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Search Results: 1 - 10 of 470847 matches for " Jonathan A Bernstein "
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Characteristics of nonallergic vasomotor rhinitis
Jonathan A Bernstein
World Allergy Organization Journal , 2009, DOI: 10.1097/wox.0b013e3181a8e389
Abstract:
Successful C1 inhibitor short-term prophylaxis during redo mitral valve replacement in a patient with hereditary angioedema
Jonathan A Bernstein, Suzanne Coleman, Arturo J Bonnin
Journal of Cardiothoracic Surgery , 2010, DOI: 10.1186/1749-8090-5-86
Abstract: Attacks of hereditary angioedema (HAE) are characterized by sudden episodes of brawny, nonpitting edema, causing discomfort and pain[1]. Areas of the body typically affected include the extremities, genitalia, trunk, gastrointestinal tract, face, and larynx. Untreated patients with HAE are at risk for deadly attacks of laryngeal swelling, where up to 30% may asphyxiate[2].HAE is an inherited autosomal dominant disorder resulting from any number of mutations in the C1 esterase inhibitor (C1 INH) gene that cause C1 INH deficiency[2]. Approximately 85% of cases are type 1 HAE, which is characterized by reduced levels of circulating C1 INH[3,4]. The remaining 15% of cases are type 2 HAE, which is characterized by dysfunctional circulating C1 INH[3,4]. A child will have a 50% chance of inheriting HAE if one parent has the disease; however, 25% of cases arise from de novo mutations[3]. Inherited angioedema with normal C1 inhibitor levels has been described and is thought to be a separate disease resulting from a factor XII missense mutation that leads to bradykinin overproduction[5,6].Histamine mediated allergic inflammation is not involved in HAE[7]. Instead, HAE attacks result from contact, complement, and fibrinolytic plasma cascade activation, where C1 INH is a suicide inhibitor[2]. People with HAE have defective C1 INH synthesis with typical C1 INH levels that are 5%-30% of normal.2 Bradykinin is generated in large quantities via the contact pathway once C1 INH is depleted (Figure 1)[2]. Excess bradykinin production leads to acute HAE attacks as a result of increased vasodilatation, vascular permeability, and contraction of nonvascular smooth muscle[3].HAE affects 1:50,000 people[8]. Fifty percent of patients will develop symptoms by age 10, although attacks have been reported in children as young as 2 years old[9]. Symptom frequency and severity may be extremely variable, even within families[4]. There may be no obvious trigger for attacks and no correlation between
IL-1 blockade as a novel approach to treatment of hyperzincemia and hypercalprotectinemia, a possible new autoinflammatory syndrome
Lionetti Geraldina,Bernstein Jonathan A,Holzinger Dirk,Jeng Michael
Pediatric Rheumatology , 2012, DOI: 10.1186/1546-0096-10-s1-a87
Abstract:
Consensus definition of nonallergic rhinopathy, previously referred to as vasomotor rhinitis, nonallergic rhinitis, and/or idiopathic rhinitis
Michael A Kaliner, James N Baraniuk, Michael Benninger, Jonathan A Bernstein, Phil Lieberman, Eli O Meltzer, Robert M Naclerio, Russell A Settipane, Judith R Farrar
World Allergy Organization Journal , 2009, DOI: 10.1097/wox.0b013e3181a8e15a
Abstract:
Consensus Description of Inclusion and Exclusion Criteria for Clinical Studies of Nonallergic Rhinopathy (NAR), Previously Referred to as Vasomotor Rhinitis (VMR), Nonallergic Rhinitis, and/or Idiopathic Rhinitis
Michael A Kaliner, James N Baraniuk, Michael S Benninger, Jonathan A Bernstein, Phil Lieberman, Eli O Meltzer, Robert M Naclerio, Russell A Settipane, Judith R Farrar
World Allergy Organization Journal , 2009, DOI: 10.1097/wox.0b013e3181b2ff8a
Abstract:
Fluorination Effects on the Structural Stability and Electronic Properties of sp3 Type Silicon Nanotubes
Alon Hever,Jonathan Bernstein,Oded Hod
Physics , 2013, DOI: 10.1021/jp4045786
Abstract: A density functional theory study of the structural and electronic properties and relative stability of fluorinated sp3 silicon nanotubes and their corresponding silicon nanowires built along various crystallographic orientations is presented. The structural stability is found to increase linearly with the fluorine surface coverage and for coverages exceeding 25% the tubular structures are predicted to be more stable than their wire-like counterparts. The bandgaps of the fully fluorinated systems are lower than those of their fully hydrogenated counterparts by up to 0.79 eV for systems having a relatively low silicon molar fraction. As the silicon molar fraction increases these differences appear to reduce. For mixed fluorination and hydrogenation surface decoration schemes the bandgaps usually lie between the values of the fully hydrogenated and fully fluorinated systems. Furthermore, the bandgap values of the silicon nanotubes are found to be more sensitive to the fluorine surface coverage than those of the silicon nanowires. These results indicate that surface functionalization may be used to control the stability of narrow quasi-one-dimensional silicon nanostructures and opens the way towards chemical tailoring of their electronic properties.
