95% CI, 1.918 to 22.483, respectively).The patients with relative adrenal insufficiency and higher blood levels of ACTH and ADH upon ROSC after cardiac arrest had a poor outcome. The effectiveness of administration of cortisol and ADH to patients upon ROSC after cardiac arrest is uncertain and ad
Celastrol, an NF-κB Inhibitor, Improves Insulin Resistance and Attenuates Renal Injury in db/db Mice
Jung Eun Kim, Mi Hwa Lee, Deok Hwa Nam, Hye Kyoung Song, Young Sun Kang, Ji Eun Lee, Hyun Wook Kim, Jin Joo Cha, Young Youl Hyun, Sang Youb Han, Kum Hyun Han, Jee Young Han, Dae Ryong Cha
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062068
Abstract: The NF-κB pathway plays an important role in chronic inflammatory and autoimmune diseases. Recently, NF-κB has also been suggested as an important mechanism linking obesity, inflammation, and metabolic disorders. However, there is no current evidence regarding the mechanism of action of NF-κB inhibition in insulin resistance and diabetic nephropathy in type 2 diabetic animal models. We investigated the effects of the NF-κB inhibitor celastrol in db/db mice. The treatment with celastrol for 2 months significantly lowered fasting plasma glucose (FPG), HbA1C and homeostasis model assessment index (HOMA-IR) levels. Celastrol also exhibited significant decreases in body weight, kidney/body weight and adiposity. Celastrol reduced insulin resistance and lipid abnormalities and led to higher plasma adiponectin levels. Celastrol treatment also significantly mitigated lipid accumulation and oxidative stress in organs including the kidney, liver and adipose tissue. The treated group also exhibited significantly lower creatinine levels and urinary albumin excretion was markedly reduced. Celastrol treatment significantly lowered mesangial expansion and suppressed type IV collagen, PAI-1 and TGFβ1 expressions in renal tissues. Celastrol also improved abnormal lipid metabolism, oxidative stress and proinflammatory cytokine activity in the kidney. In cultured podocytes, celastrol treatment abolished saturated fatty acid-induced proinflammatory cytokine synthesis. Taken together, celastrol treatment not only improved insulin resistance, glycemic control and oxidative stress, but also improved renal functional and structural changes through both metabolic and anti-inflammatory effects in the kidney. These results suggest that targeted therapy for NF-κB may be a useful new therapeutic approach for the management of type II diabetes and diabetic nephropathy.
The Effect of the Variation of the Downstream Region Distance and Butterfly Valve Angle on Flow Characteristics in a 90 Degree Bended Elbow  [PDF]
Se Youl Won, Jae Gon Lee, Jun Seok Yang
Modern Mechanical Engineering (MME) , 2014, DOI: 10.4236/mme.2014.43013
This study presents the numerical evaluation about the impact of flow disturbance near the intrados and extrados regions of the 90 degree bended elbow using CFX for several practical cases where the 90 degree bended upward elbow is located in a proximity to the butterfly valve and the butterfly valve open angle is changed. For the change of a butterfly valve open angle from 60% to 100% and the increase of the distance between a valve and a 90 degree bended elbow, the effect of FAC (Flow-Accelerated Corrosion) in the 90 degree bended elbow may be neglected because the value and distribution of the velocity and shear stress is rapidly decreased comparing with the present status installed in an industry, and the data of 100% valve open (Case 3) and L/D ≈ 5 (Case 4) are very good agreement comparing with the reference data, L/D ≈ 8 (Case 2). The reasons are that flow already maintains a fully developed condition and a steady state in spite of less distance than the reference case, L/D = 8. Therefore, smooth flow fields have approached at a 90 degree bended elbow. Then, the effect of shear stress and vortex is hardly investigated around the intrados area of 90 degree bended elbow.
