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Search Results: 1 - 10 of 31413 matches for " Jin Boon Wong "
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Matching the 'Knowing what to do' and the 'Doing what you Know' in Ethical Decision-making
Chang-Yuan Loh,Jin Boon Wong
Australasian Accounting Business and Finance Journal , 2009,
Abstract: Corporate events in the past decades have contributed to a continued interest in the ethicaldecision-making of individuals in accounting. Much of the research in ethics and educationhave relied on the assumption that the individual’s level of ethical development is related tohis/her ethical behavior. Adapting a simplified version of Thorne’s (2000)prescriptive/deliberative reasoning in a cheat-to-gain business scenario, a survey of accountingstudents suggest that ethical development may not be related to behavior. In addition,consistent with Thorne (2001), results suggest that even if individuals may ‘know what to do’for the ideal ethical decision, they may not always actually choose that path or ‘doing whatthey know’.
Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy
Yvonne Hui-Fang Teng, Wai-Jin Tan, Aye-Aye Thike, Poh-Yian Cheok, Gary Man-Kit Tse, Nan-Soon Wong, George Wai-Cheong Yip, Boon-Huat Bay, Puay-Hoon Tan
Breast Cancer Research , 2011, DOI: 10.1186/bcr2857
Abstract: Seventy samples were randomly chosen from a cohort of 653 triple negative breast tumours for EGFR mutation analysis. These samples were immunostained for EGFR protein expression and consisted of negatively stained and positively stained cases. DNA was extracted from paraffin blocks and polymerase chain reaction was performed to amplify exon regions 18 to 21 of the EGFR gene. Direct sequencing of the purified PCR products was performed.EGFR mutations were found in 8 of 70 samples (11.4%). Mutations were predominantly exon 19 deletions (4 of 70 samples, 5.7%), which clustered in the region spanning codons 746 to 759 within the kinase domain of EGFR. Two types of exon 19 deletions were seen: a 15 nucleotide deletion (del E746-A750) (2 of 70 samples) and a 24 nucleotide deletion (del S752 - I759) (2 of 70 samples). Other exon 19 mutations observed were the inversion of the complementary strand (1 of 70 samples). Exon 21 mutations included missense substitution, L858R (1 of 70 samples) and T847I (2 of 70 samples). Mutations observed were independent of EGFR protein expression determined by immunohistochemical staining.This study is among the first to document the presence and estimate the prevalence of EGFR mutations in triple negative breast cancer. These findings have potential implications for the design of clinical trials involving anti-EGFR directed therapy which currently do not select for patients based on presence of activating EGFR mutations, which may hence be underpowered to detect significant benefit in unselected populations. More complete sampling of EGFR mutation status in triple negative breast cancer is needed to determine the true mutation rate.Triple negative breast cancers, defined by the lack of estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor 2 (Her2/cerbB2/EGFR2) expression, account for 10 to 20% of all breast carcinomas in Asian and Western populations [1-7], but occur at much higher frequencies in individual
Boon-Wee Low,Boon-Yaik Ooi,and Chee-Siang Wong
International Journal of New Computer Architectures and their Applications , 2011,
Abstract: The advancement of database engine and multi-core processors technologies have enable database insertion to be implemented concurrently via multithreading programming. The objective of this work is to evaluate the performance of using multithreading technique to perform database insertion of large data set with known size to enhance the performance of data access layer (DAL) particularly on the bulk-insertion operation. The performance evaluation includes techniques such as using single database connection, multithreads the insertion process with respective database connections, single threaded bulk insertion and multithreaded bulk insertion. MySQL 5.2 and SQL Server 2008 were used and the experimental results show that the performance of databases do not scale linearly with the number of threads. This work justifies our intention in developing a smart data access layer that autonomously decides the number of threads to spawn in order to improve the performance of the DAL.
