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Search Results: 1 - 10 of 12736 matches for " Jingyuan Luo "
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Globalization of Stem Cell Science: An Examination of Current and Past Collaborative Research Networks
Jingyuan Luo, Kirstin R. W. Matthews
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073598
Abstract: Science and engineering research has becoming an increasingly international phenomenon. Traditional bibliometric studies have not captured the evolution of collaborative partnerships between countries, particularly in emerging technologies such as stem cell science, in which an immense amount of investment has been made in the past decade. Analyzing over 2,800 articles from the top journals that include stem cell research in their publications, this study demonstrates the globalization of stem cell science. From 2000 to 2010, international collaborations increased from 20.9% to 36% of all stem cell publications analyzed. The United States remains the most prolific and the most dominant country in the field in terms of publications in high impact journals. But Asian countries, particularly China are steadily gaining ground. Exhibiting the largest relative growth, the percent of Chinese-authored stem cell papers grew more than ten-fold, while the percent of Chinese-authored international papers increased over seven times from 2000 to 2010. And while the percent of total stem cell publications exhibited modest growth for European countries, the percent of international publications increased more substantially, particularly in the United Kingdom. Overall, the data indicated that traditional networks of collaboration extant in 2000 still predominate in stem cell science. Although more nations are becoming involved in international collaborations and undertaking stem cell research, many of these efforts, with the exception of those in certain Asian countries, have yet to translate into publications in high impact journals.
How Inflation Affects the Management Earnings Forecasts  [PDF]
Jingyuan Zou
American Journal of Industrial and Business Management (AJIBM) , 2019, DOI: 10.4236/ajibm.2019.91003
Abstract: I use 2005-2017 Shenzhen and Shanghai’s A-share listed company’s quarterly earnings forecasts data as sample to perform multiple regression analysis. I find that when inflation rate rises, not only management’s possibility of making earnings forecasts but also the precision and accuracy of management forecasts declines, ceteris paribus. Furthermore, I also find that when inflation rate rises, the state-owned nature of enterprises will aggravate the decline in the precision and accuracy of listed companies’ earnings forecasts.
Analysis of Seasonal Characteristics of Thermal Environment Based on Urban Sub-Pixel Land Use Types  [PDF]
Jingyuan Cheng, Youshui Zhang
Journal of Computer and Communications (JCC) , 2018, DOI: 10.4236/jcc.2018.611007
Abstract:
Seasonal variations will cause the differences in the distribution of urban thermal environment. Therefore, it is essential for analyzing the distribution of land surface temperature (LST) in different seasons under the same land use type. In this paper, fully constrained least squares method of linear spectral mixture analysis was used to extract the information of land cover fraction. According to the differences in the degree of the urban development, the study area is divided into three regions, for estimating the differences in the distribution of urban thermal environment. Ternary triangular charts were drawn to analyze the impact of each land use type on seasonal UHI. Contribution index (CI) of each land cover was calculated to analysis of the impact of each land use type on LST. The results of this study indicate that the extreme differences in temperature extremes occur in summer, followed by spring, autumn, and winter. In the spring, high LST areas appear in industrial, bare land; high LST areas in summer occur in the CBD, light industrial, and cover crops; the high LST areas in autumn appear in the CBD, high-density residential; in winter, the distribution of low-density and medium-density residential areas, crops and lawns will inhibit the urban heat island effect. The analytical methodologies that be used in this study can help to quantify urban thermal environmental functions effect of different land use type and explore the climate adaptation potential of cities.
International Stem Cell Collaboration: How Disparate Policies between the United States and the United Kingdom Impact Research
Jingyuan Luo,Jesse M. Flynn,Rachel E. Solnick,Elaine Howard Ecklund,Kirstin R. W. Matthews
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017684
Abstract: As the scientific community globalizes, it is increasingly important to understand the effects of international collaboration on the quality and quantity of research produced. While it is generally assumed that international collaboration enhances the quality of research, this phenomenon is not well examined. Stem cell research is unique in that it is both politically charged and a research area that often generates international collaborations, making it an ideal case through which to examine international collaborations. Furthermore, with promising medical applications, the research area is dynamic and responsive to a globalizing science environment. Thus, studying international collaborations in stem cell research elucidates the role of existing international networks in promoting quality research, as well as the effects that disparate national policies might have on research. This study examined the impact of collaboration on publication significance in the United States and the United Kingdom, world leaders in stem cell research with disparate policies. We reviewed publications by US and UK authors from 2008, along with their citation rates and the political factors that may have contributed to the number of international collaborations. The data demonstrated that international collaborations significantly increased an article's impact for UK and US investigators. While this applied to UK authors whether they were corresponding or secondary, this effect was most significant for US authors who were corresponding authors. While the UK exhibited a higher proportion of international publications than the US, this difference was consistent with overall trends in international scientific collaboration. The findings suggested that national stem cell policy differences and regulatory mechanisms driving international stem cell research in the US and UK did not affect the frequency of international collaborations, or even the countries with which the US and UK most often collaborated. Geographical and traditional collaborative relationships were the predominate considerations in establishing international collaborations.
Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation
Hongmei Luo, Ying Li, Chao Sun, Qiong Wu, Jingyuan Song, Yongzhen Sun, André Steinmetz, Shilin Chen
BMC Plant Biology , 2010, DOI: 10.1186/1471-2229-10-209
Abstract: For H. serrata, 36,763 unique putative transcripts were generated from 140,930 reads totaling over 57,028,559 base pairs; for P. carinatus, 31,812 unique putative transcripts were generated from 79,920 reads totaling over 30,498,684 base pairs. Using BLASTX searches of public databases, 16,274 (44.3%) unique putative transcripts from H. serrata and 14,070 (44.2%) from P. carinatus were assigned to at least one protein. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) orthology annotations revealed that the functions of the unique putative transcripts from these two species cover a similarly broad set of molecular functions, biological processes and biochemical pathways.In particular, a total of 20 H. serrata candidate cytochrome P450 genes, which are more abundant in leaves than in roots and might be involved in lycopodium alkaloid biosynthesis, were found based on the comparison of H. serrata and P. carinatus 454-ESTs and real-time PCR analysis. Four unique putative CYP450 transcripts (Hs01891, Hs04010, Hs13557 and Hs00093) which are the most likely to be involved in the biosynthesis of lycopodium alkaloids were selected based on a phylogenetic analysis. Approximately 115 H. serrata and 98 P. carinatus unique putative transcripts associated with the biosynthesis of triterpenoids, alkaloids and flavones/flavonoids were located in the 454-EST datasets. Transcripts related to phytohormone biosynthesis and signal transduction as well as transcription factors were also obtained. In addition, we discovered 2,729 and 1,573 potential SSR-motif microsatellite loci in the H. serrata and P. carinatus 454-ESTs, respectively.The 454-EST resource allowed for the first large-scale acquisition of ESTs from H. serrata and P. carinatus, which are representative members of the Huperziaceae family. We discovered many genes likely to be involved in the biosynthesis of bioactive compounds and transcriptional regulation as well as a large number of potential microsat
Generation and analysis of expressed sequence tags from a cDNA library of the fruiting body of Ganoderma lucidum
Hongmei Luo, Chao Sun, Jingyuan Song, Jin Lan, Ying Li, Xiwen Li, Shilin Chen
Chinese Medicine , 2010, DOI: 10.1186/1749-8546-5-9
Abstract: A cDNA library was constructed from the G. lucidum fruiting body. Its high-quality ESTs were assembled into unique sequences with contigs and singletons. The unique sequences were annotated according to sequence similarities to genes or proteins available in public databases. The detection of simple sequence repeats (SSRs) was preformed by online analysis.A total of 1,023 clones were randomly selected from the G. lucidum library and sequenced, yielding 879 high-quality ESTs. These ESTs showed similarities to a diverse range of genes. The sequences encoding squalene epoxidase (SE) and farnesyl-diphosphate synthase (FPS) were identified in this EST collection. Several candidate genes, such as hydrophobin, MOB2, profilin and PHO84 were detected for the first time in G. lucidum. Thirteen (13) potential SSR-motif microsatellite loci were also identified.The present study demonstrates a successful application of EST analysis in the discovery of transcripts involved in the secondary metabolite biosynthesis and the developmental regulation of G. lucidum.Ganoderma lucidum (Curtis: Fr.) P. Karst, Lingzhi in Chinese, which belongs to the Polyporaceae family, has been used in China as medicine for centuries to promote health and longevity [1,2]. In other countries, its fruiting body is used to treat a variety of ailments, such as cancers, hypertension, diabetes, and hepatitis, apart from being a dietary supplement [2-4]. G. lucidum is an anti-tumour agent that acts via immune modulation or stimulating cytokine production [5-7]. The bioactive constituents of G. lucidum include more than 120 different triterpenes and polysaccharides, proteins and other compounds [2,8].Genes involved in the triterpenoids biosynthesis pathways in G. lucidum including squalene synthase (SQS), farnesyl-Diphosphate Synthase (GlFPS) and HMG-CoA reductase (Gl -HMGR) were isolated and characterized [9-11]. Joo et al. identified a laccase gene (GLLac1) from G. lucidum [12]. However, little is known about
The Role of α-synuclein and Tau Hyperphosphorylation-Mediated Autophagy and Apoptosis in Lead-induced Learning and Memory Injury
Jianbin Zhang, Tongjian Cai, Fang Zhao, Ting Yao, Yaoming Chen, Xinqin Liu, Wenjing Luo, Jingyuan Chen
International Journal of Biological Sciences , 2012,
Abstract: Lead (Pb) is a well-known heavy metal in nature. Pb can cause pathophysiological changes in several organ systems including central nervous system. Especially, Pb can affect intelligence development and the ability of learning and memory of children. However, the toxic effects and mechanisms of Pb on learning and memory are still unclear. To clarify the mechanisms of Pb-induced neurotoxicity in hippocampus, and its effect on learning and memory, we chose Sprague-Dawley rats (SD-rats) as experimental subjects. We used Morris water maze to verify the ability of learning and memory after Pb treatment. We used immunohistofluorescence and Western blotting to detect the level of tau phosphorylation, accumulation of α-synuclein, autophagy and related signaling molecules in hippocampus. We demonstrated that Pb can cause abnormally hyperphosphorylation of tau and accumulation of α-synuclein, and these can induce hippocampal injury and the ability of learning and memory damage. To provide the new insight into the underlying mechanisms, we showed that Grp78, ATF4, caspase-3, autophagy-related proteins were induced and highly expressed following Pb-exposure. But mTOR signaling pathway was suppressed in Pb-exposed groups. Our results showed that Pb could cause hyperphosphorylation of tau and accumulation of α-synuclein, which could induce ER stress and suppress mTOR signal pathway. These can enhance type II program death (autophgy) and type I program death (apoptosis) in hippocampus, and impair the ability of learning and memory of rats. This is the first evidence showing the novel role of autophagy in the neurotoxicity of Pb.
