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Search Results: 1 - 10 of 121272 matches for " Jo?o Vinagre "
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Differentiated thyroid cancer in patients with resistance to thyroid hormone syndrome. A novel case and a review of the literature
Joo Vinagre,Glaúcia Mazeto,Paula Soares
Frontiers in Molecular Biosciences , 2014, DOI: 10.3389/fmolb.2014.00010
Abstract: Resistance to thyroid hormone (RTH) represents a syndrome in which patients present elevated circulating thyroid hormones in the presence of non-suppressed TSH. We report a novel case where a patient with RTH presented a differentiated thyroid cancer. A19 year-old female had been referred due to thyroid disease that disclosed features characteristic of a RTH. During the follow up it was detected a follicular tumor that led to the recommendation for thyroid surgical ablation, where an incidental papillary thyroid microcarcinoma (mPTC) was found. The increase of thyroglobulin (TG) levels following thyroid removal referred the patient for radioiodine treatment. Post-treatment, it was detected jugular adenopathies and the patient was subjected to cervical lymph node drainage where metastases of the mPTC were found. RTH syndrome was confirmed by the detection of a THRB germline mutation. A BRAF mutation was also found in the mPTC but not detected in the follicular adenoma or normal adjacent tissue. The young age of the patient, the rarity of BRAF mutations in childhood and the high dissemination of the malignancy, lead us to the speculation that increased TSH stimulation in a RTH background and oncogenic activation of BRAF could have served as (co) drivers and might have triggered an advanced stage of the neoplastic disease. These findings together with a review of published cases add novel information to the management of RTH patients with differentiated thyroid cancer.
Evaluation of recommender systems in streaming environments
Joo Vinagre,Alípio Mário Jorge,Joo Gama
Computer Science , 2015, DOI: 10.13140/2.1.4381.5367
Abstract: Evaluation of recommender systems is typically done with finite datasets. This means that conventional evaluation methodologies are only applicable in offline experiments, where data and models are stationary. However, in real world systems, user feedback is continuously generated, at unpredictable rates. Given this setting, one important issue is how to evaluate algorithms in such a streaming data environment. In this paper we propose a prequential evaluation protocol for recommender systems, suitable for streaming data environments, but also applicable in stationary settings. Using this protocol we are able to monitor the evolution of algorithms' accuracy over time. Furthermore, we are able to perform reliable comparative assessments of algorithms by computing significance tests over a sliding window. We argue that besides being suitable for streaming data, prequential evaluation allows the detection of phenomena that would otherwise remain unnoticed in the evaluation of both offline and online recommender systems.
How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer
Hugo Prazeres,Joana Torres,Fernando Rodrigues,Joana P. Couto,Joo Vinagre,Manuel Sobrinho-Sim?es,Paula Soares
Journal of Thyroid Research , 2011, DOI: 10.4061/2011/678357
Abstract: The significance of RET in thyroid cancer comes from solid evidence that, when inherited, an RET activating mutation primes C-cells to transform into medullary carcinomas. Moreover, environmental exposure to radiation also induces rearranged transforming RET “isoforms” that are found in papillary thyroid cancer. The RET gene codes for a tyrosine kinase receptor that targets a diverse set of intracellular signaling pathways. The nature of RET point mutations predicts differences in the mechanisms by which the receptor becomes activated and correlates with different forms of clinical presentation, age of onset, and biological aggressiveness. A number of RET-targeting Tyrosine Kinase Inhibitors (TKIs) are currently undergoing clinical trials to evaluate their effectiveness in the treatment of thyroid cancer, and it is conceivable that the RET genotype may also influence response to these compounds. The question that now emerges is whether, in the future, the rational for treatment of refractory thyroid cancer will be based on the management of an abnormal RET signal. In this paper we address the RET-targeting TKIs and review studies about the signaling properties of distinct RET mutants as a means to predict response and design combinatorial therapies for the soon to be available TKIs. 1. The RET Tyrosine Kinase Receptor Targets a Diverse Spectrum of Intracellular Signaling Pathways RET (Rearranged during Transfection) encodes a membrane receptor tyrosine kinase (RTK) composed of four extracellular cadherin-like motifs and a cysteine-rich region, a transmembrane portion, and an intracellular domain with tyrosine kinase activity [1]. The RET signaling pathways are outlined in (Figure 1). RET signals through a ligand/coreceptor/RET multiprotein complex instead of the usual receptor/ligand binding. To date, several ligands of the glial-derived neurotrophic factor (GDNF) family, which include GDNF, artemin, neurturin, and persephin and a family of GPI-linked RET coreceptors (GFR1-4), have been identified [2]. The formation of ligand/coreceptor and RET complexes results in RET dimerization and triggers autophosphorylation at intracellular tyrosine residues. Phosphorylated tyrosine 687 (Y687), serine 696 (S696), Y752, Y791, Y806, Y809, Y826, Y864, Y900, Y905, Y928, Y952, Y981, Y1015, Y1029, Y1062, Y1090, and Y1096 constitute docking sites for numerous intracellular adaptor proteins such as RAC1-guanine exchange factor (GEF) [3], growth factor receptor-bound (GRB) docking proteins GRB7/10 [4], chicken Rous sarcoma virus oncogene (c-Src), focal adhesion kinase
Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review
Alvarenga, César Augusto;Lopes, José Manuel;Vinagre, Joo;Paravidino, Paula Itagyba;Alvarenga, Marcelo;Prando, Adilson;Castilho, Lísias Nogueira;Soares, Paula;Billis, Athanase;
Sao Paulo Medical Journal , 2012, DOI: 10.1590/S1516-31802012000100010
Abstract: context: extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. case report: this report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. the patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. it was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral s100 protein expression in sustentacular cells. succinate dehydrogenase a and b-related (sdha and sdhb) expression was present in both tumors. conclusions: no genetic alterations to the vhl and sdhb genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.
Application of a Computational Tool to Study the Influence of Worn Wheels on Railway Vehicle Dynamics  [PDF]
Joo Pombo
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.52009
Abstract: The search for fast, reliable and cost effective means of transport that presents better energy efficiency and less impact on the environment has resulted in renewed interest and rapid development in railway technology. To improve its efficiency and competitiveness, modern trains are required to travel faster, with high levels of safety and comfort and with reduced Life Cycle Costs (LCC). These increasing demands for vehicle requirements imposed by railway operators and infrastructure companies include maintaining the top operational speeds of trainsets during their life cycle, having low LCC and being track friendly. This is a key issue in vehicle design and in train operation since it has a significant impact on the safety and comfort of railway systems and on the maintenance costs of vehicles and infrastructures. The purpose of this work is to analyze how the wear progression on the wheelsets affects the dynamic behavior of railways vehicles and its interaction with the track. For this purpose a vehicle, assembled with new and worn wheels, is studied in realistic operation scenarios. The influence of the wheel profile wear on the vehicle dynamic response is assessed here based on several indicators used by the railway industry. The running stability of the railway vehicles is also emphasized in this study.
Nutritional Quality and Health Benefits of Vegetables: A Review  [PDF]
Joo Silva Dias
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.310179
Abstract: Vegetables are considered essential for well-balanced diets since they supply vitamins, minerals, dietary fiber, and phytochemicals. Each vegetable group contains an unique combination and amount of these phytonutriceuticals, which distinguishes them from other groups and vegetables whithin their own group. In the daily diet vegetables have been strongly associated with improvement of gastrointestinal health, good vision, and reduced risk of heart disease, stroke, chronic diseases such as diabetes, and some forms of cancer. Some phytochemicals of vegetables are strong antioxidants and are thought to reduce the risk of chronic disease by protecting against free radical damage, by modifying metabolic activation and detoxification of carcinogens, or even by influencing processes that alter the course of tumor cells. All the vegetables may offer protection to humans against chronic diseases. Nutrition is both a quantity and a quality issue, and vegetables in all their many forms ensure an adequate intake of most vitamins and nutrients, dietary fibers, and phytochemicals which can bring a much-needed measure of balance back to diets contributing to solve many of these nutrition problems. The promotion of healthy vegetable products has coincided with a surging consumer interested in the healthy functionality of food. Because each vegetable contains a unique combination of phytonutriceuticals, a great diversity of vegetables should be eaten to ensure that individual’s diet includes a combination of phytonutriceuticals and to get all the health benefits. This article make a review and discusses the nutritional quality and health benefits of the major groups of vegetables. More interdisciplinary work is required that involves nutritional and food scientists as well as others from biomedical fields to ascertain the thrue function of specific phytonutriceuticals.