Evaluation of the Frails' Fall Efficacy by Comparing Treatments (EFFECT) on reducing fall and fear of fall in moderately frail older adults: study protocol for a randomised control trial
Boon Kwok, Kaysar Mamun, Manju Chandran, Chek Wong
Trials , 2011, DOI: 10.1186/1745-6215-12-155
Abstract: This randomised active-control trial is a comparison between the Nintendo WiiActive programme against standard gym-based rehabilitation of the older population. Eighty subjects aged above 60, fallers and non-fallers, will be recruited from the hospital outpatient clinic. The primary outcome measure is the Modified Falls Efficacy Scale and the secondary outcome measures are self-reported falls, quadriceps strength, walking agility, dynamic balance and quality of life assessments.The study is the first randomised control trial using the Nintendo Wii as a rehabilitation modality investigating a change in fall efficacy and self-reported falls. Longitudinally, the study will investigate if the interventions can successfully reduce falls and analyse the cost-effectiveness of the programme.Australia and New Zealand Clinical Trials Register (ANZCTR): ACTRN12610000576022In Singapore, there is an increasing growth of older adults (300,000) and the prevalence of falls is high with a reported incidence of 129000 per year by the Singapore Ministry of Health in 2007. The common consequences of these falls are fractures and soft tissues injuries that may lead to significant disability [1]. Fractures managed in an acute care setting contribute to rising healthcare cost [2-5]. In addition minor trauma and soft tissue injuries lead to activity avoidance and embeds the fear of further falling psychologically [6].A previous experience of fall may subsequently cause fear in the older person who will then self-restrict mobility or will depend on others for activities of daily living (ADLs) [7]. Fear of falling significantly contributes to functional decline [7] and the health and well-being of the older person [8-10]. In order to quantify the fear of fall, fall efficacy scales have been developed to assess the perceived confidence of the older population [11-13].Contribution to frailty is a history of sedentary lifestyle in the older population which results in strength and balance impai
Fed-batch Fermentation of Lactic Acid Bacteria to Improve Biomass Production: A Theoretical Approach
Boon Beng Lee,Heng Jin Tham,Eng Seng Chan
Journal of Applied Sciences , 2007,
Abstract: Recently, fed-batch fermentation has been introduced in an increasing number of fermentation processes. Previous researches showed that fed-batch fermentation can increase the biomass yield of many strains. Improvement of the biomass yield is interested because biomass from lactic acid bacteria (LAB) fermentation is widely used in food and pharmaceutical industry. The aim of this research is to study the ability and feasibility of fed-batch fermentation to improve biomass production of LAB. Appropriate model has been selected from literature. Monod equation described the substrate limitation of LAB and the product inhibition of LAB follows a non-competitive model. Furthermore, the lactic acid production follows Luedeking and Piret model. Then the models are applied to simulate the fermentation of batch and fed-batch cultures by using MATLAB. From the results of simulation, fed-batch fermentation showed that substrate limitation and substrate inhibition can be avoided. Besides that, the variable volume fed-batch fermentation also showed that product inhibition can be eliminated by diluting the product concentration with added fresh feed. However, it was found that fed-batch fermentation is not economically feasible because large amount of substrate is required to reduce the product inhibition effect. Therefore, fed-batch fermentation plays more importance role if the fermentation strain has high Ks value or low Kp value.
A Pilot Experiment with Reactor Neutrinos in Taiwan
Henry T. Wong,Jin Li
Physics , 1998, DOI: 10.1016/S0920-5632(99)00415-6
Abstract: A Collaboration comprising Taiwan and mainland Chinese scientists has been built up since 1996 to pursue a experimental program in neutrino and astro-particle physics in Taiwan. A pilot experiment to be performed at the Nuclear Power Station II in Taiwan is now under intense preparation. It will make use of a 600 kg CsI(Tl) crystal calorimeter to study various neutrino interactions. The feasibility of performing a long baseline reactor neutrino experiment will also be investigated. The conceptual design and the physics to be addressed by the pilot experiment are presented.
Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma
Weijie Poh, Winnie Wong, Huimin Ong, Myat Aung, Seng Lim, Boon Chua, Han Ho
Molecular Cancer , 2012, DOI: 10.1186/1476-4598-11-14
Abstract: Quantitative real-time PCR analysis identified frequent elevation of KLB gene expression in HCC tumors relative to matched non-tumor tissue, with a more than two-fold increase correlating with development of multiple tumors in patients. KLB-silencing in Huh7 cells decreased cell proliferation and suppressed FGFR4 downstream signaling. While transient repression of KLB-FGFR4 signaling decreased protein expression of alpha-fetoprotein (AFP), a HCC diagnostic marker, prolonged inhibition enriched for resistant HCC cells exhibiting increased liver stemness.Elevated KLB expression in HCC tissues provides further credence to the oncogenic role of increased FGFR4 signaling in HCC progression and represents a novel biomarker to identify additional patients amenable to anti-FGFR4 therapy. The restricted tissue expression profile of KLB, together with the anti-proliferative effect observed with KLB-silencing, also qualifies it as a specific and potent therapeutic target for HCC patients. The enrichment of a liver stem cell-like population in response to extended KLB-FGFR4 repression necessitates further investigation to target the development of drug resistance.With approximately 680,000 deaths in 2008, hepatocellular carcinoma (HCC) ranks third worldwide in cancer-related mortalities [1]. The majority of HCC patients present at advanced stages where curative surgical treatments are not applicable and face median survival of less than a year [2]. Moreover, traditional systemic chemotherapies have produced no significant survival benefit in advanced HCC patients [3]. Consequently, novel therapies for unresectable HCC are urgently needed to address this grim prognosis.Recently, there has been increasing interest in developing molecular-targeted therapies that can discriminate between cancer cells and their non-neoplastic counterparts by targeting proteins overexpressed in tumors. The approval of sorafenib, a multi-targeted tyrosine kinase inhibitor, for the treatment of advance
Novel antiviral activity of baicalein against dengue virus
Zandi Keivan,Teoh Boon-Teong,Sam Sing-Sin,Wong Pooi-Fong
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-214
Abstract: Background Dengue is a serious arboviral disease currently with no effective antiviral therapy or approved vaccine available. Therefore, finding the effective compound against dengue virus (DENV) replication is very important. Among the natural compounds, bioflavonoids derived mainly from plants are of interest because of their biological and medicinal benefits. Methods In the present study, antiviral activity of a bioflavonoid, baicalein, was evaluated against different stages of dengue virus type 2 (DENV-2) replication in Vero cells using focus forming unit reduction assay and quantitative RT-PCR. Results Baicalein inhibited DENV-2 replication in Vero cells with IC50= 6.46 μg/mL and SI= 17.8 when added after adsorption to the cells. The IC50 against DENV-2 was 5.39 μg/mL and SI= 21.3 when cells were treated 5 hours before virus infection and continuously up to 4 days post infection. Baicalein exhibited direct virucidal effect against DENV-2 with IC 50= 1.55 μg/mL and showed anti-adsorption effect with IC50 = 7.14 μg/mL. Conclusions Findings presented here suggest that baicalein exerts potent antiviral activity against DENV. Baicalein possesses direct virucidal activity against DENV besides its effects against dengue virus adsorption and intracellular replication of DENV-2. Baicalein, hence, should be considered for in vivo evaluation in the development of an effective antiviral compound against DENV.
Unexpected Volatility Shifts and Efficiency of Emerging Stock Market: The Case of Malaysia
Elgilani Eltahir Elshareif,Hui-Boon Tan,Mei-Foong Wong
Business Management Dynamics , 2012,
Abstract: This paper analyzed the behavior of Malaysian stock market during the intervals of high uncertainty. It highlighted the impact of unexpected volatility shifts on this small emerging Asian market, in terms of its efficiency and returns, during the past two decades. The purpose of this study was achieved through the Iterated-Cumulative-Sum-of-Squares-in-Volatility model (ICSS-EGARCH-M Model), which is one of the new approaches in market efficiency studies. The empirical results indicated the rejection of Efficient Market Hypothesis for the market when sudden volatility shifts were considered. The results also provided significant empirical evidences for positive risk-return relationship in the exchanges. In addition, the stock market was found to be more sensitive to global than local events. The asymmetrical responses to good and bad news were also part of the market behavior.
Resolving Conflicting Arguments under Uncertainties
Benson Hin Kwong Ng,Kam-Fai Wong,Boon-Toh Low
Computer Science , 2013,
Abstract: Distributed knowledge based applications in open domain rely on common sense information which is bound to be uncertain and incomplete. To draw the useful conclusions from ambiguous data, one must address uncertainties and conflicts incurred in a holistic view. No integrated frameworks are viable without an in-depth analysis of conflicts incurred by uncertainties. In this paper, we give such an analysis and based on the result, propose an integrated framework. Our framework extends definite argumentation theory to model uncertainty. It supports three views over conflicting and uncertain knowledge. Thus, knowledge engineers can draw different conclusions depending on the application context (i.e. view). We also give an illustrative example on strategical decision support to show the practical usefulness of our framework.
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