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Search Results: 1 - 10 of 402060 matches for " Joanne M. Bargman "
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Bimodal Solutions or Twice-Daily Icodextrin to Enhance Ultrafiltration in Peritoneal Dialysis Patients
Periklis Dousdampanis,Konstantina Trigka,Joanne M. Bargman
International Journal of Nephrology , 2013, DOI: 10.1155/2013/424915
Abstract:
Bimodal Solutions or Twice-Daily Icodextrin to Enhance Ultrafiltration in Peritoneal Dialysis Patients
Periklis Dousdampanis,Konstantina Trigka,Joanne M. Bargman
International Journal of Nephrology , 2013, DOI: 10.1155/2013/424915
Abstract: The efficacy and safety of icodextrin has been well established. In this paper, we will discuss the pharmacokinetics and biocompatibility of icodextrin and its clinical effect on fluid management in peritoneal dialysis patients. Novel strategies for its prescription for peritoneal dialysis patients with inadequate ultrafiltration are reviewed. 1. Introduction The use of icodextrin (ico) has been characterized as one of the major achievements in peritoneal dialysis (PD) [1]. Ico-based peritoneal dialysis solutions have been used successfully by PD practitioners for two decades. Ico is an isoosmolar alternative osmotic agent that induces ultrafiltration (UF) in peritoneal dialysis by colloid osmosis. Peritoneal absorption of ico is limited and occurs by convection via the lymphatics of the peritoneum [2]. As a result, the net pressure gradient is relatively constant, sustaining UF for the long dwell. Many clinical benefits of ico have been described, such as a reduction in total glucose load [3], equivalent or higher UF than that provided by hypertonic glucose solutions [4], and better control of fluid balance [5]. Ico is recommended for patients with poor UF and those with a high or high/high-average pattern in the peritoneal equilibrium test (PET). It is well known that UF volume correlates with patient and technique survival [6]. Glucose degradation products (GDPs) and the products of advanced glycosylation end products (AGEs) induce inflammation and fibrosis of the peritoneal membrane [7]. Minimizing dextrose exposure by using ico for the long dwell may prevent long-term detrimental changes of the peritoneal membrane. In addition, there is a growing concern about the total amount of absorbed glucose and so there is interest in the use of new alternative glucose-sparing osmotic agents. The use of a “bimodal” solution composed of glucose and ico, in order to increase sodium and fluid removal, is a promising approach [8]. Ico was used initially during the long night dwell in continuous ambulatory peritoneal dialysis (CAPD) and during the day dwell in continuous cyclic peritoneal dialysis (CCPD). Recently, the daily use of two ico exchanges has been suggested in order to minimize the glucose load and/or to increase the UF rate [9–12]. The biocompatibility of ico has been investigated; however, it should be noted that there are data suggesting that those who use icodextrin are still vulnerable to develop encapsulating peritoneal sclerosis (EPS) [13]. 2. Pharmacokinetics of Icodextrin Ico consists of a complex mixture of starch-derived water-soluble glucose
The role of antimalarials in lupus nephritis: a review
Lee Senq-J,Silverman Earl D,Bargman Joanne M
Pediatric Rheumatology , 2012, DOI: 10.1186/1546-0096-10-s1-a29
Abstract:
Comment on “Quantitative Evaluation of Commercially Available Test Kit for Ciguatera in Fish”  [PDF]
Joanne S. M. Ebesu, Cara E. Campora
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.39162
Abstract: This letter is in regards to the paper, “Quantitative evaluation of commercially available test kit for ciguatera in fish” [1]. We were compelled to respond because the entire premise of this paper is flawed, thus invalidating its stated conclusions. The data presented in the paper is derived from the opinions of four independent readers who evaluated identical Cigua-Check? test sticks to screen fish samples for ciguatoxin (CTX), the results of which were then compared with corresponding samples tested in a non-specific bioassay with questionable statistics (see Table 1 [1]). In addition to several factual errors presented in the paper, we have identified several issues with this study, such as insufficient detail and questionable data analyses, that make its interpretations unreliable.
Forming Trust in E-Mentoring: A Research Agenda  [PDF]
Joanne D. Leck, Penny M. Wood
American Journal of Industrial and Business Management (AJIBM) , 2013, DOI: 10.4236/ajibm.2013.31013
Abstract:

