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Search Results: 1 - 10 of 32666 matches for " Jo Anne Maczulski "
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SMA CARNI-VAL TRIAL PART II: A Prospective, Single-Armed Trial of L-Carnitine and Valproic Acid in Ambulatory Children with Spinal Muscular Atrophy
John T. Kissel,Charles B. Scott,Sandra P. Reyna,Thomas O. Crawford,Louise R. Simard,Kristin J. Krosschell,Gyula Acsadi,Bakri Elsheik,Mary K. Schroth,Guy D'Anjou,Bernard LaSalle,Thomas W. Prior,Susan Sorenson,Jo Anne Maczulski,Mark B. Bromberg,Gary M. Chan,Kathryn J. Swoboda
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0021296
Abstract: Multiple lines of evidence have suggested that valproic acid (VPA) might benefit patients with spinal muscular atrophy (SMA). The SMA CARNIVAL TRIAL was a two part prospective trial to evaluate oral VPA and l-carnitine in SMA children. Part 1 targeted non-ambulatory children ages 2–8 in a 12 month cross over design. We report here Part 2, a twelve month prospective, open-label trial of VPA and L-carnitine in ambulatory SMA children.
SMA CARNI-VAL Trial Part I: Double-Blind, Randomized, Placebo-Controlled Trial of L-Carnitine and Valproic Acid in Spinal Muscular Atrophy
Kathryn J. Swoboda,Charles B. Scott,Thomas O. Crawford,Louise R. Simard,Sandra P. Reyna,Kristin J. Krosschell,Gyula Acsadi,Bakri Elsheik,Mary K. Schroth,Guy D'Anjou,Bernard LaSalle,Thomas W. Prior,Susan L. Sorenson,Jo Anne Maczulski,Mark B. Bromberg,Gary M. Chan,John T. Kissel
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012140
Abstract: Valproic acid (VPA) has demonstrated potential as a therapeutic candidate for spinal muscular atrophy (SMA) in vitro and in vivo.
Targeting and Anchoring Tudor in the Pole Plasm of the Drosophila Oocyte
Jo?l Anne
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0014362
Abstract: Germline formation is a highly regulated process in all organisms. In Drosophila embryos germ cells are specified by the pole plasm, a specialized cytoplasmic region containing polar granules. Components of these granules are also present in the perinuclear ring surrounding nurse cells, the nuage. Two such molecules are the Vasa and Tudor proteins. How Tudor localizes and is maintained in the pole plasm is, however, not known.
C-Terminal Moiety of Tudor Contains Its In Vivo Activity in Drosophila
Jo?l Anne
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0014378
Abstract: In early Drosophila embryos, the germ plasm is localized to the posterior pole region and is partitioned into the germline progenitors, known as pole cells. Germ plasm, or pole plasm, contains the polar granules which form during oogenesis and are required for germline development. Components of these granules are also present in the perinuclear region of the nurse cells, the nuage. One such component is Tudor (Tud) which is a large protein containing multiple Tudor domains. It was previously reported that specific Tudor domains are required for germ cell formation and Tud localization.
Das Nutzen der Daten Anderer: Probleme, Umgangsweisen und Vorkehrungen Using Someone Else's Data: Problems, Pragmatics and Provisions El uso de los datos de otra persona: problemas, pragmática y precauciones
Jo-Anne Kelder
Forum : Qualitative Social Research , 2005,
Abstract: Im gegenw rtigen Klima der ethischen Anforderungen an Forschung werden qualitative empirische Daten oft am Ende eines jeden Forschungsprojektes archiviert. Diese qualitativen Daten k nnen dann aus unterschiedlichen Perspektiven wieder benutzt werden und stehen für andere Forschungsfragen, als die Prim rforscher(innen) im Blick hatten, zur Verfügung. Die Wiederverwendung solcher Daten spart Zeit, vermeidet unn tige Belastungen der Befragten und stützt die Interpretation selbst erhobener Daten. Im vorliegenden Beitrag wird gezeigt, wie Daten eines Forschungsprojektes akquiriert und dann mit dem Ziel analysiert wurden, ein eigenes Projekt zu begründen, das sich an der "Distributed Cognition (Dcog) theory" und der mit ihr zusammenh ngenden Methodologie der "kognitiven Ethnographie" orientiert. Die theoretischen überlegungen thematisieren den Nutzen und die Probleme bei der Anwendung unterschiedlicher Quellen und Arten von Daten für die Konstruktion eines theoretischen Zugangs zur Beobachtungssituation. Die methodologischen überlegungen zielen auf den Gebrauch (und nicht Missbrauch) von Daten Anderer und auf die schlüssige Integration von Daten, die im Laufe der Zeit und für verschiedene Zwecke gesammelt wurden. Die gegenw rtigen ethischen Richtlinien sind vom Paradigma kontrollierter Bedingungen gepr gt, wie sie in experimentellen, quantitativen Forschungsans tzen vertreten werden. Es gilt, ein neues Paradigma zu entwickeln, das den Mangel an Kontrollm glichkeiten berücksichtigt, der dem Forschen inh rent ist. Der Beitrag verweist auf den Nutzen ethischer Regeln für die Sekund rnutzung von Daten und für den Umfang an Datenschutz, den die Befragten wünschen. URN: urn:nbn:de:0114-fqs0501396 In the current climate of requirements for ethical research, qualitative research data is often archived at the end of each unique research project. Yet qualitative data is capable of being revisited from multiple perspectives, and used to answer different research questions to those envisaged by the original data collector. Using other people's data saves time, avoids unnecessarily burdening your research participants, and adds confidence in interpreting your own data. This paper is a case of how data from one research project was acquired and then analysed to ground the analysis of a separate project using Distributed Cognition (Dcog) theory and its associated methodology, cognitive ethnography. Theoretical considerations were the benefits and difficulties of using multiple sources and types of data in creating a theoretical account of the observed situation. Methodologic
Victims’ rights are human rights: The importance of recognizing victims as persons
Wemmers Jo-Anne
Temida , 2012, DOI: 10.2298/tem1202071w
Abstract: In this paper the author argues that victims’ rights are human rights. Criminal law typically views victims as witnesses to a crime against the state, thus shutting them out of the criminal justice process and only allowing them in when they are needed to testify. This is a major source of dissatisfaction for victims who seek validation in the criminal justice system. Victims are persons with rights and privileges. Crimes constitute violations of their rights as well as acts against society or the state. While human rights instruments, such as the Universal Declaration of Human Rights, do not mention crime victims specifically, a number of rights are identified, which can be viewed from the victim’s perspective. As individuals with dignity, victims have the right to recognition as persons before the law. However, such rights are only meaningful if they can be enforced.
