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Search Results: 1 - 10 of 464043 matches for " Jon A. Sanford "
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Home and Community Environmental Features, Activity Performance, and Community Participation among Older Adults with Functional Limitations
Hsiang-Yu Yang,Jon A. Sanford
Journal of Aging Research , 2012, DOI: 10.1155/2012/625758
Abstract: This paper describes relationships among home and community environmental features, activity performance in the home, and community participation potential to support aging in place. A subset of data on older adults with functional limitations ( ?? = 1 2 2 ), sixty three (63) with mobility and 59 with other limitations, were utilized in this study from a larger project's subject pool. Results showed significant and positive correlations between environmental barriers, activity dependence and difficulty at home, and less community participation in the mobility limitation group. While kitchen and bathroom features were most limiting to home performance, bathtub or shower was the only home feature, and destination social environment was the only community feature, that explained community participation. Compared to environmental features, home performance explained much more community participation. Study results provide detailed information about environmental features as well as types of home activities that can be prioritized as interventions for aging in place. 1. Introduction Changes in the person-environment relationship as well as the negative outcomes of shrinkage in “life space” (i.e., the extent of mobility of older adults as measured by the range of places in which a person engages in activities within a designated time frame) associated with aging, particularly among seniors with mobility limitations, have been long conceptualized and widely documented [1–3]. In fact, restricted life space has been recently linked to increased risk of Alzheimer’s disease [4]. Older adults have been reported to spend 80 percent of their time in their primary residence [5] and have demonstrated an “environmental centralization” of behaviors (i.e., the tendency of using a few preferred places at home where necessary or desired items are located) to maintain control and competence over the living environment [2, 6]. With almost 9 out of 10 (86%) older Americans reporting that they want to spend the rest of their lives in the homes and communities [7] in which the majority of their daily activities take place [8], a robust life space is essential for older adults to continue to engage and participate in as many home and community activities as independently and safely as possible. While prior work has consistently linked supportive home and community settings to continued performance of home activities and participation in community roles, respectively, evidence suggests that community participation, which is dependent on maintaining a wide range of life spaces
Study protocol: home-based telehealth stroke care: a randomized trial for veterans
Neale R Chumbler, Dorian K Rose, Patricia Griffiths, Patricia Quigley, Nancy McGee-Hernandez, Katherine A Carlson, Phyllis Vandenberg, Miriam C Morey, Jon Sanford, Helen Hoenig
Trials , 2010, DOI: 10.1186/1745-6215-11-74
Abstract: We describe an ongoing Phase II, 2-arm, 3-site randomized controlled trial (RCT) that determines primarily the effect of TR on physical function and secondarily the effect on disability, falls-related self-efficacy, and patient satisfaction. Fifty participants with a diagnosis of ischemic or hemorrhagic stroke will be randomly assigned to one of two groups: (a) TR; or (b) Usual Care. The TR intervention uses a combination of three videotaped visits and five telephone calls, an in-home messaging device, and additional telephonic contact as needed over a 3-month study period, to provide a progressive rehabilitative intervention with a treatment goal of safe functional mobility of the individual within an accessible home environment. Dependent variables will be measured at baseline, 3-, and 6-months and analyzed with a linear mixed-effects model across all time points.For patients recovering from stroke, the use of TR to provide home assessments and follow-up training in prescribed equipment has the potential to effectively supplement existing home health services, assist transition to home and increase efficiency. This may be particularly relevant when patients live in remote locations, as is the case for many veterans.Clinical Trials.gov Identifier: NCT00384748Stroke patients clearly benefit from intensive and coordinated inpatient care. Access to post-acute stroke in-patient rehabilitation is limited for many individuals, especially those residing in rural locations. One study found that over 75% of US veterans treated within the Department of Veterans Health Administration (VHA) with an acute stroke are cared for in hospitals without an inpatient rehabilitation bed-unit (RBU), and fewer than 10% of stroke patients are transferred to a RBU from facilities without a RBU [1].While inpatient rehabilitation care is the preferred form for many patients post-stroke, due to access and financial barriers, many patients do not have this option. Another viable option is home-
Implementing Telerehabilitation Research For Stroke Rehabilitation With Community Dwelling Veterans: Lessons Learned
Neale R Chumbler,Patricia Quigley,Jon Sanford,Patricia Griffiths
International Journal of Telerehabilitation , 2010, DOI: 10.5195/ijt.2010.6047
Abstract: Telerehabilitation (TR) is the use of telehealth technologies to provide distance support, rehabilitation services and information exchange between people with disabilities and their clinical providers. This article discusses the barriers experienced when implementing a TR multi-site randomized controlled trial for stroke patients in their homes, and the lessons learned from conducting the study. The barriers are divided into two sections: those specific to TR and those pertinent to research overall. The TR specific barriers included the rapidly changing telecommunications and health care environment and inconsistent equipment functionality. The barriers applicable to research overall included the need for telehealth research to meet regulations in diverse departments and the rapidly expanding and changing research regulations. Solutions to the barriers included having various telehealth equipment available to allow for functionality with the currently diverse telecommunications infrastructure, rigorous pilot testing all equipment in different situations, and having biomedical engineering staff on-call and on-site.
