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Search Results: 1 - 10 of 3991 matches for " Johanna Wolf "
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Comparative effectiveness of i-SCAN and high-definition white light characterizing small colonic polyps
Johanna L Chan,Li Lin,Michael Feiler,Andrew I Wolf
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i41.5905
Abstract: AIM: To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light. METHODS: This is a single-center comparative effectiveness pilot study. Polyps (n = 103) from 75 average-risk adult outpatients undergoing screening or surveillance colonoscopy between December 1, 2010 and April 1, 2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center. Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology. We determined diagnostic characteristics of i-SCAN and high-definition white light, including sensitivity, specificity, and accuracy, with regards to identifying adenomatous vs non-adenomatous polyps. Histopathologic diagnosis was the gold standard comparison. RESULTS: One hundred and three small polyps, detected from forty-three patients, were included in the analysis. The average size of the polyps evaluated in the analysis was 3.7 mm (SD 1.3 mm, range 2 mm to 8 mm). Formal histopathology revealed that 54/103 (52.4%) were adenomas, 26/103 (25.2%) were hyperplastic, and 23/103 (22.3%) were other diagnoses include “lymphoid aggregates”, “non-specific colitis,” and “no pathologic diagnosis.” Overall, the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN (71.8%, 95%CI: 62.1%-80.3%) and high-definition white light (71.8%, 95%CI: 62.1%-80.3%). However, the accuracy of each endoscopist differed substantially, where endoscopist A demonstrated 63.0% overall accuracy (95%CI: 50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy (95%CI: 77.9%-99.2%), irrespective of imaging modality. Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study. Though endoscopist A increased accuracy using i-SCAN from 59% (95%CI: 42.1%-74.4%) in the first half to 67.6% (95%CI: 49.5%-82.6%) in the second half, and endoscopist B decreased accuracy using i-SCAN from 100% (95%CI: 80.5%-100.0%) in the first half to 84.6% (95%CI: 54.6%-98.1%) in the second half, neither of these differences were statistically significant. CONCLUSION: i-SCAN and high-definition white light had similar efficacy predicting polyp histology. Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study.
Metabolic analysis of male servicemembers with transtibial amputations carrying military loads
Barri L. Schnall, MPT,Erik J. Wolf, PhD,Johanna C. Bell, MSE,Jeffrey Gambel, MD
Journal of Rehabilitation Research and Development , 2012,
Abstract: For servicemembers who have sustained amputations and wish to return to Active Duty, performing common military tasks is essential. The purpose of this study was to examine the metabolic requirements of servicemembers with transtibial amputations wearing a loaded rucksack and walking at a steady speed. We tested 12 servicemembers with unilateral transtibial amputations and 12 uninjured controls on a treadmill at two walking speeds (1.34 and 1.52 m/s) while they carried a 32.7 kg load. Oxygen consumption was recorded. Results showed that metabolic demand for the injured servicemembers was -significantly higher (8.5% at 1.34 m/s and 10.4% at 1.52 m/s) than for controls. An understanding of energy expended during load carriage by this study population is critical for decisions regarding return-to-duty requirements. Although significant differences existed between uninjured controls and those with amputations, it is important to note that those differences are less than previously published. This finding, coupled with the fact that servicemembers with transtibial amputations have redeployed, implies that, despite statistical significance, results may not be clinically relevant. Future work should include more taxing conditions to identify a threshold for potential limitations.
Wolf AS
Journal für Menopause , 1998,
