oalib

OALib Journal期刊

ISSN: 2333-9721

费用:99美元

投稿

时间不限

2017 ( 56 )

2016 ( 84 )

2015 ( 999 )

2014 ( 1660 )

自定义范围…

匹配条件: “Jing Dong” ,找到相关结果约42005条。
列表显示的所有文章,均可免费获取
第1页/共42005条
每页显示
Sampling Point Processes on Stable Unbounded Regions and Exam Simulation of Queues
Jose Blanchet,Jing Dong
Mathematics , 2012,
Abstract: Given a marked renewal point process (assuming that the marks are i.i.d.) we say that an unbounded region is stable if it contains finitely many points of the point process with probability one. In this paper we provide algorithms that allow to sample these finitely many points efficiently. We explain how exact simulation of the steady-state measure valued state descriptor of the infinite server queue follows as a simple corollary of our algorithms. We provide numerical evidence supporting that our algorithms are not only theoretically sound but also practical. Finally, having simulation optimization in mind, we also apply our results to gradient estimation of steady-state performance measures.
Perfect sampling for infinite server and loss systems
Jose Blanchet,Jing Dong
Mathematics , 2013,
Abstract: We present the first class of perfect sampling (also known as exact simulation) algorithms for the steady-state distribution of non-Markovian loss networks. We use a variation of Dominated Coupling From The Past for which we simulate a stationary infinite server queue backwards in time and analyze the running time in heavy traffic. In particular, we are able to simulate stationary renewal marked point processes in unbounded regions. We use the infinite server queue as an upper bound process to simulate loss systems. The running time analysis of our perfect sampling algorithm for loss systems is performed in the Quality-Driven (QD) and the Quality-and-Efficiency-Driven regimes. In both cases, we show that our algorithm achieves sub-exponential complexity as both the number of servers and the arrival rate increase. Moreover, in the QD regime, our algorithm achieves a nearly optimal rate of convergence.
Realizations of Affine Lie Algebra A_^(1) at Negative Levels
Jilan Dong,Naihuan Jing
Statistics , 2014, DOI: 10.1007/978-3-642-55361-5_36
Abstract: A realization of the affine Lie algebra ${A^{(1)}_1}$ and the relevant $Z$-algebra at negative level $-k$ is given in terms of parafermions. This generalizes the recent work on realization of the affine Lie algebra at the critical level.
Dynamic Economic Dispatch for Wind Power System Considering System Security and Spinning Reserve  [PDF]
Wangchao Dong, Jing Zhang, Jiejie Huang, Shenghu Li
Journal of Power and Energy Engineering (JPEE) , 2015, DOI: 10.4236/jpee.2015.34046
Abstract:

In this paper, dynamic economic dispatch model is proposed for power systems with bulk wind power integration. The wind turbine generators are assumed to partially undertake the spinning reserve for the thermal generator. A double-layer optimization model is proposed. The outer layer use the differential evolution to search for the power output of thermal generators, and the inner layer use the primal-dual interior point method to solve the OPF of the established output state. Finally, the impact of spinning reserve with wind power on power system operating is validated.

