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Search Results: 1 - 10 of 71472 matches for " Jong Y. Kim "
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MicroRNAs in pancreatic ductal adenocarcinoma
Jong Y Park,James Helm,Domenico Coppola,Donghwa Kim
World Journal of Gastroenterology , 2011,
Abstract: Ductal adenocarcinoma of the pancreas is a lethal cancer for which the only chance of long-term survival belongs to the patient with localized disease in whom a potentially curative resection can be done. Therefore, biomarkers for early detection and new therapeutic strategies are urgently needed. miRNAs are a recently discovered class of small endogenous non-coding RNAs of about 22 nucleotides that have gained attention for their role in downregulation of mRNA expression at the post-transcriptional level. miRNAs regulate proteins involved in critical cellular processes such as differentiation, proliferation, and apoptosis. Evidence suggests that deregulated miRNA expression is involved in carcinogenesis at many sites, including the pancreas. Aberrant expression of miRNAs may upregulate the expression of oncogenes or downregulate the expression of tumor suppressor genes, as well as play a role in other mechanisms of carcinogenesis. The purpose of this review is to summarize our knowledge of deregulated miRNA expression in pancreatic cancer and discuss the implication for potential translation of this knowledge into clinical practice.
Frequency resonance in Josephson-junction arrays under strong driving
Jong Soo Lim,M. Y. Choi,Beom Jun Kim
Physics , 2003,
Abstract: We study resonance behavior of a two-dimensional fully frustrated Josephson-junction array driven by high alternating currents. The signal-to-noise ratio (SNR) is examined as the frequency of the driving current is varied; revealed is a certain frequency range where the SNR is enhanced. Such resonance behavior is explained by considering the dynamic order parameter at zero temperature. We also compute the work, which corresponds to the Ohmic dissipation of the energy due to external currents, and discuss its possibility as a measure of stochastic resonance.
Biphenyl- and carvone-induced protein expression patterns in Rhodococcus sp. ACS  [PDF]
Jong-Shik Kim
Journal of Agricultural Chemistry and Environment (JACEN) , 2013, DOI: 10.4236/jacen.2013.23010
Abstract: Protein expression patterns in the polychlorinated biphenyl (PCB)-degrading Rhodococcussp. strain ACS were examined following growth on two substrates capable of inducing the enantioselective biotransformation of PCBs via different degradation pathways. Eleven
inducible proteins were identified by SDS-PAGE and characterized by LC-MS/MS. Four of the peptides, a spore coat protein, an extracellular serine protease, a spoVP, and a molecular chaperonin from Bacillus subtilis, were identified as being unique to biphenyl-induced cells, whereas anextracellular serine protease from B. subtilis was identified as being unique to carvone-induced cells.
None of the peptides identified had sequences that corresponded to known dioxygenases or other PCB-degrading enzymes of this Gram- positive bacterium, suggesting that the identified induced proteins may be involved in either PCB degradation or adaptive responses that protect cells from toxicity.


Coercive fields in ultrathin BaTiO3 capacitors
J. Y. Jo,Y. S. Kim,T. W. Noh,Jong-Gul Yoon,T. K. Song
Physics , 2006, DOI: 10.1063/1.2402238
Abstract: Thickness-dependence of coercive field (EC) was investigated in ultrathin BaTiO3 capacitors with thicknesses (d) between 30 and 5 nm. The EC appears nearly independent of d below 15 nm, and decreases slowly as d increases above 15 nm. This behavior cannot be explained by extrinsic effects, such as interfacial passive layers or strain relaxation, nor by homogeneous domain models. Based on domain nuclei formation model, the observed EC behavior is explainable via a quantitative level. A crossover of domain shape from a half-prolate spheroid to a cylinder is also suggested at d~ 15 nm, exhibiting good agreement with experimental results.
