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Search Results: 1 - 10 of 59017 matches for " Jiapeng YANG "
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Genome-Wide Association Study for Cytokines and Immunoglobulin G in Swine
Xin Lu, JianFeng Liu, WeiXuan Fu, JiaPeng Zhou, YanRu Luo, XiangDong Ding, Yang Liu, Qin Zhang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074846
Abstract: Increased disease resistance through improved immune capacity would be beneficial for the welfare and productivity of farm animals. To identify genomic regions responsible for immune capacity traits in swine, a genome-wide association study was conducted. In total, 675 pigs were included. At 21 days of age, all piglets were vaccinated with modified live classical swine fever vaccine. Blood samples were sampled when the piglets were 20 and 35 days of age, respectively. Four traits, including Interferon-gamma (IFN-γ) and Interleukin 10 (IL-10) levels, the ratio of IFN-γ to IL-10 and Immunoglobulin G (IgG) blocking percentage to CSFV in serum were measured. All the samples were genotyped for 62,163 single nucleotide polymorphisms (SNP) using the Illumina porcineSNP60k BeadChip. After quality control, 46,079 SNPs were selected for association tests based on a single-locus regression model. To tackle the issue of multiple testing, 10,000 permutations were performed to determine the chromosome-wise and genome-wise significance level. In total, 32 SNPs with chromosome-wise significance level (including 4 SNPs with genome-wise significance level) were identified. These SNPs account for 3.23% to 13.81% of the total phenotypic variance individually. For the four traits, the numbers of significant SNPs range from 5 to 15, which jointly account for 37.52%, 82.94%, 26.74% and 24.16% of the total phenotypic variance of IFN-γ, IL-10, IFN-γ/IL-10, and IgG, respectively. Several significant SNPs are located within the QTL regions reported in previous studies. Furthermore, several significant SNPs fall into the regions which harbour a number of known immunity-related genes. Results herein lay a preliminary foundation for further identifying the causal mutations affecting swine immune capacity in follow-up studies.
Study on the Relationship between the Inhalable Fine Particulate Matter of Xuanwei Coal Combustion and Lung Cancer
Jiapeng YANG, Yu CAO, Yunchao HUANG, Guangjian LI, Lianhua YE, Guangqiang ZHAO, Yujie LEI, Xiaobo CHEN, Linwei TIAN
- , 2015, DOI: : 10.3779/j.issn.1009-3419.2015.07.03
Abstract: Background and objective The high incidence of lung cancer in Xuanwei, China, has become an important restricting factor for livelihood development, thus exerting local social and economic impacts. Coal is the main fuel of the local community and also the main source of indoor pollution. This study aims to explore the coal combustion inhalable fine particulate matter (PM2.5) and its component output differences in different areas of Xuanwei, Yunnan. Moreover, the aim of this study is to investigate the relationship between inhalation of fine particles and high incidence of local lung cancer. Methods For combustion test, coal mines designated as C1, K7 and M30 were collected from LaoLin Colliery of Laibing Town, Huchang Colliery of Baoshan Town, and Taiping Colliery of Wenxing Town in Xuanwei, respectively. PM2.5 of indoor air was weighed, analyzed for elemental composition, and morphologically compared. The pathological specimen of lung cancer patients in Xuanwei who underwent operation was observed through electron microscope. Results The PM2.5 concentrations in indoor air were (8.244 ±1.460) mg/m3 (C1), (5.066±0.984) mg/m3 (K7), and (5.071±1.460) mg/m3 (M30). The differences among pairwise comparisons were statistically significant (P=0.029). The filter impurities of C1 coal seam primarily include Si- and O-enriched compounds. Moreover, three membranes that comprised other elements, including C, S, and Si, were observed. These membranes were evident from the aggregation of silica and a Ca-Al membrane. Compared with that of other coal seams, C1 coal generated a mass of impurities, in which several particles have irregular shape. We found nanoscale fine particles in some specimens of Xuanwei lung cancer patients. Conclusion The produced combustion of C1 coal was different from that of K7 and M30 coal. PM2.5 composition may be associated with the high local incidence of lung cancer.