Abstract: Mit dem Thema Phytoestrogene wird derzeit ein Neuland in der angewandten klinischen Medizin betreten, welches in der Pr vention und Gesundheitsf rderungsBeratung einen bedeutsamen Platz einnehmen kann. Es existieren bislang zwar zahlreiche Untersuchungen insbesondere zur Karzinom-Pr vention für Kolon-, Rektum-, Magen-, Prostata- und Mamma-Karzinom, jedoch ist die überwiegende Zahl der Studien mangelhaft aufgrund des statistischen Designs und der geringen Zahl an untersuchten Anwenderinnen. Prospektiv randomisierte Untersuchungen bestehen nicht. Experimentelle Studien zum Wirkmechanismus und zur biologischen Wirkung der Phytoestrogene deuten jedoch auf die Potenz und das immense Wirkpotential dieser Pflanzenestrogene hin. Eine m glichst frühzeitig begonnene, langzeitig phytoestrogenhaltige, ballaststoffreiche Kost kann anscheinend das Risiko für Wechseljahrsbeschwerden, Osteoporose und darüber hinaus für Mamma-Karzinom, Kolon- und Endometrium-Karzinom sowie kardiovaskul re Erkrankungen deutlich reduzieren. Aus diesem Grunde kann man bereits heute bei Frauen nach MammaCa, bei Vorliegen besonderer famili rer oder pers nlicher Risiken für die Entwicklung eines Mamma-Ca oder bei erh htem kardiovaskul rem Risiko zur "Sojaeinnahme" in Form von 30 g Sojamehl oder Sojadrinks pro Tag raten. Zahleiche Rezeptbücher und Anleitungen vermitteln dafür schmackhafte Zubereitungen und Kochvorschl ge. Weltweit sind alle Endokrinologen aufgefordert, sich in Zukunft über das tats chliche Wirkpotential der Phytoestrogene zu bemühen, um pr zise Daten für alternative Behandlungsm glichkeiten und Lebensstilberatung allgemein sowie nach Malignomerkrankungen zur Verfügung zu haben.
Dispersion engineering of Quantum Cascade Lasers frequency combs
Gustavo Villares,Sabine Riedi,Johanna Wolf,Dmitry Kazakov,Martin J. Süess,Mattias Beck,Jér?me Faist
Physics , 2015,
Abstract: Quantum cascade lasers are compact sources capable of generating frequency combs. Yet key characteristics - such as optical bandwidth and power-per-mode distribution - have to be improved for better addressing spectroscopy applications. Group delay dispersion plays an important role in the comb formation. In this work, we demonstrate that a dispersion compensation scheme based on a Gires-Tournois Interferometer integrated into the QCL-comb dramatically improves the comb operation regime, preventing the formation of high-phase noise regimes previously observed. The continuous-wave output power of these combs is typically $>$ 100 mW with optical spectra centered at 1330 cm$^{-1}$ (7.52 $\mu$m) with $\sim$ 70 cm$^{-1}$ of optical bandwidth. Our findings demonstrate that QCL-combs are ideal sources for chip-based frequency comb spectroscopy systems.
On-chip Dual-comb based on Quantum Cascade Laser Frequency Combs
Gustavo Villares,Johanna Wolf,Dmitry Kazakov,Martin J Süess,Andreas Hugi,Mattias Beck,Jér?me Faist
Physics , 2015,
Abstract: Dual-comb spectroscopy is emerging as one of the most appealing applications of mid-infrared frequency combs for high-resolution molecular spectroscopy, as it leverages on the unique coherence properties of frequency combs combined with the high sensitivities achievable by mid-infrared molecular spectroscopy. Here we present an on-chip dual-comb source based on mid-infrared quantum cascade laser frequency combs, where two frequency combs are integrated on a single chip. Control of the combs repetition and offset frequencies is obtained by integrating micro-heaters next to each laser. We show that a full control of the dual-comb system is possible, by measuring a multi-heterodyne beating corresponding to an optical bandwidth of 32 cm$^{-1}$ at a center frequency of 1330 cm$^{-1}$ (7.52 $\mu$m), demonstrating that this device is ideal for compact dual-comb spectroscopy systems.
Perspectives for Wearable Electronics in Healthcare and Childcare  [PDF]
Johanna Virkki, Pasi Raumonen
E-Health Telecommunication Systems and Networks (ETSN) , 2013, DOI: 10.4236/etsn.2013.23008
Abstract: This paper starts with a literature survey that introduces possibilities of wearable electronics (WE) in different healthcare and childcare applications. Next, 24 personal interviews and an Internet forum survey were conducted in Finland about the use of WE in applications mentioned above. According to the results, most of the people feel positive about clothes used for wireless identification purposes in healthcare and childcare, but when more information about the person is added that can be wirelessly read, the feelings become more negative. Several important points to consider before implementation of WE for healthcare and childcare environments were brought up.
Process Adaption and Modifications of a Nutrient Removing Wastewater Treatment Plant in Sri Lanka Operated at Low Loading Conditions  [PDF]
Johanna Berg, Stig Morling
Materials Sciences and Applications (MSA) , 2013, DOI: 10.4236/msa.2013.45038