Molecular cloning and expression analyses of porcine MAP1LC3A in the granulosa cells of normal and miniature pig
Kim Sang H,Hwang Sue Y,Min Kwan S,Yoon Jong T
Reproductive Biology and Endocrinology , 2013, DOI: 10.1186/1477-7827-11-8
Abstract: Background The members of the microtubule-associated protein 1 light chain (MAP1LC) family, especially those of the LC3 family (MAP1LC3A, B, C), are known to induce autophagy upon localization onto the autophagosomal membrane. In this regard, LC3 can be utilized as a marker for the formation of autophagosomes during the process of autophagy. The aims of this study are to clone porcine MAP1LC3A, and analyze the pattern of its expression in the ovarian tissues of normal and miniature pig ovary in an attempt to understand the distinct mode of apoptosis between two strains. Methods Rapid amplification of cDNA ends (RACE) were used to obtain the 5′ and 3′ ends of the porcine MAP1LC3A full length cDNA. Reverse-transcriptase-PCR (RT-PCR), real-time PCR, and western blot analysis were performed to examine the expression of porcine MAP1LC3A. The localization of MAP1LC3A in the ovary was determined by In situ Hybridization and Immunohistochemical staining. Results We cloned the full-length cDNA of porcine MAP1LC3A and identified an open reading frame of 980 bp encoding 121 amino acids. Based on its homology to known mammalian proteins (98%) this novel cDNA was designated as porcine MAP1LC3A and registered to the GenBank (Accession No. GU272221). We compared the expression of MAP1LC3A in the Graafian follicles of normal and miniature pigs by in situ hybridization at day 15 of the estrus cycle. While normal pigs showed a stronger expression of MAP1LC3A mRNA than miniature pigs in the theca cell area, the expression was lower in the granulosa cells. Immunofluorescence analysis of the MAP1LC3A fusion reporter protein showed the subcellular localization of porcine MAP1LC3A and ATG5 as a punctate pattern in the cytoplasm of porcine granulosa cells under stress conditions. In addition, the expressions of MAP1LC3A and ATG5 were higher in normal pigs than in miniature pigs both in the presence and absence of rapamycin. Conclusions The newly cloned porcine MAP1LC3A provides a novel autophagosomal marker in both normal and miniature pig. We demonstrated that the expression of MAP1LC3A in graafian follicle is distinct in normal and miniature pig, which may explain the unique folliculogenesis of miniature pigs.
The Antiviral Effect of High-Molecular Weight Poly-Gamma-Glutamate against Newcastle Disease Virus on Murine Macrophage Cells
Melbourne Talactac,Jong-Soo Lee,Hojin Moon,Mohammed Y. E. Chowdhury,Chul Joong Kim
Advances in Virology , 2014, DOI: 10.1155/2014/301386
Abstract: This study demonstrates the capacity of HM-γ-PGA treatment to significantly protect murine macrophage cells (RAW 264.7 cells) against NDV infection. Such protection can be explained by the induction of antiviral state of HM-γ-PGA in RAW 264.7 cells via TLR4-mediated IRF-3, IRF-7, IFN-β, and IFN-related gene induction as shown in time-dependent changes in mRNA expression confirmed by polymerase chain reaction (PCR). Moreover, the present research also showed that HM-γ-PGA can induce proinflammatory cytokine secretion in RAW 264.7 as measured by enzyme-linked immunosorbent assay (ELISA). Therefore, our findings suggest that HM-γ-PGA can be a potential antiviral substance that can inhibit NDV infection through its stimulation of antiviral state on RAW 264.7 cells. These results have been consistent with the previous studies showing that HM-γ-PGA can protect RAW 264.7 cells and mice against influenza infection. However, it should be noted that although murine macrophage cells are susceptible to NDV, they are not the natural host cells of the virus; thus further in vivo and in vitro studies involving chicken and chicken immune cells are needed to fully assess the efficacy and applicability of HM-γ-PGA in the poultry industry. 1. Introduction Newcastle disease virus (NDV) is a member of the Paramyxoviridae family under the genus Avulavirus [1, 2] and is currently designated as avian paramyxovirus virus serotype 1 (APMV-1) [3]. According to the Office International des Epizooties (OIE) in 2009, NDV strains can be classified into five pathotypes according to the clinical signs shown by the affected chickens, namely, viscerotropic velogenic (high mortality and hemorrhagic intestinal lesions), neurotropic velogenic (high mortality, respiratory, and nervous signs), mesogenic (low mortality, respiratory signs with occasional nervous signs), lentogenic (subclinical or mild infection), and asymptomatic enteric (subclinical enteric infection) ones [4]. Newcastle disease remains prevalent worldwide, though a number of live and inactivated NDV vaccines are available to control the disease [5, 6]. However, the currently available commercial vaccines have their limitations and one of them is the absence of genetic markers for serological differentiation between vaccinated and naturally infected birds. There are also reports suggesting that the types of NDV strains that have been identified circulating in poultry already showed major antigenic drift. Thus, there is a need for better NDV vaccines which can solve such problems, wherein viral vector vaccines prove to be a