Preventing False Trips of Zone 3 Protection Relays in Smart Grid
Jiapeng Zhang,Yingfei Dong
- , 2015, DOI: 10.1109/TST.2015.7085627
Abstract: While remote zone 3 protection relays are essential to power systems, their false trips are also one of main causes related to cascading blackouts. Although many methods have been developed on traditional power systems to address this issue, the past cascading failure events showed the ineffectiveness of these methods. With the development of Smart Grid (SG), new agent-based methods have been proposed to address this issue by utilizing SG real-time communications. We found that these solutions simply assume ideal communication networks and do not consider the effect of practical network constraints and resource management. In this paper, we propose several solutions to address practical network resource management and constraints, and further improve the agent-based solutions in order to prevent the false tripping of zone 3 relays in various conditions. We also analyze the potential issues of these solutions, and point out the future investigation in this direction.
Association of Inorganics Accumulation with the Activation of NF-κB Signaling Pathway and the iNOS Expression of Lung Tissue in Xuanwei Lung Cancer Patients
Jiapeng YANG, Guangjian LI, Yunchao HUANG, Lianhua YE, Yongchun ZHOU, Guangqiang ZHAO, Yujie LEI, Xiaobo CHEN, Kun WANG, Ying CHEN, Chun DAI, Yanjun ZHANG
- , 2016, DOI: : 10.3779/j.issn.1009-3419.2016.01.04
Abstract: Background and objective Indoor air pollution induces asthma, leads to chronic obstructive pulmonary disease, and may promote lung cancer. Our previous studies found that the accumulation of inorganic particulate matter that is due to indoor air pollution can lead to damage to alveolar cells and activation of signaling pathway, and ultimately provoke tumorigenesis. The aim of this study is to explore the accumulation of inorganics and activation of nuclear factor κB (NF-κB)-inducible nitric oxide synthase (iNOS) signaling pathway of lung tissue in Xuanwei lung cancer patients. Methods From December 2013 to November 2014, 48 cases Xuanwei patients with lung cancer who underwent surgical treatment from the Third Affiliated Hospital of Kunming Medical University were enrolled in this study and compared with lung cancer patients from other regions. The ultrastructure of postoperative specimens was observed by transmission electron microscopy (TEM) to explore the occurrence of inorganic particles. Serum cytokines were analyzed. Then, the expression levels of NF-κB-p65 protein and iNOS protein in postoperative specimens was explored by immunohistochemistry and Western blot. Finally, 8-OHdG accumulation in lung cancer tissues and urine was measured. Results A large number of nanoscale inorganics were observed in alveolar type II cells and macrophages located in adjacent tissues of lung cancer with Xuanwei patients. Silicon (Si) content was found in inorganic elemental analysis. The serum interleukin (IL)-1β levels (31.50±19.16) pg/mL of Xuanwei lung-cancer patients were remarkably higher than those from other regions (11.33±6.94) pg/mL (P<0.01), with statistically significant difference. The pathological tissues of Xuanwei lung-cancer patients express NF-κB-p65, and iNOS expression were significantly higher than those of patients from non-Xuanwei regions. No significant difference was found between cancerous and normal adjacent tissues. Xuanwei lung-cancer tissues and urine 8-OHdG level (40.124±8.597) ng/mgCr were significantly higher than those of patients from other regions (25.673±7.986) ng/mg Cr (P<0.05), with statistically significant difference. Conclusion The accumulation of inorganics and the activation of NF-κB-iNOS signaling pathway may contribute to Xuanwei lung cancer.
Genomic Evolution of 11 Type Strains within Family Planctomycetaceae
Min Guo, Qian Zhou, Yizhuang Zhou, Linfeng Yang, Tianxiang Liu, Jinlong Yang, Yanling Chen, Longxiang Su, Jin Xu, Jing Chen, Feng Liu, Jiapeng Chen, Wenkui Dai, Peixiang Ni, Chengxiang Fang, Ruifu Yang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086752
Abstract: The species in family Planctomycetaceae are ideal groups for investigating the origin of eukaryotes. Their cells are divided by a lipidic intracytoplasmic membrane and they share a number of eukaryote-like molecular characteristics. However, their genomic structures, potential abilities, and evolutionary status are still unknown. In this study, we searched for common protein families and a core genome/pan genome based on 11 sequenced species in family Planctomycetaceae. Then, we constructed phylogenetic tree based on their 832 common protein families. We also annotated the 11 genomes using the Clusters of Orthologous Groups database. Moreover, we predicted and reconstructed their core/pan metabolic pathways using the KEGG (Kyoto Encyclopedia of Genes and Genomes) orthology system. Subsequently, we identified genomic islands (GIs) and structural variations (SVs) among the five complete genomes and we specifically investigated the integration of two Planctomycetaceae plasmids in all 11 genomes. The results indicate that Planctomycetaceae species share diverse genomic variations and unique genomic characteristics, as well as have huge potential for human applications.
