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Search Results: 1 - 10 of 32506 matches for " John Stingl "
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Review Essay: Jugend – Jugendkultur – Techno Review Essay: Youth—Youth Culture—Techno Ensayo: Juventud – cultura juvenil – tecno
Benjamin Stingl
Forum : Qualitative Social Research , 2003,
Abstract: Das zu besprechende Buch ist ein interdisziplin rer Sammelband zur Untersuchung der sog. Techno-Kultur. Mit der Konzentration auf Erkl rungsans tze der sozialen "Entbettung" und Beschreibung einer Szene- und Eventkultur vers umt es der Sammelband, in der Breite st rkere Verbindungslinien zu Institutionalisierungs- und Selbstorganisationsprozessen Jugendlicher herzustellen und verfehlt damit z.T. sein Ziel, die Techno-Kultur von einseitigen Vorurteilen zu befreien. Die Rezension versucht, unter Rekonstruktion von Paradigmen sozial- und kulturwissenschaftlicher Jugend- und Jugendkulturforschung einen Hintergrund zum Verst ndnis von Jugendkultur als zeitspezifischer L sung jugendlicher Verhaltensunsicherheiten anzubieten. URN: urn:nbn:de:0114-fqs0302133 The book under discussion is an interdisciplinary anthology investigating German Techno culture. By reconstructing central paradigms of sociological youth and youth culture research, the review tries to establish youth culture as a time-specific solution of juvenile behavior uncertainties. With the stress on explanation patterns of social change such as "disembedding" (in the notion of Anthony GIDDENS) and emphasis on the description of a scene and event culture, the anthology fails to offer deeper insight into the lives of young people apart from techno events, thereby missing its goal to release the Techno culture from prejudices. URN: urn:nbn:de:0114-fqs0302133 El libro por discutir es una antología interdisciplinaria que investiga la tecnocultura alemana. Al reconstruir los paradigmas centrales de la investigación sociológica en jóvenes y cultura juvenil, la revisión pretende establecer ésta última como una solución de tiempo específico de las incertidumbres del comportamiento juvenil. Con el énfasis en la explicación de los patrones de cambio social tales como "desolidificación" (en la noción de Anthony GIDDENS) y el énfasis en la descripción de la escena y el evento cultura, la antología falla en ofrecer una aproximación profunda a las vidas de la gente joven aparte de los eventos tecno, por tanto, pierde su objetivo de liberar de los prejuicios a la cultura tecno. URN: urn:nbn:de:0114-fqs0302133
Review Essay: Der Mensch als Monument. Anmerkungen zur medialen sthetik des Hip-Hop Review Essay: Humans as Monuments. Notes on the Mediating Aesthetics of Hip-Hop Ensayo: Humanos como monumentos. Notas sobre la mediación estética del hip-hop
Benjamin Stingl
Forum : Qualitative Social Research , 2005,
Abstract: Das zu besprechende Buch widmet sich der Hip-Hop-Kultur in einer international vergleichenden Perspektive, mit einem deutlichen Schwerpunkt auf dem deutschsprachigen Raum. Die zu Beginn vertretene These eines medialen Vermittlungszusammenhanges von globaler Kultur und lokalen Praktiken wird zun chst nicht genauer fundiert. In der additiven Reihung seiner überwiegend gehaltvollen Beitr ge gelingt es dem Band dann aber zumindest implizit, hierfür wichtige thematische Str nge herauszupr parieren. Die Rezension bietet in ihrer Einleitung zun chst einen vorstrukturierenden Zugang zur historischen Entwicklung der kulturwissenschaftlichen Erforschung musikalischer Jugendkulturen. In einem zweiten Teil werden der Herausgeber und seine Vertreter, der Ansatz und Aufbau des Sammelbandes, sowie ausgew hlte Aspekte des Sammelbandes vorgestellt. Die Lektüre geht der Frage nach, wie die anf ngliche Leerformel der "Medienaneignung" in dem Sammelband inhaltlich gefüllt wird. Zur Diskussion stehen dabei der Begriff der kulturellen Globalisierung, das Verh ltnis von sthetischer Produktion und sozialer Erfahrung, die Logik der konomischen Globalisierung und ihre Wirkungen auf die Justierungen von Identit t, sowie die Frage der Engführung eines Minderheitendiskurses vor einem Migrationshintergrund und schlie lich die soziale Modellierung der Hip-Hop-Kultur. In einem eigenen, dritten Teil soll der Versuch unternommen werden, ein ausdrückliches Defizit des Sammelbandes zu überwinden, n mlich die Basics der