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Search Results: 1 - 10 of 10920 matches for " Jong-Seok Park "
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Korean species of Aleochara Gravenhorst subgenus Xenochara Mulsant & Rey (Coleoptera, Staphylinidae, Aleocharinae)
Jong-Seok Park,Kee-Jeong Ahn
ZooKeys , 2010, DOI: 10.3897/zookeys.60.404
Abstract: A taxonomic review of Aleochara Gravenhorst subgenus Xenochara Mulsant & Rey in Korea is presented. Five species are recognized, with one species, A. (Baryodma) intricata Mannerheim, newly transferred to the subgenus Xenochara. Aleochara (X.) asiatica Kraatz and A. (X.) peninsulae Bernhauer are reported for the first time in the Korean peninsula. A key, line drawings of diagnostic characters, and redescriptions of Korean Xenochara species are provided.
Effect of Addition of Soybean Oil and Gamma-Ray Cross-linking on the Nanoporous HDPE Membrane
Jong-Seok Park,Jong-Bae Choi,Hui-Jeong Gwon,Youn-Mook Lim,Myung Seob Khil,Phil-Hyun Kang,Young-Chang Nho
Journal of Nanomaterials , 2012, DOI: 10.1155/2012/418021
Abstract: A nanoporous high-density polyethylene (HDPE) membrane was prepared by a wet process. Soybean oil and dibutyl phthalate (DBP) were premixed as codiluents, and gamma-rays were used for the cross-linking of HDPE. The pore volume of the nanoporous HDPE membranes with soybean oil was affected by the extracted amount of oil. The tensile strength of the membrane improved with an increasing absorbed dose up to 60 kGy, but decreased at 80 kGy due to severe degradation. The ionic conductivity of the nanoporous HDPE membrane did not really change with an increasing absorbed dose because the pores had already been formed before the gamma-ray radiation. Finally, the electrochemical stability of the HDPE membrane increased when the absorbed dose increased up to 60 kGy.
Characterization and Antimicrobial Property of Poly(Acrylic Acid) Nanogel Containing Silver Particle Prepared by Electron Beam
Jong-Bae Choi,Jong-Seok Park,Myung-Seob Khil,Hui-Jeong Gwon,Youn-Mook Lim,Sung-In Jeong,Young-Min Shin,Young-Chang Nho
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140611011
Abstract: In this study, we developed a one step process to synthesize nanogel containing silver nanoparticles involving electron beam irradiation. Water-soluble silver nitrate powder is dissolved in the distilled water and then poly(acrylic acid) (PAAc) and hexane are put into this silver nitrate solution. These samples are irradiated by an electron beam to make the PAAc nanogels containing silver nanoparticles (Ag/PAAc nanogels). The nanoparticles were characterized by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). In addition, the particle size and zeta-potential were confirmed by a particle size analyzer (PSA). The antibacterial properties of the nanogels were evaluated by paper diffusion test. The Ag/PAAc nanogels had an antibacterial effect against Escherichia coli and Staphylococcus aureus. The nanogels also demonstrated a good healing effect against diabetic ulcer. The size of the Ag/PAAc nanogels decreased with increasing irradiation doses, and the absolute value of the zeta potential increased with increasing irradiation doses. Also, the Ag/PAAc nanogels exhibited good antibacterial activity against both Gram-negative and Gram-positive bacteria. In in vivo wound healing, the Ag/PAAc nanogels have a good healing effect.
