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Search Results: 1 - 10 of 108541 matches for " Jiann-Lin Chen "
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An Analytical Approach for Analysis of Slider Bearings with Non-Newtonian Lubricants
Li-Ming Chu,Hsiang-Chen Hsu,Jiann-Lin Chen
Advances in Mechanical Engineering , 2014, DOI: 10.1155/2014/404759
Abstract: In this study, a regular perturbation technique is utilized to derive the modified Reynolds equation which is applicable to power-law lubricant. The performance of slider bearings including pressure distributions, velocity distributions, film thickness, load capacity, flow rate, shear force, and friction coefficient is also derived analytically for various , flow indices ( ), and outlet film thicknesses ( ). These analytical solutions are clear to find the effects of the operation parameters rather than numerical methods. It can be simply and fast used for engineers. Subsequently, these proposed analytical solutions are used to analyze the lubrication performance of slider bearing with the power-law fluids. 1. Introduction In all geometric-shaped sliders, wedge sliders provide the simplest support for fluid lubrication, and thus they are usually used as components of thrust slider bearings. With the development of modern machines, polymer oil, especially engine oil for vehicles such as multigrade crank case oil, is usually added to the lubricating oil in order to effectively reduce the friction loss of machine parts. However, such lubricants containing polymer belong to the non-Newtonian fluid type. As a result, the non-Newtonian characteristics of lubricants have become important. In recent years, there have been a great number of models used to describe non-Newtonian fluids. Among them, the power-law model is the simplest and most widely used. Safar and Shawki [1] divided fluids into three different categories: Newtonian fluid, , which is assumed as the type of ordinary pure fluid and gas; dilatant fluids or shear-thickening fluids, , which exhibit an increase in apparent viscosity with increasing shear rate; pseudoplastic fluids, , which are characterized by linearity at extremely low and extremely high shear rates. With regard to investigating slider bearings, many scholars [2–4] have derived closed-form solutions of Newtonian fluid for different slider bearings shapes. Hamrock [5] analyzed pressure distributions, velocity distributions, maximum pressure, film thickness, load capacity per unit width, flow rate, and friction coefficient of fixed-incline slider bearings with Newtonian fluid. As mentioned above, the closed-form solutions focus on simple geometry shape and Newtonian fluid. However, many experiments have shown that base oil blended with long-chain additives to a Newtonian fluid gives the most preferable lubricant results and can improve the load-carrying capacity and reduce the friction parameter [6, 7]. Therefore, the use of
Hydrogen Storage in Iron/Carbon Nanopowder Composite Materials: Effect of Varying Spiked Iron Content on Hydrogen Adsorption
Chun-Lin Chu,Chia-Feng Chang,Jiann-Ruey Chen,Yiin-Kuen Fuh
Journal of Nanomaterials , 2013, DOI: 10.1155/2013/742075
Novel Organic Sensitizers Containing 2,6-Difunctionalized Anthracene Unit for Dye Sensitized Solar Cells
Yung-Sheng Yen,Yung-Chung Chen,Hsien-Hsin Chou,Shih-Tang Huang,Jiann T. Lin
Polymers , 2012, DOI: 10.3390/polym4031443
Abstract: A series of new organic dyes comprising different amines as electron donors, 2-(6-substituted-anthracen-2-yl)-thiophene as the π-conjugated bridge, and cyanoacrylic acid group as an electron acceptor and anchoring group, have been synthesized. There exists charge transfer transition from arylamine and anthracene to the acceptor in these compounds, as evidenced from the photophysical measurements and the computational results. Under one sun (AM 1.5) illumination, dye-sensitized solar cells (DSSCs) using these dyes as the sensitizers exhibited efficiencies ranging from 1.62% to 2.88%, surpassing that using 9,10-difunctionalized anthracene-based sensitizer.
