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Search Results: 1 - 10 of 146435 matches for " Jiang-Liu Yang "
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Towards -Induced Manganese-Containing Superoxide Dismutase Inactivation and Conformational Changes: An Integrating Study with Docking Simulations
Jiang-Liu Yang,Shang-Jun Yin,Yue-Xiu Si,Zhi-Rong Lü,Xiangrong Shao,Daeui Park,Hae Young Chung,Hai-Meng Zhou,Guo-Ying Qian,Zi-Ping Zhang
Enzyme Research , 2011, DOI: 10.4061/2011/307464
Abstract: Superoxide dismutase (SOD, EC 1.15.1.1) plays an important antioxidant defense role in skins exposed to oxygen. We studied the inhibitory effects of Al3+ on the activity and conformation of manganese-containing SOD (Mn-SOD). Mn-SOD was significantly inactivated by Al3+ in a dose-dependent manner. The kinetic studies showed that Al3+ inactivated Mn-SOD follows the first-order reaction. Al3+ increased the degree of secondary structure of Mn-SOD and also disrupted the tertiary structure of Mn-SOD, which directly resulted in enzyme inactivation. We further simulated the docking between Mn-SOD and Al3+ (binding energy for Dock 6.3: ?14.07?kcal/mol) and suggested that ASP152 and GLU157 residues were predicted to interact with Al3+, which are not located in the Mn-contained active site. Our results provide insight into the inactivation of Mn-SOD during unfolding in the presence of Al3+ and allow us to describe a ligand binding via inhibition kinetics combined with the computational prediction. 1. Introduction Superoxide dismutases (SOD, EC 1.15.1.1) are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide [1–3]. They play an important antioxidant defense role in skins exposed to oxygen. In this regard, for the treatment of systemic inflammatory diseases including skin ulcer lesions, the topical application of free Mn-SOD or Cu, Zn-SOD extracted from bovine, bacterial, and other species was dramatically effective in skin lesions [4]. It has been reported that significant increase in the levels of SOD occurs in vitiligo patients due to the increased oxidative stress [5]. The involvement of oxidative stress in chronic idiopathic urticaria associated with SOD was also reported [6]: the activity of SOD was markedly increased in lesional skin as compared with skin of healthy subjects, indicating that oxidative stress is crucially involved in chronic idiopathic urticaria and suggesting that oxidative stress is secondary to the development of inflammation. The earlier reports [7, 8] suggested that the activity of activator protein-1, which is associated with tumor promotion, was reduced in Mn-SOD transgenic mice overexpressing Mn-SOD in the skin, suggesting that Mn-SOD reduced tumor incidence by suppressing activator protein-1 activation. The mechanism of Mn-SOD catalysis is very important, and the mechanism therefore needs to be investigated from different sources using various kinetic methods. The information regarding the tertiary structure and the structural integrity of the active site of Mn-SOD is little known and in
Circulating Methylated XAF1 DNA Indicates Poor Prognosis for Gastric Cancer
Zhi-Qiang Ling, Ping Lv, Xiao-Xiao Lu, Jiang-Liu Yu, Jing Han, Li-Sha Ying, Xin Zhu, Wang-Yu Zhu, Xian-Hua Fang, Shi Wang, Yi-Chen Wu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0067195
Abstract: Background Methylated DNA in fluids may be a suitable biomarker for cancer patients. XAF1 has been shown to be frequently down-regulated in human gastric cancer (GC). Here, we investigated if XAF1 methylation in GC could be a useful biomarker. Methods Real-time RT-PCR was used to detect XAF1 mRNA expression; immunohistochemistry and western blot were used to examine XAF1 protein expression in GC tissues (n = 202) and their corresponding para-cancerous histological normal tissues (PCHNTs). Real-time methylation specific-PCR was used to investigate XAF1 promoter methylation in the same panel of GC tissues, their PCHNTs and sera. Results We confirmed frequent XAF1 down-regulation in both mRNA and protein levels in GC tissues as compared to normal controls and PCHNTs. XAF1 hypermethylation was evidenced in 83.2% (168/202) of GC tissues and 27.2% (55/202) of PCHNTs, while no methylation was detected in the 88 normal controls. The methylation level in GC tissues was significantly higher than that in PCHNTs (p<0.05). The hypermethylation of XAF1 significantly correlated with the down-regulation of XAF1 in GC tissues in both mRNA and protein levels (p<0.001 each). Moreover, we detected high frequency of XAF1 methylation (69.8%, 141 out of 202) in the sera DNAs from the same patients, while the sera DNAs from 88 non-tumor controls were negative for XAF1 methylation. The XAF1 methylation in both GC tissues and in the sera could be a good biomarker for diagnosis of GC (AUC = 0.85 for tissue and AUC = 0.91 for sera) and significantly correlated with poorer prognosis (p<0.001). In addition, after-surgery negative-to-positive transition of XAF1 methylation in sera strongly associated with tumor recurrence. Conclusions 1) Dysfunction of XAF1 is frequent and is regulated through XAF1 promoter hypermethylation; 2) Detection of circulating methylated XAF1 DNAs in the serum may be a useful biomarker in diagnosis, evaluating patient’s outcome (prognosis and recurrence) for GC patients.