Epitomize Your Photos
Peter Vajda,Ivan Ivanov,Jong-Seok Lee,Touradj Ebrahimi
International Journal of Computer Games Technology , 2011, DOI: 10.1155/2011/706893
Abstract: With the rapid growth of digital photography, sharing of photos with friends and family has become very popular. When people share their photos, they usually organize them into albums according to events or places. To tell the story of some important events in one’s life, it is desirable to have an efficient summarization tool which can help people to receive a quick overview of an album containing large number of photos. In this paper, we present and analyze an approach for photo album summarization through a novel social game “Epitome” as a Facebook application. This social game can collect research data, and, at the same time, it provides a collage or a cover photo of the user’s photo album, while the user enjoys playing the game. The proof of concept of the proposed method is demonstrated through a set of experiments on several photo albums. As a benchmark comparison to this game, we perform automatic visual analysis considering several state-of-the-art features. We also evaluate the usability of the game by making use of a questionnaire on several subjects who played the “Epitome” game. Furthermore, we address privacy issues concerning shared photos in Facebook applications. 1. Introduction Rapid growth of digital photography in recent years has increased the size of personal photo collections. People use their digital cameras or mobile phones equipped with cameras to take photos. Besides storing them on computer hard drives, they often share their digital photos with friends, family, and colleagues through social networks. Facebook (http://www.facebook.com/), Flickr (http://www.flickr.com/), and Picasa (http://picasa.google.com/) are examples of such photo sharing web sites. Some people also print their photos on post cards, calendars, or photo books, often to give them as presents or to create physical souvenirs. Photos are often organized into albums (collections) based on places, events or dates, and people. Consumers tend to take several photos from one scene, hoping that one of them will be outstanding, and this leads to large number of similar photos. Therefore, it can be very time-consuming to go through all photos in one of these albums. Summarization is an effective way to provide a quick overview of a set of photos. In this paper, album summarization is defined as selecting a set of photos from a larger collection which best represents the visual information of the entire collection. Selected photos can be used to create a collage of a given album or a cover for an album or to be included in a photo book. However, as already mentioned,
Targeting of Mycobacterium tuberculosis Heparin-Binding Hemagglutinin to Mitochondria in Macrophages
Hosung Sohn equal contributor,Jong-Seok Kim equal contributor,Sung Jae Shin,Kwangwook Kim,Choul-Jae Won,Woo Sik Kim,Ki-Nam Min,Han-Gyu Choi,Je Chul Lee,Jeong-Kyu Park,Hwa-Jung Kim
PLOS Pathogens , 2011, DOI: 10.1371/journal.ppat.1002435
Abstract: Mycobacterium tuberculosis heparin-binding hemagglutinin (HBHA), a virulence factor involved in extrapulmonary dissemination and a strong diagnostic antigen against tuberculosis, is both surface-associated and secreted. The role of HBHA in macrophages during M. tuberculosis infection, however, is less well known. Here, we show that recombinant HBHA produced by Mycobacterium smegmatis effectively induces apoptosis in murine macrophages. DNA fragmentation, nuclear condensation, caspase activation, and poly (ADP-ribose) polymerase cleavage were observed in apoptotic macrophages treated with HBHA. Enhanced reactive oxygen species (ROS) production and Bax activation were essential for HBHA-induced apoptosis, as evidenced by a restoration of the viability of macrophages pretreated with N-acetylcysteine, a potent ROS scavenger, or transfected with Bax siRNA. HBHA is targeted to the mitochondrial compartment of HBHA-treated and M. tuberculosis-infected macrophages. Dissipation of the mitochondrial transmembrane potential (ΔΨm) and depletion of cytochrome c also occurred in both macrophages and isolated mitochondria treated with HBHA. Disruption of HBHA gene led to the restoration of ΔΨm impairment in infected macrophages, resulting in reduced apoptosis. Taken together, our data suggest that HBHA may act as a strong pathogenic factor to cause apoptosis of professional phagocytes infected with M. tuberculosis.
Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis and alters Wnt/β-catenin in SW480 human colon cancer cells
Kyoung-Sub Song, Ge Li, Jong-Seok Kim, Kaipeng Jing, Tae-Dong Kim, Jin-Pyo Kim, Seung-Bo Seo, Jae-Kuk Yoo, Hae-Duck Park, Byung-Doo Hwang, Kyu Lim, Wan-Hee Yoon
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-307
Abstract: The anti-cancer effects of PL were examined in SW480 colon cancer cells by evaluating cell proliferation, invasion and matrix metallo-proteinase (MMP) activity. The anti-angiogenic effects of PL were examined by assessing human umbilical vein endothelial cell (HUVEC) proliferation and capillary tube formation. The in vivo effect of PL was evaluated in an athymic nude mouse SW480 tumor engraft model.PL (125-1000 μg/mL) significantly inhibited cell proliferation and decreased β-catenin expression in SW480 cells. Expression of cyclin D1, one of the downstream-regulated genes of β-catenin, and T-cell factor/lymphocyte enhancer binding factor (TCF/LEF) transcription activity were also significantly reduced by PL treatment. PL inhibited in vitro invasion and motility as well as the activity of MMP-9. In addition, PL treatment inhibited HUVEC proliferation and capillary tube formation. Tumor growth of SW480 cells implanted into nude mice was significantly decreased as a consequence of PL treatment, and tumor tissues from treated animals showed an increase in the apoptotic index and a decrease in β-catenin expression. Moreover, the proliferation index and microvessel density were significantly decreased.These data suggest that PL suppresses tumor growth, invasion, and angiogenesis through the inhibition of Wnt/β-catenin signaling in certain colon cancer cells.Colorectal cancer (CRC) is the third most prevalent form of cancer in men and women, with a 5-year survival rate of 63%, decreasing to 10% in patients with metastatic disease [1]. Thus, the formation of distant metastasis is the decisive and most lethal event during the course of the disease. Although recent advances in chemotherapeutic agents in CRC have been achieved, treatment options are still limited and are associated with significant morbidity and mortality.Mushroom polysaccharides are widely being used as nonspecific immunostimulants for cancer patients in Asian countries. The Polysaccharide isolated from Phell
The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma
Jaehyouk Lee, Dong-Jun Jeong, Jinsun Kim, Soonduck Lee, Jin-Hwa Park, Boogi Chang, Sam-Il Jung, Lisha Yi, Youngsoo Han, Young Yang, Keun Kim, Jong-Seok Lim, Inchul Yang, Seob Jeon, Dong Bae, Chang-Jin Kim, Myeong-Sok Lee
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-109
Abstract: Loss of KLOTHO mRNA was observed in several cervical cancer cell lines and in invasive carcinoma samples, but not during the early, preinvasive phase of primary cervical tumorigenesis. KLOTHO mRNA was restored after treatment with either the DNA demethylating agent 2'-deoxy-5-azacytidine or histone deacetylase inhibitor trichostatin A. Methylation-specific PCR and bisulfite genomic sequencing analysis of the promoter region of KLOTHO revealed CpG hypermethylation in non-KLOTHO-expressing cervical cancer cell lines and in 41% (9/22) of invasive carcinoma cases. Histone deacetylation was also found to be the major epigenetic silencing mechanism for KLOTHO in the SiHa cell line. Ectopic expression of the secreted form of KLOTHO restored anti-Wnt signaling and anti-clonogenic activity in the CaSki cell line including decreased active β-catenin levels, suppression of T-cell factor/β-catenin target genes, such as c-MYC and CCND1, and inhibition of colony growth.Epigenetic silencing of KLOTHO may occur during the late phase of cervical tumorigenesis, and consequent functional loss of KLOTHO as the secreted Wnt antagonist may contribute to aberrant activation of the canonical Wnt pathway in cervical carcinoma.Cervical carcinoma is the second most common cause of cancer death in women worldwide [1]. Several epidemiological studies have indicated that the human papillomavirus (HPV) provides the 'initial hit' in the development of cervical cancer [2]. It has been hypothesized that deregulation of the canonical Wnt signaling pathway is the 'second hit' in the multistep process of cervical carcinogenesis [3,4]. Aberrant activation of the Wnt/β-catenin signaling pathways has been regarded as a generic pathway in a variety of human malignancies [5,6]. Gain-of-function mutations centered in the N-terminus of CTNNB1 (encoding the β-catenin gene) induced these oncogenic proteins to be refractory to proteosomal degradation in many tumors. Although cytoplasmic/nuclear accumulation of β