The Magnetic Field of the Milky Way Galaxy
Jo-Anne Brown
Physics , 2010,
Abstract: Cosmic magnetic fields are an integral component of the interstellar medium (ISM), having influence on scales ranging from star formation to galactic dynamics. While observations of external galaxies offer a `birds-eye-view' of magnetic fields within galaxies, it is equally important to explore the magnetic field of our own Milky Way Galaxy, which offers a more detailed, albeit more complicated view. Over the past decade there has been a significant increase in interest in the Galactic magnetic field, fueled largely by innovations developed through the Canadian Galactic Plane Survey. In this paper, I review the current state of understanding of the Galactic magnetic field, and discuss briefly new and future observations that will provide exciting new insights about the field.
Feasibility of incorporating a bed-rest exercise program during a twin pregnancy: Case reports  [PDF]
Chantale R. Brun, Jo-Anne Hammond, Michelle F. Mottola
Open Journal of Obstetrics and Gynecology (OJOG) , 2012, DOI: 10.4236/ojog.2012.23052
Abstract: Considering the maternal risk for both short- and long-term disability imposed by activity restriction, it is of great concern that the antepartum symptoms of bed rest are still evident in the postpartum period. The benefits of bed-rest-exercise may alleviate or even prevent physiological distresses or deconditioning associated with activity restriction, thus, eliminating or stabilizing, factors that may augment existing complications. This is the first study to investigate the feasibility of incorporating a bed-rest exercise program in a specific hospitalized twin pregnancy case. The maternal physiological responses of heart rate, blood pressure and uterine contractions to a four week bed-rest resistance program were measured in a woman hospitalized due to complications during her twin pregnancy. A second participant (same diagnoses) was included as a control. The bed-rest-exercise reduced the degree of swelling in the lower extremities, promoted more energy during the day and a better night’s sleep. There were no significant differences in uterine contractions pre vs. post protocol and all babies were born healthy.
Teaching and Evaluating Graduate Attributes in Science Based Disciplines  [PDF]
George Henryk Herok, Jo-Anne Chuck, Thomas James Millar
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.47A2008

Graduate attributes, other than professional knowledge and skills, are now important outcomes for tertiary education. In science, anecdotal observations indicated minimal focus on: innovation; independent learning; communication; and societal involvement. Therefore, how graduate attributes were introduced, developed, taught and assessed into first and second year science units were investigated. Which graduate attributes were contextualized into learning objectives and activities together with how outcomes were measured and assessed were investigated. Results showed ~70% of teaching, development and assessment centred on disciplinary knowledge and most of the rest on professional skills. Oral presentations, portfolios, extended writing, and field trips comprised ~15% of assessment. Hence, a structured overview is needed to address the full scope of graduate attributes at the course level. There is an urgent need for the modern needs of tertiary education to be embraced by staff to ensure graduate attributes are attained commensurate with the expectations of the wider community.

Jo Anne Neff Van Aertselaer
Revista de Lingüística y Lenguas Aplicadas , 2006, DOI: 10.4995/rlyla.2006.683
Abstract: Both English for Academic Purposes (EAP) and English for Specific Purposes have advanced from the exploration of lexico-grammatical features during the 1980s and 1990s toward a thicker language description which includes not only lexico-grammatical features but also studies of genre-rhetorical features and of the social practices which shape academic texts in different disciplines (Berkenkotter, Huckin and Ackerman, 1991). These latter studies have tended to focus on the conventions particular to specific discourse communities. However, as Bhatia (2002) has pointed out, there is significant overlap in such genres as research abstracts and introduction sections and perhaps in textbook language as well. This paper addresses an area of overlap in the academic writing of Spanish university students in English: the construction of authorial voice by through the use of impersonalization strategies. The analysis presented here shows that Spanish students transfer rhetorical conventions from Spanish into English, particularly in the case of the we strategy and, in the writing of more advanced students, the se passive strategy.
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