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Search Results: 1 - 10 of 53452 matches for " Jiang-Miao Hu "
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Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4β-Triazole Rings
Cheng-Ting Zi,Feng-Qing Xu,Gen-Tao Li,Yan Li,Zhong-Tao Ding,Jun Zhou,Zi-Hua Jiang,Jiang-Miao Hu
Molecules , 2013, DOI: 10.3390/molecules181113992
Abstract: A series of 4 β-triazole-linked glucose podophyllotoxin conjugates have been designed and synthesized by employing a click chemistry approach. All the compounds were evaluated for their anticancer activity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using MTT assays. Most of these triazole derivatives have good anticancer activity. Among them, compound 35 showed the highest potency against all five cancer cell lines tested, with IC 50 values ranging from 0.59 to 2.90 μM, which is significantly more active than the drug etoposide currently in clinical use. Structure-activity relationship analysis reveals that the acyl substitution on the glucose residue, the length of oligoethylene glycol linker, and the 4'-demethylation of podophyllotoxin scaffold can significantly affect the potency of the anticancer activity. Most notably, derivatives with a perbutyrylated glucose residue show much higher activity than their counterparts with either a free glucose or a peracetylated glucose residue.
Two new ent-kaurane diterpenoids from Albizia mollis (Wall.) Boiv
Cheng, Zhong-Quan;Yang, Dan;Liu, Yu-Qing;Hu, Jiang-Miao;Jiang, He-Zhong;Wang, Peng-Cheng;Li, Ning;Zhou, Jun;Zhao, You-Xing;
Journal of the Brazilian Chemical Society , 2010, DOI: 10.1590/S0103-50532010000900025
Abstract: two new kaurane diterpenoids, 3α, 16β, 17-trihydroxy-ent-kaurane 3-o-β-d-glucopyranoside and 2β,3α-dihydroxy-ent-kaur-15-en-17-oic acid 3-o-β-d-glucopyranoside, were isolated from the bark of albizia mollis (wall.) boiv. the structures of two new compounds were elucidated by extensive 1d- and 2d-nmr spectroscopic methods in combination with ms experiments.
Chemical components of Dendrobium crepidatum and their neurite outgrowth enhancing activities
Cheng-Bo Li,Cong Wang,Wei-Wei Fan,Fa-Wu Dong,Feng-Qing Xu,Qin-Li Wan,Huai-Rong Luo,Yu-Qing Liu,Jiang-Miao Hu,Jun Zhou
Natural Products and Bioprospecting , 2013, DOI: 10.1007/s13659-012-0103-3
Abstract: 15 compounds, including two new ones crepidatuols A (1) and B (2) were isolated from the stems of Dendrobium crepidatum. The planar structures of these compounds were elucidated by spectroscopic methods (NMR, MS, UV, and IR) and comparison with those from literatures. 10 compounds were send for enhancing activities on nerve growth factor (NGF) medicated neurite outgrowth in PC12 cells and the results indicated that crepidatuol A (1), confusarin and 3-(2-acetoxy-5-methoxy)-phenylpropanol showed enhancing activities at the concentration of 10.0 μM.
Tight-binding calculation of growth mechanism of graphene on Ni(111) surface
Zhou Chen,Hu Jing,Tian Yuan,Zhao Qianying,Miao Ling,Jiang Jianjun
Physics , 2012,