IntNetDB v1.0: an integrated protein-protein interaction network database generated by a probabilistic model
Kai Xia, Dong Dong, Jing-Dong J Han
BMC Bioinformatics , 2006, DOI: 10.1186/1471-2105-7-508
Abstract: By applying a probabilistic model, we integrated 27 heterogeneous genomic, proteomic and functional annotation datasets to predict PPI networks in human. In addition to previously studied data types, we show that phenotypic distances and genetic interactions can also be integrated to predict PPIs. We further built an easy-to-use, updatable integrated PPI database, the Integrated Network Database (IntNetDB) online, to provide automatic prediction and visualization of PPI network among genes of interest. The networks can be visualized in SVG (Scalable Vector Graphics) format for zooming in or out. IntNetDB also provides a tool to extract topologically highly connected network neighborhoods from a specific network for further exploration and research. Using the MCODE (Molecular Complex Detections) algorithm, 190 such neighborhoods were detected among all the predicted interactions. The predicted PPIs can also be mapped to worm, fly and mouse interologs.IntNetDB includes 180,010 predicted protein-protein interactions among 9,901 human proteins and represents a useful resource for the research community. Our study has increased prediction coverage by five-fold. IntNetDB also provides easy-to-use network visualization and analysis tools that allow biological researchers unfamiliar with computational biology to access and analyze data over the internet. The web interface of IntNetDB is freely accessible at http://hanlab.genetics.ac.cn/IntNetDB.htm webcite. Visualization requires Mozilla version 1.8 (or higher) or Internet Explorer with installation of SVGviewer.Protein-protein interactions (PPIs) underlie most biological processes. Dissecting the PPI network for a particular biological process may provide important clues into molecular mechanisms of the process [1]. Recently, large-scale experimental studies have generated many PPI datasets in different model organisms by yeast two-hybrid (Y2H) screens [2-8] and by co-affinity purification (co-AP) followed by mass spectrom
Comparing the biological coherence of network clusters identified by different detection algorithms
Dong Dong,Bing Zhou,Jing-Dong J. Han
Chinese Science Bulletin , 2007, DOI: 10.1007/s11434-007-0454-z
Abstract: Protein-protein interaction networks serve to carry out basic molecular activity in the cell. Detecting the modular structures from the protein-protein interaction network is important for understanding the organization, function and dynamics of a biological system. In order to identify functional neighborhoods based on network topology, many network cluster identification algorithms have been developed. However, each algorithm might dissect a network from a different aspect and may provide different insight on the network partition. In order to objectively evaluate the performance of four commonly used cluster detection algorithms: molecular complex detection (MCODE), NetworkBlast, shortest-distance clustering (SDC) and Girvan-Newman (G-N) algorithm, we compared the biological coherence of the network clusters found by these algorithms through a uniform evaluation framework. Each algorithm was utilized to find network clusters in two different protein-protein interaction networks with various parameters. Comparison of the resulting network clusters indicates that clusters found by MCODE and SDC are of higher biological coherence than those by NetworkBlast and G-N algorithm.
Highly Variable Chloroplast Markers for Evaluating Plant Phylogeny at Low Taxonomic Levels and for DNA Barcoding
Wenpan Dong, Jing Liu, Jing Yu, Ling Wang, Shiliang Zhou
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035071
Abstract: Background At present, plant molecular systematics and DNA barcoding techniques rely heavily on the use of chloroplast gene sequences. Because of the relatively low evolutionary rates of chloroplast genes, there are very few choices suitable for molecular studies on angiosperms at low taxonomic levels, and for DNA barcoding of species. Methodology/Principal Findings We scanned the entire chloroplast genomes of 12 genera to search for highly variable regions. The sequence data of 9 genera were from GenBank and 3 genera were of our own. We identified nearly 5% of the most variable loci from all variable loci in the chloroplast genomes of each genus, and then selected 23 loci that were present in at least three genera. The 23 loci included 4 coding regions, 2 introns, and 17 intergenic spacers. Of the 23 loci, the most variable (in order from highest variability to lowest) were intergenic regions ycf1-a, trnK, rpl32-trnL, and trnH-psbA, followed by trnSUGA-trnGUCC, petA-psbJ, rps16-trnQ, ndhC-trnV, ycf1-b, ndhF, rpoB-trnC, psbE-petL, and rbcL-accD. Three loci, trnSUGA-trnGUCC, trnT-psbD, and trnW-psaJ, showed very high nucleotide diversity per site (π values) across three genera. Other loci may have strong potential for resolving phylogenetic and species identification problems at the species level. The loci accD-psaI, rbcL-accD, rpl32-trnL, rps16-trnQ, and ycf1 are absent from some genera. To amplify and sequence the highly variable loci identified in this study, we designed primers from their conserved flanking regions. We tested the applicability of the primers to amplify target sequences in eight species representing basal angiosperms, monocots, eudicots, rosids, and asterids, and confirmed that the primers amplified the desired sequences of these species. Significance/Conclusions Chloroplast genome sequences contain regions that are highly variable. Such regions are the first consideration when screening the suitable loci to resolve closely related species or genera in phylogenetic analyses, and for DNA barcoding.
The diagnostic significance of glucose-6-phosphate isomerase (G6PI) antigen and anti-G6PI antibody in rheumatoid arthritis patients  [PDF]
Daren Yang, Huinan Ge, Jing Dong, Xiongxiong Zhu, Gang Sun, Weiguo Ouyang, Linhui Wang, Guoxing Zhang
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.48108
Abstract:

