oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 64 )

2018 ( 96 )

2017 ( 101 )

2016 ( 143 )

Custom range...

Search Results: 1 - 10 of 32447 matches for " John Smythies "
All listed articles are free for downloading (OA Articles)
Page 1 /32447
Display every page Item
Some Aspects of the Normal Role of Neuromodulators in the Immune System  [PDF]
John Smythies
Neuroscience & Medicine (NM) , 2011, DOI: 10.4236/nm.2011.23035
Abstract: This review covers recent advances in our knowledge of the role of a group of the most prominent neurotransmitters and neuromodulators in the field of the immune reactions of the body. The neurotransmitters and neuromodulators covered are the three catecholamines (epinephrine, noradrenaline and dopamine), serotonin, acetylcholine (both nicotinic and muscarinic functions), and histamine.
The Role of Abnormalities Related to the One Carbon Cycle in Depression and Schizophrenia  [PDF]
John Smythies
Neuroscience & Medicine (NM) , 2012, DOI: 10.4236/nm.2012.31015
Abstract: This paper reviews our present knowledge of the role of the one-carbon cycle in mood disorder and schizophrenia with particular attention to S-adenosyl methionine (SAM). After an historical introduction the clinical data is first reviewed of the anti-depressant action of SAM, in particular a survey of double blind placebo-controlled trials. Then follows an account of the biochemical parameters of the action of SAM, in particular the role of folic acid and 5-methyltetrahydrofolate (vitamin B9), polyamines, homocysteine, together with epigenetic studies. In schizophrenia the effect of oral l-methionine on worsening the symptoms of some chronic schizophrenics has been known since 1961. Recent epigenetic research covered has addressed the mechanism of this reaction. This includes the role of SAM in modulating DNA methyltransferase-1 mRNA activity, cytosine 5-methylation, spine numbers and the expression of mRNAs encoding for reelin and GAD67 in GABAergic neurons in the frontal cortex in schizophrenia. There is also evidence that marker D8S542 located within the methionine sulfoxide reductase (MSRA) gene may be involved in schizophrenia as well as 677C > T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene. The possible roles of homocysteine and methionine S-adenosyl transferase kinetics are also discussed.
Schizophrenia: One Coat of Many Colors
John Smythies
Frontiers in Psychiatry , 2013, DOI: 10.3389/fpsyt.2013.00043
Abstract:
Interactions between the spike code and the epigenetic code during information processing in the brain
John Smythies,Lawrence Edelstein
Frontiers in Molecular Neuroscience , 2013, DOI: 10.3389/fnmol.2013.00017
Abstract:
Transsynaptic modality codes in the brain: possible involvement of synchronized spike timing, microRNAs, exosomes and epigenetic processes
John Smythies,Lawrence Edelstein
Frontiers in Integrative Neuroscience , 2013, DOI: 10.3389/fnint.2012.00126
Abstract: This paper surveys two different mechanisms by which a presynaptic cell can modulate the structure and function of the postsynaptic cell. We first present the evidence that this occurs, and then discuss two mechanisms that could bring this about. The first hypothesis relates to the long lasting effects that the spike patterns of presynaptic axons may exert by modulating activity–inducible programs in postsynaptic cells. The second hypothesis is based on recently obtained evidence that, the afferent neuron at the neuromuscular junction buds off exosomes at its synapse and carries a cargo of Wg and Evi, which are large molecular transsynaptic signaling agents (LMTSAs). Further evidence indicates that many types of neurons bud off exosomes containing payloads of various lipids, proteins, and types of RNA. The evidence suggests that they are transmitted across the synapse and are taken up by the postsynaptic structure either by perisynaptic or exosynaptic mechanisms, thus mediating the transfer of information between neurons. To date, the molecular hypothesis has been limited to local interactions within the synapse of concern. In this paper, we explore the possibility that this represents a mechanism for information transfer involving the postsynaptic neuron as a whole. This entails a review of the known functions of these molecules in neuronal physiology, together with an estimate of the possible types of information they could carry and how they might affect neurocomputations.
Telocytes, exosomes, gap junctions and the cytoskeleton: the makings of a primitive nervous system?
John Smythies,Lawrence Edelstein
Frontiers in Cellular Neuroscience , 2014, DOI: 10.3389/fncel.2013.00278
Abstract:
The desferrioxamine-prochlorperazine coma—clue to the role of dopamine-iron recycling in the synthesis of hydrogen peroxide in the brain
John Smythies,Lawrence Edelstein
Frontiers in Molecular Neuroscience , 2014, DOI: 10.3389/fnmol.2014.00074
Abstract:
Hypotheses concerning how Otx2 makes its incredible journey: a hitchhiker on the road to Rome?
Lawrence Edelstein,John Smythies
Frontiers in Molecular Neuroscience , 2013, DOI: 10.3389/fnmol.2013.00055
Abstract:
Spike Dynamic and Epigenetic Malfunctions in Epilepsy: A Tale of Two Codes
John Smythies,Lawrence Edelstein
Frontiers in Neurology , 2013, DOI: 10.3389/fneur.2013.00063
Abstract:
Hypotheses relating to the function of the claustrum II: does the claustrum use frequency codes?
John Smythies,Lawrence Edelstein
Frontiers in Integrative Neuroscience , 2014, DOI: 10.3389/fnint.2014.00007
Abstract:
Page 1 /32447
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.