Gr?bner-Shirshov bases for $L$-algebras
L. A. Bokut,Yuqun Chen,Jiapeng Huang
Mathematics , 2010, DOI: 10.1142/S0218196713500094
Abstract: In this paper, we firstly establish Composition-Diamond lemma for $\Omega$-algebras. We give a Gr\"{o}bner-Shirshov basis of the free $L$-algebra as a quotient algebra of a free $\Omega$-algebra, and then the normal form of the free $L$-algebra is obtained. We secondly establish Composition-Diamond lemma for $L$-algebras. As applications, we give Gr\"{o}bner-Shirshov bases of the free dialgebra and the free product of two $L$-algebras, and then we show four embedding theorems of $L$-algebras: 1) Every countably generated $L$-algebra can be embedded into a two-generated $L$-algebra. 2) Every $L$-algebra can be embedded into a simple $L$-algebra. 3) Every countably generated $L$-algebra over a countable field can be embedded into a simple two-generated $L$-algebra. 4) Three arbitrary $L$-algebras $A$, $B$, $C$ over a field $k$ can be embedded into a simple $L$-algebra generated by $B$ and $C$ if $|k|\leq \dim(B*C)$ and $|A|\leq|B*C|$, where $B*C$ is the free product of $B$ and $C$.
TaCIPK29, a CBL-Interacting Protein Kinase Gene from Wheat, Confers Salt Stress Tolerance in Transgenic Tobacco
Xiaomin Deng, Wei Hu, Shuya Wei, Shiyi Zhou, Fan Zhang, Jiapeng Han, Lihong Chen, Yin Li, Jialu Feng, Bin Fang, Qingchen Luo, Shasha Li, Yunyi Liu, Guangxiao Yang, Guangyuan He
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069881
Abstract: Calcineurin B-like protein-interacting protein kinases (CIPKs) have been found to be responsive to abiotic stress. However, their precise functions and the related molecular mechanisms in abiotic stress tolerance are not completely understood, especially in wheat. In the present study, TaCIPK29 was identified as a new member of CIPK gene family in wheat. TaCIPK29 transcript increased after NaCl, cold, methyl viologen (MV), abscisic acid (ABA) and ethylene treatments. Over-expression of TaCIPK29 in tobacco resulted in increased salt tolerance, which was demonstrated by higher germination rates, longer root lengths and better growth status of transgenic tobacco plants compared to controls when both were treated with salt stress. Physiological measurements indicated that transgenic tobacco seedlings retained high K+/Na+ ratios and Ca2+ content by up-regulating some transporter genes expression and also possessed lower H2O2 levels and reduced membrane injury by increasing the expression and activities of catalase (CAT) and peroxidase (POD) under salt stress. Moreover, transgenic lines conferred tolerance to oxidative stress by increasing the activity and expression of CAT. Finally, TaCIPK29 was located throughout cells and it preferentially interacted with TaCBL2, TaCBL3, NtCBL2, NtCBL3 and NtCAT1. Taken together, our results showed that TaCIPK29 functions as a positive factor under salt stress and is involved in regulating cations and reactive oxygen species (ROS) homeostasis.
