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Search Results: 1 - 10 of 410968 matches for " Jonathan M Coutinho "
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Ethnicity and thrombolysis in ischemic stroke: a hospital based study in Amsterdam
Jonathan M Coutinho, Eva C Klaver, Yvo B Roos, Jan Stam, Paul J Nederkoorn
BMC Neurology , 2011, DOI: 10.1186/1471-2377-11-81
Abstract: Retrospective single-centre study. Patients admitted with an ischemic stroke between 2003 and 2008 were included. Ethnicity was determined by self-identification and stratified into white and non-white (all other ethnicities). The main outcome measure was the difference in thrombolysis rate between white and non-white patients. Logistic regression analysis was used to identify potential confounders of the relation between ethnicity and thrombolysis.510 patients were included, 392 (77%) white and 118 (23%) non-white. Non-white patients were younger (median 69 vs. 60 years, p < 0.001), had a higher blood pressure at admission (median systolic 150 vs. 160 mmHg, p = 0.02) and a lower stroke severity (median NIHSS 5 vs. 4, p = 0.04). Non-white patients were significantly less often treated with thrombolysis compared to white patients (odds ratio 0.34, 95% CI 0.17-0.71), which was partly explained by a later arrival at the hospital. After adjustment for potential confounders (late arrival, age, blood pressure above upper limit for thrombolysis, and oral anticoagulation use), a trend towards a lower thrombolysis rate in non-whites remained (adjusted odds ratio 0.38, 95% CI 0.13 to 1.16).Non-white stroke patients less often received thrombolysis than white patients, partly as a result of a delay in presentation. In this single centre study, potential bias due to hospital differences or insurance status could be ruled out as a cause. The magnitude of the difference is worrisome and requires further investigation. Modifiable causes, such as patient delay, awareness of stroke symptoms, language barriers and treatment of cardiovascular risk factors, should be addressed specifically in these ethnic groups in future stroke campaigns.Despite its proven efficacy, only a minority of patients with an acute ischemic stroke are treated with intravenous thrombolysis [1-3]. A delay in hospital presentation is the most important reason why this treatment is withheld from stroke patients [
Malnutrition and hepatic fibrosis in murine schistosomiasis
Coutinho, Eridan M;
Memórias do Instituto Oswaldo Cruz , 2004, DOI: 10.1590/S0074-02762004000900015
Abstract: in this paper, four different approaches attempting to reproduce the schistosomal liver fibrosis in undernourished mice are reported: shifting from a deficient to a balanced diet and vice-versa, repeated infections, influence of the genetic background, and immunological response. infections were performed with 30 cercariae of schistosoma mansoni and lasted at least four months. undernourished mice were unable to reproduce the picture of "pipestem" fibrosis, except the c57 bl/10 inbred strain, four out of 21 mice developing the liver lesion. a link of this histological finding to the type of parasite strain can not be discarded at the moment. repeated infections increased collagen deposition mainly in well nourished animals (seven out of 16 swiss mice developed "pipestem"-like fibrosis). in undernourished infected swiss mice the serum levels of soluble egg antigen specific antibodies igg1, igg2a, igg2b, and igg3 were two to four times lower than those detected for well nourished controls. the decreased humoral immune response coupled to the morphological, morphometric, and biochemical results reinforce the influence of the host nutritional status on the connective tissue changes of hepatic schistosomiasis.
Patobiologia da desnutri??o nas doen?as parasitárias
Coutinho, Eridan M.;
Memórias do Instituto Oswaldo Cruz , 1980, DOI: 10.1590/S0074-02761980000200007
Abstract: the use of the theory of the general systems for studying the parasitic diseases has led to a better comprehension of the host parasite relationships and of the varying differences found in morbidity and biology of the parasitic diseases. since environment has been considered an ecosystem of the individual, it can act upon man either by a direct action of the parasite on the host or as a determinant of food deficiencies. among the consequences of the direct action of the infectious agent on the nutritional status of the host we can observe generalized catabolic disturbances. also, secondary malabsorption syndromes and haematological alterations like aneamias of several types can be developed in the host's body by different mechanisms. the effects of undernutrition on the biology of the parasites are still better understood and, in the present paper, the schistosomiasis mansoni was taken as an example because of its medical and public health significance in the nosologic picture of northeast brazil. mice were fed with semi-purified and "natural" diets (similar to those consumed by the population living in endemic areas of northeast brazil where important endemic foci of this parasite are found). finally, an analysis of the immunologic response in the pathobiology of nutrition /infection interrelationships was made, with special reference to the negative role of protein and iron deficiencies on cellular immunity.
