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Search Results: 1 - 10 of 34781 matches for " John Chia "
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Functional Dyspepsia and Chronic Gastritis Associated with Enteroviruses  [PDF]
John K. Chia, Andrew Y. Chia, David Wang, Rabiha El-Habbal
Open Journal of Gastroenterology (OJGas) , 2015, DOI: 10.4236/ojgas.2015.54005
Abstract: After decades of research, functional dyspepsia (FD) remains one of the most elusive gastrointestinal disorders. Endoscopic appearance of mild inflammation of the gastric mucosa without ulceration and microscopic evidence of mild chronic inflammation are often considered as normal findings since no etiology could be found other than H. Pylori. Enteroviruses infect the gastrointestinal tract and have been shown to persist in the stomach of symptomatic patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In this study, we evaluated FD patients with and without the diagnosis of ME/CFS, and were able to support the viral protein staining with finding of double-stranded RNA in 63% of the same stomach biopsies by immunoperoxidase staining. Furthermore, we clarified the possible cross-reaction with creatine kinase brain subtype (CKB), present in parietal cells, using antibody competition experiments and western blot analysis of stomach proteins. Viral protein+ and dsRNA+ biopsies were infectious in SCID mice. More research is needed to elucidate the mechanism of enterovirus infection of the stomach associated with FD and chronic gastritis.
Chronic Enterovirus D68 Bronchiolitis Causing Severe Respiratory Insufficiency  [PDF]
John Chia, Andrew Chia, David Wang, Rabiha El-Habbal, Deren Sinkowitz
Open Journal of Respiratory Diseases (OJRD) , 2016, DOI: 10.4236/ojrd.2016.63007
Abstract: Human enteroviruses are less well-known causes of acute bronchiolitis. In recent years, Enterovirus D68 [EV D68] has emerged as significant cause of epidemic viral bronchiolitis and pneumonia in the United States and other countries. Chronic bronchiolitis has not been previously attributed to EV D68. We documented EV D68 in open lung biopsies of a young adult patient who was frequently admitted to the hospital for severe exacerbation of respiratory infections and subsequently developed progressive respiratory insufficiency. The difficulty of diagnosis and potential economic impact of this illness is discussed.
Supergravity and Two-Field Inflation Effects in Right-Handed Sneutrino-Modified D-term Inflation
Lin, Chia-Min;McDonald, John
High Energy Physics - Phenomenology , 2007, DOI: 10.1103/PhysRevD.77.063529
Abstract: We extend previous work on the minimal D-term inflation model modified by Right-Handed (RH) sneutrino fields to include additional inflaton-sector SUGRA corrections and two-field inflation effects. We show that SUGRA corrections simultaneously allow n_{s} to be within 3-year WMAP limits and the cosmic string contribution to the CMB power spectrum to be less than 5%. For gauge coupling g < 1, the CMB contribution from cosmic strings is predicted to be at least 1% while the spectral index is predicted to be less than 0.968 for a CMB string contribution less than 5%. Treating the inflaton-RH sneutrino system as a two-field inflation model, we show that the time-dependence of the RH sneutrino field strongly modifies the single-field results for values of RH sneutrino mass m_{\Phi} > 0.1 H. The running spectral index is \alpha = -0.0002 when m_{\Phi} < 0.1 H but increases to positive values as m_{\Phi}/H increases, with \alpha > 0.008 for m_{\Phi} > 1.0 H.
Echovirus 18 Infection Is Associated with Crohn’s Disease  [PDF]
John Chia, Andrew Chia, David Wang, Rabiha El-Habbal, Sitaraman Jyotheeswaran, Eric McCloud
Open Journal of Gastroenterology (OJGas) , 2019, DOI: 10.4236/ojgas.2019.98020
Abstract: Background: Enterovirus (EV) can cause gastroenteritis and are known to replicate in Peyer’s patches of terminal ileum. EV has been found in the intestinal specimens from immunocompromised patients with regional enteritis, and another study demonstrates the presence of enterovirus in the resected terminal ileum of immunocompetent pediatric patients with Crohn’s disease (CD). Cluster outbreaks of CD have also been reported in the literature but the cause of the disease remains elusive. Materials and Methods: A small cluster of pathologically proven CD occurred in our geographic area in 2004-2005, concurrently with an epidemic of Echovirus 18 (E18) meningitis. Serum samples of these and other CD patients and control subjects were tested for neutralizing antibodies of 11 common typeable enteroviruses and Echovirus 18; and tissue samples of CD patients, and terminal ileum and colon biopsies of normal controls were tested for the presence of viral capsid protein 1 (VP1) by immunoperoxidase staining. Results: Immunoperoxidase staining demonstrated VP1 in a rare epithelial granuloma, in diseased muscle of terminal ileum and also in colon biopsies of CD patients. Significantly elevated E18 neutralizing antibody was found in patients with pathologically-proven Crohn’s disease, as compared to control subjects. Conclusion: In this small observational study, EV VP1 is consistently demonstrated in tissue samples of CD patients as compared to control subjects; and neutralizing antibody for E18 was found in all of the patients with available serum samples. Larger cross-sectional studies will be needed to define the role of E18 in this chronic disease.
