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Search Results: 1 - 10 of 19743 matches for " Joana Quéren Frujuelle Kehdi "
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Lilian Agg Garcia,Janaína Carvalho,Joana Quéren Frujuelle Kehdi,Claudia Lemos Baumrucker
Fólio : Revista de Letras , 2011,
Abstract: This article aims to present reflections about the possible advantages and disadvantages of the use of translation in the English classes in two public schools from Santa Catarina State highlighting some situations in which translating would be justifiable over the English Language learning and teaching process. Two study cases were analyzed and they illustrated the effects provided by some moderate and exaggerated uses of translation from English into Portuguese during such classes. The survey attempts to describe the way two English teachers from two state secondary schools in Itapema and Joinville, Santa Catarina, made use of translation over their lessons as well as how successful their students’ learning was. The results of it show that the reasonable use of translation might be helpful unless its aims are clear and tend to develop a better learning of the students.
A sintaxe em Mattoso Camara
Kehdi, Válter;
DELTA: Documenta??o de Estudos em Lingüística Teórica e Aplicada , 2004, DOI: 10.1590/S0102-44502004000300009
Abstract: in the literature about mattoso camara's work, there is practically no reference to his studies in syntax. the purpose of this article is to show that the author has also worked in portuguese syntax in all its extension. his considerations concerning simple and complex clauses are deeply stimulating and, considering his predominantly formalist approach, they cannot be interpreted as a simple retaking of the traditional view.
O modelo de bandas cambiais tradicional por uma abordagem de op??es
Molan, Maurício Kehdi;
Revista de Administra??o de Empresas , 2000, DOI: 10.1590/S0034-75902000000300007
Abstract: most of the recent research about the behavior of exchange rates in a target zone regime is based in 1991 krugman's model. the presence of limits makes an asset to behave as a combined price of options, and the goal of this research is to use this approach and compare its results to those obtained by the classical model. these results are different in some aspects and similar in others, providing some insights to a better comprehension of the subject.
Territórios do Acompanhamento Terapêutico
Cristiana Kehdi Gerab
Revista Latinoamericana de Psicopatologia Fundamental , 2010, DOI: 10.1590/s1415-47142010000200014
Knocking-Down Cyclin A2 by siRNA Suppresses Apoptosis and Switches Differentiation Pathways in K562 Cells upon Administration with Doxorubicin
Xiaohui Wang, Yujun Song, Jinsong Ren, Xiaogang Qu
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0006665
Abstract: Cyclin A2 is critical for the initiation of DNA replication, transcription and cell cycle regulation. Cumulative evidences indicate that the deregulation of cyclin A2 is tightly linked to the chromosomal instability, neoplastic transformation and tumor proliferation. Here we report that treatment of chronic myelogenous leukaemia K562 cells with doxorubicin results in an accumulation of cyclin A2 and follows by induction of apoptotic cell death. To investigate the potential preclinical relevance, K562 cells were transiently transfected with the siRNA targeting cyclin A2 by functionalized single wall carbon nanotubes. Knocking down the expression of cyclin A2 in K562 cells suppressed doxorubicin-induced growth arrest and cell apoptosis. Upon administration with doxorubicin, K562 cells with reduced cyclin A2 showed a significant decrease in erythroid differentiation, and a small fraction of cells were differentiated along megakaryocytic and monocyte-macrophage pathways. The results demonstrate the pro-apoptotic role of cyclin A2 and suggest that cyclin A2 is a key regulator of cell differentiation. To the best of our knowledge, this is the first report that knocking down expression of one gene switches differentiation pathways of human myeloid leukemia K562 cells.
Active regions’ setting of the extracellular ligandbinding domain of human interleukin-6 receptor
Yunfang Ren,Hong Qu,Jiannan Feng,Song Li,Beifen Shen
Chinese Science Bulletin , 2000, DOI: 10.1007/BF02886075
Abstract: The reliable three dimensional (3-D) structure of the extracellular ligand-binding domain (V106-P322) of human interleukin-6 receptor (hIL-6R) has been constructed by means of computer-guided homology modeling techniques using the crystal structure of the extracellular ligand-binding region (K52–L251) of human growth hormone receptor (hGHR) as templet. The space location of some key residues which influence the combination ability between the receptor and the ligand has been observed and the effects of point mutagenesis of the four conservative cysteine residues on the space conformation are analyzed. The results show that the space conformation of the side-chain carboxyl of E305 plays a key role in the ligand-binding ability. Furthermore, the space conformation of the side-chain carboxyl of E305 is very important for the electrostatic potential complementarity between hIL-6R and hIL-6 according to the docking method.
