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Search Results: 1 - 10 of 24134 matches for " Jihong Jiang "
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The Cytoskeletal Protein RHAMM and ERK1/2 Activity Maintain the Pluripotency of Murine Embryonic Stem Cells
Jihong Jiang, Pooja Mohan, Christopher A. Maxwell
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073548
Abstract: Receptor for hyaluronan mediated motility (RHAMM, encoded by HMMR) may be a cell-surface receptor for hyaluronan that regulates embryonic stem cell pluripotency and differentiation, however, a precise mechanism for its action is not known. We examined murine embryonic stem cells with and without hemizygous genomic mutation of Hmmr/RHAMM, but we were not able to find RHAMM on the cell-surface. Rather, RHAMM localized to the microtubule cytoskeleton and along mitotic spindles. Genomic loss of Hmmr/RHAMM did not alter cell cycle progression but augmented differentiation and attenuated pluripotency in murine embryonic stem cells. Through a candidate screen of small-molecule kinase inhibitors, we identified ERK1/2 and aurora kinase A as barrier kinases whose inhibition was sufficient to rescue pluripotency in RHAMM+/- murine embryonic stem cells. Thus, RHAMM is not found on the cell-surface of embryonic stem cells, but it is required to maintain pluripotency and its dominant mechanism of action is through the modulation of signal transduction pathways at microtubules.
Bioinformatic prediction of selenoprotein genes in the dolphin genome
Hua Chen,Liang Jiang,JiaZuan Ni,Qiong Liu,JiHong Zhang
Chinese Science Bulletin , 2012, DOI: 10.1007/s11434-011-4970-5
Abstract: Selenium (Se), an essential trace element in vivo, is present mainly as selenocystein (Sec) in various selenoproteins. The Sec residue is translated from an in-frame TGA codon, which traditionally functions as a stop codon. Prediction of selenoprotein genes is difficult due to the lack of an effective method for distinguishing the dual function of the TGA codon in the open reading frame of a selenoprotein gene. In this article a eukaryotic bioinformatic prediction system that we have developed was used to predict selenoprotein genes from the genome of the common bottlenose dolphin, Tursiops truncatus. Sixteen selenoprotein genes were predicted, including selenoprotein P and glutathione peroxidase. In particular, a type II iodothyronine deiodinase was found to have two Sec residues, while the type I iodothyronine deiodinase gene has two alternative splice forms. These results provide important information for the investigation of the relationship between a variety of selenoproteins and the evolution of the marine-living dolphin.
Effects of insulin resistance and testosterone on the participation of cyclooxygenase isoforms in vascular reactivity
Harish Vasudevan, Sally Lau, Jihong Jiang, et al
Journal of Experimental Pharmacology , 2010, DOI: http://dx.doi.org/10.2147/JEP.S14989
Abstract: ts of insulin resistance and testosterone on the participation of cyclooxygenase isoforms in vascular reactivity Original Research (2291) Total Article Views Authors: Harish Vasudevan, Sally Lau, Jihong Jiang, et al Published Date December 2010 Volume 2010:2 Pages 169 - 179 DOI: http://dx.doi.org/10.2147/JEP.S14989 Harish Vasudevan1, Sally Lau1, Jihong Jiang2, John H McNeill1 1Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada; 2Pediatric Oncology, Children and Women's Hospital, Child and Family Research Institute, Vancouver, British Columbia, Canada Abstract: Testosterone plays an important role in mediating hypertension and altered vascular reactivity associated with insulin resistance. In addition to other pathways, testosterone-dependent changes in aortic cyclooxygenase (COX-2) mRNA levels affect blood pressure following insulin resistance. However their effects on vascular tone are unclear. We studied the changes in contraction response to phenylephrine (PE) in the aorta and superior mesenteric artery (SMA) from intact and gonadectomized fructose-fed rats. Constriction response to PE was studied in tissues incubated with the COX-1 and COX-2-selective antagonists, SC-560 and NS-398, respectively, and indomethacin, in addition to assessing its role in endothelium-dependent relaxation. Finally changes in COX-2 protein expression and plasma thromboxane A2 (TXA2), a downstream vasoconstrictor metabolite of COX-2, were measured. In fructose-fed rats, castration prevented the increase in blood pressure but not insulin resistance. The involvement of COX-2 in mediating the alpha-adrenergic vasoconstriction was higher in intact rat aorta compared to COX-1, which was prevented by castration. However, in the SMA, COX-2 participation was dependent on testosterone alone. Fructose-induced attenuation of endothelial relaxation was restored by indomethacin, which suggests a pro-vasoconstrictor role for COX. Both diet and testosterone did not alter vascular COX-2 expression thus suggesting the involvement of downstream testosterone-dependent pathways. This is supported by increased plasma TXA2 in the castrated rats compared to intact rats. Isoform-specific actions of COX are tissue-selective in states of insulin resistance and involve potential testosterone-dependent downstream targets. Further studies are needed to investigate the role of androgens and insulin resistance in vascular arachidonic acid metabolism.