Objective: To investigate whether glucose-6-phosphate isomerase (G6PI) antigen and anti-G6PI antibodies could be applied for the clinical diagnostic markers of rheumatoid arthritis (RA) and its associations with RA activity states. Methods: The levels of G6PI antigens and anti-G6PI Abs in sera from 176 RA patients in different states, 35 non-RA patients and 100 healthy donors and in synovia fluids from 33 patients and 11 non-RA patients were measured by ELISA. Results: The sensitivity and specificity of G6PI antigens in the RA patients were 75.0% and 93.3%, respectively. The levels of serum G6PI antigens in 176 RA patients were significantly higher than non-RA patients and the health controls. Especially, there was a significant difference between the active phase and the inactive phase in G6PI antigens levels. The levels of G6PI antigens in synovia fluid were also significantly higher in RA groups than in non-RA patients. With the values of the anti-G6PI Abs in sera, there were no marked differences among RA, non-RA patients and health controls. Also, there was no significant difference between the active phase and the inactive phase in RA patients. However, there were no significant differences of G6PI and anti-G6PI between RA patients and health controls in synovial fluid. Conclusions: G6PI is highly correlated with the activity states of RA, and could be applied for a clinical biomarker with high sensitivity and specificity for the diagnosis of RA.

The development and evaluation of single cell suspension from wheat and barley as a model system; a first step towards functional genomics application
Jing Dong, Steve Bowra, Eva Vincze
BMC Plant Biology , 2010, DOI: 10.1186/1471-2229-10-239
Abstract: We established growth conditions to allow routine culturing of somatic cells in 24 well microtiter plate format. Evaluation of the wheat and barley cell suspension as model cell system is a multi step process. As an initial step in the evaluation procedure we chose to study the impact of selected abiotic stress elicitors at the physiological, biochemical and molecular level. We report the results of osmotic stress imposed by NaCl and PEG. As proline is an important osmoprotectant of the cereal cells, colorimetric assay for proline detection was developed for small volumes (200 μl). We performed RT-PCR experiments to study the change in the expression of the genes encoding Δ1-pyrroline-5-carboxylate synthetase (P5CS) and Δ1-pyrroline-5-carboxylate reductase (PC5R) in response to abiotic stress.We found differences between the wheat and barley suspension cultures, barley being more tolerant to the applied osmotic stresses. We suggested a model to explain the obtained differences in stress tolerance between the two species. The suspension cell cultures have proven useful for determining changes in proline concentration and expression level of genes (P5CS, P5CR) under various treatments and we suggest that the cells can be used as a model host system to study gene expression and regulation in monocots.Plant cell culture has a very long history. It was in 1902, when German botanist Gottlieb Haberlandt published the article "Cultuversuche mit isolierten Pflanzenzellen" which described his vision of the totipotency of plant cells [1]. Since then plant cell suspension cultures have been used not only for clonal plant propagation but also to investigate the physiological, biochemical, and molecular aspects of various cellular functions. For instance, isolated plant cells have been extensively used to study photosynthesis [2], ion transport [3,4], secondary metabolite production [5], cell growth and differentiation [6] and programmed cell death [7]. Recently Arabidopsis and Z
Membrane molecules in induction of apoptosis of thymocytes by mouse thymic dendritic cells which express Fas ligands
Haidong Dong,Jing Chen,Weifeng Chen
Science China Life Sciences , 1998, DOI: 10.1007/BF02882726
Abstract: Apoptosis of thymocytes is involved in the negative selection of thymus, but it remains unclear how the cell death of thymocytes is regulated by the thymic stromal cells. By using immunohistochemistry, TdT-mediated dUTP nick end labeling (TUNEL) and flow cytometry methods, it was found that Fas ligand was expressed in the thymic medulla and a mouse thymic medullary type dendritic cell line (MTSC4). The DNA fragmentation and TUNEL positive staining of thymocytes were detected in 6 h of cocultures with MTSC4. 97 % of the thymocytes which bound to MTSC4 were Fas antigen positive cells. The DNA fragmentation of thymocytes induced by MTSC4 was inhibited by the addition of 20 mmol/L N-acetyl galactosamin monosaccharide and the pretreatment of a monoclonal antibody (PF-18-3) which recognized a putative antigen on MTSC4. These results suggested that the mechanisms of induction of cell death by stromal cells may include the interactions of multiple cell surface molecules, in addition to the Fas/Fas ligand system.
第1页/共42005条
每页显示


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.