A Quirky Little Higgs Model
Cai, Haiying;Cheng, Hsin-Chia;Terning, John
High Energy Physics - Phenomenology , 2008, DOI: 10.1088/1126-6708/2009/05/045
Abstract: We consider an extra dimensional model where the quadratically divergent top loop contribution to the Higgs mass is cancelled by an uncolored heavy "top quirk" charged under a different SU(3) gauge group. The cancellation is enforced by bulk gauge symmetries. Thus we have an unusual type of little Higgs model which has some quirky signatures. The top partner in this model could be identified at the Large Hadron Collider due to macroscopic strings that connect quirk and anti-quirks. The model can undergo radiative electroweak symmetry breaking and is consistent with precision electroweak measurements.
Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice
Chia Elizabeth,Kagota Satomi,Wijekoon Enoka P,McGuire John J
BMC Pharmacology , 2011, DOI: 10.1186/1471-2210-11-10
Abstract: Background Under conditions of cardiovascular dysfunction, protease-activated receptor 2 (PAR2) agonists maintain vasodilatation activity, which has been attributed to increased cyclooxygenase-2, nitric oxide synthase and calcium-activated potassium channel (SK3.1) activities. Protease-activated receptor 2 agonist mediated vasodilatation is unknown under conditions of dysfunction caused by angiotensin II. The main purpose of our study was to determine whether PAR2-induced vasodilatation of resistance arteries was attenuated by prolonged angiotensin II treatment in mice. We compared the vasodilatation of resistance-type arteries (mesenteric) from angiotensin II-treated PAR2 wild-type mice (WT) induced by PAR2 agonist 2-furoyl-LIGRLO-amide (2fly) to the responses obtained in controls (saline treatment). We also investigated arterial vasodilatation in angiotensin II-treated PAR2 deficient (PAR2-/-) mice. Results 2fly-induced relaxations of untreated arteries from angiotensin II-treated WT were not different than saline-treated WT. Treatment of arteries with nitric oxide synthase inhibitor and SK3.1 inhibitor (L-NAME + TRAM-34) blocked 2fly in angiotensin II-treated WT. Protein and mRNA expression of cyclooxygenase-1 and -2 were increased, and cyclooxygenase activity increased the sensitivity of arteries to 2fly in only angiotensin II-treated WT. These protective vasodilatation mechanisms were selective for 2fly compared with acetylcholine- and nitroprusside-induced relaxations which were attenuated by angiotensin II; PAR2-/- were protected against this attenuation of nitroprusside. Conclusions PAR2-mediated vasodilatation of resistance type arteries is protected against the negative effects of angiotensin II-induced vascular dysfunction in mice. In conditions of endothelial dysfunction, angiotensin II induction of cyclooxygenases increases sensitivity to PAR2 agonist and the preserved vasodilatation mechanism involves activation of SK3.1.
Superoxide Dismutase 1 and tgSOD1G93A Mouse Spinal Cord Seed Fibrils, Suggesting a Propagative Cell Death Mechanism in Amyotrophic Lateral Sclerosis
Ruth Chia,M. Howard Tattum,Samantha Jones,John Collinge,Elizabeth M. C. Fisher,Graham S. Jackson
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010627
Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that specifically affects motor neurons and leads to a progressive and ultimately fatal loss of function, resulting in death typically within 3 to 5 years of diagnosis. The disease starts with a focal centre of weakness, such as one limb, and appears to spread to other parts of the body. Mutations in superoxide dismutase 1 (SOD1) are known to cause disease and it is generally accepted they lead to pathology not by loss of enzymatic activity but by gain of some unknown toxic function(s). Although different mutations lead to varying tendencies of SOD1 to aggregate, we suggest abnormal proteins share a common misfolding pathway that leads to the formation of amyloid fibrils.