Three-dimensional structure and function study on the active region in the extracellular ligand-binding domain of human IL-6 receptor
Yunfang Ren,Jiannan Feng,Hong Qu,Song Li,Beifen Shen
Science China Life Sciences , 2000, DOI: 10.1007/BF02879308
Abstract: In this study the three-dimensional (3-D) model of the ligand-binding domain (V106-P322) of human interleukin-6 receptor (hIL-6 R) was constructed by computer-guided homology modeling technique using the crystal structure of the ligand-binding domain (K52-L251) of human growth hormone receptor (hGHR) as templet. Furthermore, the active binding region of the 3-D model of hIL-6R with the ligand (hIL-6) was predicted. In light of the structural characteristics of the active region, a hydrophobic pocket shielded by two hydrophilic residues (E115 and E505) of the region was identified by a combination of molecular modelling and the site-directed or double-site mutation of the twelve crucial residues in the ligand-binding domain of hIL-6R (V106-P322). We observed and analyzed the effects of these mutants on the spatial conformation of the pocket-like region of hIL-6 R. The results indicated that any site-directed mutation of the five Cys residues (four conservative Cys residues: Cys121, Cys132, Cys165, Cys176; near membrane Cys residue: Cys193) or each double-site mutation of the five residues in WSEWS motif of hIL-6R (V106-P322) makes the corresponding spatial conformation of the pocket region block the linkage between hIL-6 R and hIL-6. However, the influence of the site-directed mutation of Cys211 and Cys277 individually on the conformation of the pocket region benefits the interaction between hIL-6R and hIL-6. Our study suggests that the predicted hydrophobic pocket in the 3-D model of hIL-6R (V106-P322) is the critical molecular basis for the binding of hIL-6R with its ligand, and the active pocket may be used as a target for designing small hIL-6R-inhibiting molecules in our further study.
Journal of the Chilean Chemical Society , 2008,
Abstract: The Bray-Liebhafsky reaction exhibits different nonlinear behaviors during the iodate catalyzed decomposition of acidic hydrogen peroxide in the different conditions. Both the chaotic and regular oscillations were observed. The largest Lyapunov exponent (λL), the power spectram and the log(P)-log(f) dependence for power spectram were used to evalúate these nonlinear behaviors. The effect of initial concentration of reactants on the types of oscillations and the initial potential (E o) were discussed in detail. The possible mechanism of the Bray-Liebhafsky reaction was also approached in this work
A novel receptor-targeted gene delivery system for cancer gene therapy
Peikun Tian,Shengjun Ren,Changchun Ren,Qingshan Teng,Shumin Qu,Ming Yao,Jianren Gu
Science China Life Sciences , 1999, DOI: 10.1007/BF02880059
Abstract: Some growth factor receptors, such as insulin like growth factor I and II receptor (IGF I R, IGF II R) and epidermal growth factor receptor (EGF R), have been proved to be over-expressed in a variety of human cancers derived from different tissue origins. Based on this molecular alteration, a polypeptide conjugate gene delivery system was designed and synthesized. It contains three essential moieties: a ligand oligopeptide (LOP) for receptor recognition, a polycationic polypeptide (PCP) such as protamine (PA) or poly-L-lysine (PL) as a backbone for DNA binding and an endosome-releasing oligopeptide (EROP) such as influenza haemagglutinin oligopeptide (HA20) for endosomolysis. These components are covalently conjugated as LOP-PCP-HA20 or in the form of a mixture of LOP-PCP and HA20-PCP. A 14 amino acid E5 was designed and synthesized as LOP for IGF I R and IGF II R, and a 16 amino acid GE7 as LOP for EGF R. Both E5 and GE7 systems could form stable complex with the plasmid DNA as E5-PCP/ DNA/PCP-HA20 and GE7-PCP/DNA/PCP-HA20. Using bacterial β-galactosidase gene (pSVβ-gal) as a reporter, the present system is able to efficiently target exogenous gene to human cancer cells of different tissue types with high efficiency bothin vitro and in implanted tumors in nude mice. It was also demonstrated that the transduced genes were highly expressed in cancer cells bothin vitro andin vivo. The present system will provide a novel effective vehicle to target therapeutic genes into cancer cells in gene therapy.
Expression of cyclin-dependent kinase inhibitor genes induces apoptosis in human hepatoma cell line
Ren Changchun,Tian Peikun,Qu Shumiin,Teng Qingshan,Jiang Huiqiu,Zheng Yahai,Ren Shengjun,Gu Jianren
Chinese Science Bulletin , 1997, DOI: 10.1007/BF02883203
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