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Search Results: 1 - 10 of 15027 matches for " Jinhua Tang "
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Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy
Jinhua Tang,Haidong Yan,Shougang Zhuang
International Journal of Nephrology , 2012, DOI: 10.1155/2012/608397
Abstract: Obesity-related glomerulopathy is an increasing cause of end-stage renal disease. Obesity has been considered a state of chronic low-grade systemic inflammation and chronic oxidative stress. Augmented inflammation in adipose and kidney tissues promotes the progression of kidney damage in obesity. Adipose tissue, which is accumulated in obesity, is a key endocrine organ that produces multiple biologically active molecules, including leptin, adiponectin, resistin, that affect inflammation, and subsequent deregulation of cell function in renal glomeruli that leads to pathological changes. Oxidative stress is also associated with obesity-related renal diseases and may trigger the initiation or progression of renal damage in obesity. In this paper, we focus on inflammation and oxidative stress in the progression of obesity-related glomerulopathy and possible interventions to prevent kidney injury in obesity. 1. Introduction Obesity has become a heavy public health problem in the United States, with a prevalence among adults increasing to 32% from 13% between the 1960s and 2004 [1]. Currently, 66% of adults and 16% of children and adolescents are overweight or obese [1]. Although obesity has long been recognized as an independent risk factor for cardiovascular diseases and diabetes mellitus, newer research points to obesity as an important risk factor for chronic kidney diseases (CKDs) [2–4]. In 1974, Weisinger et al. [5] firstly reported that massive obese patients developed nephrotic-range proteinuria. Subsequent studies confirmed that obesity could induce renal injury, namely, obesity-related glomerulopathy (ORG) [6–8]. A large-scale clinicopathologic study including 6818 renal biopsies from 1986 to 2000 revealed a progressive increase in biopsy incidence of ORG from 0.2% in 1986–1990 to 2.0% in 1996–2000 [8]. The tenfold increase in incidence of ORG over 15 years suggests a newly emerging epidemic [8]. The clinical characteristics of subjects with ORG typically manifest with nephrotic or subnephrotic proteinuria, accompanied by renal insufficiency [8–10]. Histologically, ORG presents as focal segmental glomerulosclerosis (FSGS) and glomerular hypertrophy or glomerular hypertrophy alone and relatively decreased podocyte density and number and mild foot process fusion [8, 11, 12]. Clinically, it is distinguished from idiopathic FSGS (I-FSGS) by its lower incidence of nephrotic syndrome, more benign course, and slower progression of proteinuria and renal failure [8, 11]. ORG is an increasing cause of end-stage renal disease (ESRD). The pathophysiology of ORG
About the Riemann Hypothesis  [PDF]
Jinhua Fei
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.43061
Abstract: The Riemann hypothesis is part of Hilbert’s eighth problem in David Hilbert’s list of 23 unsolved problems. It is also one of the Clay Mathematics Institute’s Millennium Prize Problems. Some mathematicians consider it the most important unresolved problem in pure mathematics. Many mathematicians made a lot of efforts; they don’t have to prove the Riemann hypothesis. In this paper, I use the analytic methods to deny the Riemann Hypothesis; if there’s something wrong, please criticize and correct me.
Application of Sandwich Learning in the Theory Teaching of Histology and Embryology for First-Year Medical Students  [PDF]
Jinhua Wang, Liqing Li, Hai Li, Chunying Luo, Jianhai Chen, Xiaoyan Fang, Yongzhi Huang, Qiongzhi Zhao, Hailing Huang, Qichuan Huang, Biao Li, Qianli Tang
Creative Education (CE) , 2018, DOI: 10.4236/ce.2018.911118
Abstract: Objective: To investigate the effect of Sandwich Learning (SL) in the theory teaching of Histology and Embryology. Methods: 110 freshmen majoring in clinical medicine were randomly chosen as the experimental group of Sandwich Learning, while 111 students at the same grade were chosen as the control group for traditional lecture-style teaching. After different teaching, students from both groups were surveyed by questionnaires. And they had to take examinations about theoretical knowledge and specimen of Histology and Embryology. Then the same group of teachers marked all the exam papers according to the same scoring standards. Results: There were significantly differences in the averages of the final exam about theoretical knowledge, regular assignments and final scores between two groups. Difference in results of specimen assessment was not statistically significant. The questionnaire survey results showed that students affirmed the effect of sandwich learning in improving learning initiative, sense of responsibility and communication skills in study. Conclusion: The research shows that the application of Sandwich Learning has good teaching effect in theory teaching of Histology and Embryology and helps to cultivate the comprehensive ability of medical students.