The Sri Lankan national water authority, that is The National Water Supply and Drainage Board (NWS&DB) has taken a new wastewater treatment plant into operation at Ja Ela, North of Colombo. The plant has been in operation since September 2011. In April 2012, it was concluded how a test of the aeration efficiency and a performance test should be carried out. The tests have been based on the actual loading of the plant and the analysis results from the daily process control. The evaluation of the aeration efficiency is not reported in this paper. The paper presents the overall performance of the water treatment part of the plant during start-up conditions, from fall 2011 through the first five months of 2012. The results from the operation are found in Table 1. An important circumstance at the plant is the current very low loading in comparison with the design load. This fact has resulted in an introduction of an intermittent mode of the aeration (nitrification) reactor. Based on operation figures, during more than a month (May 2012), it has been possible to give a realistic assessment of the overall performance. The most striking results are summarized as follows: 1) The intermittent operation has enabled an energy efficient operation of the plant. By the introduction of the intermittent aeration, the energy consumption has been reduced by around 75%, compared with the continuous operation mode; 2) The plant performance during the intermittent operation has been improved with respect to virtually all important pollu

Personal Perspectives: Individual Privacy in the IOT  [PDF]
Johanna Virkki, Liquan Chen
Advances in Internet of Things (AIT) , 2013, DOI: 10.4236/ait.2013.32003

The Internet of Things (IOT) is the extension of the Internet to the next level, i.e., bringing the Internet to the real physical world of things. In this research, 22 people working with different aspects of IOT development were interviewed in Finland and in China, in order to investigate their thoughts and personal opinions on the IOT and the individual privacy in the IOT. This paper presents the background of the IOT, interviews and collected answers, as well as highlights of collected free comments.

Privacy of Wearable Electronics in the Healthcare and Childcare Sectors: A Survey of Personal Perspectives from Finland and the United Kingdom  [PDF]
Johanna Virkki, Rebecca Aggarwal
Journal of Information Security (JIS) , 2014, DOI: 10.4236/jis.2014.52005

The innovative development of Wearable Electronics (WE) is creating exciting opportunities for application across many industries. Two sectors with high potential are healthcare and childcare. However, it is in these two sectors where the challenges of privacy are presumed to be of the highest. In order to ascertain the personal views of people about potential privacy problems in WE application in these two sectors, interviews with questionnaires were conducted in two different countries: Finland and the United Kingdom (UK). The results indicated that the majority of people in both countries are positive about the use of WE in healthcare and childcare environments. However, when more information is added to be read wirelessly, the attitudes become more negative. In general, the application of WE is more favorable in the UK and the reason as to the difference will make for interesting further research. Several interesting viewpoints and concerns were presented in the interviews. It can be concluded that the implementation of WE in these two sectors will require the collaboration of work on several areas and the development of versatile user studies.

ANCA-Associated Vasculitides—An Update  [PDF]
Johanna Kegel, Torsten Kirsch
Health (Health) , 2014, DOI: 10.4236/health.2014.614209
Abstract: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are characterized by destruction of small vessels, granulomatous inflammation of the respiratory tract and necrotizing glomerulonephritis. This review describes the clinical diagnosis and therapy as well as the patho-physiology of ANCA-associated vasculitides with a specific focus on the interplay of ANCAs with activated neutrophils and the deleterious pathophysiological consequences of neutrophil-endothelium interaction.
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