Mentoring has been identified as a valuable tool for learning and career development, as well as organizational advancement. E-mentoring has increased in popularity as a means of creating global access to mentors while reducing organizational training costs, and reducing both time and geographical constraints for mentors and mentees. E-mentoring has proven to most benefit the mentee and mentor when mutual trust has been established. However, e-mentoring is still a relatively new phenomenon and it is unclear how online trust is established and sustained between mentors and mentees. This paper presents a research agenda to better understand how trust is formed in e-mentoring.

The Role of Proteoglycans in Contributing to Placental Thrombosis and Fetal Growth Restriction
Joanne M. Said
Journal of Pregnancy , 2011, DOI: 10.1155/2011/928381
Abstract: Fetal growth restriction is an important pregnancy complication that has major consequences for the fetus and neonate as well as an increased risk of long-term morbidity extending into adulthood. The precise aetiology of most cases of fetal growth restriction is unknown although placental thrombosis is a common feature in many of these cases. This paper will outline the potential role of proteoglycans in contributing to placental thrombosis and fetal growth restriction. 1. Introduction Adverse pregnancy outcomes remain a major cause of perinatal and paediatric morbidity and mortality, and subsequent morbidity into adult life. One of the key causes of adverse pregnancy outcome is fetal growth restriction (FGR). Fetal growth restriction describes a situation in which the fetus fails to achieve its full growth potential in utero. While an aetiology can be ascribed in a number of cases, the precise aetiology remains uncertain in up to 70% of cases. The ability to predict “at risk” pregnancies is limited, and therapeutic strategies are largely restricted to ultrasound surveillance for evidence of fetal decompensation secondary to hypoxia and then timely intervention by delivery. There is a trade off between delivering too early with the resultant risks of prematurity and delaying delivery with the attendant risks associated with hypoxia, neurological damage, and fetal demise. Of further concern is the accumulating evidence that growth-restricted fetuses are at increased risk of long-term postnatal sequelae including obesity, type II diabetes, hypertension, cardiovascular disease, and premature death [1]. While a number of maternal and fetal factors have been identified which contribute to FGR, the aetiologies of the vast majority of cases remain uncertain [2]. The pathogenesis of FGR appears to be related to abnormalities in the placental vascular flow [3] possibly due to microvascular thrombosis within the placenta [4]. The importance of understanding the mechanisms that control coagulation within the placenta cannot be overemphasised. Dysregulation of coagulation within the placenta is one of the few mechanisms which may potentially be amenable to therapy via anticoagulant treatment (including the development of specific targeted anticoagulants), hence it is imperative that this hitherto unexplored area of placental function be rigorously investigated. 2. Regulation of Thrombin within the Placenta Normal human pregnancy is characterised by increased thrombin generation resulting in a shift towards a hypercoaguable state [5]. Amongst factors responsible for
86 GHz Very Long Baseline Polarimetry of 3C273 and 3C279 with the Coordinated Millimeter VLBI Array
Joanne M. Attridge
Physics , 2001, DOI: 10.1086/320505
Abstract: 86 GHz Very Long Baseline Polarimetry probes magnetic field structures within the cores of Active Galactic Nuclei at higher angular resolutions and a spectral octave higher than previously achievable. Observations of 3C273 and 3C279 taken in April 2000 with the Coordinated Millimeter VLBI Array have resulted in the first total intensity (Stokes I) and linear polarization VLBI images reported of any source at 86 GHz. These results reveal the 86 GHz electric vector position angles within the jets of 3C273 and 3C279 to be orthogonal to each other, and the core of 3C273 to be unpolarized. If this lack of polarization is due to Faraday depolarization alone, the dispersion in rotation measure is >=90000 rad/m^2 for the core of 3C273.
Small RNAs and Transgenerational Epigenetic Variation  [PDF]
Joanne R. M. Lee, Zane Duxbury, Ming-Bo Wang
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.43082
Abstract:

Small RNAs are found in eukaryotes and are responsible for regulation of chromatin structure, RNA processing and stability, translation and transcription. 24-nt small interfering RNA (siRNA) are known to mediate gene inactivation via the RNA-directed DNA methylation pathway (RdDM) and are important for natural heritable changes in plant species. DNA cytosine methylation can be maintained between generations and this may be important for accelerated adaption to stress conditions. Research is currently focused toward the epigenetic response to disease, the stability of DNA methylation over generations, the elucidation of newly discovered pathways for de novo DNA methylation, and the application of epigenetic variation to breeding programs. This review aims to give a brief but comprehensive examination on small RNAs and transgenerational epigenetic variation.