Hip-Hop-Kultur, das "Sampling" und das "Signifying" und die soziale Differenzierung der Szenen vor dem Hintergrund vorangegangener Jugendkulturen zu thematisieren und in einen Zusammenhang mit den genannten Str ngen zu bringen. Ziel der erg nzenden Skizze ist es, über einen engen Minderheitendiskurs hinaus, der sich so nur abseits des medialen Mainstreams (der Minderheiten) abspielt, gerade auch die hiesige sthetik des letzteren als komplexe Krise der Artikulation eigener und kollektiver Identit t zu plausibilisieren. In einer paradoxen Bewegung k nnen die zu schildernden technischen Grundlagen und ihre sozio-kognitiven Auswirkungen, die zuerst zu dieser Krise geführt haben, nun gerade zu deren überwindung eingesetzt werden. Diese Kreuzung findet ihren Niederschlag sowohl im Prozess der sthetischen Vermittlung als auch in der sozialen Vermittlung zwischen Eigenem und der Community der Hip-Hop-Kultur. URN: urn:nbn:de:0114-fqs0502231 This book dedicates itself to an exploration of the hip-hop culture from an internationally comparative perspective, but with a clear emphasi
A Systematic Extended Iterative Solution for QCD
M. Stingl
Physics , 1995, DOI: 10.1007/BF01285154
Abstract: An outline is given of an extended perturbative solution of Euclidean QCD which systematically accounts for a class of nonperturbative effects, while allowing renormalization by the perturbative counterterms. Proper vertices Gamma are approximated by a double sequence Gamma[r,p], with r the degree of rational approximation w.r.t. the QCD mass scale Lambda, nonanalytic in the coupling g, and p the order of perturbative corrections in g-squared, calculated from Gamma[r,0] - rather than from the perturbative Feynman rules Gamma(0)(pert) - as a starting point. The mechanism allowing the nonperturbative terms to reproduce themselves in the Dyson-Schwinger equations preserves perturbative renormalizability and is tied to the divergence structure of the theory. As a result, it restricts the self-consistency problem for the Gamma[r,0] rigorously - i.e. without decoupling approximations - to the superficially divergent vertices. An interesting aspect of the scheme is that rational-function sequences for the propagators allow subsequences describing short-lived excitations. The method is calculational, in that it allows known techniques of loop computation to be used while dealing with integrands of truly nonperturbative content.
The devil is in the methods: lineage tracing, functional screens and sequencing, hormones, tumour-stroma interactions, and expansion of human breast tumours as xenografts
María dM Vivanco, John Stingl, Robert B Clarke, Mohamed Bentires-Alj
Breast Cancer Research , 2011, DOI: 10.1186/bcr3021
Abstract: The third international meeting of the European Network for Breast Development and Cancer (ENBDC) again promoted the sharing of protocols and ideas between groups working on breast development and cancer. Graduate students, postdocs and research associates were encouraged to attend. The following topics were covered in depth: functional screens and sequencing, hormones, lineage tracing, the propagation of human breast tumours as xenografts and tumour-stroma interactions.Chris Lord from the Breakthrough Breast Cancer Research Centre at the Institute of Cancer Research in London presented examples of the power of genome-wide functional screens. First, his group combined tamoxifen treatment of breast cancer cells in vitro and a small interfering RNA (siRNA) screen for kinases in an approach to identify events leading to tamoxifen sensitivity and tamoxifen resistance. They identified low cyclin-dependent kinase (CDK)10 expression as an important mediator of resistance to endocrine therapy in breast cancer. Knockdown of CDK10 blocked its inhibitory effect on ETS2, which in turn induced transcription of c-Raf and led to activation of the ERK/mitogen-activated protein kinase (MAPK) pathway and resistance to tamoxifen [1]. They also used a pooled genome-wide small hairpin RNA (shRNA) screen in the presence or absence of tamoxifen, coupled with massively parallel sequencing, and identified groups of genes the silencing of which increased sensitivity (for example C10orf72, C15orf55/NUT, EDF1, ING5, KRAS) or resistance (for example, BAP1, CLPP, GPRC5D, NAE1, NF1) to tamoxifen [2]. Second, they used a synthetic lethal unbiased shRNA screen for identifying sensitizers to a poly (ADP-ribose) polymerase (PARP) inhibitor in BRCA1 wild-type breast cancer cells. Knockdown of RAD51D, a novel ovarian cancer susceptibility gene, dramatically increased cell death upon PARP inhibition [3]. Third, they used a kinome-wide siRNA screen to identify genetic dependencies of breast cancer cell l