Princípios de epidemiologia clínica aplicada à cardiologia
Coutinho Mário
Arquivos Brasileiros de Cardiologia , 1998,
Abstract:
8th International Symposium on Schistosomiasis
Coutinho Eridan M
Memórias do Instituto Oswaldo Cruz , 2002,
Abstract:
Big Five Personality Traits and Occupy Wall Street  [PDF]
Costas Panagopoulos, Jonathan M. Lehrfeld
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.615193
Abstract: We investigated Big Five personality traits for a novel sample of individuals engaged in politically and economically-charged protest activity at the Occupy Wall Street demonstrations in New York City. We gathered data about protesters’ personality traits by administering the TIPI battery in a survey conducted in October 2011. We compared distributions of Big Five traits for the sample with population norms. We expected our sample to show higher levels of extraversion, openness, and emotional stability, and lower levels of agreeableness, compared to norms, with no difference in conscientiousness. We found mixed support for our hypotheses: our sample showed higher levels of emotional stability and extraversion, lower levels of agreeableness, and no differences in conscientiousness, but lower levels of openness.
Impacts of Modern Glacier Changes on Surface Water Resources in Western and Northern Mongolia  [PDF]
Alexander Orkhonselenge, Jonathan M. Harbor
Journal of Water Resource and Protection (JWARP) , 2018, DOI: 10.4236/jwarp.2018.106031
Abstract: Water trapped in glaciers and in lakes impounded by landforms created by glaciers (glacial lakes) are an important component of the hydrology and water resources in high mountain areas of Central Asia. Changes in modern glaciers and glacial lakes are an important component of the hydrology of watersheds in the Mongolian Altai and Khuvsgul Mountain Ranges, western and northern Mongolia, respectively. Here we focus on Mt. Ikh Turgen and Mt. Munkh Saridag, isolated mountains of the Mongolian Altai and Khuvsgul Mountain Ranges, respectively. We use remote sensing to track changes in modern glaciers over time with mapping at scales of 1:200,000 for Mt. Ikh Turgen and 1:90,000 for Mt. Munkh Saridag based on imagery from Google Earth, 30 m resolution Aster Digital Elevation Model (DEM) and 30 m resolution Landsat 5 TM. Mt. Ikh Turgen lost 45.6% of its total glacier area between 1970 (41.4 km2) and 2011 (18.9 km2) and the Equilibrium Line Altitude (ELA) of the glaciers increased in elevation by 98 m and 144 m on north and south aspects, respectively. Mt. Munkh Saridag lost 57.3% of its total glacier area between 1970 (901 m2) and 2007 (381 m2) and the local ELA rose by 47 m and 80 m on north and south aspects, respectively. These mountains are located at similar latitudes, and so the greater percentage loss of glacier area in Mt. Munkh Saridag and faster changes in ELAs in Mt. Ikh Turgen may reflect variations in elevation and aspect, duration of solar radiation, and vulnerability to solar radiation, as well as variations in glacier scale. This study demonstrates the importance of spatial analyses of modern glaciers in understanding the context of hydrological changes within which any sustainable water resource management plan must be situated.
Metais pesados do solo após aplica??o de biossólido: II - Disponibilidade
Borges, M. R.;Coutinho, E. L. M.;
Revista Brasileira de Ciência do Solo , 2004, DOI: 10.1590/S0100-06832004000300016
Abstract: the use of industrial and city wastes with high heavy metal contents in agriculture have increased the need for obtaining the concentration of such elements that are available in the soil. thus, a greenhouse experiment was carried out at the fcav-unesp, in jaboticabal, s?o paulo state, brazil in order to compare analysis methods (dtpa, hcl 0.1 mol l-1, mehlich-1, and mehlich-3) to evaluate the cu, mn, ni, pb, and zn availability for corn (zea mays l.) plants in two soils (an eutrustox and a ultipsamment). a complete randomized design with three replications of treatments in a 2 × 2 × 5 factorial arrangement (two soils, presence or absence of lime, and five sewage sludge rates) was used. in the limed treatments the soils were amended with agricultural lime to raise the soil ph (cacl2) to 5.3. the sewage sludge rates (dry weight basis) were equivalent to 0, 10, 20, 40, and 60 t ha-1. all the extractants tested proved inefficient to evaluate availability of all metals concurrently. the inclusion of the soil ph in the regression models significantly improved the relationship between the amounts of mn accumulated in the shoot and those extracted with dtpa, hcl 0.1 mol l-1, mehlich-1, and mehlich-3.