Coastal Reservoirs Strategy for Water Resource Development—A Review of Future Trend  [PDF]
Jianli Liu, Shuqing Yang, Changbo Jiang
Journal of Water Resource and Protection (JWARP) , 2013, DOI: 10.4236/jwarp.2013.53A034
Abstract:
Water use and access become a more and more important determinant of environmental equity and human development according to the view held by the UN [1]. Water scarcity is one of the major crises which has overarching implications for other world problems especially poverty, hunger, ecosystem degradation, desertification, climate change, threatening world peace and security [2]. In the decades to come, freshwater consumed by human will get to a tipping point. Many projects and concepts have been proposed and implemented for several years to improve the effectiveness of using water. These research activities can be grouped as: desalination plants; water detention (like rainwater tanks for collection and reuse); wastewater reuse; dams and reservoirs. This paper summarized the characters of these water solutions. But these methods can’t provide enough fresh water due to limitations imposed by these methods as well as following industry and population’s development. To overcome these shortcomings, coastal reservoir strategy is proposed in the paper. This new strategy is technically feasible, environmentally sustainable and cost effective by demonstration and comparison.
Enhanced parametric amplification in slow-light photonic crystal waveguides
Yang Liu,Chun Jiang
Chinese Science Bulletin , 2009, DOI: 10.1007/s11434-009-0369-y
Abstract: We demonstrate both theoretically and numerically that slow light can enhance the parametric process of silicon in photonic crystal line-defect waveguides. Specifically, to get the desired gain, the pump power for a given gain medium length or the gain medium length for given pump power can be reduced by (c/v g n)2 when slow light waveguides are used, where n is the material index of conventional waveguide, v g is the group velocity of the slow light waveguide and c is the light velocity in vacuum.
Dynamic K-Best Sphere Decoding Algorithms for MIMO Detection  [PDF]
Chengzhe Piao, Yang Liu, Kaihua Jiang, Xinyu Mao
Communications and Network (CN) , 2013, DOI: 10.4236/cn.2013.53B2020
Abstract: Multiple Input Multiple Output (MIMO) technology is of great significance in high data rate wireless communication. The K-Best Sphere Decoding (K-Best SD) algorithm was proposed as a powerful method for MIMO detection that can approach near-optimal performance. However, some extra computational complexity is contained in K-Best SD. In this paper, we propose an improved K-Best SD to reduce the complexity of conventional K-Best SD by assigning K for each level dynamically following some rules. Simulation proves that the performance degradation of the improved K-Best SD is very little and the complexity is significantly reduced.
“River effect” of radiofrequency ablation on relevant regional hepatocytes in living swine liver: a preliminary pathological study
Kai JIANG,Ji-ye CHEN,Yang LIU,Jiang LIU
Medical Journal of Chinese People's Liberation Army , 2013,
Abstract: Objective  To establish the animal model of radiofrequency ablation (RFA) on living swine liver, and observe the pathologic changes caused by the "river effect (RE)"of RFA on relevant regional hepatocytes. Methods  Three target segments of liver of each of 6 Guangxi BA-MA mini pigs were selected for ablation. Under the guidance of sonography, the tip of RFA electrode was inserted into the liver close to segmental outflow vessel, and every ablated point was heated for 6 minutes. Pathological changes of relevant downstream region along portal vein and hepatic artery were observed under microscope after RFA. Results  The ablated region of the liver was oblong in shape with outer diameter of 2.2±1.1cm on gross inspection. Thermal damage (e.g. obvious dilated blood sinuses, with abundant inflammatory cell infiltration in portal vein region and necrosis of hepatocytes, etc.) was observed in downstream region of the relevant portal vein under microscope after RFA. However, liver tissue in adjacent area around the vessel was intact, and no obvious thermal damage was found. Conclusion  The "river effect" during RFA for liver tissue may lead to thermal damage to hepatocytes along the downstream region of the regional portal vein, and this effect decreases gradually toward the surface of liver segment.
