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Search Results: 1 - 10 of 23419 matches for " Jixin Shi "
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Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine
Gang Chen,Jixin Shi,Zhigang Hu,Chunhua Hang
Mediators of Inflammation , 2008, DOI: 10.1155/2008/716458
Abstract: Although N-acetylcysteine (NAC) has been shown to be neuroprotective for traumatic brain injury (TBI), the mechanisms for this beneficial effect are still poorly understood. Cerebral inflammation plays an important role in the pathogenesis of secondary brain injury after TBI. However, it has not been investigated whether NAC modulates TBI-induced cerebral inflammatory response. In this work, we investigated the effect of NAC administration on cortical expressions of nuclear factor kappa B (NF-B) and inflammatory proteins such as interleukin-1 (IL-1), tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and intercellular adhesion molecule-1 (ICAM-1) after TBI. As a result, we found that NF-B, proinflammatory cytokines, and ICAM-1 were increased in all injured animals. In animals given NAC post-TBI, NF-B, IL-1, TNF-, and ICAM-1 were decreased in comparison to vehicle-treated animals. Measures of IL-6 showed no change after NAC treatment. NAC administration reduced brain edema, BBB permeability, and apoptotic index in the injured brain. The results suggest that post-TBI NAC administration may attenuate inflammatory response in the injured rat brain, and this may be one mechanism by which NAC ameliorates secondary brain damage following TBI.
Combinatorial administration of insulin and vitamin C alleviates the cerebral vasospasm after experimental subarachnoid hemorrhage in rabbit
Shouchun Li, Jinghui Xue, Jixin Shi, Hongxia Yin, Zhiwen Zhang
BMC Neuroscience , 2011, DOI: 10.1186/1471-2202-12-77
Abstract: Five days after SAH, there is obvious basilar artery spasm in SAH group, whose average vascular cross-sectional area (233,099 ± 16,750 μm2) is significantly smaller than that in control group (462,128 ± 74,756 μm2), which is also significantly different from those in SAH + insulin group (221,114 ± 43,457 μm2) and SAH + vitamin C group (237,820 ± 21,703 μm2). SAH + insulin + vitamin C group shows no evident vasospasm and maintains a vascular cross-sectional area of 425,530 ± 45,503 μm2, which is significantly different from that in SAH group. Insulin receptor α (InRα) expression is significantly downregulated in the vascular endothelial cells of SAH, SAH + insulin, and SAH + vitamin C groups (P < 0.01) but remains unchanged in vascular endothelial cells of SAH + insulin + vitamin C group (P > 0.05). Five days after SAH, serum and cerebrospinal fluid NO levels in SAH, SAH + insulin, and SAH + vitamin C groups decrease significantly (P < 0.01) compared to that in control group, whereas the reduction is not evident in SAH + insulin + vitamin C group (P > 0.05).Combinatorial treatment with insulin and vitamin C has effectively relieved the CVS after SAH in rabbit, possibly through increasing the InRα expression and NO level, whereas treatment with insulin or vitamin C alone fails to do so.CVS is a common serious complication after the spontaneous SAH. It induces and aggravates cerebral ischemic injury and becomes one of the major causes of disability and mortality after aneurysm rupture. Although some medications like non-selective calcium blockers can be administered, there is still lack of especially effective clinical treatment to alleviate and improve CVS [1]. How to prevent and improve CVS is an urgent problem facing the neurosurgeons. Studies have confirmed that in addition to regulating metabolism, promoting cell growth and proliferation, and inhibiting apoptosis, insulin also plays a strong vasoactive role, dilates the vessels, increases blood flow, and improves
Analysis of major components in water based stamp pad inks and their imprints by ultra high performance liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry

ZHANG Qing,ZOU Jixin,SHI Gaojun,ZHANG Lijuan,

色谱 , 2010,
Abstract: Ultra high performance liquid chromatography-mass spectrometry (UHPLC-MS) technology and gas chromatography-mass spectrometry (GC-MS) technology were used to qualitatively analyze the major components in water based stamp pad inks including major colorants and volatile components. After the samples were supersonically extracted and then centrifuged, UHPLC-MS was used to separate and identify the major colorants. A ZORBAX Eclipse Plus Phenyl-Hexyl (50 mm×4.6 mm, 1.8 μm) column and 15 mmol/L ammonium acetate-acetonitrile were utilized for the separation and negative selected ion monitoring mode (SIM) was set for the MS analysis. An HP-INNOWAX (30 m×0.25 mm, 0.25 μm) column was employed in the GC-MS analysis with the full-scan mode to determine the volatiles. This study demonstrated that the major colorants in the inks and their imprints were Acid Red R, Eosin Y and Pigment Red 112| and the major volatiles were glycerol, 1,2-propanediol, etc. The method is rapid and accurate. It also demonstrates that the method can meet the requirements for imprint determination in material evidence identification. The work provides a reliable tool for the categorization research in the forensic sciences.
