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Search Results: 1 - 10 of 79994 matches for " Jin Yan-Ping "
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A consistency contribution based bayesian network model for medical diagnosis  [PDF]
Yan-Ping Yang
Journal of Biomedical Science and Engineering (JBiSE) , 2010, DOI: 10.4236/jbise.2010.35068
Abstract: This paper presents an effective Bayesian network model for medical diagnosis. The proposed approach consists of two stages. In the first stage, a novel feature selection algorithm with consideration of feature interaction is used to get an undirected network to construct the skeleton of BN as small as possible. In the second stage for greedy search, several methods are integrated together to enhance searching performance by either pruning search space or overcoming the optima of search algorithm. In the experiments, six disease datasets from UCI machine learning database were chosen and six off-the-shelf classification algorithms were used for comparison. The result showed that the proposed approach has better classification accuracy and AUC. The proposed method was also applied in a real world case for hypertension prediction. And it presented good capability of finding high risk factors for hypertension, which is useful for the prevention and treatment of hypertension. Compared with other methods, the proposed method has the better performance.
Allopolyploid speciation and ongoing backcrossing between diploid progenitor and tetraploid progeny lineages in the Achillea millefolium species complex: analyses of single-copy nuclear genes and genomic AFLP
Jin-Xiu Ma, Yan-Nan Li, Claus Vogl, Friedrich Ehrendorfer, Yan-Ping Guo
BMC Evolutionary Biology , 2010, DOI: 10.1186/1471-2148-10-100
Abstract: In both the ncpGS and the PgiC gene tree, haplotype sequences of the diploid A. setacea-2x and A. asplenifolia-2x group into two clades corresponding to the two species, though lineage sorting seems incomplete for the PgiC gene. In contrast, A. collina-4x and its suspected backcross plants show homeologous gene copies: sequences from the same tetraploid individual plant are placed in both diploid clades. Semi-congruent splits of an AFLP Neighbor Net link not only A. collina-4x to both diploid species, but some 4x individuals in a polymorphic population with mixed ploidy levels to A. setacea-2x on one hand and to A. collina-4x on the other, indicating allopolyploid speciation as well as hybridization across ploidal levels.The findings of this study clearly demonstrate the hybrid origin of Achillea collina-4x, the ongoing backcrossing between the diploid progenitor and their tetraploid progeny lineages. Such repeated hybridizations are likely the cause of the great genetic and phenotypic variation and ecological differentiation of the polyploid taxa in Achillea millefolium agg.According to the genealogical species concept, species are defined as multi-locus "genotypic clusters" that remain distinct even in the presence of gene flow among each other [1-3]. "Hybridization is thus a normal feature of species biology" [1]. Hybridization and its results, e.g., introgression, segregation of new types without backcrossing, and allopolyploidy, have long been speculated as major forces behind "evolutionary bursts" [4]. Indeed, plant species and populations arisen from hybridization and polyploidy often exhibit more complicated patterns of variation than their progenitors, i.e., their diploid sister groups, and are ecologically divergent, presumably under local selection. Furthermore, when gene flow is present between the diverged progenies or between the parental and daughter lineages, the genetic and phenotypic complexity of the populations could be enhanced. All these proces
Correlation between polymorphism of ACE gene I/D and ACE2 gene A9570G and atrial fibrillation
Ya-zhu WANG,Ying LI,Jin-qi FAN,Yan-ping XU
Medical Journal of Chinese People's Liberation Army , 2011,
Abstract: Objective To investigate the correlation between the polymorphism of angiotensin converting enzyme(ACE) gene I/D and angiotensin converting enzyme 2(ACE2) gene A9570G and atrial fibrillation.Methods In chronological order of hospitalization,305 patients were selected and divided into two groups: atrial fibrillation group(148 cases) and control group(157cases without atrial fibrillation).The control group was matched with the atrial fibrillation group in terms of age,gender,and presence of left ventricular dysfunction,coronary heart disease,diabetes,and primary hypertension.The polymorphisms of the ACE gene I/D and ACE2 gene A9570G were genotyped with polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) and gene sequencing approach.Results There were no statistical differences between the atrial fibrillation group and the control group in genotype distribution and allele frequencies of the ACE gene I/D(P=0.841;OR=0.948,95% CI 0.680-1.322,P=0.755).Moreover,there was no significant difference among the different genotypes of ACE gene I/D in the left and right atrial dimensions(P=0.887 and P=0.664,respectively).In the male subgroup,there was no statistical difference in the ACE2 gene A9570G polymorphism between the two groups(OR=1.631,95% CI 0.880-3.023,P=0.119).However,in the subgroup of males with atrial fibrillation,the left and right atrial dimensions of subjects with G genotype(40.1±6.4 and 40.1±5.7mm,respectively) were larger than those with A genotype(37.0±4.4 and 36.5±4.4mm,respectively),indicating a statistical difference(P=0.028,P=0.010).In the female subgroup,there were no statistical differences between the atrial fibrillation group and the control group in the genotype distribution and allele frequencies of the ACE2 gene A9570G polymorphism(P=0.286;OR=1.415,95% CI 0.885-2.264,P=0.146).In the subgroup of females with atrial fibrillation,no significant difference was found in the left or right atrial dimension among the different genotypes of ACE2 gene A9570G polymorphism(P=0.924 and P=0.432,respectively).Conclusions No significant correlation exists between the genotype distribution and allele frequencies of ACE gene I/D and ACE2 gene A9570G polymorphism and atrial fibrillation.However,in males with atrial fibrillation,the G genotype in the ACE2 gene A9570G polymorphism may be a risk factor for the prediction of atrial enlargement.
