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Search Results: 1 - 10 of 4760 matches for " Joe Pitt-Francis "
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Multimodal Imaging Techniques for the Extraction of Detailed Geometrical and Physiological Information for Use in Multi-Scale Models of Colorectal Cancer and Treatment of Individual Patients
Joe Pitt-Francis,Dan Chen,Mark Slaymaker,Andrew Simpson,Michael Brady,Ingeborg van Leeuwen,Fiona Reddington,Phil Quirke,Gina Brown,David Gavaghan
Computational and Mathematical Methods in Medicine , 2006, DOI: 10.1080/10273660600969083
Abstract: A vast array of mathematical models have been proposed for all stages of cancer formation across a wide range of spatio–temporal scales. Attention is now turning to coupling these models across scales and building models of “virtual tumours” for use in in silico testing of novel drugs and treatment regimes. This leads naturally to the requirement for detailed knowledge of the underlying geometry and physiological properties of individual tumours for use in: (i) multi-scale mathematical models of in vivo tumour growth and development; (ii) fusion of multi-scale, multimodal medical imaging techniques to improve the diagnosis and treatment of individual patients; and (iii) training of cancer specialists and surgeons.
Ten Simple Rules for Effective Computational Research
James M. Osborne ,Miguel O. Bernabeu,Maria Bruna,Ben Calderhead,Jonathan Cooper,Neil Dalchau,Sara-Jane Dunn,Alexander G. Fletcher,Robin Freeman,Derek Groen,Bernhard Knapp,Greg J. McInerny,Gary R. Mirams,Joe Pitt-Francis,Biswa Sengupta,David W. Wright,Christian A. Yates,David J. Gavaghan,Stephen Emmott,Charlotte Deane
PLOS Computational Biology , 2014, DOI: doi/10.1371/journal.pcbi.1003506
Abstract:
Chaste: An Open Source C++ Library for Computational Physiology and Biology
Gary R. Mirams ,Christopher J. Arthurs,Miguel O. Bernabeu,Rafel Bordas,Jonathan Cooper,Alberto Corrias,Yohan Davit,Sara-Jane Dunn,Alexander G. Fletcher,Daniel G. Harvey,Megan E. Marsh,James M. Osborne,Pras Pathmanathan,Joe Pitt-Francis,James Southern,Nejib Zemzemi,David J. Gavaghan
PLOS Computational Biology , 2013, DOI: 10.1371/journal.pcbi.1002970
Abstract: Chaste — Cancer, Heart And Soft Tissue Environment — is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology. Code development has been driven by two initial applications: cardiac electrophysiology and cancer development. A large number of cardiac electrophysiology studies have been enabled and performed, including high-performance computational investigations of defibrillation on realistic human cardiac geometries. New models for the initiation and growth of tumours have been developed. In particular, cell-based simulations have provided novel insight into the role of stem cells in the colorectal crypt. Chaste is constantly evolving and is now being applied to a far wider range of problems. The code provides modules for handling common scientific computing components, such as meshes and solvers for ordinary and partial differential equations (ODEs/PDEs). Re-use of these components avoids the need for researchers to ‘re-invent the wheel’ with each new project, accelerating the rate of progress in new applications. Chaste is developed using industrially-derived techniques, in particular test-driven development, to ensure code quality, re-use and reliability. In this article we provide examples that illustrate the types of problems Chaste can be used to solve, which can be run on a desktop computer. We highlight some scientific studies that have used or are using Chaste, and the insights they have provided. The source code, both for specific releases and the development version, is available to download under an open source Berkeley Software Distribution (BSD) licence at http://www.cs.ox.ac.uk/chaste, together with details of a mailing list and links to documentation and tutorials.
