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Search Results: 1 - 10 of 104141 matches for " Jinsheng Zhang "
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Noise-Induced Tinnitus Using Individualized Gap Detection Analysis and Its Relationship with Hyperacusis, Anxiety, and Spatial Cognition
Edward Pace, Jinsheng Zhang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075011
Abstract: Tinnitus has a complex etiology that involves auditory and non-auditory factors and may be accompanied by hyperacusis, anxiety and cognitive changes. Thus far, investigations of the interrelationship between tinnitus and auditory and non-auditory impairment have yielded conflicting results. To further address this issue, we noise exposed rats and assessed them for tinnitus using a gap detection behavioral paradigm combined with statistically-driven analysis to diagnose tinnitus in individual rats. We also tested rats for hearing detection, responsivity, and loss using prepulse inhibition and auditory brainstem response, and for spatial cognition and anxiety using Morris water maze and elevated plus maze. We found that our tinnitus diagnosis method reliably separated noise-exposed rats into tinnitus(+) and tinnitus(?) groups and detected no evidence of tinnitus in tinnitus(?) and control rats. In addition, the tinnitus(+) group demonstrated enhanced startle amplitude, indicating hyperacusis-like behavior. Despite these results, neither tinnitus, hyperacusis nor hearing loss yielded any significant effects on spatial learning and memory or anxiety, though a majority of rats with the highest anxiety levels had tinnitus. These findings showed that we were able to develop a clinically relevant tinnitus(+) group and that our diagnosis method is sound. At the same time, like clinical studies, we found that tinnitus does not always result in cognitive-emotional dysfunction, although tinnitus may predispose subjects to certain impairment like anxiety. Other behavioral assessments may be needed to further define the relationship between tinnitus and anxiety, cognitive deficits, and other impairments.
Structural Analysis and Optimal Design for Water Tube Panel in an Alkali Recovery Boiler  [PDF]
Zaili Zhao, Jinsheng Xiao, Ying Wu, Xiaojun Zhang, Zhiming Wang
Engineering (ENG) , 2010, DOI: 10.4236/eng.2010.25046
Abstract: Alkali recovery aiming at recovering NaOH is the best available technology in China's pulp and paper industry; an alkali recovery boiler is a popular one among all alkali recovery units. For the purpose of designing the most reasonable tube-panel of an evaporator in a 1500 t/d alkali recovery boiler, a total of 8 kinds of cases are put forward for finite element analysis. The modeling, meshing and calculation are carried out for each case. The stress values and their distribution rules are revealed in this paper. The slotting size for the water tubes panel is analyzed by using the optimum design module of ANSYS. After all cases are compared with each other, the optimal one is developed and exemplified in conclusion.
A Mathematical Model of Biomass Briquette Fuel Combustion  [PDF]
Jingxia Sui, Xiang Xu, Bo Zhang, Changjiang Huang, Jinsheng Lv
Energy and Power Engineering (EPE) , 2013, DOI: 10.4236/epe.2013.54B001
Abstract: The numerical simulation model is proposed according to the characteristics of the biomass briquette fuels, which involves two main areas of interest: the solid combustion model in the bed and the out-of-bed gas combustion model. The contents and characteristics of 3 kinds of biomass and coals were experimentally tested. The biomass fuels compared with the coal fuel have the following characteristics: 1) Higher volatile content, lower fixed carbon content and calorific value; 2) Lower carbon content, higher oxygen content; 3) Lower ignition temperature, faster burning velocity. The discredited equations were established by the finite element analysis method, which analyzed the fuel endothermic process on the grate, while the out-of-bed gas combustion process was simulated by CFD. These two processes are strongly coupled. The results of the numerical simulation contain the steady state temperature distribution, oxygen distribution, carbon dioxide distribution and so on, which are used to judge burning effect and provide the correct furnace transformation method.
GDOP’s Influence on Observable Degree of Multi-Antenna GPS/SINS Integrated Attitude Measuring System  [PDF]
Hao He, Yuhang Zheng, Dongfang Yang, Jinsheng Zhang, Shicheng Wang
World Journal of Engineering and Technology (WJET) , 2015, DOI: 10.4236/wjet.2015.33C054
Abstract:

GDOP’s influence on observable degree is studied by analyzing a multi-antenna GPS/SINS attitude measuring system. Firstly, the mathematical model of the attitude measuring system, whose observations are single-differences, is provided; Secondly, it is proved that the model can be studied by PWCS theory, and GDOP’s influence on observable degree is explained intuitively. Then, the variance of observable degree is studied by simulation while GDOP is different, and the result is analysed. Simulation results show that, the observable degree becomes worse with the increasing GDOP value. Therefore, while designing such kind of Kalman filter, the influence to observable degree which made by GDOP should be considered adequately.