Tibiofemoral Joint Forces during the Stance Phase of Gait after ACL Reconstruction  [PDF]
Brooke A. Sanford, John L. Williams, Audrey R. Zucker-Levin, William M. Mihalko
Open Journal of Biophysics (OJBIPHY) , 2013, DOI: 10.4236/ojbiphy.2013.34033

The main goals of anterior cruciate ligament reconstruction (ACLR) are to restore knee function and prevent development of osteoarthritis (OA). However, the incidence of early-onset OA remains higher in patients following ACLR. The purpose of this study was to compare the computed tibiofemoral joint (TFJ) forces and muscle forces of ACLR knees to those of BMI-matched control subjects during the stance phase of gait. We hypothesized that the use of principal component analysis would allow us to characterize alterations in three-dimensional TFJ loads and muscle forces after ACLR as compared to a healthy control population. Of the eight ACLR knees, four displayed an abnormal TFJ compressive force. In three of these four ACLR knees that displayed abnormal compressive forces, one of the major muscles/muscle groups crossing the knee also deviated from the control group. We believe that each subject has a unique response to their injury, reconstructive surgery, and rehabilitation.

麦类作物学报 , 1986, DOI: 10.7606/j.issn.1009-1041.1986.05.107
Abstract: 普通小麦的籽粒产量是单位面积粒数和粒重的函数.粒重取决于籽粒生长速率和持续期.籽粒数及其影响因素已受到了人们的重视,但对籽粒生长特性与产量的关系及其在育种中的价值尚未详细研究.
Comparison of fluorescence-based techniques for the quantification of particle-induced hydroxyl radicals
Corey A Cohn, Sanford R Simon, Martin AA Schoonen
Particle and Fibre Toxicology , 2008, DOI: 10.1186/1743-8977-5-2
Abstract: APF, amplex ultrared, and DCFH react similarly to the presence of hydroxyl radicals. Proxyl fluorescamine and tempo-9-ac do not react with hydroxyl radicals directly, which reduces their sensitivity. Since both DCFH and amplex ultrared will react with reactive oxygen species other than hydroxyl radicals and another highly reactive species, peroxynitite, they lack specificity.The most useful probe evaluated here for hydroxyl radicals formed from cell-free particle suspensions is APF due to its sensitivity and selectivity.The particle-induced formation of hydroxyl radicals has gained considerable attention by toxicologists, environmental scientists, and geochemists [1]. The hydroxyl radical is a molecule with an unpaired electron, which will react nonspecifically with most organic molecules within nanoseconds after their formation [2]. It is included in a group of molecules termed reactive oxygen species (ROS), which also includes hydrogen peroxide (H2O2) and superoxide (O2?-). Hydroxyl radicals (?OH) have been implicated in genotoxicity [3,4] and oxidative stress [4-6] that may contribute to lung disease upon exposure to asbestos [7], silica [3,8], and other airborne particulate matter [9,10]. Hence, ?OH formation in vitro and in vivo has been used as an indicator for particulate-induced toxicity potential [3-5,11-14].The detection of hydroxyl radicals is not a trivial process; detection methods require high sensitivity, high selectivity, and low detection. The extreme reactivity of ?OH precludes its direct detection by conventional spectroscopic methods, and instead, techniques employ reaction of ?OH with a target molecule (probe). Upon reaction, the probe's characteristics such as light absorption, fluorescence, and/or electron spin resonance may change. These changes in the probe's characteristics can be correlated with estimated concentrations of ?OH (or another ROS) generated under controlled conditions. The resulting calibration curve can then be used to quanti
The influence of food supply on the response of Olympia oyster larvae to ocean acidification
A. Hettinger,E. Sanford,T. M. Hill,J. D. Hosfelt
Biogeosciences Discussions , 2013, DOI: 10.5194/bgd-10-5781-2013
Abstract: Increases in atmospheric carbon dioxide drive accompanying changes in the marine carbonate system as carbon dioxide (CO2) enters seawater and alters its pH (termed "ocean acidification"). However, such changes do not occur in isolation, and other environmental factors have the potential to modulate the consequences of altered ocean chemistry. Given that physiological mechanisms used by organisms to confront acidification can be energetically costly, we explored the potential for food supply to influence the response of Olympia oyster (Ostrea lurida) larvae to ocean acidification. In laboratory experiments, we reared oyster larvae under a factorial combination of pCO2 and food level. High food availability offset the negative consequences of elevated pCO2 on larval shell growth and total dry weight. Low food availability, in contrast, exacerbated these impacts. In both cases, effects of food and pCO2 interacted additively rather than synergistically, indicating that they operated independently. Despite the potential for abundant resources to counteract the consequences of ocean acidification, impacts were never completely negated, suggesting that even under conditions of enhanced primary production and elevated food availability, impacts of ocean acidification may still accrue in some consumers.