Relaxation dynamics and interrupted coarsening in irrationally frustrated superconducting arrays
Gun Sang Jeon,Sung Jong Lee,Bongsoo Kim,M. Y. Choi
Physics , 2008, DOI: 10.1103/PhysRevB.78.024523
Abstract: Equilibrium and non-equilibrium relaxation behaviors of two-dimensional superconducting arrays are investigated via numerical simulations at low temperatures in the presence of incommensurate transverse magnetic fields, with frustration parameter f= (3-\sqrt{5})/2. We find that the non-equilibrium relaxation, beginning with random initial states quenched to low temperatures, exhibits a three-stage relaxation of chirality autocorrelations. At the early stage, the relaxation is found to be described by the von Schweidler form. Then it exhibits power-law behavior in the intermediate time scale and faster decay in the long-time limit, which together can be fitted to the Ogielski form; for longer waiting times, this crosses over to a stretched exponential form. We argue that the power-law behavior in the intermediate time scale may be understood as a consequence of the coarsening behavior, leading to the local vortex order corresponding to f=2/5 ground-state configurations. High mobility of the vortices in the domain boundaries, generating slow wandering motion of the domain walls, may provide mechanism of dynamic heterogeneity and account for the long-time stretched exponential relaxation behavior. It is expected that such meandering fluctuations of the low-temperature structure give rise to finite resistivity at those low temperatures; this appears consistent with the zero-temperature resistive transition in the limit of irrational frustration.
Dynamic transition and resonance in current-driven arrays of Josephson junctions
Gun Sang Jeon,Jong Soo Lim,Hyun Jin Kim,M. Y. Choi
Physics , 2002, DOI: 10.1103/PhysRevB.66.024511
Abstract: We consider a two-dimensional fully frustrated Josephson-junction array, which is driven uniformly by oscillating currents. As the temperature is lowered, there emerges a dynamic phase transition to an ordered state with nonzero dynamic order parameter for small currents. The transition temperature decreases monotonically with the driving amplitude, approaching zero at a certain critical value of the amplitude. Above the critical value, the disordered phase and the dynamically ordered phase are observed to appear alternatively. The characteristic stochastic resonance behavior of the system is also examined, which reveals that the resonance behavior of odd and even harmonics can be different according to the zero-temperature state.
Phase Transitions in Models for Coupled Charge-Density Waves
Minchul Lee,Eun-Ah Kim,Jong Soo Lim,M. Y. Choi
Physics , 2004, DOI: 10.1103/PhysRevB.69.115117
Abstract: Various phase transitions in models for coupled charge-density waves are investigated by means of the $\epsilon$-expansion, mean-field theory, and Monte Carlo simulations. At zero temperature the effective action for the system with appropriate commensurability effects is mapped onto the three- or four-dimensional \XY model, depending on spatiotemporal fluctuations, under the corresponding symmetry-breaking fields. It is revealed that the three- and four-dimensional systems display a single transition between the clock order (with broken Z$_M$ symmetry) and disorder. The nature of the phase transition depends crucially on the commensurability factor $M$: For $M \ge 4$, in particular, the transition belongs to the same university class as the \XY model. On the other hand, in the presence of misfit causing frustration in the charge-density wave, the inter-chain coupling is observed to favor either the commensurate state or the incommensurate state depending on the initial configuration; this gives rise to hysteresis around the commensurate-incommensurate transition. Boundaries separating such phases with different symmetries are obtained in the parameter space consisting of the temperature, symmetry-breaking field, fluctuation strength, inter-chain coupling, and misfit.
Critical currents for vortex defect motion in superconducting arrays
Jong Soo Lim,M. Y. Choi,Beom Jun Kim,J. Choi
Physics , 2005, DOI: 10.1103/PhysRevB.71.100505
Abstract: We study numerically the motion of vortices in two-dimensional arrays of resistively shunted Josephson junctions. An extra vortex is created in the ground states by introducing novel boundary conditions and made mobile by applying external currents. We then measure critical currents and the corresponding pinning energy barriers to vortex motion, which in the unfrustrated case agree well with previous theoretical and experimental findings. In the fully frustrated case our results also give good agreement with experimental ones, in sharp contrast with the existing theoretical prediction. A physical explanation is provided in relation with the vortex motion observed in simulations.
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