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Search Results: 1 - 10 of 18461 matches for " Jinmin Peng "
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Sepsis-related stress response: known knowns, known unknowns, and unknown unknowns
Jinmin Peng, Bin Du
Critical Care , 2010, DOI: 10.1186/cc9103
Abstract: In this issue of Critical Care, Lesur and colleagues [1] report the differential profile of stress response in septic and non-septic patients. Adrenocorticotropic hormone (ACTH) and ACTH/cortisol ratio were lower whereas baseline cortisol, procalcitonin (PCT), and stromal cellderived factor-1-alpha (SDF-1α) were higher in septic patients than in non-septic patients. Furthermore, a probability score incorporating ACTH, cortisol, and PCT by multivariate logistic regression analysis predicted sepsis better than sepsis score or PCT did [1].The response of hypothalamic-pituitary-adrenal (HPA) axis to the sustained stress of severe illness has been the focus of many studies in recent years. In healthy subjects, cortisol secretion by adrenal cortex is regulated by ACTH secretion by the pituitary, which in turn is regulated primarily by hypothalamic secretion of corticotropinreleasing hormone (CRH), whereas cortisol inhibits both ACTH and CRH production through a negative feedback [2-4].However, HPA stress response during sepsis is much more complex and is poorly defined. Plasma cortisol levels may be low, normal, or high in sepsis [2,5] but nonetheless inadequate to control the inflammatory response and meet the elevated metabolic demand [5]. This effect is termed relative adrenal insufficiency (RAI), also known as critical illness-related corticosteroid insufficiency (CIRCI) [2,3,6].Other factors are involved in the HPA stress response during sepsis [6,7]. In rodent models, arginine vasopressin (AVP) was shown to increase endogenous adrenal ACTH secretion [7]. Apelin, a neuropeptide originating from paraventricular and supraopitc nuclei, acts on HPA axis regulation by releasing CRH and ACTH and by reducing AVP [7]. Copeptin, a 39-amino acid glycopeptide, makes up the pre-pro-vasopressin molecule together with neurophysin II and AVP and serves as a surrogate marker to assess AVP plasma concentrations in septic shock [8]. In normal rats, the chemokine SDF-1α and its recepto
Season, Environment Stress and Refrigerated Storage Affect Genomic DNA Isolation of Tung Tree  [PDF]
Lingling Zhang, Yue Pan, Jinmin Fu, Junhua Peng
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.311188
Abstract: Many metabolites in leaf tissue disturbed plant genomic DNA isolation and always varied when leaves was harvested from different environments. Objective of this study was to investigate whether season, environment stress and refrigerated storage affect genomic DNA isolation of tung tree leaves. Five types of young leaves and two DNA isolation protocols, the recycling CTAB protocol I and II, were adopted to carry out the experiment. Our results showed that both leaf type and protocol affected DNA isolation of tung tree. Using the recycling CTAB protocol II, though little DNA were obtained from three types of young leaves, the other two have satisfying results. Whereas the recycling CTAB protocol I could produce high yield genomic DNA from all the five types of young leaves. All the detectable DNA samples in agarose gel electrophoresis were good templates for PCR reaction. Season, environment stress and refrigerated storage had a big effect on genomic DNA isolation of tung tree. The recycling CTAB protocol I was proved to be an effective and universal protocol for DNA isolation of tung tree. Five types of young leaves could all act as the tissue for isolation of genomic DNA, but the summer healthy young leaves without long-time refrigerated storage are the best. The optimal leaf tissue will benefit DNA isolation of plant species.
