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Search Results: 1 - 10 of 46188 matches for " Jin-Su Jung "
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Early Termination and Pipelining for Hardware Implementation of Fast H.264 Intraprediction Targeting Mobile HD Applications
Jin-Su Jung,Genhua Jin,Hyuk-Jae Lee
EURASIP Journal on Advances in Signal Processing , 2008, DOI: 10.1155/2008/542735
Abstract: H.264/AVC adopts aggressive compression algorithms at the cost of increased computational complexity. To speed up the H.264/AVC intraframe coding, this paper proposes two novel techniques: early termination and pipelined execution. In P slices, intra 4 —4 and 16 —16 predictions are early terminated with the threshold determined by the cost of motion estimation. In I slices, intra 4 —4 prediction is early terminated with the threshold derived from intra 16 —16 prediction. The threshold function is chosen as a monotonically decreasing linear function with its optimal coefficients determined by experiments. For the pipelined execution of 4 —4 intrapredictions, the processing order of 4 —4 blocks is changed to reduce the dependencies between consecutively processed blocks. In I slices, computation for 4 —4 intraprediction is reduced by 19 percent with the proposed early termination. In P slices, computations for 4 —4 and 16 —16 intrapredictions are reduced by more than 81 and 91 percents, respectively. The pipelined execution reduces the computation time by 41 percent. In spite of the speed-up by the proposed methods, degradation in rate-distortion performance is negligible. The proposed pipelined execution is integrated with other H.264/AVC hardware accelerators and fabricated as an SoC using Dongbu 0.13 ¢ € ‰ m technology.
Alcohol consumption and carotid artery structure in Korean adults aged 50 years and older
Young-Hoon Lee, Min-Ho Shin, Sun-Seog Kweon, Sung-Woo Choi, Hye-Yeon Kim, So-Yeon Ryu, Bok-Hee Kim, Jung-Ae Rhee, Jin-Su Choi
BMC Public Health , 2009, DOI: 10.1186/1471-2458-9-358
Abstract: The study population consisted of 4302 community-dwelling Koreans (1577 men and 2725 women) aged 50 years and over. All the subjects had participated in the baseline survey of the Dong-gu Study conducted between 2007 and 2008. Daily alcohol consumption was determined by the number and frequency of alcoholic beverages consumed. We measured common carotid artery intima-media thickness (CCA-IMT), common carotid and bulb IMT (CB-IMT), carotid plaques, and the diameter of the common carotid artery (CCA-diameter) using high-resolution B-mode ultrasonography. We used analysis of covariance and multiple logistic regressions to determine the relationship between alcohol consumption and carotid artery parameters.CCA-IMT and CB-IMT were negatively correlated with alcohol consumption after controlling for cardiovascular risk factors in men (p for linear trend = 0.009 and = 0.038, respectively). The multivariate-adjusted odds ratio (OR) for carotid plaques was significantly higher in men who consumed >40.0 g/d (OR = 1.81, 95% CI = 1.13-2.91), although a significant positive correlation was observed between alcohol consumption and carotid plaques (p for linear trend = 0.027). Neither carotid IMT nor carotid plaques were correlated with alcohol intake in women. Alcohol intake was positively correlated with CCA-diameter adjusted for carotid IMT and plaques in the multivariate-adjusted model in both sexes (p for linear trend <0.001 for men and 0.020 for women).The results of our study indicate that alcohol consumption is inversely related to carotid IMT and positively related to carotid plaques in men, but not women. However, alcohol intake is positively associated with CCA-diameter in both men and women. Additional large population-based prospective studies are needed to confirm the effects of alcohol consumption on carotid artery structure.Cumulative epidemiologic evidence indicates a J-shaped or a U-shaped association between alcohol consumption and cardiovascular disease morbidi
Cumulative smoking exposure, duration of smoking cessation, and peripheral arterial disease in middle-aged and older Korean men
Young-Hoon Lee, Min-Ho Shin, Sun-Seog Kweon, Jin-Su Choi, Jung-Ae Rhee, Hye-Ran Ahn, Woo-Jun Yun, So-Yeon Ryu, Bok-Hee Kim, Hae-Sung Nam, Seul-Ki Jeong, Kyeong-Soo Park