Methods in Mammary Gland Development and Cancer: the second ENDBC meeting - intravital imaging, genomics, modeling and metastasis
John Stingl, Matthew J Smalley, Marina A Glukhova, Mohamed Bentires-Alj
Breast Cancer Research , 2010, DOI: 10.1186/bcr2630
Abstract: The European Network for Breast Development and Cancer (ENBDC) organized its second meeting to foster interactions and the sharing of protocols between groups working on breast development and cancer. Graduate students, postdocs and research associates were encouraged to attend. The meeting included discussions on genomics, bioinformatics, intravital microscopy, disseminated tumor cells, ex vivo culture and in vivo models for studying breast cancer.Nuno Barbosa-Morais (Cancer Research UK, Cambridge Research Institute) discussed the importance of the correct annotation of microarray probes and of being sure that a probe truly maps to the gene of interest. Further problems to consider are probes that map to intron-exon boundaries, the presence of SNPs, and alternative splicing, which, as is becoming apparent, occurs on a far wider scale than previously appreciated. Splicing may lead to difficulties when summarizing data from multiple probes apparently mapping to the same gene but which in fact detect different splice variants. Overall, it is clear that whatever array platform is being used, application of the latest, most reliable annotation is important. In a test of annotation reliability, it was found that Refseq annotations are a more reliable guide to probe identity than GenBank/UniGene.Britta Weigelt (Cancer Research UK, London Research Institute) spoke on the design of gene expression microarray studies, which fall into three types. The first, class comparison, is a supervised analysis to define molecular differences between predefined groups. The second, class prediction, is a supervised analysis where, after identifying the transcriptional differences between predefined groups, a genomic classifier (signature) is defined to classify new samples. It has become clear that class prediction signatures mainly identify tumors with high proliferation, although they do perform well in identifying poor prognosis tumors of the estrogen receptor-positive type. The third
Extended Iterative Scheme for QCD: the Four-Gluon Vertex
L. Driesen,M. Stingl
Physics , 1998, DOI: 10.1007/s100500050247
Abstract: We study the self-consistency problem of the generalized Feynman rule (nonperturbatively modified vertex of zeroth perturbative order) for the 4-gluon vertex function in the framework of an extended perturbation scheme accounting for non-analytic coupling dependence through the Lambda scale. Tensorial structure is restricted to a minimal dynamically closed basis set. The self-consistency conditions are obtained at one loop, in Landau gauge, and at the lowest approximation level (r=1) of interest for QCD. At this level, they are found to be linear in the nonperturbative 4-gluon coefficients, but strongly overdetermined due to the lack of manifest Bose symmetry in the relevant Dyson-Schwinger equation. The observed near decoupling from the 2-and-3-point conditions permits least-squares quasisolutions for given 2-and-3-point input within an effective one-parameter freedom. We present such solutions for N_F=2 massless quarks and for the pure gluon theory, adapted to the 2-and-3-point coefficients determined previously.
PENNON: Software for linear and nonlinear matrix inequalities
Michal Kocvara,Michael Stingl
Mathematics , 2015,
Abstract: The goal of this paper is to present an overview of the software collection for the solution of linear and nonlinear semidefinite optimization problems PENNON. In the first part we present theoretical and practical details of the underlying algorithm and several implementation issues. In the second part we introduce the particular codes PENSDP, PENBMI and PENNON, focus on some specific features of these codes and show how they can be used for the solution of selected problems.