Clinical review: Critical care medicine in mainland China
Bin Du, Xiuming Xi, Dechang Chen, Jinmin Peng, China Critical Care Clinical Trial Group (CCCCTG)
Critical Care , 2010, DOI: 10.1186/cc8222
Abstract: During the past three decades - the era of economic liberalization in mainland China - China has had one of the world's fastest growing economies. However, healthcare development in China is far behind its economic growth. The performance of China's healthcare system was rated poorly compared to that of other countries according to The World Health Report 2000 - Health Systems: Improving Performance [1].In China, total healthcare expenditure accounts for 4.5% to 5.6% of gross domestic product (Table 1). Although the trend shows that an increasing proportion of total healthcare expenditure has been funded by the government since 2001, the government paid only 20.3% of the expenditure in 2007 [2,3]. On the other hand, the urban basic healthcare insurance program in China is still in a development period, covering only 359.5 million people (52.2% of the urban population, or 27.1% of the total population) in 2008 [3]. However, other forms of insurance program are under development, especially in rural areas.Healthcare in mainland China is not cheap. The annual cost of medical care for a citizen in China increased from US dollars (USD) 42.9 in 2001 to USD 125.7 in 2008, corresponding to 7.2% and 10.1% of annual income per capita, respectively (Table 1).Although advanced life support techniques, especially positive pressure ventilation, inspired the development of critical care medicine in Europe and North America in the 1950s, critical care medicine is still one of the newest disciplines of clinical medicine in mainland China.As in many other countries, critical care was initially practiced in a variety of postoperative recovery rooms and/or an isolation area within the general ward. It is well recognized that the first ICU in mainland China was set up in the Peking Union Medical College Hospital in 1982, in the form of a surgical ICU with only one bed [4,5]. Two years later, it became the first Department of Critical Care Medicine in mainland China, with a seven-bed gen
The Association between MTHFR Gene Polymorphisms and Hepatocellular Carcinoma Risk: A Meta-Analysis
Xue Qin, Qiliu Peng, Zhiping Chen, Yan Deng, Shan Huang, Juanjuan Xu, Haiwei Li, Shan Li, Jinmin Zhao
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056070
Abstract: Background The association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and hepatocellular carcinoma (HCC) risk was inconsistent and underpowered. To clarify the effects of MTHFR gene polymorphisms on the risk of HCC, a meta-analysis of all available studies relating C677T and/or A1298C polymorphisms of MTHFR gene to the risk of HCC was conducted. Methods The authors searched PubMed, EMBASE, Cochrane Library, Web of Science, and Chinese Biomedical Literature database (CBM) for the period up to July 2012. Data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Metaregression and subgroup analyses were performed to identify the source of heterogeneity. Results Finally, 12 studies with 2,351 cases and 4,091 controls were included for C677T polymorphism and 6 studies with 1,333 cases and 1,878 controls were included for A1298C polymorphism. With respect to A1298C polymorphism, significantly decreased HCC risk was found in the overall population (CC vs. AA: OR = 0.660, 95%CI 0.460–0.946, P = 0.024; recessive model: OR = 0.667, 95%CI = 0.470–0.948, P = 0.024). In subgroup analyses, significantly decreased HCC risk was found in Asian population (CC vs. AA: OR = 0.647, 95%CI = 0.435–0.963; P = 0.032) and population-based studies (CC vs. AA: OR = 0.519, 95%CI = 0.327–0.823; P = 0.005). With respect to C677T polymorphism, no significant association with HCC risk was demonstrated in overall and stratified analyses. Conclusions We concluded that MTHFR A1298C polymorphism may play a protective role in the carcinogenesis of HCC. Further large and well-designed studies are needed to confirm this association.