Multifunctional Proteins Bridge Mitosis with Motility and Cancer with Inflammation and Arthritis
Jihong Jiang,Rosaely Casalegno-Garduno,Helen Chen,Anita Schmitt
The Scientific World Journal , 2010, DOI: 10.1100/tsw.2010.141
hsa-miR-125a-5p Enhances Invasion Ability in Non-Small Lung Carcinoma Cell Lines
Lili JIANG,Qingfu ZHANG,Jihong CHANG,Xueshan QIU
Chinese Journal of Lung Cancer , 2009,
Abstract: Background and objective MicroRNAs (miRNAs) are short non-coding RNAs that posttranscriptionally regulate gene expression by partially binding complementary to target sites in mRNAs. Although some impaired miRNA regulations have been observed in many human cancers, the functions of miR-125a are still unclear. The aim of this study is to investigate the expression of hsa-miR-125a-5p in NSCLC cell lines and the relationship between hsa-miR-125a-5p and the invasion of lung cancer cells. Methods The expression of hsa-miR-125a-5p and the effectiveness for a given period time after being transfected sense hsa-miR-125a-5p 2’-O-methyl oligonucleotide, which were 24 h, 36 h, 48 h, 60 h and 72 h, were examined by realtime PCR. Meanwhile, we investigated the modification of invasive ability in A549 and NCI-H460 cells by transwell. Results Real-time PCR showed that hsa-miR-125a-5p was poorly-expressed in 6 lung cancer cell lines, especially in LH7, NCI-H460, SPC-A-1 and A549. The highest expression of hsa-miR-125a-5p occurred in the cells transfected with sense hsa-miR-125a-5p 2’-O-methyl oligonucleotide 36 h. Furthermore, the invasive abilities of A549 and NCI-H46O were enhanced by up-regulating hsa-miR-125a-5p. Conclusion hsa-miR-125a-5p was poorly-expressed in lung cancer cells and it could enhance lung cancer cell invasion by up-regulating hsa-miR-125a-5p.
Using Dashboard for Lean Revenue Cycle Management  [PDF]
Jihong Zeng, John Zhang
iBusiness (IB) , 2013, DOI: 10.4236/ib.2013.53B021

Lean methodologies are increasingly deployed by healthcare providers to improve billing and collection process in revenue cycle management. Measurement on key performance metrics generates large amount of data. Traditional tabular and spreadsheet form analytics are not efficient to support enterprise scale lean improvement sustainability. This paper introduces a new breed of visual dashboard technology and its value as emerging differentiator from traditional business intelligence, especially in the rapid deployment and usability perspective. We present an exemplary case of using QlikView dashboard for lean revenue cycle management. Initial evaluation result is promising and indicates the dashboard empowers end users with intuitive and interactive experience, ad-hoc questions and answers. Integrating performance dashboard with enterprise data governance, predictive modeling will be evaluated further in future study.