Frequent Episodic Vertigo is an Unexpected Side Effect of Flutamide  [PDF]
Jiann-Jy Chen, Dem-Lion Chen
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.24043
Abstract: An 82-year-old male suffered from prostatic cancer five years ago. Since then, he has taken flutamide and was bothered with episodic vertigo (EV) every morning. In order to treat prostatic cancer, flutamide was not discontinued, but conservative treatment and life-style change were recommended. Finally, EV actually subsided. Herein, we report the rare case, in which EV was an unexpected side effect of flutamide. Herein we review his whole history, physical examination, vestibular function test, electronystagmogram, caloric test, awake encephalogram, blood examinations, color-coded duplex ultrasonogram and magnetic resonance imaging/angiogram to suggest a mechanism of flutamide responsible for EV.
Investigating Properties of the Cardiovascular System Using Innovative Analysis Algorithms Based on Ensemble Empirical Mode Decomposition
Jia-Rong Yeh,Tzu-Yu Lin,Yun Chen,Wei-Zen Sun,Maysam F. Abbod,Jiann-Shing Shieh
Computational and Mathematical Methods in Medicine , 2012, DOI: 10.1155/2012/943431
Abstract: Cardiovascular system is known to be nonlinear and nonstationary. Traditional linear assessments algorithms of arterial stiffness and systemic resistance of cardiac system accompany the problem of nonstationary or inconvenience in practical applications. In this pilot study, two new assessment methods were developed: the first is ensemble empirical mode decomposition based reflection index (EEMD-RI) while the second is based on the phase shift between ECG and BP on cardiac oscillation. Both methods utilise the EEMD algorithm which is suitable for nonlinear and nonstationary systems. These methods were used to investigate the properties of arterial stiffness and systemic resistance for a pig’s cardiovascular system via ECG and blood pressure (BP). This experiment simulated a sequence of continuous changes of blood pressure arising from steady condition to high blood pressure by clamping the artery and an inverse by relaxing the artery. As a hypothesis, the arterial stiffness and systemic resistance should vary with the blood pressure due to clamping and relaxing the artery. The results show statistically significant correlations between BP, EEMD-based RI, and the phase shift between ECG and BP on cardiac oscillation. The two assessments results demonstrate the merits of the EEMD for signal analysis.
Photosensized Controlling Benzyl Methacrylate-Based Matrix Enhanced Eu3+ Narrow-Band Emission for Fluorescence Applications
Jiann-Fong Lee,Hsuen-Li Chen,Geneh-Siang Lee,Shao-Chin Tseng,Mei-Hsiang Lin,Wen-Bin Liau
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13033718
Abstract: This study synthesized a europium (Eu 3+) complex Eu(DBM) 3Cl-MIP (DBM = dibenzoyl methane; Cl-MIP = 2-(2-chlorophenyl)-1-methyl-1 H-imidazo[4,5-f][1,10]phenanthroline) dispersed in a benzyl methacrylate (BMA) monomer and treated with ultraviolet (UV) light for polymerization. Spectral results showed that the europium complex containing an antenna, Cl-MIP, which had higher triplet energy into the Eu 3+ energy level, was an energetically enhanced europium emission. Typical stacking behaviors of π–π interactions between the ligands and the Eu 3+-ion were analyzed using single crystal X-ray diffraction. Regarding the luminescence performance of this europium composite, the ligand/defect emission was suppressed by dispersion in a poly-BMA (PBMA) matrix. The underlying mechanism of the effective enhancement of the pure Eu 3+ emission was attributed to the combined effects of structural modifications, defect emissions, and carrier charge transfer. Fluorescence spectra were compared to the composite of optimized Eu 3+ emission where they were subsequently chelated to four metal ions via carboxylate groups on the BMA unit. The optical enhanced europium composite clearly demonstrated highly efficient optical responses and is, therefore a promising application as an optical detection material.