Exogenous Vitamin K3 and Peroxides Can Alleviate Hypoxia in Bean Seedlings (Phaseolus vulgaris L.)  [PDF]
C. B. Rajashekar, Jinmin Fu, Anju Giri
American Journal of Plant Sciences (AJPS) , 2014, DOI: 10.4236/ajps.2014.522355

Oxygen limiting conditions are a common occurrence in root zones of most crop plants and can adversely affect nearly all aspects of plant growth and development including its survival. The objective of this study was to determine the effectiveness of a novel redox cycling agent, vitamin K3, and various peroxides including hydrogen peroxide, calcium peroxide and magnesium peroxide in alleviating the effects of hypoxia in bean seedlings grown in nutrient culture. All the anti-hypoxic agents including vitamin K3 had a positive impact on the overall growth of bean seedlings under hypoxic conditions, but their responses were variable depending on the concentration. With regard to shoot growth, vitamin K3 (5 μM) increased the leaf area significantly, by more than 58% over the hypoxic control plants and produced the highest stem fresh weight similar to calcium peroxide (20 μM) and magnesium peroxide (10 μM). In addition, the use of vitamin K3 resulted in the highest accumulation of chlorophyll (chla + chlb) in the leaves, an increase of nearly two-fold over the hypoxic control plants. Furthermore under hypoxia, calcium peroxide (20 μM) and magnesium peroxide (10 μM) produced the highest leaf biomass (FW) followed by vitamin K3. Vitamin K3 (1 μM) also favored root growth in bean seedlings under hypoxia; it produced the largest increase in root length and root biomass (DW) similar to calcium peroxide and magnesium peroxide. Based on the overall shoot and root growth response of bean seedlings to various anti-hypoxic substances under hypoxic conditions, calcium peroxide, magnesium peroxide and vitamin K3

Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis
Xue Qin, Qiliu Peng, Aiping Qin, Zhiping Chen, Liwen Lin, Yan Deng, Li Xie, Juanjuan Xu, Haiwei Li, Taijie Li, Shan Li, Jinmin Zhao
Diagnostic Pathology , 2012, DOI: 10.1186/1746-1596-7-136
Abstract: Systematic searches of the PubMed, Embase and Cochrane Library were performed. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association.A total of 56 studies including 34,358 breast cancer cases and 45,429 controls were included. Overall, no significant associations between the COMT Val158Met polymorphism and breast cancer risk were found for LL versus HH, HL versus HH, LL versus HL, recessive model LL versus HL+HH, and dominant model LL+HL versus HH. In subgroup analysis by ethnicity, source of controls, and menopausal status, there was still no significant association detected in any of the genetic models.Our meta-analysis results suggest that the COMT Val158Met polymorphism may not contribute to breast cancer susceptibility.The virtual slides(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs4806123577708417 webciteBreast cancer is one of the most frequently occurring cancer and cancer-related deaths are highly prevalent worldwide, which has become a major public health challenge [1]. The mechanism of developing breast cancer is still unclear. It has been widely accepted that exposure to circulating estrogen may be important in the development of breast cancer. Since estrogen biosynthesis and metabolism consist of many translation and transcription steps, the genes involved in these processes may contribute to the level of estrogen and thereby influence the susceptibility to breast cancer. Among the genes identified, BRCA1 and BRCA2 mutations have been reported to be associated with a dominantly inherited increased risk of the disease. However, they only account for about 5% of breast cancer occurrences [2]. This fact leaves the possibility that low-penetrance genetic factors are likely to explain most of disease cases.Catechol-O-methyltransferase (COMT) is an important phase II enzyme involved in the conjugation and inactivation of catechol estrogens [3]. COMT is exp
An Updated Meta-Analysis on the Association of MDM2 SNP309 Polymorphism with Colorectal Cancer Risk
Xue Qin, Qiliu Peng, Weizhong Tang, Xianjun Lao, Zhiping Chen, Hao Lai, Yan Deng, Cuiju Mo, Jingzhe Sui, Junrong Wu, Limin Zhai, Shi Yang, Shan Li, Jinmin Zhao
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076031
Abstract: Background The mouse double minute 2 (MDM2) gene encodes a phosphoprotein that interacts with P53 and negatively regulates its activity. The SNP309 polymorphism (T-G) in the promoter of MDM2 gene has been reported to be associated with enhanced MDM2 expression and tumor development. Studies investigating the association between MDM2 SNP309 polymorphism and colorectal cancer (CRC) risk reported conflicting results. We performed a meta-analysis of all available studies to explore the association of this polymorphism with CRC risk. Methods All studies published up to July 2013 on the association between MDM2 SNP309 polymorphism and CRC risk were identified by searching electronic databases PubMed, EMBASE, and Chinese Biomedical Literature database (CBM) databases. The association between the MDM2 SNP309 polymorphism and CRC risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Results A total of 14 case-control studies including 4460 CRC cases and 4828 controls were identified. We did not find a significant association between the MDM2 SNP309 polymorphism and CRC risk in all genetic models in overall population. However, in subgroup analysis by ethnicity, significant associations were found in Asians (TG vs. TT: OR = 1.197, 95% CI = 1.055–1.358, P=0.005; GG+TG vs. TT: OR = 1.246, 95% CI = 1.106–1.404, P=0.000) and Africans. When stratified by HWE in controls, significantly increased risk was also found among the studies consistent with HWE (TG vs. TT: OR = 1.166, 95% CI = 1.037–1.311, P= 0.010). In subgroup analysis according to p53 mutation status, and gender, no any significant association was detected. Conclusions The present meta-analysis suggests that the MDM2 is a candidate gene for CRC susceptibility. The MDM2 SNP309 polymorphism may be a risk factor for CRC in Asians.
