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Search Results: 1 - 10 of 145628 matches for " Joe B; Brackett "
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Recovery of Oocytes from Bovine Ovarian Tissue Transplanted in Nod Scid Mice
Hugo J. Hernandez-Fonseca,Pablo Bosch,David Wininger,Joe B. Massey,Benjamin G. Brackett
Journal of Animal and Veterinary Advances , 2012,
Abstract: Hormonal stimulation following xenografting of ovarian tissue into immunodeficient mice promoted antral follicle development. Efficient retrieval of oocytes contained in these antral follicles is crucial in implementing a protocol involving xenotransplantation for fertility preservation of cancer patients. Using a bovine model, our objective was to recover oocytes from calf ovarian tissue transplanted into immunodeficient mice. Fresh pieces of ovarian cortex, 1-2 mm3, from calves were placed in subcutaneous spaces of male NOD SCID mice. Hormonal treatments were initiated 3 days after surgery. Control mice (n=3) received saline while treated mice (n=4/group) received daily intraperitoneal injections of either 4 IU of FSH plus 4 IU of LH, 4 IU of FSH or 1 IU of FSH for 14 days. Forty eight to 72 h after the last injection, mice were euthanized and ovarian grafts were recovered. Serial sections of hematoxylin and eosin stained grafts were used for classifying and counting follicles. Randomly selected unstained ovarian sections were immunostained for nuclear proliferation antigen to ascertain viability. Other grafts were used for oocyte retrieval. Recovered oocytes were stained with orcein to assess maturation. Recovery of grafts (%) was no different across treatment groups. Treatment with FSH plus LH enhanced follicular development, but did not improve oocyte recovery. Evidence of maturation was only observed after incubation in vitro. We conclude that oocytes can be retrieved from xenotransplanted bovine ovarian tissue.
Bull spermatozoa express receptors for platelet-activating factor
Bosch,Pablo; Roudebush,William E; McGraw,Royal A; Mel DeJarnette,J; Marshall,Clifton E; Massey,Joe B; Brackett,Benjamin G;
Revista Científica , 2009,
Abstract: platelet-activating factor (paf; 1-o-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a ubiquitous phospholipid that is implicated in the mediation of a wide variety of reproductive processes. to better understand the role of paf in bovine reproduction, it was designed experiments to: (a) determine whether bull spermatozoa express receptors for paf and (b) study the effect of exogenous paf on in vitro sperm physiology (i.e., capacitation, acrosome reaction, motility, and fertilizing ability). bull sperm express paf receptor as determined by two approaches: rt-pcr and immunofluorescence. however, exposure of spermatozoa to different concentrations of exogenous paf (10-11-10-6 m) did not affect capacitation, acrosome reaction or motility. consistent with these findings, coculture of gametes in medium containing increasing concentrations of paf (1 x 10-8-8 x 10-6 m) did not improve in vitro fertilization outcome as measured by percentage of inseminated oocytes reaching 2-cell stage 48 h after fertilization. in contrast, paf at 8 x 10-6 m concentration significantly inhibited ivf. in conclusion, although bull sperm have paf receptors, exposure of bull spermatozoa to exogenous paf failed to enhance the sperm function parameters measured in this study. additional studies are warranted to elucidate the biological role of paf on bull spermatozoa.
The Perspicuity of the Scriptures: Presupposition, Principle or Phantasm
Kristian Brackett
Kairos : Evangelical Journal of Theology , 2010,
Abstract: The doctrine of the perspicuity of the Scriptures was clearly articulated and strongly defended by the Reformers. Evangelical Christians today also need to reaffirm and defend this biblical doctrine. This article addresses the importance of this doctrine and looks at different definitions of this doctrine as well as its limitations. In the second part, theological and biblical evidence supporting the perspicuity of the Scriptures is presented. In the final section, the author suggests an answer to the question of whether the perspicuity of the Scriptures is a presupposition brought to the biblical text or a principle of interpretation.
Inspiring Student Self-Motivation
Virginia Brackett
InSight : A Journal of Scholarly Teaching , 2007,
Abstract: While normally appreciative of the invitation to join colleagues in a discussion of pedagogy and what “works” in the classroom, I have in most instances reluctantly participated in discussion of student motivation. I dip my toe into this philosophical quagmire only if permitted license to substitute the phrase student inspiration in place of student motivation. I also find it helpful to turn the rhetorical tables, as it were, and consider self-motivation on the part of students. The concept of individuals who hold some sense of self that a classroom mentor may nurture through student inspiration is one in which I place a modicum of trust. To “inspire” is literally to “breathe in,” to actively pull sustenance from a proffered external source. Active student determination based on some sense of self may couple with instructor inspiration to promote academic success.