A Case of Possible Neurosarcoidosis Presenting as Intractable Headache and Panhypopituitarism
Jin Kyung Hwang,Joo Hee Cho,So Young Park,Jung Il Son,Uk Jo,Sang Ouk Chin,Yun Jung Lee,Moon Chan Choi,Sang Youl Rhee,Eui Jong Kim,Suk Chon
Case Reports in Endocrinology , 2013, DOI: 10.1155/2013/816236
Abstract: Sarcoidosis is a chronic multisystemic inflammatory disease of unknown etiology, which is characterized by noncaseating granulomatous inflammation of the involved organs. It is known that neurosarcoidosis involving the nervous system occurs in about 5% of patients with sarcoidosis. However, neurosarcoidosis without systemic involvement is extremely rare. We present a case of suspicious neurosarcoidosis affecting the pituitary gland, which was manifested as chronic uncontrolled headache, panhypopituitarism, central diabetes insipidus, and hypercalcemia. Though the biopsy at the pituitary lesion was not performed due to the high risk of surgical complication, treatment was needed urgently and we started steroid therapy. After steroid therapy, we observed the immediate symptom relief with improved hypercalcemia. According to the follow-up examination, no recurrent symptom was seen, and resolution of the pituitary lesion with improving panhypopituitarism was noted. 1. Introduction Sarcoidosis is a noncaseating granulomatous disease that can affect any system of the body [1]. Neurosarcoidosis involves the nervous system and occurs in less than 5% of patients with systemic sarcoidosis. Isolated neurosarcoidosis without systemic involvement is extremely rare [2]. We describe a case of possible neurosarcoidosis of the pituitary gland without any other systemic involvement. The patient presented with panhypopituitarism, central diabetes insipidus, and hypercalcemia. Sellar magnetic resonance imaging (MRI) showed an infiltrating mass of the pituitary gland with invasion of stalk and cavernous sinus. Steroid therapy resulted in the resolution of the pituitary lesion on sellar MRI and all symptoms. 2. Case Presentation A 39-year-old man presented to our clinic with nausea and headache. He reported that these symptoms had waxed and waned for five years and were aggravated for three weeks before admission. His medical history revealed that he had been diagnosed with a pituitary microadenoma at the age of thirty four with symptoms of polyuria, polydipsia, and severe headache. Initial sellar MRI showed a pituitary microadenoma with stalk deviation and thickening (Figure 1(a)). An anterior pituitary function test revealed minimal elevation of prolactin (20.2?ng/mL) with no other significant abnormalities. He began to take lisuride hydrogen maleate, which decreased his serum prolactin level. Although intranasal vasopressin therapy significantly relieved the polyuria and polydipsia, his headache did not subside, and, thus, intermittent low-dose steroid therapy was
The Effects of RF Sputtering Power and Gas Pressure on Structural and Electrical Properties of ITiO Thin Film
Accarat Chaoumead,Youl-moon Sung,Dong-Joo Kwak
Advances in Condensed Matter Physics , 2012, DOI: 10.1155/2012/651587
Abstract: Transparent conductive titanium-doped indium oxide (ITiO) films were deposited on corning glass substrates by RF magnetron sputtering method. The effects of RF sputtering power and Ar gas pressure on the structural and electrical properties of the films were investigated experimentally, using a 2.5?wt% TiO2-doped In2O3 target. The deposition rate was in the range of around ?nm/min under the experimental conditions of ?mTorr of gas pressure and ?W of RF power. The lowest volume resistivity of -cm and the average optical transmittance of 75% were obtained for the ITiO film, prepared at RF power of 300?W and Ar gas pressure of 15?mTorr. This volume resistivity of -cm is low enough as a transparent conducting layer in various electrooptical devices, and it is comparable with that of ITO or ZnO:Al conducting layer. 1. Introduction In the last decade transparent conducting thin films have attracted much attention due to their wide range of applications in electrooptical devices. High-quality transparent conducting films are characterized by a high transmittance in the optical range from 400 to 800?nm and by an electrical resistivity as low as possible. Moreover, the increases in use of transparent electrodes for many optical devices such as solar cell, PDP, and heat mirrors, so forth, have accelerated the development of inexpensive transparent materials. Indiumtinoxide (ITO) and aluminum-doped zinc oxide (ZnO:Al) thin films have been widely used as a transparent conducting electrode of various electrooptical devices. F-doped tinoxide (FTO) has been also well used, especially in a dye-sensitized solar cell (DSC). However, the FTO/ITO films, which are prepared by the chemical vapor deposition (CVD) method, are costly and complicated for mass production. The FTO/ITO films have also limitations in their infrared ray (IR) transmission and thermal resistance as a transparent conductor. Titanium-doped indiumoxide (ITiO) has also emerged as a transparent conducting oxide (TCO) because it has a low sheet resistance, aside from its high mobility and near-IR transmittance. The properties of ITiO layer show that the long-wavelength falloff in transmittance does not occur until 1500?nm compared to about 1000?nm for an 8??/sq sheet resistivity [1]. Usually, DSCs are still responsive in the 1000–1100?nm range. Thus, they benefit from the improved TCO layer transmission in this near-IR wavelength range [2]. Therefore, the electrical and optical properties of ITiO thin film should be studied in order to investigate the possible application of the film as a transparent