Structural stability and electronic properties of SP3 type silicon nanotubes
Alon Hever,Jonathan Bernstein,Oded Hod
Physics , 2012, DOI: 10.1063/1.4767389
Abstract: A density functional theory study of the structural and electronic properties and relative stability of narrow SP3 silicon nanotubes of different growth orientations is presented. All nanotubes studied and their corresponding wire structures are found to be meta-stable with the wires being more energetically stable. Silicon nanotubes show a dramatic bandgap increase of up to 68% with respect to the corresponding wires. Furthermore, a direct relation between the bandgap of the system and the molar fraction of the passivating hydrogen contents is found. These results suggest that by careful control over their crystallographic growth orientation, dimensions, and chemical composition it should be possible to design and fabricate silicon nanotubes with desired electronic properties.
Opening Remarks at Chiral Dynamics 2006:Experimental Tests of Chiral Symmetry Breaking
Bernstein, A. M.
High Energy Physics - Phenomenology , 2007,
Abstract: A physical introduction to the basics of chiral dynamics is presented. Emphasis is placed on experimental tests which have generally demonstrated a strong confirmation of the predictions of chiral perturbation theory, a low energy effective field theory of QCD. Special attention is paid to a few cases where discrepancies exist, requiring further work. Some desirable future tests are also recommended.
Pions: Experimental Tests of Chiral Symmetry Breaking
Bernstein, A. M.
High Energy Physics - Phenomenology , 2013,
Abstract: Based on the spontaneous breaking of chiral symmetry, chiral perturbation theory (ChPT) is believed to approximate confinement scale QCD. Dedicated and increasingly accurate experiments and improving lattice calculations are confirming this belief, and we are entering a new era in which we can test confinement scale QCD in some well chosen reactions. This is demonstrated with an overview of low energy experimental tests of ChPT predictions of $\pi\pi$ scattering, pion properties, $\pi$N scattering and electromagnetic pion production. These predictions have been shown to be consistent with QCD in the meson sector by increasingly accurate lattice calculations. At present there is good agreement between experiment and ChPT calculations, including the $\pi\pi$ and $\pi$N s wave scattering lengths and the $\pi^{0}$ lifetime. Recent, accurate pionic atom data are in agreement with chiral calculations once isospin breaking effects due to the mass difference of the up and down quarks are taken into account, as was required to extract the $\pi\pi$ scattering lengths. In addition to tests of the theory, comparisons between $\pi\pi$ and $\pi$N interactions based on general chiral principles are discussed. Lattice calculations are now providing results for the fundamental, long and inconclusively studied, $\pi$N $\sigma$ term and the contribution of the strange quark to the mass of the proton. Increasingly accurate experiments in electromagnetic pion production experiments from the proton which test ChPT calculations (and their energy region of validity) are presented. These experiments are also beginning to measure the final state $\pi$N interaction. This paper is based on the concluding remarks made at the Chiral Dynamics Workshop CD12 held at Jefferson Lab in Aug. 2012.
The Adaptive Value of Polymorphism in an Alpine Ant, FormicaNeorufibarbis Gelida Wheeler
Ruth A. Bernstein
Psyche , 1976, DOI: 10.1155/1976/52542
Abstract:
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