Abstract: The nucleation of graphene on Ni surface, as well as on the step, is studied using a tight binding method of SCC-DFTB. The result demonstrates that the fcc configuration has the lowest total energy and thus is the most stable one compared to the other two structures when benzene ring is absorbed on the Ni(111) surface. The activity of marginal growth graphene's carbon atoms decreases from the boundary to the center, when they are absorbed on the substrate. Graphene layer can grow continuously on step surface formed by intersection of Ni(111) and Ni(1-11) surface. Meanwhile, a mismatch will occur between the layer and Ni surface and thus leads to flaws when the layer grows larger. Reducing the mismatch between the graphene and the step surface will benefit the growth of graphene of large area and high quality.
The Progresses of preparation and modification of graphene on substrate
Tian Yuan,Zhao Qian-Ying,Hu Jing,Zhou Chen,Miao Ling,Jiang Jian-Jun
Physics , 2012,
Abstract: It is significant to prepare large area of high quality graphene for the study of the characteristics of graphene and the research of the nano-devices based on graphene. This paper summarizes the experiment progresses and mechanism of graphene grown on different substrates. Nowadays, we can obtain the large area of high quality graphene by using the methods, such as CVD, epitaxial growth, etc. The interaction between the graphene and the substrates is closely related to the mismatch of the lattice, weakness of the bonds and the transformation of the electrons, which has a great influence on geometry, energy band and the properties of electrons of the graphene. The combination of the experiment and the calculation can make deeper understanding of the mechanism of the effects between graphene and different substrates, which can be served as a guide for further study.
Complete resection of isolated pancreatic metastatic melanoma: A case report and review of the literature
Miao-Xia He, Bin Song, Hui Jiang, Xian-Gui Hu, Yi-Jie Zhang, Jian-Ming Zheng
World Journal of Gastroenterology , 2010,
Abstract: Isolated metastatic melanoma of the pancreas is very rare. Currently, there is very limited experience with surgical resection of pancreatic metastasis. The potential benefit of metastasectomy can improve the quality of life and survival time of patients. We present a case of a 39-year-old Chinese male with a solitary pancreatic tumor which was considered a cystic benign lesion for years. Pathology and immunohistochemistry showed that the tumor in pancreatic tail was a metastasis from a malignant melanoma of the eyeball. No other metastastic foci were found in abdomen. The tumor was completely resected with combined distal pancreatectomy and splenectomy. The patient has survived 25 mo without any signs of local recurrence or other metastatic lesions after operation, indicating that complete surgical resection of a solitary metastatic melanoma of the pancreas can prolong the survival time of patients.
Landscape pattern change at the upper reaches of Minjiang River and its driving force