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-94
Abstract: The study population consisted of 2517 community-dwelling Korean men aged 50 years and older. Information on smoking characteristics such as smoking status, pack-years of smoking, and years since quitting smoking was collected using a standardized questionnaire. PAD was defined as an ankle-brachial index (ABI) less than 0.90 in either leg.The odds ratio (OR, 95% confidence interval) of PAD was 2.31 (1.20-4.42) for former smokers and 4.30 (2.13-8.66) for current smokers, after adjusting for other cardiovascular risk factors. There was a significant dose-response relationship between pack-years of smoking and PAD. Compared with those who had never smoked, the multivariate-adjusted ORs of PAD for smokers of 0.1-20.0, 20.1-40.0, and >40.0 pack-years were 2.15 (1.06-4.38), 2.24 (1.08-4.65), and 2.93 (1.41-6.09), respectively. There was a significant decrease in PAD risk as the years since quitting smoking increased. The multivariate-adjusted ORs of PAD for 11-20 and ≥21 years smoking cessation were 0.41 (0.19-0.86) and 0.49 (0.24-0.98), compared with current smokers.Cumulative smoking exposure and duration of smoking cessation were significantly associated with PAD in middle aged and older Korean men.Peripheral arterial disease (PAD), one of the major manifestations of generalized atherosclerotic disease, results from a narrowing of arteries in the lower extremities, as a result of progressive atherosclerosis [1]. Although PAD is a marker of coronary and cerebral atherosclerotic vascular disease, PAD is a commonly overlooked condition in primary care settings, because most patients are asymptomatic. However, people with PAD, even if asymptomatic, have an increased risk of future cardiovascular events and related mortality [2-4]. The ankle-brachial index (ABI), the ratio of systolic blood pressure in the ankle to that in the arm, is a simple, reproducible, and non-invasive test to diagnose PAD and has been used to diagnose and evaluate the severity of PAD in the lower ext
PARP-1 Val762Ala polymorphism is associated with reduced risk of non-Hodgkin lymphoma in Korean males
Xue Jin, Hee Kim, Il-Kwon Lee, Kyeong-Soo Park, Hyeoung-Joon Kim, Jin-Su Choi, Sang Juhng, Chan Choi
BMC Medical Genetics , 2010, DOI: 10.1186/1471-2350-11-38
Abstract: Subjects from a Korean population consisting of 573 NHL patients and 721 controls were genotyped for 5 PARP-1 polymorphisms (Asp81Asp, Ala284Ala, Lys352Lys, IVS13+118A>G, and Val762Ala) using High Resolution Melting polymerase chain reaction (PCR) and an automatic sequencer.None of the 5 polymorphisms were associated with overall risk for NHL. However, the Val762Ala polymorphism was associated with reduced risk for NHL in males [odds ratio (OR), 0.62; 95% confidence interval (CI), 0.41-0.93 for CC genotype and OR, 0.84; 95% CI, 0.60-1.16 for TC genotype] with a trend toward a gene dose effect (p for trend, 0.02). The Asp81Asp (p for trend, 0.04) and Lys352Lys (p for trend, 0.03) polymorphisms revealed the same trend. In an association study of PARP-1 haplotypes, the haplotype-ACAAC was associated with decreased risk of NHL in males (OR, 0.75; 95% CI, 0.59-0.94).The present data suggest that Val762Ala, Asp81Asp, and Lys352Lys polymorphisms and the haplotype-ACAAC in PARP-1 are associated with reduced risk of NHL in Korean males.Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy worldwide. It represents 4% of cancers, and is the fifth commonly diagnosed cancer in the United States [1]. Its rates are over 10/100,000 in the United States, Australia, and Western Europe, while less than 5/100,000 in Southern and Eastern Asia [2].PARP-1 is a nuclear enzyme that catalyzes the poly(ADP-ribosyl)ation of target proteins in response to DNA damage; it is involved in DNA repair, cell death, proliferation, genome integrity, and modulation of gene transcription [3,4]. PARP-1 is involved in base excision reaction, which repairs DNA damage induced by chemical alterations, reactive oxidative species, and ionizing radiation. In addition, PARP-1 activation mediates apoptosis through the induction of translocation of apoptosis-inducing factor from the mitochondria to the nucleus [5].The effect of PARP-1 on carcinogenesis is still unclear and controversial. PARP-1 activa