Correlation set analysis: detecting active regulators in disease populations using prior causal knowledge
Chia-Ling Huang, John Lamb, Leonid Chindelevitch, Jarek Kostrowicki, Justin Guinney, Charles DeLisi, Daniel Ziemek
BMC Bioinformatics , 2012, DOI: 10.1186/1471-2105-13-46
Abstract: We present a simple data-driven method, Correlation Set Analysis (CSA), for comprehensively detecting active regulators in disease populations by integrating co-expression analysis and a specific type of literature-derived causal relationships. Instead of investigating the co-expression level between regulators and their regulatees, we focus on coherence of regulatees of a regulator. Using simulated datasets we show that our method performs very well at recovering even weak regulatory relationships with a low false discovery rate. Using three separate real biological datasets we were able to recover well known and as yet undescribed, active regulators for each disease population. The results are represented as a rank-ordered list of regulators, and reveals both single and higher-order regulatory relationships.CSA is an intuitive data-driven way of selecting directed perturbation experiments that are relevant to a disease population of interest and represent a starting point for further investigation. Our findings demonstrate that combining co-expression analysis on regulatee sets with a literature-derived network can successfully identify causal regulators and help develop possible hypothesis to explain disease progression.Fundamental functions of living cells are controlled by regulatory relations between genes and proteins. Most cell types respond to changes in their environment (e.g. drug treatments or disease causing mutations) by altering their transcriptional patterns. More than a decade ago, it became possible to measure snapshots of all transcript levels in a given tissue sample using microarray technology. Since then, advances in technology have multiplied and the cost of experiments has decreased significantly. As a consequence, cell lines, animal models as well as clinical subjects in drug trials or in the general population [1] have been characterized on a molecular level. One crucial problem in such studies is the detection of active key regulators; i.e
Clinical presentation and endoscopic features of primary gastric Burkitt lymphoma in childhood, presenting as a protein-losing enteropathy: a case report
Jenny Hui Chia Chieng, John Garrett, Steven Leslie Ding, Michael Sullivan
Journal of Medical Case Reports , 2009, DOI: 10.4076/1752-1947-3-7256
Abstract: We report a 9-year-old boy who presented with gross oedema, ascites and respiratory distress caused by a protein-losing enteropathy. Initial imaging investigations were non-diagnostic but gastroduodenal endoscopy revealed massive involvement of the gastric mucosa with a primary Burkitt lymphoma. His subsequent clinical progress and disease response were monitored directly by endoscopy and he remains in clinical remission 4 years after initial diagnosis.This is the first case report of primary Burkitt lymphoma presenting as a protein-losing enteropathy. The clinical course and progress of the patient were monitored by sequential endoscopic biopsy, histology and molecular analysis by fluorescence in situ hybridisation.Protein-losing enteropathy (PLE) has many causes including gastrointestinal lymphoma [1-3], however, there are no reports of protein-losing enteropathy caused by a primary gastric lymphoma in childhood. Here we report the clinical presentation, endoscopic features and outcome of a child with PLE caused by Burkitt lymphoma of the stomach.A previously healthy 9-year-old boy with normal growth and development presented with progressive pallor, peripheral oedema and respiratory distress. Examination showed pallor, pitting oedema, and respiratory distress. No lymphadenopathy, jaundice, hepatosplenomegaly or abdominal masses were present, and the remainder of the physical examination was normal.Investigations showed hypoalbuminaemia; albumin 16 g/L, and total protein 27 g/L, with normal liver and renal function. The urine was normal with no proteinuria or haematuria. Haemoglobin (Hb) was 89 g/L, white blood cell count (WCC) 16.6 × 109/L, but neutrophils and lymphocytes and blood film were normal.The chest X-ray (CXR) showed consolidation in the right lower lobe and an abdominal ultrasound scan was normal.At gastroduodenal endoscopy, multiple raised large (2 to 3 cm in diameter) ulcerated tumours of the greater curvature of the gastric body were seen (Figure 1)
Measuring end-users' opinions for establishing a usercentred Electronic Health Record (EHR) system from the perspective of nurses
Yu Su,Yung; Than Win,Khin; Fulcher,John; Chia Chiu,Herng;
Journal of theoretical and applied electronic commerce research , 2009, DOI: 10.4067/S0718-18762009000200005
Abstract: establishing an acceptable user-centred electronic health record (ehr) system is a challenging task for healthcare providers due to the need for such systems to meet the requirements of its user population. concerned nurses are the main end-users of ehr systems. based on knowledge of evidence-based management (ebm) and the issues (goals and methods) of health information systems (his) evaluation, this research was performed in four regional teaching hospitals by adopting a quantitative approach research design to perform "goal-based evaluation" research. the results of path analysis indicated that 17 of 21 hypotheses were accepted in this study. in addition, the results of one-way anova with scheff test comparisons indicated that age is the most important variable in measuring system quality, service quality, safety quality, user use and user satisfaction; education is important in measuring service quality; and seniority is important in measuring system quality, service quality and user use. furthermore, the results of linear regression indicated that only one hypothesis is affected by the demographic variable education. in summary, this empirical investigation provided evidence-based knowledge to explain nurses' opinions of ehr systems success, and to distinguish which demographic variables influence their viewpoints of using such systems in southern taiwan.
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