Multi-Branch Fractional Multi-Bit Differential Detection of Continuous Phase Modulation with Decision Feedback  [PDF]
Jinhua Sun, Xiaojun Wu
Communications and Network (CN) , 2011, DOI: 10.4236/cn.2011.31004
Abstract: Differential detection of continuous phase modulation suffers from significant intersymbol interference. To reduce bit error rate, multi-branch fractional multi-bit differential detection (MFMDD) with decision feed-back is proposed. By introducing decision feedback in multi-bit differential detected signals, severe inter-symbol interference can be removed. Simulation results show that the proposed structure can greatly im-proves the performance compared with MFMDD without decision feedback, and the performance of 9 FMDD is very near to the performance of the coherent detection.
Nonlinear Bending of Piezoelectric Cylindrical Shell Reinforced with BNNTs under Electro-Thermo-Mechanical Loadings  [PDF]
Jinhua Yang, Pengjun Zhang
Materials Sciences and Applications (MSA) , 2015, DOI: 10.4236/msa.2015.68076
Abstract: Under combined electro-thermo-mechanical loadings, the nonlinear bending of piezoelectric cylindrical shell reinforced with boron nitride nanotubes (BNNTs) is investigated in this paper. By employing nonlinear strains based on Donnell shell theory and utilizing piezoelectric theory including thermal effects, the constitutive relations of the piezoelectric shell reinforced with BNNTs are established. Then the governing equations of the structure are derived through variational principle and resolved by applying the finite difference method. In numerical examples, the effects of geometric nonlinear, voltage, temperature, as well as volume fraction on the deflection and bending moment of axisymmetrical piezoelectric cylindrical shell reinforced with BNNTs are discussed in detail.
Pax6 Directly Down-Regulates Pcsk1n Expression Thereby Regulating PC1/3 Dependent Proinsulin Processing
Ting Liu, Yanxia Zhao, Na Tang, Ruopeng Feng, Xiaolong Yang, Nicole Lu, Jinhua Wen, Lingsong Li
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046934
Abstract: Background Heterozygous paired box6 (Pax6) mutations lead to abnormal glucose metabolism in mice older than 6 months as well as in human beings. Our previous study found that Pax6 deficiency caused down-expression of prohormone convertase 1/3 (Pcsk1), resulting in defective proinsulin processing. As a protein cleaving enzyme, in addition to its expression, the activity of PC1/3 is closely related to its function. We therefore hypothesize that Pax6 mutation alters the activity of PC1/3, which affects proinsulin processing. Methodology/Principal Findings Using quantitative RT-PCR, western blot and enzyme assay, we found that PC1/3 C-terminal cleavage and its activity were compromised in Pax6 R266Stop mutant mice, and the expression of Pcsk1n, a potent inhibitor of PC1/3, was elevated by Pax6 deficiency in the mutant mice and MIN6 cells. We confirmed the effect of proSAAS, the protein encoded by Pcsk1n, on PC1/3 C-terminal cleavage and its activity by Pcsk1n RNAi in MIN6 cells. Furthermore, by luciferase-reporter analysis, chromatin immunoprecipitation, and electrophoretic mobility shift assay, we revealed that Pax6 bound to Pcsk1n promoter and directly down-regulated its expression. Finally, by co-transfecting Pax6 siRNA with Pcsk1n siRNA, we showed that Pax6 knock-down inhibited proinsulin processing and that this effect could be rescued by proSAAS down-regulation. These findings confirm that Pax6 regulates proinsulin processing partially through proSAAS-mediated PC1/3 processing and activity. Conclusions/Significance Collectively, the above experiments demonstrate that Pax6 can directly down-regulate Pcsk1n expression, which negatively affects PC1/3 C-terminal cleavage and activity and subsequently participates in proinsulin processing. We identified proSAAS as a novel down-regulated target of Pax6 in the regulation of glucose metabolism. This study also provides a complete molecular mechanism for the Pax6 deficiency-caused diabetes.