Neuroimaging in the early diagnosis of neurodegenerative disease
A Jon Stoessl
Translational Neurodegeneration , 2012, DOI: 10.1186/2047-9158-1-5
Abstract: Neurodegenerative disorders, of which Alzheimer's (AD) and Parkinson's (PD) diseases are the most common, take an enormous toll on affected patients and their families. For example, a recent analysis indicates that dementia and PD combined affect more than 7.5 million Europeans, at an estimated annual cost of €120 billion [1] and incalculable suffering. While symptomatic therapies are currently available, they are at best imperfect (PD), at worst provide only modest benefit (dementia) and they do not have any convincing impact on the inexorable progression of the underlying disorder. Advances in basic neuroscience make it increasingly likely that disease modifying therapies will be developed but these are likely to have maximal impact if they are introduced early in the course of the illness. Early disease detection would permit the provision of such therapies to those most likely to benefit from them, at the time that they are most likely to be effective. Early diagnosis permits the identification of people appropriate for inclusion in clinical trials of novel therapies and the exclusion of those who are not. Finally, early diagnosis allows better prognostication and appropriate resource utilization.A variety of neuroimaging techniques may be useful for the early diagnosis of neurodegenerative disorders, but one should first consider the goal. Early diagnosis may refer to the timely correct differentiation of a specific disease entity from other conditions that may mimic it in early stages, or it may refer to the early detection of central nervous system dysfunction, prior to the emergence of clinical symptoms. The latter application is more likely to be of interest in populations at increased risk of disease, and could be useful for identification of subjects to participate in trials of neuroprotective agents, or ultimately to try and halt disease progression once effective disease-modifying interventions have been identified.In the case of PD, the two major diagn
Staggered Baryon Operators with Flavor SU(3) Quantum Numbers
Jon A. Bailey
Physics , 2006, DOI: 10.1103/PhysRevD.75.114505
Abstract: The construction of the first baryon operators for staggered lattice QCD exploited the taste symmetry to emulate physical quark flavor; contemporary 2+1 flavor simulations explicitly include three physical quark flavors and necessitate interpreting a valence sector with twelve quarks. After discussing expected features of the resulting baryon spectrum, I consider the spectra of operators transforming irreducibly under SU(3)xGTS, the direct product of flavor SU(3) and the geometrical time-slice group of the 1-flavor staggered theory. I then describe the construction of a set of maximally local baryon operators transforming irreducibly under SU(3)xGTS and enumerate this set. In principle, the operators listed here could be used to extract the masses of all the lightest spin-1/2 and spin-3/2 baryon resonances of staggered QCD. Using appropriate operators from this set in partially quenched simulations should allow for particularly clean 2+1 flavor calculations of the masses of the nucleon and the lightest decuplet.
Chiral forms and three-flavor operators for staggered baryons
Jon A. Bailey
Physics , 2006,
Abstract: In staggered QCD, many staggered baryons correspond to each physical state. Taste violations lift the continuum degeneracies of the baryons and introduce nonzero off-diagonal elements in the mass matrix. While presenting no problem of principle, these splittings and mixings complicate analyses of simulation results. However, in special cases operators with good SU(3) quantum numbers can be used to circumvent the splittings and mixings. I review what has been learned from staggered chiral perturbation theory, outline a program of attack for the amenable cases, and summarize the present status of work on the staggered chiral forms and operators with good SU(3)xGTS quantum numbers.
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