Differential Immune Responses to Segniliparus rotundus and Segniliparus rugosus Infection and Analysis of Their Comparative Virulence Profiles
Jong-Seok Kim, Woo Sik Kim, Keehoon Lee, Choul-Jae Won, Jin Man Kim, Seok-Yong Eum, Won-Jung Koh, Sung Jae Shin
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0059646
Abstract: Two closely related bacterial species, Segniliparus rotundus and Segniliparus rugosus, have emerged as important human pathogens, but little is known about the immune responses they elicit or their comparative pathophysiologies. To determine the virulence and immune responses of the two species, we compared their abilities to grow in phagocytic and non-phagocytic cells. Both species maintained non-replicating states within A549 epithelial cells. S. rugosus persisted longer and multiplied more rapidly inside murine bone marrow-derived macrophages (BMDMs), induced more pro-inflammatory cytokines, and induced higher levels of macrophage necrosis. Activation of BMDMs by both species was mediated by toll-like receptor 2 (TLR2), followed by mitogen-activated protein kinases (MAPK) and nuclear factor κB (NF-κB) signaling pathways, indicating a critical role for TLR2 in Segniliparus-induced macrophage activation. S. rugosus triggered faster and stronger activation of MAPK signaling and IκB degradation, indicating that S. rugosus induces more pro-inflammatory cytokines than S. rotundus. Multifocal granulomatous inflammations in the liver and lung were observed in mice infected with S. rugosus, but S. rotundus was rapidly cleared from all organs tested within 15 days post-infection. Furthermore, S. rugosus induced faster infiltration of innate immune cells such as neutrophils and macrophages to the lung than S. rotundus. Our results suggest that S. rugosus is more virulent and induces a stronger immune response than S. rotundus.
Lane Detection with Moving Vehicles Using Color Information
Nasim Arshad,Kwang-Seok Moon,Seung-Seob Park,Jong-Nam Kim
Lecture Notes in Engineering and Computer Science , 2011,
Prognostic and Predictive Value of KRAS Mutations in Advanced Non-Small Cell Lung Cancer
Jong-Mu Sun, Deok Won Hwang, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064816
Abstract: Clinical implications of KRAS mutations in advanced non-small cell lung cancer remain unclear. We retrospectively evaluated the prognostic and predictive value of KRAS mutations in patients with advanced NSCLC. Among 484 patients with available results for both KRAS and EGFR mutations, 39 (8%) had KRAS and 182 (38%) EGFR mutations, with two cases having both mutations. The median overall survivals for patients with KRAS mutations, EGFR mutations, or both wild types were 7.7, 38.0, and 15.0 months, respectively (P<0.001). The KRAS mutation was an independent poor prognostic factor in the multivariate analysis (hazard ratio = 2.6, 95% CI: 1.8–3.7). Response rates and progression-free survival (PFS) for the pemetrexed-based regimen in the KRAS mutation group were 14% and 2.1 months, inferior to those (28% and 3.9 months) in the KRAS wild type group. KRAS mutation tended to be associated with inferior treatment outcomes after gemcitabine-based chemotherapy, while there was no difference regarding taxane-based regimen. Although the clinical outcomes to EGFR tyrosine kinase inhibitors (TKIs) seemed to be better in patients with KRAS wild type than those with KRAS mutations, there was no statistical difference in response rates and PFS according to KRAS mutation status when EGFR mutation status was considered. Two patients with both KRAS and EGFR mutations showed partial response to EGFR TKIs. Although G12D mutation appeared more frequently in never smokers, there was no difference in clinical outcomes according to KRAS genotypes. These results suggested KRAS mutations have an independent prognostic value but a limited predictive role for EGFR TKIs or cytotoxic chemotherapy in advanced NSCLC.
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