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Search Results: 1 - 10 of 8323 matches for " JianYong Shao "
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Tumor suppressor BLU inhibits proliferation of nasopharyngeal carcinoma cells by regulation of cell cycle, c-Jun N-terminal kinase and the cyclin D1 promoter
Xiangning Zhang, Hui Liu, Binbin Li, Peichun Huang, Jianyong Shao, Zhiwei He
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-267
Abstract: BLU was re-expressed in nasopharyngeal carcinoma cells by transfection or viral infection. Clonogenic growth was assayed; cell cycle was analyzed by flow cytometry-based DNA content detection; c-Jun N-terminal kinase (JNK) and cyclin D1 promoter activities were measured by reporter gene assay, and phosphorylation was measured by immunoblotting. The data for each pair of groups were compared with Student t tests.BLU inhibits clonogenic growth of nasopharyngeal carcinoma cells, arrests cell cycle at G1 phase, downregulates JNK and cyclin D1 promoter activities, and inhibits phosphorylation of c-Jun.BLU inhibits growth of nasopharyngeal carcinoma cells by regulation of the JNK-cyclin D1 axis to exert tumor suppression.
Dirac Cosmology and the Acceleration of the Contemporary Universe
Cheng-Gang Shao,Jianyong Shen,Bin Wang,Ru-Keng Su
Physics , 2005, DOI: 10.1088/0264-9381/23/11/003
Abstract: A model is suggested to unify the Einstein GR and Dirac Cosmology. There is one adjusted parameter $b_2$ in our model. After adjusting the parameter $b_2$ in the model by using the supernova data, we have calculated the gravitational constant $\bar G$ and the physical quantities of $a(t)$, $q(t)$ and $\rho_r(t)/ \rho_b(t)$ by using the present day quantities as the initial conditions and found that the equation of state parameter $w_{\theta}$ equals to -0.83, the ratio of the density of the addition creation $\Omega_{\Lambda}=0.8$ and the ratio of the density of the matter including multiplication creation, radiation and normal matter $\Omega_m =0.2$ at present. The results are self-consistent and in good agreement with present knowledge in cosmology. These results suggest that the addition creation and multiplication creation in Dirac cosmology play the role of the dark energy and dark matter.
Application of nanomaterials in two-terminal resistive-switching memory devices
Jianyong Ouyang
Nano Reviews , 2010, DOI: 10.3402/nano.v1i0.5118
Abstract: Nanometer materials have been attracting strong attention due to their interesting structure and properties. Many important practical applications have been demonstrated for nanometer materials based on their unique properties. This article provides a review on the fabrication, electrical characterization, and memory application of two-terminal resistive-switching devices using nanomaterials as the active components, including metal and semiconductor nanoparticles (NPs), nanotubes, nanowires, and graphenes. There are mainly two types of device architectures for the two-terminal devices with NPs. One has a triple-layer structure with a metal film sandwiched between two organic semiconductor layers, and the other has a single polymer film blended with NPs. These devices can be electrically switched between two states with significant different resistances, i.e. the ‘ON’ and ‘OFF’ states. These render the devices important application as two-terminal non-volatile memory devices. The electrical behavior of these devices can be affected by the materials in the active layer and the electrodes. Though the mechanism for the electrical switches has been in argument, it is generally believed that the resistive switches are related to charge storage on the NPs. Resistive switches were also observed on crossbars formed by nanotubes, nanowires, and graphene ribbons. The resistive switches are due to nanoelectromechanical behavior of the materials. The Coulombic interaction of transient charges on the nanomaterials affects the configurable gap of the crossbars, which results into significant change in current through the crossbars. These nanoelectromechanical devices can be used as fast-response and high-density memory devices as well. Dr. Jianyong Ouyang received his bachelor degree from the Tsinghua University in Beijing, China, and MSc from the Institute of Chemistry, Chinese Academy of Science. He received his PhD from the Institute for Molecular Science, Graduate University for Advanced Studies, Japan. After working as an assistant professor at the Japanese Advanced Institute of Science and Technology, and subsequently as a postdoctoral researcher at the University of California, Los Angeles, he joined as an assistant professor in 2006 at the National University of Singapore. His current research interests include organic/polymeric electronic materials and devices, nanometer materials and devices, energy materials and devices.
On Two Cryogenic Systems of High Purity Germanium Detector  [PDF]
Jianyong Zhang, Xiao Cai, Xiaohu Mo
Detection (Detection) , 2013, DOI: 10.4236/detection.2013.12003
Abstract: Two cryogenic systems of high purity germanium detector, liquid nitrogen and mechanical cooler, are expounded, to- gether with explanations of merits and demerits for each kind of cooling methods. The resolutions of detector to the characteristic lines of 152Eu under different cooling conditions are studied. The laboratory results indicate that the me- chanical cooler (X-Cooler II) is an ideal replacement candidate for the liquid nitrogen cooling system that is being util- ized by BEMS at BEPC-II.