An event-related potential study of working memory in children
Rong Liu,Chunyan Guo,Yang Jiang
Chinese Science Bulletin , 2006, DOI: 10.1007/s11434-006-2001-8
Abstract: To examine the neural mechanisms of working memory in children, event-related potentials (ERPs) were recorded from the 12–13 year-old while they performed a delayed match-to-sample task. The ERP results revealed that new and studied objects both evoked a late positive ERP component peaking around 350 ms during the working memory process. New objects evoke a more positive ERP waveform than the studied objects. The scalp distribution showed that the frontal-central electrode sites were associated with object working memory processes. When tracking new or studied targets among visual distracters, ERPs of targets and distracters revealed differential responses as early as 150 ms. The visual targets evoked larger and more positive ERP responses than the distracters. The typical old-new effect was observed between ERPs of studied and new distracters. However, ERPs of new and studied targets differed at about 250 ms, in which new targets evoked more positive-going and slightly earlier ERP responses. In addition, a P3a component was found for new targets only, and was absent in ERPs of studied targets at frontal and central sites. The present study results reveal the spatial and temporal characteristics of neural mechanisms underlying working memory in children, some of which are distinct from those in adults.
Sino-American Textile Trade Balance and Trade Friction
Ningchuan Jiang,Yi Yang,Lu Liu
International Journal of Business and Management , 2009, DOI: 10.5539/ijbm.v3n8p53
Abstract: In recent years, there has been severe unbalance in Sino-American trade. China has remained trade surplus of large volume to America, especially in textile products trade, so America has a lot of trade friction with China. This article collects information of unbalanced condition in Sino-American Textile trade, analyzes the reasons for this kind of trade friction, and proposes an opinion that China has to modify the policy of developing country by foreign trade to realize trade balance of textile products.
Synthesis and Properties of Novel Non-Ionic Polyurethane Dispersion Based on Hydroxylated Tung Oil and Alicyclic Isocyanates  [PDF]
Xiaomin Yang, Baixia Ren, Zhiyong Ren, Lei Jiang, Wentao Liu, Chengshen Zhu
Journal of Materials Science and Chemical Engineering (MSCE) , 2015, DOI: 10.4236/msce.2015.31013
Abstract:

Hydroxylated Tung oil (HTO) based nonionic polyurethane dispersion (HTO-NPUD) were synthesized using dicyclohexyl methane diisocyanate (HMDI) and HTO as main hydrophobic materials whereas polyethylene glycol-800 (PEG-800) as hydrophilic chain extender. To effectively study the effects of HTO on properties of NPUD, polypropylene glycol-400(PPG-400) based NPUD was prepared by HMDI reacting with PPG-400 and PEG-800. The structures of those novel nonionic polyurethane dispersions were characterized by FTIR and 1H NMR. Moreover, particle size and size distribution, cloud point and surface tension had been investigated. Results showed that, by comparing with PPG based NPUD (PPG-NPUD), the introduction of HTO into NPUD result in larger particle size and more uniformed particle size distribution, higher cloud point and lower surface tension.

Plasmonic-dielectric compound grating with high group-index and transmission
Lei Dai,Yang Liu,Chun Jiang
Physics , 2010, DOI: 10.1364/OE.19.001461
Abstract: We propose a compound system consisting of a dielectric grating and a plasmonic resonance cavity embedded in the grating. Based on the interference effect between the surface mode supported by the dielectric grating and the plasmonic-induced cavity mode, this system could achieve slow light with group index more than 200 and transmission more than 75%. Meanwhile, we examine the effects of the period numbers of the compound system and photonic crystal superlattice made up of alternate layers of the grating and air on the properties of slow light.
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