Sequence analysis of four caprine mitochondria DNA lineages
Yan-Ping Wu,Jun-Hong Huo,Wei-Jun Guan,Jin-Fang Xie
Italian Journal of Animal Science , 2012, DOI: 10.4081/ijas.2012.e69
Abstract: The complete mitochondrial DNA (mtDNA) (16640bp in length) was sequenced from four Chinese goat lineages representing the four major mtDNA haplogroups in goats. A total of 124 single nucleotide polymorphisms (SNPs) were found in encoding regions, and the overall ratio of transitions:transversions was 40:1 revealing a heavy transition/transversion rate in domestic goats. Eighteen non-synonymous sites were found for the total number of SNPs; the sites did not affect the predicted functions of protein for these four goat mtDNA lineages. In the region for coding tRNA and rRNA, SNPs occurred in loops, unstructured single strand and stems that were conformed with the principle of G-U pairing. We came to the conclusion that these substitutions could not change secondary structure of RNAs, and there was no positive selection on goat mitochondrial coding region according to the result of dN/dS (0.0399-0.1529) by comparing the goat with other reported mitochondrial genomes.
Congruences on the Number of Restricted $m$-ary Partitions
Qing-Hu Hou,Hai-Tao Jin,Yan-Ping Mu,Li Zhang
Mathematics , 2015,
Abstract: Andrews, Brietzke, R\o dseth and Sellers proved an infinite family of congruences on the number of the restricted $m$-ary partitions when $m$ is a prime. In this note, we show that these congruences hold for arbitrary positive integer $m$ and thus confirm the conjecture of Andrews, et al.
Effect of main inclusions on crack initiation in bearing steel in the very high cycle fatigue regime
Chao Gu,Yan-ping Bao,Peng Gan,Min Wang,Jin-shan He
- , 2018, DOI: https://doi.org/10.1007/s12613-018-1609-4
Abstract: This work aims to investigate the effect of main inclusions on crack initiation in bearing steel in the very high cycle fatigue (VHCF) regime. The size and type of inclusions in the steel were quantitatively analyzed, and VHCF tests were performed. Some fatigue cracks were found to be initiated in the gaps between inclusions (Al2O3, MgO-Al2O3) and the matrix, while other cracks originated from the interior of inclusions (TiN, MnS). To explain the related mechanism, the tessellated stresses between inclusions and the matrix were calculated and compared with the yield stress of the matrix. Results revealed that the inclusions could be classified into two types under VHCF; of these two, only one type could be regarded as holes. Findings in this research provide a better understanding of how inclusions affect the high cycle fatigue properties of bearing steel.
Multiple Partial Attacks on Complex Networks
YIN Yan-Ping,ZHANG Duan-Ming,TAN Jin,PAN Gui-Jun,HE Min-Hua,

中国物理快报 , 2008,
Abstract: We numerically investigate the effect of four kinds of partial attacks of multiple targets on the Barabasi--Albert (BA) scale-free network and the Erdos--Renyi (ER) random network. Comparing with the effect of single target complete knockout we find that partial attacks of multiple targets may produce an effect higher than the complete knockout of a single target on both BA scale-free network and ER random network. We also find that the BA scale-free networkseems to be more susceptible to multi-target partial attacks than the ER random network.