Comparison of activity levels measured by a wrist worn accelerometer and direct observation in young children  [PDF]
Kurosh Djafarian, John R. Speakman, Joanne Stewart, Diane M. Jackson
Open Journal of Pediatrics (OJPed) , 2013, DOI: 10.4236/ojped.2013.34076
Abstract:

Introduction: Motion sensors are mechanical and electronic devices, which detect the body movement and provide an estimate of physical activity in children and adults. However, they need to be validated against criterion methods such as direct observation. The purpose of this study was to validate a wrist worn accelerometer to quantify the physical activity of children, by comparison to direct observation using the Children’s Activity Rating Scale (CARS). Materials and Methods: Data were recorded from 42 children, aged 3 - 5 years (22 boys and 20 girls), of whom each was observed each minute for 2 hours using Children’s Activity Rating Scale (CARS) while they wore the Actiwatch. Results: The CARS score and activity counts from the accelerometer were averaged over 1- to 10-minute periods across all individuals. There was a significant positive correlation between the mean CARS scores and the mean Actiwatch counts over simultaneous 1- to 10-minute periods ranging from r = 0.41 to r = 0.63 (P < 0.001). To assess validity of the data, a cross validation method was applied. There was no significant difference between the predicted and the observed CARS scores in the validation sample. Given the data from the Actiwatch (averaged over a 5-minute epoch), the equivalent CARS score could be calculated with a 95% confidence level of plus or minus 0.74 CARS units. Conclusion: These data suggest that the Actiwatch (a wrist worn accelerometer) is a valid tool for assessing levels of physical activity in young children.

Understanding the Person through Narrative
Joanne M. Hall,Jill Powell
Nursing Research and Practice , 2011, DOI: 10.1155/2011/293837
Abstract: Mental health nurses need to know their clients at depth, and to comprehend their social contexts in order to provide holistic care. Knowing persons through their stories, narratives they tell, provides contextual detail and person-revealing characteristics that make them individuals. Narratives are an everyday means of communicating experience, and there is a place for storytelling in nearly all cultures. Thus narrative is a culturally congruent way to ascertain and understand experiences. This means the nurse should ask questions such as “How did that come about?” versus why questions. A narrative approach stands in contrast to a yes/no algorithmic process in conversing with clients. Eliciting stories illustrates the social context of events, and implicitly provides answers to questions of feeling and meaning. Here we include background on narrative, insights from narrative research, and clinical wisdom in explaining how narratively understanding the person can improve mental health nursing services. Implications for theory, practice, and research are discussed. 1. Understanding the Person through Narrative Asking “What is your story? “will provide more knowledge about persons than asking “How are you?” Mental health nurses want to provide holistic care with in depth knowledge of persons in the context of their daily lives. How can we as nurses deeply know individuals without knowing their particular stories? These are the questions being considered in steadily increasing narrative-based health research [1–6]. New insights from this research as well as the principles of narrative can inform mental health nursing practice, because stories are the form of language most often used to convey experiences. 2. Narratives and Nursing Narratives have been central to nursing and will continue to be so. Nursing has a long history of using narratives in the form of clinical stories in communicating about patients, and in relating information among practitioners [7–10]. The patient history is based in part on narrative information as context for specific findings from examination [11, 12]. Thus narrative has relevance to nursing practice on several levels. Mental health is a field of nursing practice that might benefit from an even greater understanding and use of narrative in specific subpopulations, and at transitional points in the individual person’s life. Examples of transitional points are times of crisis, developmental milestones, relationship changes, getting a psychiatric diagnosis, and exacerbations. As persons, we use narrative to frame everyday events
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