Mastectomy Blood Loss: Can We Predict the Need for Blood Transfusion?  [PDF]
Joe Nat Clegg-Lamptey, Jonathan C. B. Dakubo
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.520164
Abstract: Background: Bleeding during total mastectomy and axillary clearance is inevitable, and blood transfusion is often required when bleeding is excessive. Objectives: To predict the probability of transfusion, we tested the hypothesis: “The blood loss during total mastectomy and axillary clearance in Accra is related to the stage of the disease and the size of the breast”. Design: Patients undergoing total mastectomy and axillary clearance were prospectively studied from June 2008 to June 2011. The breast and used swabs were weighed immediately after surgery, and patients’ full blood count was checked before and after surgery. Setting: Surgical wards and theatres of the Korle Bu Teaching Hospital, Accra. Results: There were 80 women, aged 31 to 85 (Mean 50, SD 3.4) years, with body mass index between 20 and 46 (mean 23.7, median 28). Fifty one (63.8%) had Stage 3 disease, and 47 (58.8%) required neoadjuvant chemotherapy. Pre-operative haemoglobin was 9.5 g/dl to 14.9g/dl (mean 11.6 g/dl, SD 1.1). Post-operative haemoglobin was 9.2 g/dl - 13.4 g/dl (mean 10.9, SD 0.97). The mean drop in haemoglobin level was 0.75 g/dl. None of the 80 patients received blood transfusion. There was a linear increase in breast weight with increasing BMI. Blood loss ranged from 95 g to 1185 g, with majority (59; 73.8%) losing between 100 and 400 gram blood. Only 2 patients (2.5%) lost more than 1000 g of blood. Less than 400 g of blood was lost with breast weights below 2 kg. Above that, blood loss increased to more significant volumes. Conclusions: Blood loss during total mastectomy and axillary clearance in Accra was directly related to the size of the breast. There was, however, inconclusive association between tumour stage and blood loss.
Infertility in Men with Spinal Cord Injury: Research and Treatment
Nancy L. Brackett
Scientifica , 2012, DOI: 10.6064/2012/578257
Abstract:
Zorn: Avant/Après/Passé
John Lowell Brackett
Avant : Journal of Philosophical-Interdisciplinary Vanguard , 2012,
Abstract: Witold Wachowski’s brief exchange with John Zorn provides us with many valuable insights relating to the composer’s aesthetic. Zorn’s professed antipathy towards audiences, his faith in the creative instinct of the “artist,” and his belief in the transcendental nature of musical works (as a gateway into a world of “truth” and “beauty”) are all refrains commonly encountered in many interviews with the composer. Given the fact that Zorn emphasizes these themes in his very short interview with Wachowski, we can assume that these ideas form the core of Zorn’s musical and artistic aesthetic. For any person with even a basic knowledge of Western aesthetic traditions, however, these same aesthetic features and positions characterize musical institutions common to the Western art tradition, particularly the “romantic” ideal of music and composers that developed in the nineteenth century. Philosophers (most notably Hegel and Kant) along with music critics and composers (such as Friedrich Schiller, E.T.A. Hoffmann, Friedrich Schlegel, Robert Schumann, and Eduard Hanslick) all contributed to the development of a romantic musical aesthetic in the nineteenth century that emphasized the role of the artist (as a “genius” or “god-like”) who created “works” that – through purely musical relations that exist irregardless of the listener’s abilities – reveal hidden worlds of truth and beauty, worlds far-removed from the humdrum concerns of daily existence. Given the close (nearly one-to-one) correspondences between Zorn and aestheticians/philosophers of the nineteenth century, one could make the argument that Zorn holds a “romantic” view of music and art.