A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011–2012 Influenza Season in Korea: A Multi-Center Study
Seong-Heon Wie, Byung Hak So, Joon Young Song, Hee Jin Cheong, Yu Bin Seo, Sung Hyuk Choi, Ji Yun Noh, Ji Hyeon Baek, Jin Soo Lee, Hyo Youl Kim, Young Keun Kim, Won Suk Choi, Jacob Lee, Hye Won Jeong, Woo Joo Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062685
Abstract: Background During the 2011/2012 winter influenza season in the Republic of Korea, influenza A (H3N2) was the predominant virus in the first peak period of influenza activity during the second half of January 2012. On the other hand, influenza B was the predominant virus in the second peak period of influenza activity during the second half of March 2012. The objectives of this study were to compare the clinical and epidemiological characteristics of patients with laboratory-confirmed influenza A or influenza B. Methodology/Principal Findings We analyzed data from 2,129 adult patients with influenza-like illnesses who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012. Of 850 patients with laboratory-confirmed influenza, 656 (77.2%) had influenza A (H3N2), and 194 (22.8%) influenza B. Age, and the frequencies of cardiovascular disorders, diabetes, hypertension were significantly higher in patients with influenza A (H3N2) (P<0.05). The frequencies of leukopenia or thrombocytopenia in patients with influenza B at initial presentation were statistically higher than those in patients with influenza A (H3N2) (P<0.05). The rate of hospitalization, and length of hospital stay were statistically higher in patients with influenza A (H3N2) (P<0.05), and of the 79 hospitalized patients, the frequency of diabetes, hypertension, cases having at least one of the comorbid conditions, and the proportion of elderly were significantly higher in patients with influenza A (H3N2) (P<0.05). Conclusions The proportion of males to females and elderly population were significantly higher for influenza A (H3N2) patients group compared with influenza B group. Hypertension, diabetes, chronic lung diseases, cardiovascular disorders, and neuromuscular diseases were independently associated with hospitalization due to influenza. Physicians should assess and treat the underlying comorbid conditions as well as influenza viral infections for the appropriate management of patients with influenza.
Simple and Versatile Molecular Method of Copy-Number Measurement Using Cloned Competitors
Hyun-Kyoung Kim, Hai-Li Hwang, Seong-Yeol Park, Kwang Man Lee, Won Cheol Park, Han-Seong Kim, Tae-Hyun Um, Young Jun Hong, Jin Kyung Lee, Sun-Young Joo, Ju-Young Seoh, Yeong-Wook Song, Soo-Youl Kim, Yong-Nyun Kim, Kyeong-Man Hong
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069414
Abstract: Variations and alterations of copy numbers (CNVs and CNAs) carry disease susceptibility and drug responsiveness implications. Although there are many molecular methods to measure copy numbers, sensitivity, reproducibility, cost, and time issues remain. In the present study, we were able to solve those problems utilizing our modified real competitive PCR method with cloned competitors (mrcPCR). First, the mrcPCR for ERBB2 copy number was established, and the results were comparable to current standard methods but with a shorter assay time and a lower cost. Second, the mrcPCR assays for 24 drug-target genes were established, and the results in a panel of NCI-60 cells were comparable to those from real-time PCR and microarray. Third, the mrcPCR results for FCGR3A and the FCGR3B CNVs were comparable to those by the paralog ratio test (PRT), but without PRT's limitations. These results suggest that mrcPCR is comparable to the currently available standard or the most sensitive methods. In addition, mrcPCR would be invaluable for measurement of CNVs in genes with variants of similar structures, because combination of the other methods is not necessary, along with its other advantages such as short assay time, small sample amount requirement, and applicability to all sequences and genes.
Applying Lipson's state models to marked graph diagrams of surface-links
Yewon Joung,Seiichi Kamada,Sang Youl Lee
Mathematics , 2014,
Abstract: A. S. Lipson constructed two state models yielding the same classical link invariant obtained from the Kauffman polynomial $F(a,z)$. In this paper, we apply Lipson's state models to marked graph diagrams of surface-links, and observe when they induce surface-link invariants.
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