Neutrino Oscillations and Superluminal Propagation, in OPERA or Otherwise  [PDF]
Joo Magueijo
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.41013
Abstract:

We digress on the implications of recent claims of superluminal neutrino propagation. No matter how we turn it around such behaviour is very odd and sits uncomfortably even within far-fetched theories. In the context of non-linear realizations of the Lorentz group (where superluminal misbehaviour is run of the mill) one has to accept rather contrived constructions to predict superluminal properties for the neutrino. The simplest explanation is to require that at least one of the mass states be tachyonic. We show that due to neutrino mixing, the flavor energy does not suffer from the usual runaway pathologies of tachyons. For non-tachyonic mass states the theories become more speculative. A neutrino specific dispersion relation is exhibited, rendering the amplitude of the effect reasonable for a standard Planck energy. This uses the fact that the beam energy is close to the geometrical average of the neutrino and Planck mass; or, seen in another way, the beam energy is unexceptional but its gamma factor is very large. A dispersion relation crossing over from a low energy bradyonic branch to a high energy tachyonic one is also considered. We comment on consistency with SN 1987Awithin these models.

Avalia o sobre a participa o de cirurgi es-dentistas em equipes de assistência ao paciente = Assessment of the participation of dental surgeons in patient care teams
Rodolfo José Gomes de Araújo,Nicole Patrícia de Lima Vinagre,Jaqueline Montoril Santiago Sampaio
Acta Scientiarum : Health Sciences , 2009,
Abstract: A presen a de equipes de assistência ao paciente se faz necessária em ambiente hospitalar, principalmente no que concerne aos pacientes mais debilitados, presentes em unidades de tratamento intensivo. Porém, esta equipe n o é contemplada pela participa o de todos os profissionais da saúde, visto que o cirurgi o-dentista, por exemplo, acha-se fora deste panorama; o que é contraditório, pois a saúde bucal pode ser determinante na melhora ou piora do quadro de saúde de um paciente em UTI’s. O escopo deste trabalho é demonstrar, por meio de entrevistas realizadas com profissionais de enfermagem em 12hospitais da cidade de Belém, Estado do Pará, regi o Norte do Brasil, a sua atua o em equipes multi/interdisciplinares atuantes em unidades de tratamento intensivo e se a presen a de cirurgi es-dentistas é necessária nestas equipes. O levantamento realizado nestapesquisa mostrou que 98% dos entrevistados participam de equipes interdisciplinares e 86% acham necessária a presen a de cirurgi es-dentistas nas mesmas. Aliar, portanto, o conhecimento de um profissional de odontologia ao de uma equipe biomédica é, sim, degrande valia ao paciente. The presence of patient assistance team becomes necessary in a hospital environment, especially for more debilitated patients hospitalized in Intensive Care Units (ICUs). However, not all health professionals act in ICUs. Dental surgeons, for example, are not found in this environment – which is contradictory, considering that oral health may be determinant to establish the patient’s health status in the ICU. The purpose of this study is to demonstrate, through interviews carried out with nursing professionals from 12hospitals in Belem (northern Brazil), the participation of these professionals in multi/interdisciplinary teams in Intensive Care Units and verify whether the presence of dental surgeons is needed. The assessment revealed that 98% of the interviewers are part ofinterdisciplinary teams, and 86% of them consider necessary the presence of dental surgeons. It was therefore concluded that to combine the knowledge of a dentistry professional to a biomedical staff is very important for the patient.