NRTI-Associated hyperlactataemia and lactic acidosis
J Pitt
Southern African Journal of HIV Medicine , 2003,
Abstract:
The Epistemological Engine
Joseph Pitt
Philosophica , 1983,
Abstract:
Weapons of Mass Distortion: A Narrative
Jonathan PITT
Journal of Unschooling and Alternative Learning , 2011,
Abstract: In this personal narrative I contend that the traditional conventions of schooling can distort and mislead us in mainstream schools and universities. The long-term consequences of these practices have paved the way for the corporate curriculum's privatization agenda for what Illich (1971) hailed as the 'hidden curriculum' of our consumer-based society.
Are the ASISA Standards with Respect to Unit Trust Classification Representative of Homogeneous Risk Classes?  [PDF]
Joe Kainja
Journal of Financial Risk Management (JFRM) , 2016, DOI: 10.4236/jfrm.2016.52008
Abstract: We examine the information content of South African (SA) equity unit trusts to investigate whether risk is heterogeneous between investment objective groups and homogeneous within groups because those characteristics are vital to proper investment decision making. We find risk differences within SA equity groups especially in the Equity-General and Equity-Growth. However, in the other categories, the systematic risk differences depended on the choice of benchmark. Those risk differences may have significant implications for investors. Examination of between-group risk revealed that not all the equity categories were heterogeneous. We also find that the choice of benchmark is critical when measuring and comparing performance characteristics of funds.
Scleroderma, Stress and CAM Utilization
Ka-Kit Hui,Michael Francis Johnston,Marc Brodsky,Joe Tafur,Mai Kim Ho
Evidence-Based Complementary and Alternative Medicine , 2009, DOI: 10.1093/ecam/nem142
Abstract: Scleroderma is an autoimmune disease influenced by interplay among genetic and environmental factors, of which one is stress. Complementary and alternative medicine (CAM) is frequently used to treat stress and those diseases in which stress has been implicated. Results are presented from a survey of patients with scleroderma. Respondents were a convenient sample of those attending a national conference in Las Vegas in 2002. Findings implicate stress in the onset, continuation and exacerbation of scleroderma. The implication is that CAM providers may be filling an important patient need in their provision of services that identify and treat stress and its related disorders.
Current Controlled Trials in Cardiovascular Medicine: a new journal for a new age (http://cvm.controlled-trials.com)
Curt Furberg, Bertram Pitt
Trials , 2000, DOI: 10.1186/cvm-1-1-001
Abstract: This journal is the first of a family of journals planned by Current Controlled Trials (a member of the Current Science Group), each focusing on a different area of medicine. All will make full use of the new technology to meet the needs of clinical investigators and those who use the results of clinical trials to improve health care. Four innovative features distinguish these journals from most existing publications. The first is full text open access to reports of primary research. All primary research reports that we publish will be made available free, both on our website (http://cvm.controlled-trials.com) and on BioMed Central (http://biomedcentral.com), as well as being made immediately available on PubMed Central (http://pubmedcentral.nih.gov), the open access repository of primary biomedical research set up by the US National Institutes of Health. This means that authors can be sure that their work will be fully accessible to researchers and users of research around the world.The second innovation is that authors of primary research will retain the copyright for their work, which means that they will be free to circulate their data and articles to others.The third innovation is that we have a bias towards rather than against publication. All trials that are methodologically and ethically sound will be accepted for publication, after peer review and appropriate revision, whether their findings are positive or negative, and whether or not they are considered on their own to make a substantial contribution to the knowledge base. By doing this, while maintaining the scientific validity of published reports of trials, we aim to limit the tendency towards publishing only positive results of trials and to make the data from clinical trials more easily accessible for systematic review and meta-analysis.The fourth innovation is that we aim to support trials (and investigators) from inspiration to publication and beyond. We will do this in several ways. We will encour
Davis Baird: "Thing Knowledge: A Philosophy of Scientific Instruments", Berkeley 2004 (book review)
Joseph C. Pitt
Hyle : International Journal for Philosophy of Chemistry , 2005,
Abstract: book review of Davis Baird: "Thing Knowledge: A Philosophy of Scientific Instruments", Berkeley 2004
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