Vaccination Enhances Early Immune Responses in White Shrimp Litopenaeus vannamei after Secondary Exposure to Vibrio alginolyticus
Yong-Chin Lin, Jiann-Chu Chen, Wan Zabidii W. Morni, Dedi Fazriansyah Putra, Chien-Lun Huang, Chang-Che Li, Jen-Fang Hsieh
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069722
Abstract: Background Recent work suggested that the presence of specific memory or some form of adaptive immunity occurs in insects and shrimp. Hypervariable pattern recognition molecules, known as Down syndrome cell adhesion molecules, are able to mount specific recognition, and immune priming in invertebrates. In the present study, we attempted to understand the immune response pattern of white shrimp Litopenaeus vannamei which received primary (PE) and secondary exposure (SE) to Vibrio alginolyticus. Methodology Immune parameters and proliferation of haematopoietic tissues (HPTs) of shrimp which had received PE and SE to V. alginolyticus were measured. In the PE trial, the immune parameters and proliferation of HPTs of shrimp that received heat-killed V. alginolyticus (HVa) and formalin-inactivated V. alginolyticus (FVa) were measured. Mortality, immune parameters and proliferation of HPTs of 7-day-HVa-PE shrimp (shrimp that received primary exposure to HVa after 7 days) and 7-day-FVa-PE shrimp (shrimp that received primary exposure to FVa after 7 days) following SE to live V. alginolyticus (LVa) were measured. Phagocytic activity and clearance efficiency were examined for the 7~35-day-HVa-PE and FVa-PE shrimp. Results HVa-receiving shrimp showed an earlier increase in the immune response on day 1, whereas FVa-receiving shrimp showed a late increase in the immune response on day 5. The 7-day-FVa-PE shrimp showed enhancement of immunity when encountering SE to LVa, whereas 7-day-HVa-PE shrimp showed a minor enhancement in immunity. 7-day-FVa-PE shrimp showed higher proliferation and an HPT mitotic index. Both phagocytic activity and clearance maintained higher for both HVa-PE and FVa-PE shrimp after 28 days. Conclusions HVa- and FVa-receiving shrimp showed the bacteria agglutinated prior to being phagocytised. FVa functions as a vaccine, whereas HVa functions as an inducer and can be used as an immune adjuvant. A combined mixture of FVa and HVa can serve as a “vaccine component” to modulate the immunity of shrimp.
WNT10A Plays an Oncogenic Role in Renal Cell Carcinoma by Activating WNT/β-catenin Pathway
Ren-Jun Hsu, Jar-Yi Ho, Tai-Lung Cha, Dah-Shyong Yu, Chieh-Lin Wu, Wei-Ping Huang, Pauling Chu, Ying-Hsin Chen, Jiann-Torng Chen, Cheng-Ping Yu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047649
Abstract: Renal cell carcinoma (RCC) is a malignancy with poor prognosis. WNT/β-catenin signaling dysregulation, especially β-catenin overactivation and WNT antagonist silencing, is associated with RCC carcinogenesis and progression. However, the role of WNT ligands in RCC has not yet been determined. We screened 19 WNT ligands from normal kidney and RCC cell lines and tissues and found that WNT10A was significantly increased in RCC cell lines and tissues as compared to that in normal controls. The clinical significance of increase in WNT10A was evaluated by performing an immunohistochemical association study in a 19-year follow-up cohort comprising 284 RCC and 267 benign renal disease (BRD) patients. The results of this study showed that WNT10A was dramatically upregulated in RCC tissues as compared to that in BRD tissues. This result suggests that WNT10A, nuclear β-catenin, and nuclear cyclin D1 act as independent risk factors for RCC carcinogenesis and progression, with accumulative risk effects. Molecular validation of cell line models with gain- or loss-of-function designs showed that forced WNT10A expression induced RCC cell proliferation and aggressiveness, including higher chemoresistance, cell migration, invasiveness, and cell transformation, due to the activation of β-catenin-dependent signaling. Conversely, WNT10A siRNA knockdown decreased cell proliferation and aggressiveness of RCC cells. In conclusion, we showed that WNT10A acts as an autocrine oncogene both in RCC carcinogenesis and progression by activating WNT/β-catenin signaling.
Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan
Yi-Chen Hsieh, Sudha Seshadri, Wen-Ting Chung, Fang-I Hsieh, Yi-Hsiang Hsu, Huey-Juan Lin, Hung-Pin Tseng, Li-Ming Lien, Chyi-Huey Bai, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Chin-I Chen, Chia-Chen Yu, Hung-Yi Chiou, the Formosa Stroke Genetic Consortium (FSGC)
Journal of Biomedical Science , 2012, DOI: 10.1186/1423-0127-19-1
Abstract: We examined the relations of these two SNPs to the odds of new-onset ischemic stroke, ischemic stroke subtypes, and to the one year risk of stroke-related death or recurrent stroke following initial stroke in a case-control study. A total of 765 consecutive patients who had first-ever ischemic stroke were compared to 977 stroke-free, age-matched controls. SNPs were genotyped by Taqman fluorescent allelic discrimination assay. The association between ischemic stroke and SNPs were analyzed by multivariate logistic regression. Cox proportional hazard model was used to assess the effect of individual SNPs on stroke-related mortality or recurrent stroke.There was no significant association between SNP rs12425791 and rs11833579 and ischemic stroke after multiple testing corrections. However, the marginal significant association was observed between SNP rs12425791 and large artery atherosclerosis under recessive model (OR, 2.30; 95%CI, 1.22-4.34; q-value = 0.062). Among the 765 ischemic stroke patients, 59 died or developed a recurrent stroke. After adjustment for age, sex, vascular risk factors and baseline stroke severity, Cox proportional hazard analysis indicated that the hazard ratios were 2.76 (95%CI, 1.34-5.68; q-value, 0.02) and 2.15 (95%CI, 1.15-4.02; q-value, 0.03) for individuals with homozygous variant allele of rs12425791 and rs11833579, respectively.This is a precedent study that found genetic variants of rs12425791 and rs11833579 on chromosome 12p13 are independent predictors of stroke-related mortality or stroke recurrence in patients with incident ischemic stroke in Taiwan. Further study is needed to explore the details of the physiological function and the molecular mechanisms underlying the association of this genetic locus with ischemic stroke.A genome-wide association study (GWAS) conducted by the Cohorts for Heart and Aging Research Consortium in Genetic Epidemiology (CHARGE) reported a novel association between ischemic stroke and 2 single nucleotide
The effects of the bacterial interaction with visible-light responsive titania photocatalyst on the bactericidal performance
Chia-Liang Cheng, Der-Shan Sun, Wen-Chen Chu, Yao-Hsuan Tseng, Han-Chen Ho, Jia-Bin Wang, Pei-Hua Chung, Jiann-Hwa Chen, Pei-Jane Tsai, Nien-Tsung Lin, Mei-Shiuan Yu, Hsin-Hou Chang
Journal of Biomedical Science , 2009, DOI: 10.1186/1423-0127-16-7
Abstract: The widespread use of antibiotics and the emergence of more resistant and virulent strains of microorganisms [1-3] have caused an urgent need to develop alternative sterilization technologies. Using the superb photocatalytic effect of titanium dioxide (TiO2) is a conceptually feasible technology for this material is easy and inexpensive to produce in industrial scale. Photocatalytic TiO2 substrates have been shown to eliminate organic compounds and to function as disinfectants [4]. Upon ultraviolet (UV) light excitation, the photon energy excites valence band electron and generates pairs of electrons and holes (electron-vacancy in valence band) that diffuse and are trapped on or near the TiO2 surface. These excited electrons and holes have strong reducing and oxidizing activity and react with atmospheric water and oxygen to yield reactive species such as hydroxyl radicals (.OH) and superoxide anions (O2-) [5]. These radicals, .OH and O2- are extremely reactive upon contact with organic compounds. Complete oxidation of organic compounds and bacterial cells to carbon dioxide could be achieved [6,7]. Reactive oxygen species (ROS), such as .OH, O2-, and hydrogen peroxide (H2O2) generated on the light irradiated TiO2 surfaces, were shown to operate in concert to attack polyunsaturated phospholipids in bacteria [4]. Traditional TiO2 photocatalyst, however, is effective only upon irradiation of UV-light at levels that would also induce serious damage to human cells. This greatly restricts the potential applications of TiO2 substrates for use in our living environments. Recently, nitrogen or metal ion-doped anatase based TiO2 photocatalysts have been identified to be active upon visible-light illumination [8,9], offering the possibility to overcome this problem.It is believed that nanometer-sized anatase phase particles have large surface area are efficient for the decomposition of pollutants in air and in water [10]. Furthermore, it is also found that the presence of anata
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