Signal transduction-related responses to phytohormones and environmental challenges in sugarcane
Flávia R Rocha, Flávia S Papini-Terzi, Milton Y Nishiyama, Ricardo ZN Vêncio, Renato Vicentini, Rodrigo DC Duarte, Vicente E de Rosa, Fabiano Vinagre, Carla Barsalobres, Ane H Medeiros, Fabiana A Rodrigues, Eugênio C Ulian, S?nia M Zingaretti, Joo A Galbiatti, Raul S Almeida, Antonio VO Figueira, Adriana S Hemerly, Marcio C Silva-Filho, Marcelo Menossi, Gláucia M Souza
BMC Genomics , 2007, DOI: 10.1186/1471-2164-8-71
Abstract: Adopting an outliers searching method 179 genes with strikingly different expression levels were identified as differentially expressed in at least one of the treatments analysed. Self Organizing Maps were used to cluster the expression profiles of 695 genes that showed a highly correlated expression pattern among replicates. The expression data for 22 genes was evaluated for 36 experimental data points by quantitative RT-PCR indicating a validation rate of 80.5% using three biological experimental replicates. The SUCAST Database was created that provides public access to the data described in this work, linked to tissue expression profiling and the SUCAST gene category and sequence analysis. The SUCAST database also includes a categorization of the sugarcane kinome based on a phylogenetic grouping that included 182 undefined kinases.An extensive study on the sugarcane transcriptome was performed. Sugarcane genes responsive to phytohormones and to challenges sugarcane commonly deals with in the field were identified. Additionally, the protein kinases were annotated based on a phylogenetic approach. The experimental design and statistical analysis applied proved robust to unravel genes associated with a diverse array of conditions attributing novel functions to previously unknown or undefined genes. The data consolidated in the SUCAST database resource can guide further studies and be useful for the development of improved sugarcane varieties.Sugarcane is an increasingly economically attractive crop, used for the production of approximately 60% of the world's sugar and also of ethanol, a low-carbon emission fuel. Sugarcane varieties with improved tolerance to adverse environmental conditions are highly desirable. Unfavorable environmental factors are the major culprits of losses in agriculture and can reduce average productivity by 65% to 87% depending on the crop [1]. Crops better fit to withstand biotic and abiotic stresses have been selected by traditional genetic
Lipolysis of emulsion models of triglyceride-rich lipoproteins is altered in male patients with abdominal aorta aneurysm
Hosni, J.J.;Vinagre, C.G.;Mady, C.;Maranh?o, R.C.;
Brazilian Journal of Medical and Biological Research , 2007, DOI: 10.1590/S0100-879X2007000300004
Abstract: disorders of the lipid metabolism may play a role in the genesis of abdominal aorta aneurysm. the present study examined the intravascular catabolism of chylomicrons, the lipoproteins that carry the dietary lipids absorbed by the intestine in the circulation in patients with abdominal aorta aneurysm. thirteen male patients (72 ± 5 years) with abdominal aorta aneurysm with normal plasma lipid profile and 13 healthy male control subjects (73 ± 5 years) participated in the study. the method of chylomicron-like emulsions was used to evaluate this metabolism. the emulsion labeled with 14c-cholesteryl oleate and 3h-triolein was injected intravenously in both groups. blood samples were taken at regular intervals over 60 min to determine the decay curves. the fractional clearance rate (fcr) of the radioactive labels was calculated by compartmental analysis. the fcr of the emulsion with 3h-triolein was smaller in the aortic aneurysm patients than in controls (0.025 ± 0.017 vs 0.039 ± 0.019 min-1; p < 0.05), but the fcr of 14c-cholesteryl oleate of both groups did not differ. in conclusion, as indicated by the triglyceride fcr, chylomicron lipolysis is diminished in male patients with aortic aneurysm, whereas the remnant removal which is traced by the cholesteryl oleate fcr is not altered. the results suggest that defects in the chylomicron metabolism may represent a risk factor for development of abdominal aortic aneurysm.
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