Electrical Resistivity Survey in Bukit Bunuh, Malaysia for Subsurface Structure of Meteorite Impact Study  [PDF]
Mark Jinmin, Rosli Saad, Mokhtar Saidin, Andy A. Bery
Open Journal of Geology (OJG) , 2013, DOI: 10.4236/ojg.2013.32B008

An electrical resistivity tomography (ERT) study was conducted at Bukit Bunuh, Lenggong Perak (Malaysia). The study is to justify the features and environmental subsurface geological structure which is due to the meteorite impact. The ERT survey used resistivity equipments comprises of 4 survey lines with 5 m electrode intervals, covering an area of approximately 64 km2. The survey lines were carried out using ‘roll-along’ technique. The data were processed and analysed using RES2DINV, Excel and Surfer software in order to produce electrical resistivity tomography for qualitative interpretations. The results show the variation of resistivity value and faults. The 2-D resistivity results generally show the study area was divided into two main zones, alluvium with resistivity value of 10 - 800 Ωm, and bedrock with resistivity value of > 1500 Ωm and depth of 20 - 40 m. There are lots of fractured zones which are different than normal, identified along the survey lines. The South-North line shows the fractured zones were identified at 760 - 3800 m and 4700 - 5900 m. The West-East line, the fractured zone was identified at 1545 - 6570 m and North-West to South-East line, the fractured zone was identified at 740 - 5850 m. Meanwhile, South-West to North-East line, the fractured zone was identified at 720 - 1520 m. These interesting results were indicated at position of longitude; 100.965 - 100.978 and latitude; 5.056



第四纪研究 , 2002,
Abstract: Professor Li Lianjie was one of the initiators and educators in China soil science. Though he was the Academician of Chinese Academy of Sciences and first degree professor, he always earnestly instructed his graduate students, and sufficiently cared for our study and life. I was one of his doctor graduates in his later teaching time. Although he was seventy years old that time, and couldn′t go to far rural fundamental research, he led us to establish a doctor practice base point in Taipingzhuang, Nankou town, Changping District, Beijing. During more than ten years, he carried on the soil investigation and classification, ancient soil and the Quaternary geology and instructed numerous graduates and doctor graduates by using this base point. Field practice was his main instruction form. The unclear issues, which occurred in office and process of editing thesis, were always taken to demonstrate in field. He thought that "person always staying in office can′t study the soil". The same thesis was often edited many times. He led and organized comprehensive research and soil investigation in all his life. He was certainly "Travel five thousand kilometers, read ten thousand books". He often remembered clearly the process that he went through himself. He often enlightened us must think daringly according to fact, on the other hand he encouraged us to learn through nature and practice, affronted the life fearlessly, and couldn′t give up for temporarily difficulty. There were many interesting and valuable stories about him, for example, understanding what the meaning "earth" and "loam" of soil science. What is called "earth" which represents partial slightly alkaline land. What is called "loam" which represents partial slightly acidic land. So the "earth" and "loam" come into being Chinese "soil". He optimistically affronted the life in all his life, tightly connected his study to agricultural practice. These spirits are worth studying for us through life. $$$$
Some comments on "discussion on tensile failure criterion of brittle material under complex stress state"

CHEN Jinmin,

力学与实践 , 2007,
Abstract: 对"复杂应力条件下脆性材料的受拉破坏准则"一文中所应用公式的2个例子提出讨论.
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