Effect of long-term service on the precipitates in P92 steel
Yan-ping Zeng,Jin-dou Jia,Wen-he Cai,Shu-qing Dong,Zhi-chun Wang
- , 2018, DOI: https://doi.org/10.1007/s12613-018-1640-5
Abstract: The precipitates in P92 steel after long-term service in an ultra-supercritical unit were investigated by field-emission scanning electron microscopy and transmission electron microscopy and were found to mainly consist of M23C6 carbides, Laves phase, and MX carbonitrides. No Z-phase was observed. M23C6 carbides and Laves phase were found not only on prior austenite grain boundaries, martensite lath boundaries, and subgrain boundaries but also in lath interiors, where two types of MX carbonitrides—Nb-rich and V-rich particles— were also observed but the “winged” complexes were hardly found. Each kind of precipitate within the martensite laths exhibited multifarious morphologies, suggesting that a morphological change of precipitates occurred during long-term service. The M23C6 carbides and Laves phase coarsened substantially, and the latter grew faster than the former. However, MX carbonitrides exhibited a relatively low coarsening rate. The effect of the evolution of the precipitate phases on the creep rupture strength of P92 steel was discussed.
ABL-N-induced apoptosis in human breast cancer cells is partially mediated by c-Jun NH2-terminal kinase activation
Bin Liu, Mei Han, Rong-Hua Sun, Jun-Jie Wang, Yan-Ping Zhang, Di-Qun Zhang, Jin-Kun Wen
Breast Cancer Research , 2010, DOI: 10.1186/bcr2475
Abstract: We investigated the effects of ABL-N on the induction of apoptosis in human breast cancer cells and further examined the underlying mechanisms. Moreover, tumor growth inhibition of ABL-N was done in xenograft models.ABL-N induced the activation of caspase-3 in estrogen receptor (ER)-negative cell lines MDA-MB-231 and MDA-MB-468, as evidenced by the cleavage of endogenous substrate Poly (ADP-ribose) polymerase (PARP). Pretreatment of cells with pan-caspase inhibitor z-VAD-fmk or caspase-3-specific inhibitor z-DEVD-fmk inhibited ABL-N-induced apoptosis. ABL-N treatment also resulted in an increase in the expression of pro-apoptotic members (Bax and Bad) with a concomitant decrease in Bcl-2. Furthermore, c-Jun-NH2-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase (p38) were activated in the apoptosis induced by ABL-N and JNK-specific inhibitor SP600125 and JNK small interfering RNA (siRNA) antagonized ABL-N-mediated apoptosis. However, the p38-specific inhibitor SB203580 had no effect upon these processes. Moreover, neither of the caspase inhibitors prevented ABL-N-induced JNK activation, indicating that JNK is upstream of caspases in ABL-N-initiated apoptosis. Additionally, in a nude mice xenograft experiment, ABL-N significantly inhibited the tumor growth of MDA-MB-231 cells.ABL-N induces apoptosis in breast cancer cells through the activation of caspases and JNK signaling pathways. Moreover, ABL-N treatment causes a significant inhibition of tumor growth in vivo. Therefore, it is thought that ABL-N might be a potential drug for use in breast cancer prevention and intervention.Breast cancer is one of the most common cancers among women in both developed and underdeveloped countries. It is the malignancy with the highest incidence and death rate for women [1,2]. However, the efficacy of the present drugs is very limited, and it is urgent to find the anticancer compounds that can target multiple points in the apoptotic cascade to achieve synergistic
The Alloying of Ti, C, N in Bulk α -Fe and Their Effects on Bond Characters
Ti, C, N在α-Fe基中的合金化效应及对键合性质的影响

Xue Jin-Xiang,Zhang Ri-Guang,Liu Yan-Ping,Wang Bao-Jun,

物理学报 , 2012,
Abstract: The electronic structures and the bond characters of bulk α -Fe with Ti, C, N additions are studied using the first-principls pseudopotential plane-wave method. The total energy and the cohesive energy are calculated, and the Mulliken population, the overlap population, the density of states and the charge density are also analyzed, which can give a microscopic reason why the mechanical property is improved after the infiltration of Ti, C, N into bulk Fe. The calculated results show that with the alloying element Ti(0-12.5 at%), C(0-11.11 at%), N(0-11.11 at%) contents increasing, the cohesive energy of alloy increases slowly and the structure keeps stable. The additions of Ti, C, N into the alloy enhance the reciprocal hybridization in Fermi energy level, and the binding abilities of Ti, C, N, Fe become stronger. The pseudo-gap near the Fermi energy level means the coexistence of covalent and metallic bonds in alloy. With the contents of alloying elements increasing, the covalent bondings between C, N and Ti, Fe become stronger, and part of C and N atoms will be bound to Ti atoms and form TiC and TiN particles, thereby strengthening the dispersion.
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