Tolerance, Oxygen Consumption and Ammonia Excretion of Ophiopholis sarsii vadicola in Different Temperatures and Salinities Tolerance, Oxygen Consumption and Ammonia Excretion of Ophiopholis sarsii vadicola in Different Temperatures and Salinities
FANG Jinghui,ZHANG Jihong,JIANG Zengjie,ZHAO Xuewei,JIANG Xu,DU Meirong,GAO Yaping,FANG Jianguang
- , 2015,
Abstract: There are more than 2000 species of brittle stars in the world. For most of them, many scientific questions including basic characteristics of eco-physiology are still unknown. In the present study, Ophiopholis sarsii vadicola acclimated at 15℃, salinity 31, were assessed for temperature and salinity tolerance. Its oxygen consumption and ammonia excretion were studied at different temperatures(5, 10, 15, 20, 25℃) and salinities(25, 30, 35). O. sarsii vadicola could tolerate 0–24℃ and no brittle star was dead in the salinity range of 19–48 in the experimental situation. Two-way ANOVA showed that the oxygen consumption and ammonia excretion normalized with both dry mass and wet mass, Q10, which is used to describe the temperature sensitivity of respiration, and moisture content were significantly affected by temperature and salinity, and the combined effects of the two factors were significant. Stepwise multiple regression analysis revealed that logarithmic oxygen consumption and ammonia excretion showed a significant positive relationship with logarithmic temperature and salinity. The logarithmic moisture content of the brittle stars showed an inverse relationship with logarithmic salinity, but a positive relationship with logarithmic temperature. This suggests that the tolerance of temperature and salinity of brittle stars is closely related to their living environment, and that the effects of temperature on oxygen consumption are more significant at higher salinity, and that the ammonia excretion is less affected by salinity at lower temperatures
Hierarchical MAS Based Control Strategy for Microgrid
Zhe Xiao,Tinghua Li,Ming Huang,Jihong Shi,Jingjing Yang,Jiang Yu,Wei Wu
Energies , 2010, DOI: 10.3390/en3091622
Abstract: Microgrids have become a hot topic driven by the dual pressures of environmental protection concerns and the energy crisis. In this paper, a challenge for the distributed control of a modern electric grid incorporating clusters of residential microgrids is elaborated and a hierarchical multi-agent system (MAS) is proposed as a solution. The issues of how to realize the hierarchical MAS and how to improve coordination and control strategies are discussed. Based on MATLAB and ZEUS platforms, bilateral switching between grid-connected mode and island mode is performed under control of the proposed MAS to enhance and support its effectiveness.
Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells
Lili Jiang, Qin Huang, Siyang Zhang, Qingfu Zhang, Jihong Chang, Xueshan Qiu, Enhua Wang
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-318
Abstract: Expression of hsa-miR-125a-3p/5p in NSCLC tissues was explored using real-time PCR. The relationships between hsa-miR-125a-3p/5p expression and pathological stage or lymph node metastasis were assessed using the Spearman correlation test. For in vitro studies, lung cancer cells were transfected with sense and antisense 2'-O-methyl oligonucleotides for gain-of-function and loss-of-function experiments. Transwell experiments were performed to evaluate cellular migration and invasion.Expression of hsa-miR-125a-3p/5p was lower in NSCLC tissues than in adjacent normal lung tissues (LAC). Furthermore, the results from the Spearman correlation test showed a negative relationship between hsa-miR-125a-3p expression and pathological stage or lymph node metastasis and an inverse relationship between hsa-miR-125a-5p expression and pathological stage or lymph node metastasis. In vitro gain-of-function experiments indicated that hsa-miR-125a-3p and hsa-miR-125a-5p function in an opposing manner, suppressing or enhancing cell migration and invasion in A549 and SPC-A-1 cell lines, respectively. These opposing functions were further validated by suppression of hsa-miR-125a-3p and hsa-miR-125a-5p expression in loss-of-function experiments.Hsa-miR-125a-3p and hsa-miR-125a-5p play distinct roles in regulation of invasive and metastatic capabilities of lung cancer cells, consistent with the opposing correlations between the expression of these miRNAs and lymph node metastasis in NSCLC. These results provide new insights into the roles of miR-125a family members in the development of NSCLC.MicroRNAs (miRNAs) are a class of endogenous, noncoding RNAs, approximately 20-24 nucleotides in length, that are derived from longer transcripts termed pri-miRNAs and pre-miRNAs [1-5]. MiRNAs recognize target mRNAs through partial complementarity to specific sequences within the mRNAs and posttranscriptionally regulate gene expression in multicellular organisms [6-9]. Emerging evidence has shown that

Ji Zhen,Zhang Jihong,Jiang Yifeng,

电子与信息学报 , 2001,
Abstract: In this paper, the wavelet transform is used to increase the invisibility of the digital image watermark because it can exploit the temporal and spatial phenomena of human visual system. The more robustness can be achieved if watermarks are first spread and then modulated with pseudo noise spread sequence. The multiple address characteristic of spread spectrum will also help multiple watermarking. The performances of the proposed digital image watermarking algorithm based on wavelet transform combined with spread spectrum theory are discussed in this paper, such as resisting the damages from JPEG compression, random noising, geometrical transformation and multiple watermarking.
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