Reddish Orange Long-Lasting Phosphorescence in KY3F10:Sm3+ for X-Ray or Cathode Ray Tubes

ZHANG Jin-Su,ZHONG Hai-Yang,SUN Jia-Shi,CHENG Li-Hong,LI Xiang-Ping,CHEN Bao-Jiu,

中国物理快报 , 2012,
Higher normal ranges of urine albumin-to-creatinine ratio are independently associated with carotid intima-media thickness
Sun-Seog Kweon, Min-Ho Shin, Young-Hoon Lee, Jin-Su Choi, Hae-Sung Nam, Kyeong-Soo Park, Do-Hyung Kim, Seul-Ki Jeong
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-112
Abstract: We performed a cross-sectional study in adults aged 45 to 74 years who were living in Namwon City, South Korea. Both common CIMTs were measured, and mean values were calculated. Normal values of UACR were defined as <30mg/g and categorized into quintiles; less than 6.50, 6.51-9.79, 9.80-13.49, 13.50-18.89, and more than 18.90 mg/g. The association between the quintiles of UACR and common CIMT was analyzed and stratified by sex.A total of 7555 participants (3084 men and 4471 women) with normal UACR were enrolled in the present study. Common CIMT was positively and independently associated with increasing quintiles of UACR in men and women, even after adjusting for potential confounders including age and cardiovascular risk factors. Compared to the first quintile, the fifth quintile showed odds ratios of 1.80 (95% confidence intervals, 1.26-2.55) and 1.97 (1.28-3.04) for increased CIMT (>0.9mm) in men and women, respectively.Higher UACR values within normal ranges (<30 mg/g) were positively and independently associated with CIMT in a Korean general population, suggesting that higher normal values of UACR might be a risk marker of subclinical carotid atherosclerosis.Atherosclerosis and its associated vascular effects including cardiovascular disease (CVD), stroke, peripheral arterial disease, and end-stage renal disease has become a leading cause of disability and mortality in both developed and developing countries [1]. For an effective prevention of vascular diseases, it would be reasonable to discuss the limitations of conventional risk equations due to the increase in obesity, metabolic syndrome, and type 2 diabetes. And it needs to be developed for biomarkers that are relevant to the risk in those individuals [2].Elevations in albumin excretion are indicative of glomerular injury mainly due to type 2 diabetes or hypertension [3]. Rather than using 24-hr urine collections, spot urine tests can determine urinary albumin-to-creatinine ratios (UACR), making it easier
hESC Expansion and Stemness Are Independent of Connexin Forty-Three-Mediated Intercellular Communication between hESCs and hASC Feeder Cells
Jin-Su Kim, Daekee Kwon, Seung-Taeh Hwang, Dong Ryul Lee, Sung Han Shim, Hee-Chun Kim, Hansoo Park, Won Kim, Myung-Kwan Han, Soo-Hong Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069175
Abstract: Background Human embryonic stem cells (hESCs) are a promising and powerful source of cells for applications in regenerative medicine, tissue engineering, cell-based therapies, and drug discovery. Many researchers have employed conventional culture techniques using feeder cells to expand hESCs in significant numbers, although feeder-free culture techniques have recently been developed. In regard to stem cell expansion, gap junctional intercellular communication (GJIC) is thought to play an important role in hESC survival and differentiation. Indeed, it has been reported that hESC-hESC communication through connexin 43 (Cx43, one of the major gap junctional proteins) is crucial for the maintenance of hESC stemness during expansion. However, the role of GJIC between hESCs and feeder cells is unclear and has not yet been reported. Methodology/Principal Findings This study therefore examined whether a direct Cx43-mediated interaction between hESCs and human adipose-derived stem cells (hASCs) influences the maintenance of hESC stemness. Over 10 passages, hESCs cultured on a layer of Cx43-downregulated hASC feeder cells showed normal morphology, proliferation (colony growth), and stemness, as assessed by alkaline phosphatase (AP), OCT4 (POU5F1-Human gene Nomenclature Database), SOX2, and NANOG expression. Conclusions/Significance These results demonstrate that Cx43-mediated GJIC between hESCs and hASC feeder cells is not an important factor for the conservation of hESC stemness and expansion.
Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population
Lian-Hua Cui, Min-Ho Shin, Sun-Seog Kweon, Hee Kim, Hye-Rim Song, Jin-Mei Piao, Jin-Su Choi, Hyun Shim, Jun Hwang, Hyeong-Rok Kim, Young-Kyu Park, Soo-Hyun Kim
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-236
Abstract: We conducted a population-based large-scale case-control study involving 2,213 patients with newly diagnosed gastric cancer, 1,829 patients with newly diagnosed colorectal cancer, and 1,700 healthy controls. Genotyping was performed with peripheral blood DNA for MTHFR C677T polymorphisms. The statistical significance was estimated by logistic regression analysis.The MTHFR C677T frequencies of CC, CT, and TT genotypes were 35.2%, 47.5%, and 17.3% among stomach cancer, 34%, 50.5%, and 15.5% in colorectal cancer, and 31.8%, 50.7%, and 17.5% in the controls, respectively. The MTHFR 677TT genotype showed a weak opposite association with colorectal cancer compared to the homozygous CC genotype [adjusted age and sex odds ratio (OR) = 0.792, 95% confidence interval (CI) = 0.638-0.984, P = 0.035]. Subjects with the MTHFR 677CT showed a significantly reduced risk of gastric cancer compared whose with the 677CC genotype (age- and sex-adjusted OR = 0.810; 95% CI = 0.696-0.942, P = 0.006). We also observed no significant interactions between the MTHFR C677T polymorphism and smoking or drinking in the risk of gastric and colorectal cancer.The T allele was found to provide a weak protective association with gastric cancer and colorectal cancer.Although gastric cancer incidence and mortality have been decreasing around the world, it is still the most common cause of cancer death in Korea for both sexes [1]. Colorectal cancer is very common and has increased rapidly along with the westernization of lifestyle in Korea. Although Helicobacter pylori (H. pylori) strains have been proposed to be a major cause of gastric cancer, they do not provide a complete explanation. Epidemio- logical studies have indicated an association between folate intake and a reduced risk of certain cancers [2-5], including gastric cancer [4] and colorectal cancer [3]. Folate deficiencies may result in abnormal DNA methylation and uncontrolled gene expression leading to malignant transformation [6,7].Methylene
Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population
Lian-Hua Cui, Min-Ho Shin, Hee Kim, Hye-Rim Song, Jin-Mei Piao, Sun-Seog Kweon, Jin-Su Choi, Woo-Jun Yun, Young-Chul Kim, In-Jae Oh, Kyu-Sik Kim
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-28
Abstract: We conducted a large-scale, case-control study involving 3938 patients with newly diagnosed lung cancer and 1700 healthy controls. Genotyping was performed with peripheral blood DNA for MTHFR C677T polymorphisms. Statistical significance was estimated by logistic regression analysis.The MTHFR C677T frequencies of CC, CT, and TT genotypes were 34.5%, 48.5%, and 17% among lung cancer patients, and 31.8%, 50.7%, and 17.5% in the controls, respectively. The MTHFR 677CT and TT genotype showed a weak protection against lung cancer compared with the homozygous CC genotype, although the results did not reach statistical significance. The age- and gender-adjusted odds ratio (OR) of overall lung cancer was 0.90 (95% confidence interval (CI), 0.77-1.04) for MTHFR 677 CT and 0.88 (95% CI, 0.71-1.07) for MTHFR 677TT. However, after stratification analysis by histological type, the MTHFR 677CT genotype showed a significantly decreased risk for squamous cell carcinoma (age- and gender-adjusted OR, 0.78; 95% CI, 0.64-0.96). The combination of 677 TT homozygous with 677 CT heterozygous also appeared to have a protection effect on the risk of squamous cell carcinoma. We observed no significant interaction between the MTHFR C677T polymorphism and age and gender or smoking habit.This is the first reported study focusing on the association between MTHFR C677T polymorphisms and the risk of lung cancer in a Korean population. The T allele was found to provide a weak protective association with lung squamous cell carcinoma.Lung cancer is the leading cause of cancer-related death worldwide. The incidence and mortality of lung cancer have been significantly and constantly increasing over the past two decades in Korea [1-3]. According to the Korean National Cancer Registry, the age-standardized incidence rate for lung cancer of Korean population was 47.5/100,000 for men and 13.3/100,000 for women in 2007 [2], it has become the second most common malignant tumor following gastric cancer. The r
Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population
Jin-Mei Piao, Min-Ho Shin, Sun-Seog Kweon, Hee Nam Kim, Jin-Su Choi, Woo-Kyun Bae, Hyun-Jeong Shim, Hyeong-Rok Kim, Young-Kyu Park, Yoo-Duk Choi, Soo-Hyun Kim
World Journal of Gastroenterology , 2009,
Abstract: AIM: To evaluate the association of glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) null genotypes with the risk of gastric cancer (GC) and colorectal cancer (CRC) in a South Korean population.METHODS: We conducted a population-based, large-scale case-control study including 2213 GCs, 1829 CRCs, and 1699 controls. Null and non-null genotypes of GSTM1 and GSTT1 were determined using real-time PCR.RESULTS: The null genotypes of GSTM1 and GSTT1 were not significantly associated with elevated risk of gastric (OR = 1.070, 95% CI = 0.935-1.224; OR = 1.101, 95% CI = 0.963-1.259, respectively) or colorectal cancer (OR = 1.065, 95% CI = 0.923-1.228; OR = 1.041, 95% CI = 0.903-1.200, respectively). The frequency of the combined null GST genotype was not different between the two cancer groups and controls. Moreover, smoking, drinking, and age did not modify the association between these genotypes and the risk of gastric or colorectal cancer.CONCLUSION: GSTM1 and GSTT1 null genotypes were not associated with increased risk of GC or CRC in Koreans.
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