Characterisation of microRNA expression in post-natal mouse mammary gland development
Stefanie Avril-Sassen, Leonard D Goldstein, John Stingl, Cherie Blenkiron, John Le Quesne, Inmaculada Spiteri, Konstantina Karagavriilidou, Christine J Watson, Simon Tavaré, Eric A Miska, Carlos Caldas
BMC Genomics , 2009, DOI: 10.1186/1471-2164-10-548
Abstract: We measured the expression of 318 individual murine miRNAs by bead-based flow-cytometric profiling of whole mouse mammary glands throughout a 16-point developmental time course, including juvenile, puberty, mature virgin, gestation, lactation, and involution stages. In parallel whole-genome mRNA expression data were obtained.One third (n = 102) of all murine miRNAs analysed were detected during mammary gland development. MicroRNAs were represented in seven temporally co-expressed clusters, which were enriched for both miRNAs belonging to the same family and breast cancer-associated miRNAs. Global miRNA and mRNA expression was significantly reduced during lactation and the early stages of involution after weaning. For most detected miRNA families we did not observe systematic changes in the expression of predicted targets. For miRNA families whose targets did show changes, we observed inverse patterns of miRNA and target expression. The data sets are made publicly available and the combined expression profiles represent an important community resource for mammary gland biology research.MicroRNAs were expressed in likely co-regulated clusters during mammary gland development. Breast cancer-associated miRNAs were significantly enriched in these clusters. The mechanism and functional consequences of this miRNA co-regulation provide new avenues for research into mammary gland biology and generate candidates for functional validation.MicroRNAs (miRNAs) are a class of small non-coding RNA, approximately 23 nucleotides in length, which regulate gene expression post-transcriptionally and play a key role in development and specific biological processes such as cell proliferation, differentiation, and apoptosis [1-3]. MicroRNAs regulate their target genes through direct degradation of the messenger RNA (mRNA) and/or translational inhibition [4-7]. While subsets of miRNAs are specifically expressed during early mammalian development [8], others are essential for morphogenesis o
Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland
Mona Shehata, Andrew Teschendorff, Gemma Sharp, Nikola Novcic, I Alasdair Russell, Stefanie Avril, Michael Prater, Peter Eirew, Carlos Caldas, Christine J Watson, John Stingl
Breast Cancer Research , 2012, DOI: 10.1186/bcr3334
Abstract: We used fluorescence-activated cell sorting along with in vitro and in vivo functional assays to examine the growth and differentiation properties of distinct subsets of human and mouse mammary epithelial cells. We also examined how loss of steroid hormones influenced these populations in vivo. Gene expression profiles were also obtained for all the purified cell populations and correlated to those obtained from breast tumours.The luminal cell compartment of the mouse mammary gland can be resolved into nonclonogenic oestrogen receptor-positive (ER+) luminal cells, ER+ luminal progenitors and oestrogen receptor-negative (ER-) luminal progenitors. The ER+ luminal progenitors are unique in regard to cell survival, as they are relatively insensitive to loss of oestrogen and progesterone when compared with the other types of mammary epithelial cells. Analysis of normal human breast tissue reveals a similar hierarchical organisation composed of nonclonogenic luminal cells, and relatively differentiated (EpCAM+CD49f+ALDH-) and undifferentiated (EpCAM+CD49f+ALDH+) luminal progenitors. In addition, approximately one-quarter of human breast samples examined contained an additional population that had a distinct luminal progenitor phenotype, characterised by low expression of ERBB3 and low proliferative potential. Parent-progeny relationship experiments demonstrated that all luminal progenitor populations in both species are highly plastic and, at low frequencies, can generate progeny representing all mammary cell types. The ER- luminal progenitors in the mouse and the ALDH+ luminal progenitors in the human appear to be analogous populations since they both have gene signatures that are associated with alveolar differentiation and resemble those obtained from basal-like breast tumours.The luminal cell compartment in the mammary epithelium is more heterogeneous than initially perceived since progenitors of varying levels of luminal cell differentiation and proliferative capacit
Developmental Changes in the in Vitro Activated Regenerative Activity of Primitive Mammary Epithelial Cells
Maisam Makarem,Nagarajan Kannan,Long V. Nguyen,David J. H. F. Knapp,Sneha Balani,Michael D. Prater,John Stingl,Afshin Raouf,Oksana Nemirovsky,Peter Eirew,Connie J. Eaves
PLOS Biology , 2013, DOI: 10.1371/journal.pbio.1001630
Abstract: Many normal adult tissues contain rare stem cells with extensive self-maintaining regenerative potential. During development, the stem cells of the hematopoietic and neural systems undergo intrinsically specified changes in their self-renewal potential. In the mouse, mammary stem cells with transplantable regenerative activity are first detectable a few days before birth. They share some phenotypic properties with their adult counterparts but are enriched in a subpopulation that displays a distinct gene expression profile. Here we show that fetal mammary epithelial cells have a greater direct and inducible growth potential than their adult counterparts. The latter feature is revealed in a novel culture system that enables large numbers of in vitro clonogenic progenitors as well as mammary stem cells with serially transplantable activity to be produced within 7 days from single fetal or adult input cells. We further show that these responses are highly dependent on novel factors produced by fibroblasts. These findings provide new avenues for elucidating mechanisms that regulate normal mammary epithelial stem cell properties at the single-cell level, how these change during development, and how their perturbation may contribute to transformation.
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