HU Zhibin,HE Xingyuan,JIANG Xiaobo,ZHAO Yonghua,HU Yuanman,CHANG Yu,LI Yuehui,HAN Wenquan,LIU Miao,

应用生态学报 , 2004,
Abstract: The upper reaches of Minjiang River is an ecological sensitive and vulnerable area in southwest of China.It is of great significance to the ecological pattern safety in China.In this study,we analyzed the landscape pattern change through the interpretation of TM imageries in 1986,1995 and 2000.The results showed that the matrix landscape in this area was grass landscape.Forest landscape patches were embedded in the grass landscape.The forest landscape area increased from 1986 to 1995 and decreased from 1995 to 2000.However,the number of patches of forest landscape was increasing during all the time.This suggested that the intensity of anthropogenic disturbances including harvesting,forest landscape reclaiming and excessive grazing were persistently increasing from 1986 to 2000.The ecological driving forces of the landscape change in this area were the intensified anthropogenic disturbances as a result of the population boom including the predacious harvesting of forest and excessive grazing.The natural disturbances such as the global climatic change also partly influenced the landscape change in this area.
miR-27b Represses Migration of Mouse MSCs to Burned Margins and Prolongs Wound Repair through Silencing SDF-1a
Mu-Han Lü, Chang-Jiang Hu, Ling Chen, Xi Peng, Jian Chen, Jiong-Yu Hu, Miao Teng, Guang-Ping Liang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068972
Abstract: Background Interactions between stromal cell-derived factor-1α (SDF-1α) and its cognate receptor CXCR4 are crucial for the recruitment of mesenchymal stem cells (MSCs) from bone marrow (BM) reservoirs to damaged tissues for repair during alarm situations. MicroRNAs are differentially expressed in stem cell niches, suggesting a specialized role in stem cell regulation. Here, we gain insight into the molecular mechanisms involved in regulating SDF-1α. Methods MSCs from green fluorescent protein transgenic male mice were transfused to irradiated recipient female C57BL/6 mice, and skin burn model of bone marrow-chimeric mice were constructed. Six miRNAs with differential expression in burned murine skin tissue compared to normal skin tissue were identified using microarrays and bioinformatics. The expression of miR-27b and SDF-1α was examined in burned murine skin tissue using quantitative real-time PCR (qPCR) and immunohistochemistry (IHC), enzyme-linked immunosorbent assay (ELISA). The Correlation of miR-27b and SDF-1α expression was analyzed by Pearson analysis Correlation. miRNAs suppressed SDF-1α protein expression by binding directly to its 3′UTR using western blot and luciferase reporter assay. The importance of miRNAs in MSCs chemotaxis was further estimated by decreasing SDF-1α in vivo and in vitro. Results miR-23a, miR-27a and miR-27b expression was significantly lower in the burned skin than in the normal skin (p<0.05). We also found that several miRNAs suppressed SDF-1α protein expression, while just miR-27a and miR-27b directly bound to the SDF-1α 3′UTR. Moreover, the forced over-expression of miR-27a and miR-27b significantly reduced the directional migration of mMSCs in vitro. However, only miR-27b in burn wound margins significantly inhibited the mobilization of MSCs to the epidermis. Conclusion miR-27b may be a unique signature of the stem cell niche in burned mouse skin and can suppress the directional migration of mMSCs by targeting SDF-1α by binding directly to its 3′UTR.
A Study of Smog Issues and PM2.5 Pollutant Control Strategies in China  [PDF]
David Hu, Juyuan Jiang
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.47086

The increased occurrence of smoggy days in major Chinese cities is of major concern to the general public. This paper explores the major sources of PM2.5 pollutants, a key contributor to the smog in Beijing, one of China’s largest cities. Evidence indicates that the secondary PM2.5 particles formed through NOx, SOx, NH3, VOCs, etc. have a strong impact on human health. As a result, PM2.5 pollution control should not simply focus on controlling particulate emission, but should involve adopting an integrated multi-pollutant control strategy. In addition to identifying the major sources of PM2.5, this paper explores its impact on environmental and human health. Although the intention of this research is not to provide solutions for reducing PM2.5 pollution, the paper analyzes the United States’ experience with establishing PM2.5 standards and mandates. Specifically, this paper focuses on the air quality control strategies adopted in California since the 1940s and draws parallels with present-day China. The research suggests that adequate government regulation, public awareness, regional collaboration and industrial compliance are keys to successfully controlling PM2.5 pollution.

PM2.5 Pollution and Risk for Lung Cancer: A Rising Issue in China  [PDF]
David Hu, Juyuan Jiang
Journal of Environmental Protection (JEP) , 2014, DOI: 10.4236/jep.2014.58074

This study is focused on the linkage between lung cancer incidence rates and PM2.5 pollution. Researches conducted by leading research organizations in U.S. and Europe were reviewed and analyzed, and strong evidence exists that elevated fine particulate air pollution exposures are associated with significant increases in lung cancer mortality. The linkage between fine particulate air pollution and lung cancer motility is observed even after controlling for cigarette smoking, occupational exposure, and other risk factors. This finding is in alignment with observations in China which show an upward trend of lung cancer incidences coupled with a downward trend in the number of smokers. Currently, China lacks systematic research on the effect of PM2.5 on lung cancer. As a result, this paper investigated studies on the linkage between pollution and lung cancer incidence from decades of research conducted in the U.S. and Europe. One important step in solving this issue in China is through classifying PM2.5 pollution as a human cacinogen. Adequate government regulation, public awareness, regional collaboration and industrial compliance are also key to the successful control of PM2.5 pollution and smog.

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