Progress in the development of therapeutic antibodies targeting prion proteins and β-amyloid peptides
JinSheng He,Ying Zhang,Tao Hong
Science China Life Sciences , 2010, DOI: 10.1007/s11427-010-4043-z
Abstract: Prion diseases and Alzheimer’s disease (AD) are characterized by protein misfolding, and can lead to dementia. However, prion diseases are infectious and transmissible, while AD is not. The similarities and differences between these diseases have led researchers to perform comparative studies. In the last 2 decades, progress has been made in immunotherapy using anti-prion protein and anti-β-amyloid antibodies. In this study, we review new ideas and strategies for therapeutic antibodies targeting prion diseases and AD through conformation dependence.
Mode of Talents Training in Media --- A Comparative Research between Mainland China and Taiwan
Chih-Chung Chen,Jinsheng Zhang
Asian Social Science , 2009, DOI: 10.5539/ass.v5n12p11
Abstract: In China, with increasing maturity of media and continuous emergence of new media, demand on media managers is urgent day by day. However, media management itself is a subject with combination of compound, pluralism, theory and practice. It is easy to train common journalists, but it is quite difficult to train media talents of high quality proficient in management. This article is going to mainly compare modes of talent training between Taiwan and Mainland China, and will emphasize especially on training mechanism of media talents in colleges and universities in Taiwan, in the hope of offering reference for talent training in Mainland China.
Pollution Characteristics of PM2.5 during a Typical Haze Episode in Xiamen, China  [PDF]
Fuwang Zhang, Jinsheng Chen, Tianxue Qiu, Liqian Yin, Xiaoqiu Chen, Jianshuan Yu
Atmospheric and Climate Sciences (ACS) , 2013, DOI: 10.4236/acs.2013.34044
Abstract:

In this study, mass concentrations and chemical compositions of fine particles, mass concentrations of coarse particles, light extinction, and meteorological parameters in the atmosphere ofXiamenwere presented and analyzed to study the chemical and optical characteristics of a typical haze episode from Dec 25, 2010 to Jan 1, 2011. The major chemical compositions of PM2.5, such as water soluble inorganic ions (WSIIs), carbonaceous fractions (mainly composed of organic carbon (OC) and elemental carbon (EC)), and elements were determined. The results showed that with the typical haze episode process, the concentrations of PM2.5 mass, WSIIs, OC, EC, and TE first increased and then decreased. The average concentrations of PM2.5 mass in the stages of Before Haze, During Haze, and After Haze were (88.80 ± 19.97), (135.41 ± 36.20), and (96.35 ± 36.26) μg/m3, respectively. The corresponding average concentrations of secondary organic carbon (SOC) were 6.72, 8.18, and 10.39 μg/m3, accounting for 46.5%, 27.0%, and 61.0% of OC, respectively. S42- , NO3-, and NH4+ were three major WSIIs species, accounting for 31.4%, 26.0%, and 12.1% of total WSIIs. The major elements in PM2.5 were S, K, Fe, Zn, Pb, Ti, and Mn, covering 97.9% of the total elements, while the percentage of the other ten elements was only 2.1%. The average value of light extinction coefficients (bext) was 371.0 ±147.1 Mm-1 during the typical haze episode. The average percentage contributions to bext were 39.3% for organic mass, 19.9% for elemental carbon, 16.0% for ammonium sulfate, 13.0% for coarse mass, and 11.8% for ammonium nitrate.

Immunohistochemical Expression and Prognostic Value of CD97 and Its Ligand CD55 in Primary Gallbladder Carcinoma
Jinsheng Wu,Liu Lei,Shaochuang Wang,Dianhua Gu,Jianhuai Zhang
Journal of Biomedicine and Biotechnology , 2012, DOI: 10.1155/2012/587672
Abstract: Background. CD97 as a member of the EGF-TM7 family with adhesive properties plays an important role in tumor aggressiveness by binding its cellular ligand CD55, which is a complement regulatory protein expressed by cells to protect them from bystander complement attack. Previous studies have shown that CD97 and CD55 both play important roles in tumor dedifferentiation, migration, invasiveness, and metastasis. The aim of this study was to investigate CD97 and CD55 expression in primary gallbladder carcinoma (GBC) and their prognostic significance. Methods. Immunohistochemistry was used to investigate the expression of CD97 and CD55 proteins in 138 patients with GBC. Results. CD97 and CD55 were absent or only weakly expressed in the normal epithelium of the gallbladder but in 69.6% (96/138) and 65.2% (90/138) of GBC, respectively, remarkably at the invasive front of the tumors. In addition, CD97 and CD55 expressions were both significantly associated with high histologic grade (both =0.009), advanced pathologic T stage (=0.01 and 0.009, resp.) and clinical stage (both =0.009), and positive venous/lymphatic invasion (both =0.009). Multivariate analyses showed that CD97 (hazard ratio, 3.236; =0.02) and CD55 (hazard ratio, 3.209; =0.02) expressions and clinical stage (hazard ratio, 3.918; =0.01) were independent risk factor for overall survival. Conclusion. Our results provide convincing evidence for the first time that the expressions of CD97 and CD55 are both upregulated in human GBC. The expression levels of CD97 and CD55 in GBC were associated with the severity of the tumor. Furthermore, CD97 and CD55 expressions were independent poor prognostic factors for overall survival in patients with GBC.