Differentiation potential of STRO-1+ dental pulp stem cells changes during cell passaging
Jinhua Yu, Huixia He, Chunbo Tang, Guangdong Zhang, Yuanfei Li, Ruoning Wang, Junnan Shi, Yan Jin
BMC Cell Biology , 2010, DOI: 10.1186/1471-2121-11-32
Abstract: DPSCs were isolated from human/rat dental pulps by the magnetic activated cell sorting based on STRO-1 expression, cultured and passaged in the conventional culture media. The biological features of STRO-1+ DPSCs at the 1st and 9th passages were investigated. During the long-term passage, the proliferation ability of human STRO-1+ DPSCs was downregulated as indicated by the growth kinetics. When compared with STRO-1+ DPSCs at the 1st passage (DPSC-P1), the expression of mature osteoblast-specific genes/proteins (alkaline phosphatase, bone sialoprotein, osterix, and osteopontin), odontoblast-specific gene/protein (dentin sialophosphoprotein and dentin sialoprotein), and chondrocyte-specific gene/protein (type II collagen) was significantly upregulated in human STRO-1+ DPSCs at the 9th passage (DPSC-P9). Furthermore, human DPSC-P9 cells in the mineralization-inducing media presented higher levels of alkaline phosphatase at day 3 and day 7 respectively, and produced more mineralized matrix than DPSC-P9 cells at day 14. In vivo transplantation results showed that rat DPSC-P1 cell pellets developed into dentin, bone and cartilage structures respectively, while DPSC-P9 cells can only generate bone tissues.These findings suggest that STRO-1+ DPSCs consist of several interrelated subpopulations which can spontaneously differentiate into odontoblasts, osteoblasts, and chondrocytes. The differentiation capacity of these DPSCs changes during cell passaging, and DPSCs at the 9th passage restrict their differentiation potential to the osteoblast lineage in vivo.During the odontogenesis, reciprocal epithelial-mesenchymal interactions are of paramount importance to the tooth initiation and subsequent dental morphogenesis [1-4]. At the beginning of odontogenesis, the ectomesenchyme provide the initial inductive signals and bring about the formation of dental placode. Subsequent cell proliferation, condensation, polarization, and differentiation of the epithelium and mesenchyme cont
Numerical study on combustion of diluted methanol-air premixed mixtures
JianJun Zheng,ZhiYuan Zhang,ZuoHua Huang,ErJiang Hu,ChengLong Tang,JinHua Wang
Chinese Science Bulletin , 2010, DOI: 10.1007/s11434-009-0709-y
Abstract: The effect of nitrogen dilution on the premixed combustion characteristics and flame structure of laminar premixed methanol-air-nitrogen mixtures are analyzed numerically based on an extended methanol oxidation mechanism. The laminar burning velocities, the mass burning fluxes, the adiabatic flame temperature, the global activation temperature, the Zeldovich number, the effective Lewis number and the laminar flame structure of the methanol-air-nitrogen mixtures are obtained under different nitrogen dilution ratios. Comparison between experiments and numerical simulations show that the extended methanol oxidation mechanism can well reproduce the laminar burning velocities for lean and near stoichiometric methanol-air-nitrogen mixtures. The laminar burning velocities and the mass burning fluxes decrease with the increase of nitrogen dilution ratio and the effect is more obvious for the lean mixture. The effective Lewis number of the mixture increases with the increase of nitrogen dilution ratio, and the diffusive-thermal instability of the flame front is decreased by the nitrogen addition. Nitrogen addition can suppress the hydrodynamic instability of methanol-air-nitrogen flames. The decrease of the mole fraction of OH and H is mainly responsible for the suppressed effect of nitrogen diluent on the chemical reaction in the methanol-air-nitrogen laminar premixed flames, and the NO x and formaldehyde emissions are decreased by the nitrogen addition.

TANG Changguo,ZHU Jinhua,ZHENG Xiulin,

材料研究学报 , 1996,
Abstract: Laser spallation approach has been employed to measure the interface strength of Fe/ TiN,By adjusting the laser parameters in the tests,the laser-induced spallation can just occur along the interface of Fe / TiN. The spalling process of TiN coating can be

TANG ChangguoZHU Jinhua,ZHOU Huijiu,

材料研究学报 , 1996,
Abstract: Dynamic tension tests were employed to study the effect of strain rate on plastisity for three metallic materials, strain rate ranges from 10-4 to 103 s-1. A phenomenon of plastisity-increasing induced by high strain rate is found for tested materials, which is associated with "adiabatic heating" of specimens,deformation twinning, formation and suppression of phase transformation induced by strain.
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