FastUniq: A Fast De Novo Duplicates Removal Tool for Paired Short Reads
Haibin Xu, Xiang Luo, Jun Qian, Xiaohui Pang, Jingyuan Song, Guangrui Qian, Jinhui Chen, Shilin Chen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052249
Abstract: The presence of duplicates introduced by PCR amplification is a major issue in paired short reads from next-generation sequencing platforms. These duplicates might have a serious impact on research applications, such as scaffolding in whole-genome sequencing and discovering large-scale genome variations, and are usually removed. We present FastUniq as a fast de novo tool for removal of duplicates in paired short reads. FastUniq identifies duplicates by comparing sequences between read pairs and does not require complete genome sequences as prerequisites. FastUniq is capable of simultaneously handling reads with different lengths and results in highly efficient running time, which increases linearly at an average speed of 87 million reads per 10 minutes. FastUniq is freely available at http://sourceforge.net/projects/fastuniq?/.
Antinociceptive Effect of Tetrandrine on LPS-Induced Hyperalgesia via the Inhibition of IKKβ Phosphorylation and the COX-2/PGE2 Pathway in Mice
Hengguang Zhao, Fuling Luo, Hongzhong Li, Li Zhang, Yongfen Yi, Jingyuan Wan
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094586
Abstract: Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid that is isolated from the Stephania Tetrandra. It is known to possess anti-inflammatory and immunomodulatory effects. We have shown that TET can effectively suppress the production of bacterial lipopolysaccharide (LPS)-induced inflammatory mediators, including cyclooxygenases (COXs), in macrophages. However, whether TET has an antinociceptive effect on LPS-induced hyperalgesia is unknown. In the present study, we investigated the potential antinociceptive effects of TET and the mechanisms by which it elicits its effects on LPS-induced hyperalgesia. LPS effectively evoked hyperalgesia and induced the production of PGE2 in the sera, brain tissues, and cultured astroglia. TET pretreatment attenuated all of these effects. LPS also activated inhibitor of κB (IκB) kinase β (IKKβ) and its downstream components in the IκB/nuclear factor (NF)-κB signaling pathway, including COX-2; the increase in expression levels of these components was significantly abolished by TET. Furthermore, in primary astroglia, knockdown of IKKβ, but not IKKα, reversed the effects of TET on the LPS-induced increase in IκB phosphorylation, P65 phosphorylation, and COX-2. Our results suggest that TET can effectively exert antinociceptive effects on LPS-induced hyperalgesia in mice by inhibiting IKKβ phosphorylation, which leads to the reduction in the production of important pain mediators, such as PGE2 and COX-2, via the IKKβ/IκB/NF-κB pathway.
A Knowledge Maturity Model for Aerospace Product Development  [PDF]
Qian Jia, Jingyuan Bi, Jingyuan Bi, Liwei Wang, Yukun Yang
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.29026
Abstract:

At present, China's aerospace product development mission are characterized by mammoth task and high responsibility, in which situation, the role of knowledge in business process is particularly prominent. Although we have realized the importance of the problem, and embarked on the accumulation job, the problem faced is that we lack the criteria to judge our harvest, which spontaneously caused that we cannot define the quality and practical value of accumulated knowledge. Focusing of above problems, the paper puts forward a knowledge maturity model for aerospace product development, which divides knowledge maturity into 6 levels according to development process. Criteria of each level as well as translation condition to next grade is elaborated, assessment note is specially stated, aiming at offering enterprises a potent method for knowledge system construction and evaluation.

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