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Search Results: 1 - 10 of 16206 matches for " Joan Clària "
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New Insights into the Role of Macrophages in Adipose Tissue Inflammation and Fatty Liver Disease: Modulation by Endogenous Omega-3 Fatty Acid-Derived Lipid Mediators
Joan Clària,Esther Titos
Frontiers in Immunology , 2011, DOI: 10.3389/fimmu.2011.00049
Abstract: Obesity is causally linked to a chronic state of “low-grade” inflammation in adipose tissue. Prolonged, unremitting inflammation in this tissue has a direct impact on insulin-sensitive tissues (i.e., liver) and its timely resolution is a critical step toward reducing the prevalence of related co-morbidities such as insulin resistance and non-alcoholic fatty liver disease. This article describes the current state-of-the-art knowledge and novel insights into the role of macrophages in adipose tissue inflammation, with special emphasis on the progressive changes in macrophage polarization observed over the course of obesity. In addition, this article extends the discussion to the contribution of Kupffer cells, the liver resident macrophages, to metabolic liver disease. Special attention is given to the modulation of macrophage responses by omega-3-PUFAs, and more importantly by resolvins, which are potent anti-inflammatory and pro-resolving autacoids generated from docosahexaenoic and eicosapentaenoic acids. In fact, resolvins have been shown to work as endogenous “stop signals” in inflamed adipose tissue and to return this tissue to homeostasis by inducing a phenotypic switch in macrophage polarization toward a pro-resolving phenotype. Collectively, this article offers new views on the role of macrophages in metabolic disease and their modulation by endogenously generated omega-3-PUFA-derived lipid mediators.
Resolution of Adipose Tissue Inflammation
Ana González-Périz,Joan Clària
The Scientific World Journal , 2010, DOI: 10.1100/tsw.2010.77
A Rare Case of Diaphragmatic Mass: The Key to Diagnosis of a Lung Adenocarcinoma  [PDF]
Cláudia Rocha, Vera Clérigo, Lígia Fernandes, André Rodrigues, Dora Sargento, Glória Silva
Advances in Lung Cancer (ALC) , 2014, DOI: 10.4236/alc.2014.33009
Abstract: Lung cancer is a leading cause of death due to malignancy worldwide. Diaphragmatic metastasis secondary to primary lung cancer is rare. In the literature, only a few cases have been described as the majority of cases of diaphragmatic metastasis which are secondary to gastrointestinal neoplasia. The authors report a rare case of diaphragmmatic metastasis from a primary adenocarcinoma of the lung in a 76-year-old female patient with no history of active or passive smoking with progressive worsening fatigue, asthenia, malaise, and unquantified weight loss with three months of evolution, associated with pleuritic chest pain and edema of the lower limbs for fifteen days previous to hospital admission. Chest X-ray showed elevation of the right hemi-diaphragm and thoracic-abdominal-pelvic computed tomography revealed a complex multilobuled mass with neoformative characteristics intersecting the diaphragm and invading the dome liver and the right lung region. Biopsy of the mass was performed whose histological examination was consistent with moderately differentiated adenocarcinoma. Immunohistochemical examination was positive for cytokeratin 7 and negative forcytokeratin 20, suggesting primary lung tumor. A positron emission tomography was performed without uptake in other locations. Diagnosis of adenocarcinoma with diaphragmatic metastasis was then admitted and the patient started chemotherapy with carboplatin and gemcitabine. The patient died six months after the diagnosis. The authors also present a brief theoretical discussion based on the current and scarce literature on this rare entity.
Infective Endocarditis with Negative Cultures: A Defiant Diagnosis  [PDF]
Cláudia Rocha, Vera Clérigo, Lígia Fernandes, André Rodrigues, Dora Sargento, Glória Silva
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.38101

The diagnosis and management of blood culture-negative endocarditis constitute a real clinical challenge and a systemic approach is necessary for a successful outcome. The authors report a case of a female patient aged 26, with previous clinical history of valve disease and heart failure NYHA class II, with decompensation of co-morbidities associated with fever, productive cough, nonselective anorexia and unquantified weight loss with one month of evolution with negative blood cultures. Transesophageal echocardiography revealed the presence of severe pulmonary hypertension and mitral valve vegetations in the context of positive serology for Q fever. Herein, the authors report a case of blood culture-negative endocarditis and present a brief review on the management of this medical condition. We highlighted the diagnostic difficulties of blood culture-negative endocarditis and subacute clinical presentation, which sometimes present with fever of unknown origin and complaints of deterioration of cardiac function, thus creating a challenging differential diagnosis.

Gangrenous Cholecystitis with Atypical Presentation in an Elderly Diabetic Woman  [PDF]
Vera Clérigo, Cláudia Rocha, André Rodrigues, Lígia Fernandes, Dora Sargento, Glória Silva
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.39110

In elderly patients, numerous factors subsidize the diagnostic challenge and high incidence of complications in this specific population, taking gangrenous cholecystitis as a critical example. The aim of this work is to report an unusual case of gangrenous choleystitis in an elderly diabetic women and its atypical clinical presentation. A 79-year-old female patient came to our observation; her medical history showed nausea and vomiting of about 2 hours which rapidly ended with symptomatic therapy, without recurrence, and a 3-week history of intermittent fever associated with productive cough. No abdominal discomfort was declared. Physical examination of the abdomen was negative. Laboratory analysis revealed leukocytosis with the remaining criteria within the normal range. After 2 days, she started with a mildabdominal pain in the epigastric region that rapidly progressed to the right upper quadrant, right flank and right iliac fossa, without nausea, vomiting or fever. Abdominal computer tomography findings revealed thickness of the gall-bladder and important densification of the vascular bed. Acute cholecystitis was diagnosed. The patient was then submitted to a laparoscopic cholecystectomy under general anaesthesia with findings suggestive of gangrenous acute cholecystitis confirmed by histologic examination of the specimen. Delays in diagnosing acute cholecystitis in specific populations, such as elderly diabetics, result in a higher prevalence of morbidity and mortality due to potentially serious complications as gangrenous cholecystitis. Consequently, the diagnosis should be measured and investigated promptly in order to prevent poor outcomes.