Realization of a Covert Communication System Over the Public Switching Telephone Network
Jixin Liu,Zheming Lu
Information Technology Journal , 2009,
Abstract: In this study, a covert communication applying the vector quantization based information hiding algorithm and the Public Switching Telephone Network (PSTN) is implemented. The system aims at offering good security of the secret binary image message and the real-time performance that is very important for the speech calling of the telephone service. Therefore, we adopt a simple and effective encryption method for the secret binary image message prior to the embedding process. The embedding position is also protected by using a secret key. By using these methods, the requirement of short-term protection in the bursting phone call communication for the secret binary image message and the real-time encryption are both fulfilled. Furthermore, an information hiding algorithm based on vector quantization is proposed and the advantage of it is discussed. We evaluate the system with the ITU-T G.729a standard speech codec in StegoPhone, which is our platform for research on covert communication technology via PSTN. The experimental results show that our method has negligible hearing effects on the conversation speech and meet the requirement of the real-time calling conversation communication via PSTN.
Multivariate saddlepoint approximations in tail probability and conditional inference
John Kolassa,Jixin Li
Statistics , 2010, DOI: 10.3150/09-BEJ237
Abstract: We extend known saddlepoint tail probability approximations to multivariate cases, including multivariate conditional cases. Our approximation applies to both continuous and lattice variables, and requires the existence of a cumulant generating function. The method is applied to some examples, including a real data set from a case-control study of endometrial cancer. The method contains less terms and is easier to implement than existing methods, while showing an accuracy comparable to those methods.
Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274
Jinxuan Hou, Jixin Dong, Lijun Sun, Liying Geng, Jing Wang, Jialin Zheng, Yan Li, Julia Bridge, Steven H Hinrichs, Shi-Jian Ding
Journal of Translational Medicine , 2011, DOI: 10.1186/1479-5876-9-64
Abstract: The expression level of phosphorylated c-Met in RMS cell lines (RD, CW9019 and RH30) and tumor tissues was assessed by phospho-RTK array and immunohistochemistry, respectively. The inhibition effects of SU11274 on RMS cells were studied with regard to intracellular signaling, cell proliferation, cell cycle and cell migration.A high level of phosphorylated c-Met was detected in 2 alveolar RMS cell lines (CW9019 and RH30) and 14 out of 24 RMS tissue samples, whereas relatively low levels of phospho-c-Met were observed in the embryonic RMS cell line (RD). The small molecule SU11274 could significantly reduce the phosphorylation of c-Met, resulting in inhibition of cell proliferation, G1 phase arrest of cell cycle and blocking of cell migration in CW9019 and RH30 cell lines.These results might support the role of c-Met in the development and progression of RMS. Furthermore, the inhibitor of c-Met, SU11274, could be an effective targeting therapy reagent for RMS, especially alveolar RMS.Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in childhood, accounting for up to 50% of all soft tissue sarcomas [1]. While in adults, RMS represents about 15-20% of all soft tissue sarcomas [2]. There are two main histologically distinct subtypes of RMS: embryonal RMS (ERMS) and alveolar RMS (ARMS) [3]. ERMS is composed of spindle-shaped cells with a stromal rich appearance and occurs mainly in the head and neck region. It is the most frequently diagnosed variant with a generally good prognosis and presents early with an onset around the age of 2-5 years [3,4]. In contrast, ARMS consists of small, round, densely packed cells and occurs more often in the trunk and extremities. ARMS is primarily diagnosed in adolescents and is associated with a poor prognosis as patients often present with metastatic disease [5]. Chemotherapy is the most common therapeutic option for RMS. The regimens are typically based on variations of the well-established vincristine, actinomycin D and cyc
Cost Control of the Transmission Congestion Management in Electricity Systems Based on Ant Colony Algorithm  [PDF]
Bin Liu, Jixin Kang, Nan Jiang, Yuanwei Jing
Energy and Power Engineering (EPE) , 2011, DOI: 10.4236/epe.2011.31003
Abstract: This paper investigates the cost control problem of congestion management model in the real-time power systems. An improved optimal congestion cost model is built by introducing the congestion factor in dealing with the cases: opening the generator side and load side simultaneously. The problem of real-time congestion management is transformed to a nonlinear programming problem. While the transmission congestion is maximum, the adjustment cost is minimum based on the ant colony algorithm, and the global optimal solu-tion is obtained. Simulation results show that the improved optimal model can obviously reduce the adjust-ment cost and the designed algorithm is safe and easy to implement.