Zorn: Avant/Après/Passé [przek ad]
John Lowell Brackett
Avant : Journal of Philosophical-Interdisciplinary Vanguard , 2012,
Abstract: Krótki wywiad Witolda Wachowskiego z Johnem Zornem zawiera wiele cennych spostrze eń zwi zanych z estetyk tego kompozytora. Rzekoma niech Zorna do publiczno ci, jego wiara w kreatywny instynkt artysty” oraz jego przekonanie o transcendentalnej naturze dzie muzycznych (które s bram do wiata prawdy” i pi kna”) niczym refren powtarzaj si w wielu wywiadach z muzykiem. Zorn w krótkim wywiadzie z Wachowskim podkre la w a nie te przekonania, dlatego mo emy przyj , e stanowi one fundament jego muzycznej i artystycznej estetyki. Dla ka dego, kto posiad cho by podstawow wiedz o zachodniej tradycji estetycznej, jest jasne, e te same cechy i stanowiska estetyczne charakteryzuj muzyczne instytucje wspólne dla zachodniej tradycji artystycznej, a w szczególno ci romantyczny” idea muzyki i kompozytora rozwini ty w XIX wieku. Filozofowie (g ównie Hegel i Kant) razem z krytykami muzycznymi i kompozytorami (Schiller, Hoffmann, Schlegel, Schuman, Hanslick) przyczynili si do stworzenia romantycznej estetyki muzycznej w XIX wieku, akcentuj cej rol artysty ( geniusza” lub boga”), który tworzy dzie a” ods aniaj ce – poprzez czysto muzyczne zwi zki istniej ce niezale nie od wra liwo ci s uchacza – ukryte wiaty prawdy i pi kna, wiaty odleg e od trosk ycia codziennego. Zwa ywszy na bliskie zwi zki Zorna z estetykami/filozofami XIX-wiecznymi, mo na powiedzie , e wyznaje on romantyczny” pogl d na muzyk i sztuk .
Infertility in Men with Spinal Cord Injury: Research and Treatment
Nancy L. Brackett
Scientifica , 2012, DOI: 10.6064/2012/578257
Abstract: Spinal cord injury (SCI) occurs most often to young men. Following SCI, most men are infertile due to a combination of erectile dysfunction, ejaculatory dysfunction and semen abnormalities. Erectile dysfunction may be treated by the same therapies that are used in the general population. Similarly, the same treatments that are effective to assist conception in couples with non-SCI male factor patients are effective in assisting conception in SCI male-factor patients. The most apparent differences in male-factor symptoms between SCI and non-SCI patients are the high occurrences of anejaculation and atypical semen profiles in men with SCI. Methods available to assist ejaculation in men with SCI include penile vibratory stimulation and EEJ. Use of surgical sperm retrieval as the first line of treatment for anejaculation in men with SCI is controversial. Most men with SCI have a unique semen profile characterized by normal sperm concentration, but abnormally low sperm motility. Toxic substances in the semen contribute to this problem. Despite impaired sperm parameters, pregnancy outcomes using sperm from men with SCI are similar to pregnancy outcomes using sperm from non-SCI men. Future studies should focus on improving natural ejaculation and improving semen quality in these men. 1. Introduction Spinal cord injury occurs most often to young men at the peak of their reproductive health [1]. In the United States, 80% of new injuries occur to men between the ages of 16 and 45 [2]. Similar statistics are found worldwide [3–12]. Owing to the fact that the most common causes of injury include motor vehicle accidents, violence, sport-related injuries, and falls, it has been assumed that the gender disparity is due to more men than women engaging risk-taking behavior that leads to injury. The actual reason for the disparity is unknown. There is some evidence suggesting that hormones, rather than behavior, may contribute to the disparity. For example, it has been shown that estrogen may be neuroprotective and/or that testosterone may be neurotoxic after injury [13, 14]. Following SCI, most men have severely impaired fertility characterized by erectile dysfunction (ED), ejaculatory dysfunction, and semen abnormalities [15–18]. This paper will discuss current treatments for infertility in men with SCI, including treatments for ED as well as methods of semen retrieval. A discussion of the latest research findings regarding causes of abnormal semen quality will also be presented. The paper will conclude with recommendations for treating infertile couples with a male
Summing Over World-Sheet Boundaries
Michael B. Green,Joe Polchinski
Physics , 1994, DOI: 10.1016/0370-2693(94)90367-0
Abstract: The moduli associated with boundaries in a Riemann surface are parametrized by the positions and strengths of electric charges. This suggests a method for summing over orientable Riemann surfaces with Dirichlet boundary conditions on the embedding coordinates. A light-cone parameterization of such boundaries is also discussed.
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