Swimming Heart: A Pleural, Pulmonary and Pericardial Disseminated Thymoma  [PDF]
Lígia Fernandes, André Rodrigues, Vera Clérigo, Cláudia Rocha, Dora Sargento, Glória Silva
Open Journal of Clinical Diagnostics (OJCD) , 2014, DOI: 10.4236/ojcd.2014.44030
Abstract: Thymoma is the most common neoplasm of the anterior mediastinum and accounts for one quarter of all mediastinal tumours and half of all anterior mediastinal masses. Pericardial effusion may be present in approximately 20% of cases. This report presents a patient with a previously diagnosed thymoma without surgical indication and with poor response to chemotherapy and radiotherapy who had a pericardial effusion that likely resulted from the malignancy dissemination to pericardium.
L'ensenyament de la història i el living history
Joan Santacana,ria Serrat Antolí
Temps d'Educació , 2002,
Abstract: Hi ha diferents estratègies per apropar la història als escolars. La utilització de les fonts primàries (objectes, documents, etc.) esdevé una estratègia important per fer viure els temps passats. Els objectes i els documents del passat ens permeten intervenir a partir del plantejament d’enigmes i preguntes que l’alumnat pot anar resolent a partir d’una veritable recerca històrica. Una de les estratègies utilitzades en el món anglosaxó és el living history. Es tracta de fer reviure el passat a través de la representació de fets, estil de vida i personatges propis d’una època determinada. Aquesta estratègia s’empra en espais de presentació del patrimoni, especialment en museus i assentaments històrics i arqueològics. Dos elements són fonamentals en aquest tipus d’intervencions: la preparació del context de presentació del patrimoni i els mediadors entre la institució o espai patrimonial i els visitants. A continuació, es presenta, de manera concreta, el cas de Colonial Williamsburg, institució dels EUA pionera en la utilització d’aquesta estratègia de presentació i interpretació del patrimoni històric i arqueològic. There are different strategies to bring history and students closer. The use of primary sources (such as objects, documents and the like) is an important strategy to relive past times. Objects and documents from the past allow students to participate by posing enigmas and questions that they can solve through a true historical research. One of the strategies used in the Anglo-Saxon society is living history. It is based on reliving the past by a representation of the facts, the way of life and the characters that belong to a certain era. This strategy is used in heritage exhibition sites, especially in museums and historical and archeological sites. There are two crucial elements in this didactical strategy: the preparation of the heritage presentation context and the mediators between the institution or heritage site and the visitors. Below the case of Colonial Williamsburg is presented in a detailed way. Colonial Williamsburg is an American institution which is a pioneer in the use of this strategy of presentation and interpretation of the historical and archeological heritage. Existen diferentes estrategias para acercar la historia a los escolares. El uso de las fuentes primarias (objetos, documentos, etc.) deviene una estrategia importante para hacer vivir los tiempos pasados. Los objetos y los documentos del pasado nos permiten intervenir a partir del planteamiento de enigmas y preguntas que los alumnos pueden ir resolviendo a partir
Uma História Sonhada
Costa, Cléria Botêlho da;
Revista Brasileira de História , 1997, DOI: 10.1590/S0102-01881997000200007
Abstract: the article discusses the relation between oral history, literature and the imaginary. it shows that literature and oral history are both narrative, or in other words, they are recreations of reality where fact and creation interweave to form historical knowledge.
O gênero artigo de opini?o: diagnóstico e interven??o na forma??o inicial de professores de português
Hilá, Cláudia Valéria Doná;
Trabalhos em Linguística Aplicada , 2008, DOI: 10.1590/S0103-18132008000100011
Abstract: situated in the field of applied linguistics, the study, linked to the research group "interaction and writing in the teaching and learning process" (uem/cnpq), is grounded on the socio-historical perspective of language and has two main objectives: i) to present a diagnosis of the opinion article genre done with pre-service teachers of the portuguese from the teaching education program at the state university of maringá, demonstrating their difficulties in doing the didactic transposition of the genre; ii) to reflect about an intervention plan offered by two of the pre-service teachers. one of their lesson plans designed for high school students constituted the research corpus. data revealed that there was no internalization of the enunciative theories, concepts and knowledge by the pre-service teachers, making the didactic transposition process difficult. the didactic sequence (ds) was an important tool for changing the initial diagnosis in the face of difficulties.
Uma História Sonhada
Costa Cléria Botêlho da
Revista Brasileira de História , 1997,
Abstract: O texto discute a rela o entre história oral, literatura e imaginário. Mostra que a história oral e a literatura se constituem numa narrativa, ou seja, s o reconstru es da realidade em que o fato e a cria o se entrela am na constru o do conhecimento histórico.
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