Analysis of Influence Factors of Tide-Dominated Estuaries Based on Deposition Numerical Simulation  [PDF]
Tao Tang, Jixin Huang, Yanshu Yin, Wenjie Feng
Open Journal of Yangtze Oil and Gas (OJOGas) , 2018, DOI: 10.4236/ojogas.2018.32012
Abstract: Tide-dominated estuaries sedimentary reservoir is a hot area of sedimentology research in recent years, and the important target of oil and gas exploration is one of the relatively few sedimentary systems. Based on the study of underground reservoirs, outcrop and modern sedimentation, scholars believe that the estuary is a sedimentary system formed by transgressive system tract, which is composed of a complex subfacies environment with obvious changes. Its formation is influenced by many factors. The purpose of this paper is to simulate the deposition process of estuaries by Delft-3D software, and to reveal the main controlling factors of estuarine reservoir formation. The factors are as follows. 1) The size of the river flow has a destructive effect on the formation of the estuarine sand bar in the estuary, but the effect is small. 2) Tidal energy plays a constructive role in estuarine sand bars in estuaries, and it is also the main force for the formation of estuarine reservoirs. 3) The composition of the sediments has an obvious influence on the formation of the estuarine reservoir, and the content of the mud is an important factor for the retention of the estuarine sand bar.
Properties of Phase Transformation of Ferroelectric Thin Films with Surface Layers  [PDF]
Lian Cui, Xu Xu, JiXin Che, Zelong He, Huijie Xue, Tianquan Lv
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.29125
Abstract: Using the generalized Ginzburg-Landau-Devonshire theory, the characteristics of phase transformation of a ferroelectric thin film with surface layers are investigated. We study the effect of the surface layer on the properties (coercive field, critical thickness) of a ferroelectric thin film. Our theoretical results show that the surface layer is likely to answer for the emergence of phase transformation.
The evolutionary history of Cytochrome P450 genes in four filamentous Ascomycetes
Jixin Deng, Ignazio Carbone, Ralph A Dean
BMC Evolutionary Biology , 2007, DOI: 10.1186/1471-2148-7-30
Abstract: A total of 376 P450 genes were assigned to 168 families according to standard nomenclature. On average, only 1 to 2 genes per family were in each genome. To resolve conflicting results between different clustering analyses and standard family designation, a higher order relationship was formulated. 376 genes were clustered into 115 clans. Subsequently a novel approach based on parsimony was developed to build the evolutionary models. Based on these analyses, a core of 30 distinct clans of P450s was defined. The core clans experienced contraction in all four fungal lineages while new clans expanded in all with exception of NC. MG experienced more genes and clans gains compared to the other fungi. Parsimonious analyses unanimously supported one species topology for the four fungi.The four studied fungi exhibit unprecedented diversity in their P450omes in terms of coding sequence, intron-exon structures and genome locations, suggesting a complicated evolutionary history of P450s in filamentous Ascomycetes. Clan classification and a novel strategy were developed to study evolutionary history. Contraction of core clans and expansion of novel clans were identified. The exception was the NC lineage, which exhibited pure P450 gene loss.Fungi comprise a large and diverse kingdom of organisms. It is estimated that as many as 1.5 million species exist in the planet today [1,2]. Most described fungi grow by producing long, multi-celled hyphae, and are known as filamentous fungi. Filamentous fungi occupy a wide range of ecological niches with diverse life histories and physiological processes. Many live as saprotrophs decomposing and absorbing nutrients from dead materials while others have evolved the ability to be pathogens deriving their nutrients from living or dying hosts. Taking advantage of available genome sequences to explore the evolution of important gene families may help shed light on the processes that have allowed fungi to exploit diverse habitats.The P450-contain
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