The Preparation and Properties of Microheater Based on Graphene Oxide and Micro/Nanofiber

杨剑鑫, 史可樟, 李锡均, 郑嘉鹏, 史萌, 蔡祥, 朱德斌, 邢晓波,
Yang Jianxin
,Shi Kezhang,Li Xijun,Zheng Jiapeng,Shi Meng,Cai Xiang,Zhu Debin,Xing Xiaobo

- , 2015, DOI: 10.6054/j.jscnun.2015.05.018
Abstract: 利用近红外光在微纳光纤传输时产生的强烈倏逝场效应将氧化石墨烯沉积在微纳光纤表面,组装成具有优异光热转换性能的氧化石墨烯-微纳光纤,得到一种新型的光驱动微加热器. 通入较小功率的近红外光,微加热器能诱导各种液体(例如N,N-二甲基甲酰胺、去离子水)产生高温相变进而产生微泡,显示了良好的光热转换效应. 结果表明,在N,N-二甲基甲酰胺中,微泡按一定周期循环生长,重复搅动液体. 在微流芯片中,这些微泡可用于操控微纳米颗粒、微纳米线等. 〖JP2〗在去离子水中,产生的微泡结构稳定、不易破裂,可用于聚集微粒等. 该微加热器具有制备简单、尺寸小、损耗低、激发功率小、效率高等优良特性,在微机电系统、微流控芯片等领域具有良好的应用前景. 〖JP〗
: An optical technique is developed by depositing graphene oxide (GO) onto a micro/nanofiber (MNF), which can act as a novel light-driven microheater based on the strong evanescent field from MNF and the photothermal property of GO. Excited by the low-power near-infrared light, GO-MNF is capable of initiating the phase transition of surrounding solvent (such as N,N-dimethylformamide, deionized water) to generate photothermal microbubbles. As a result, in the N,N-dimethylformamide, the microbubbles grows in a certain cycle, and stirs the liquid repeated. In the microfluidic chip, the microbubbles can manipulate micro/nano particles and wires. In the deionized water, the microbubble is stable and not easy to break, which can be used to gather particles. The microheater has the superiorities of easy fabrication, small size, low loss, low excitation power, and high efficiency, which would have prospective applications in micro-electromechanical systems, lab-on-a-chip, and other techniques
Study on Carbon Nanocomposite Counterelectrode for Dye-Sensitized Solar Cells
Yiming Chen,Haiyan Zhang,Yuting Chen,Jiapeng Lin
Journal of Nanomaterials , 2012, DOI: 10.1155/2012/601736
Abstract: Carbon nanocomposite electrodes were prepared by adding carbon nanotubes (CNTs) into carbon black as counterelectrodes of dye-sensitized solar cells(DSSCs). The morphology and structure of carbon nanocomposite electrodes were studied by scanning electron microscopy. The influence of CNTs on the electrochemical performance of carbon nanocomposite electrodes is investigated by cyclic voltammetry and electrochemical impedance spectroscopy. Carbon nano composite electrodes with CNTs exhibit a highly interconnected network structure with high electrical conductivity and good catalytic activity. The influence of different CNTs content in carbon nanocomposite electrodes on the open-circuit voltage, short-circuit current, and filling factor of DSSCs is also investigated. DSSCs with 10% CNTs content exhibit the best photovoltaic performance in our experiments.
Effectiveness of 10 polymorphic microsatellite markers for parentage and pedigree analysis in plateau pika (Ochotona curzoniae)
Kexin Li, Jianing Geng, Jiapeng Qu, Yanming Zhang, Songnian Hu
BMC Genetics , 2010, DOI: 10.1186/1471-2156-11-101
Abstract: The error in parentage assignment using a combination of these 10 loci was very low as indicated by their power of discrimination (0.803 - 0.932), power of exclusion (0.351 - 0.887), and an effectiveness of the combined probability of exclusion in parentage assignment of 99.999%.All the offspring of a family could be assigned to their biological mother; and their father or relatives could also be identified. This set of markers therefore provides a powerful and efficient tool for parentage assignment and other population analyses in the plateau pika.Plateau pikas (Ochotona curzoniae) are small lagomorphs that inhabit the high alpine grasslands of the Tibetan plateau of China. They live in cohesive families and occupy burrow systems. Plateau pikas exhibit monogamy, polygyny, polyandry and promiscuous mating systems [1]. Approximately 57.8% of pikas exhibit philopatry, and dispersal movements are extremely restricted, although some dispersal may occur to ensure spatial separation of kin that may otherwise mate [2]. Inbreeding would be expected to occur under these circumstances. Dominant males monopolize mating in order to maximise reproductive fitness and minimise inbreeding depression. Previous methods to determine the level of inbreeding and how it affects the population depended mainly on direct observation due to the lack of molecular tools. Although family group behaviors have been described through observation in the plateau pika [2-5], details of family structures lack corroborative molecular evidence. In some breeding systems such as lekking, polygyny, polyandry and cooperative breeding, it may be impossible to determine parentage from direct observations [6]. Therefore, molecular tools such as microsatellites markers are necessary to obtain genetic information about family structure, social behavior and dispersal. Microsatellite markers, also called short tandem repeats (STRs), are ideal molecular markers for various genetic studies because they are highly p
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