Identification of novel maize miRNAs by measuring the precision of precursor processing
Yinping Jiao, Weibin Song, Mei Zhang, Jinsheng Lai
BMC Plant Biology , 2011, DOI: 10.1186/1471-2229-11-141
Abstract: To find new miRNA in this important crop, small RNAs from mixed tissues were sequenced, resulting in over 15 million unique sequences. Our sequencing effort validated 23 of the 28 known maize miRNA families, including 49 unique miRNAs. Using a newly established criterion, based on the precision of miRNA processing from precursors, we identified 66 novel miRNAs in maize. These miRNAs can be grouped into 58 families, 54 of which have not been identified in any other species. Five new miRNAs were validated by northern blot. Moreover, we found targets for 23 of the 66 new miRNAs. The targets of two of these newly identified miRNAs were confirmed by 5'RACE.We have implemented a novel method of identifying miRNA by measuring the precision of miRNA processing from precursors. Using this method, 66 novel miRNAs and 50 potential miRNAs have been identified in maize.MiRNAs are known to play crucial roles in the regulation of gene expression in plants [1], including functions such as, leaf polarity, auxin response, floral identity, flowering time, and stress response [2-7]. MiRNAs are typically ~21 nucleotides in length. In plants, miRNA genes are transcribed by RNA polymerasell into primary miRNA transcripts (pri-miRNA) which can form imperfect stem-loop secondary structure [8,9]. Then the pri-miRNAs are trimmed and spliced into miRNA/miRNA* duplex by Dicer-like1 (DCL1) with the help of dsRNA binding protein HYL1 and dsRNA methylase HEN1 [1,10-12]. The length of the pre-miRNAs in plants ranges from about 80-nt to 300-nt, and is more variable than in animals. After being transported to the cytoplasm, the mature miRNAs can match to the corresponding target mRNAs through RNA-induced silencing complex (RISC) and the miRNA* are thought to be degraded [1,13]. MiRNAs regulate their target mRNA either by cleaving in the middle of their binding sites or by translational repression [14,15]. The plant miRNAs are highly complementary to their targets with about 0~4 nucleotides mismatches
A Study on the Hydrotreating of Coal Hydroliquefaction Residue and its Kinetics
Jue Huang,Xilan Lu,Dexiang Zhang,Jinsheng Gao
Energies , 2010, DOI: 10.3390/en3091576
Abstract: Hydro-conversion of coal hydroliquefaction residue obtained from a 6t/day pilot plant of Shenhua Group in Shanghai was carried out under the hydrotreating condition. The coal hydroliquefaction residue and its product were extracted in sequence with n-hexane, toluene and tetrahydrofuran in a Soxhlet apparatus. The n-hexane soluble fractions increased with the increase of reaction temperature and time. Its amount increased from 14.14% to a maximum of 40.86% under the conditions of 470 °C and 30 min, which meant that moderate extension of coal residence time in the coal hydroliquefaction reactor is beneficial to the increase of oil yield. A 4-lumped kinetic model of coal hydroliquefaction residue hydro-conversion was performed using solubility-based lumped fractions. In the model, the tetrahydrofuran insoluble fractions were classified into two parts: easily reactive part and unreactive part. The kinetic parameters were estimated by a fourth-order Runge-Kutta method and a nonlinear least squares method, and the apparent activation energies were calculated according to the Arrhenius Equation. A large quantity of total catalyst consisting of remained liquefaction catalyst, part of the mineral from raw coal and additive Fe-based catalyst could considerably reduce the apparent activation energy of hydro-conversion for the toluene insoluble/tetrahydrofuran insoluble fractions to 36.79 kJ?mol -1. The calculated values of the model coincided well with the experimental values.
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