Metais pesados do solo após aplica??o de biossólido: I - Fracionamento
Borges, M. R.;Coutinho, E. L. M.;
Revista Brasileira de Ciência do Solo , 2004, DOI: 10.1590/S0100-06832004000300015
Abstract: the effects of ph changes and sewage sludge application on the distribution of cu, mn, ni, pb, and zn among exchangeable, organic, amorphous fe and al oxides, crystalline fe and al oxides, and residual fractions of two soils (and eutrustox and a ultipsamment) were studied in a greenhouse experiment carried out at the fcav-unesp, in jaboticabal (sp), brazil. the heavy metal contents in these fractions were related to those extracted with dtpa, hcl 0.1 mol l-1, mehlich-1, and mehlich-3 extractants and the metal contents of corn shoot (zea mays l.) as well. a complete randomized design with three replications of treatments in a 2 × 2 × 5 factorial arrangement (two soils, presence or absence of lime, and five sewage sludge rates) was used. in the limed treatments the soils were amended with agricultural lime to raise the soil ph (cacl2) to 5.3. the sewage sludge rates (dry weight basis) were equivalent to 0, 10, 20, 40, and 60 t ha-1. the soil fractionation showed that most metals were strongly associated to oxides and residual fractions. in the sandy soil a greater proportion of metals were found in more bioavailable fractions (exchangeable and organic matter-bound) in comparison to the fine-textured soil. an increase in soil ph caused a redistribution of the metals from the exchangeable fraction to those bound to organic matter or oxides. multiple regression analysis showed that the metals extracted by dtpa, hcl 0.1 mol l-1, mehlich-1, and mehlich-3, and the metals in the corn shoot were mainly associated to soil exchangeable and organic fractions.
Ground- and Surface-Water Interactions of a Pumice Aquifer in a Headwaters Watershed: Round Meadow, Fremont-Winema National Forest, Oregon, USA  [PDF]
Jonathan M. Weatherford, Michael L. Cummings
Journal of Water Resource and Protection (JWARP) , 2016, DOI: 10.4236/jwarp.2016.811081
Abstract: Plinian pumice fall from the Holocene eruption of Mount Mazama in the Cascade volcanic arc is an unconfined, perched aquifer in south-central Oregon. The pumice aquifer provides near-surface groundwater storage that maintains biologically diverse wetland environments. Wetland environments reflect post-eruption disruption of the once uniform pumice blanket by fluvial and lacustrine processes operating within the template of the pre-eruption landscape. In the 8.6 km2 Round Meadow watershed the pumice aquifer interacts with a seasonally flooded meadow, fen, springs, and perennial stream. The laterally uniform, isotropic pumice aquifer is disrupted by flat-bottomed ephemeral stream valleys that drain to the seasonally flooded meadow. Surface water levels in the seasonally flooded meadow are controlled by a knickpoint developed on bedrock. The underlying aquifer is confined by a layer of glass-rich diatomaceous silt grading upward to organic-rich silt. Here, the aquifer is comprised of remnants of the pumice deposit, lag sand, and reworked pumice. The water level in the confined aquifer is maintained by recharge from the unconfined pumice aquifer following flow pathways beneath ephemeral stream valleys. The fen is developed on a down-thrown block of welded tuff and pre-eruption diatomaceous silt. Water levels in the fen are sensitive to inter-annual variations in precipitation. Low discharge, low temperature (5.0°C to 6.5°C), and low conductivity (30 to 50 μS/cm) springs appear to be fracture controlled and rising through welded tuff. Spring discharge and seepage through pumice from the welded tuff support perennial flow in the creek that also carries discharge from the seasonally flooded meadow when water levels are high enough to cross the knickpoint.
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