Nonlinear dispersive scale Alfvén waves inmagnetosphere-ionosphere coupling: Physical processes and simulation results
MingXian Zhao,JianYong Lu
Chinese Science Bulletin , 2012, DOI: 10.1007/s11434-011-4905-1
Abstract: Dispersive Alfvén waves (DAWs) have been demonstrated to play a significant role in auroral generation of the magnetosphere-ionosphere coupling system. Starting from a two fluid reduced MHD model, we summarize the frequency, temporal and spatial characteristics of magnetospheric DAWs. Then, the nonlinear kinetic and inertial scale Alfvén waves are studied, and we review some theoretical aspects and simulation results of dispersive Alfvén waves in Earth’s magnetosphere. It is shown that dispersive standing Alfvén waves can generate the field-aligned currents which transport energy into the auroral ionosphere, where it is dissipated by Joule heating and energy lost due to electron precipitation. The Joule dissipation can heat the ionospheric electron and produce changes in the ionospheric Pedersen conductivity. As a feedback, the conducting ionosphere can also strongly affect the magnetospheric currents. The ponderomotive force can cause the plasma to move along the field line, and generate ionospheric density cavity. The nonlinear structuring can lead to a dispersive scale to accelerate auroral particle, and the Alfvén waves can be trapped within the density cavity. Finally, we show the nonlinear decay of dispersive Alfvén waves related to two anti-propagating electron fluxes observed in the auroral zone.
Engineering-Oriented Practical Training Methodology for Undergraduate and a Case Study
Jianyong Zuo,Zhongkai Chen
Research Journal of Applied Sciences, Engineering and Technology , 2013,
Abstract: In this study, the education method which is different from traditional Chinese education methods for its accentuation of practical training is proposed. Compared with traditional engineering education methods, engineering-oriented practical training methodology is student-centered, contains various educational activities, requires interdisciplinary skills, values teamwork and have more objective evaluation methods. Based on the educational case of anti-skid control of railway train, a semi-physical simulation platform is introduced with details in design philosophy, system structure, operator interface and training process. The intention of creating the platform is to provide the students who use it with more hands-on experience since one of the key factors in transfer of learning is the diversion of practice. Based on the knowledge transfer theory, we encourage our students to do their work more independently and freely and the corresponding scores of their performance prove that the students who are better-rounded tend to perform well in the training courses we offered while those only with straight a scores may not outperform their classmates. Thus, the results indicate that this mode is effective in education and instructive to the reform of technological college education.
P2P Model Based on Isolated Broadcast Domains  [PDF]
Jianchun Li, Gongbing Guo, Jianyong Li, Daoying Huang
Advances in Internet of Things (AIT) , 2012, DOI: 10.4236/ait.2012.23009
Abstract: Resource location is the most important issue for Peer-to-Peer (P2P) system and flooding is the fundamental mechanism for unstructured P2P systems. Redundant messages will exponential growth with flooding scope increasing which severely influences the scalability of the system. In this paper, a new P2P model based on isolated broadcast domains is given to reduce the amount of redundant messages by limiting the radius of messages transmitted. Analysis and experiments show that this model can guarantee coverage of nodes and significantly reduce the amount of redundant messages generated.
Preprocessing of Separating Leukocytes Based on Setting Parameters of Lightness Transformation  [PDF]
Jianyong Cai, Lili Luo, Rongtai Cai, Lijin Lin, Juan Cai
Journal of Signal and Information Processing (JSIP) , 2013, DOI: 10.4236/jsip.2013.44051
Abstract: This paper proposed a new algorithm to separate leukocytes from cytological image by setting parameters of lightness transformation based on the RGB color space, which can make the targets’ color in different areas. In our procedure, an operator is employed in using color features. According to their histogram distribution of hue component in HSL color space after enhancing the contrast of image in RGB color space, the threshold of segmentation between leukocyte and erythrocyte could be achieved well. Especially, this algorithm is more efficient than monochrome for leukocyte segmentation, and the results of experiments show that it provides a good tool for cytological image, which can increase accuracy of segmentation of leukocyte.
Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation
Robert Valentine, Christopher W Dawson, Chunfang Hu, Khilan M Shah, Thomas J Owen, Kathryn L Date, Sonia P Maia, Jianyong Shao, John R Arrand, Lawrence S Young, John D O'Neil
Molecular Cancer , 2010, DOI: 10.1186/1476-4598-9-1
Abstract: In this report we demonstrate that EBNA1 inhibits the canonical NF-κB pathway in carcinoma lines by inhibiting the phosphorylation of IKKα/β. In agreement with this observation we find a reduction in the phosphorylation of IκBα and reduced phosphorylation and nuclear translocation of p65, resulting in a reduction in the amount of p65 in nuclear NF-κB complexes. Similar effects were also found in carcinoma lines infected with recombinant EBV and in the EBV-positive NPC-derived cell line C666-1. Inhibition of NF-κB was dependent upon regions of EBNA1 essential for gene transactivation whilst the interaction with the deubiquitinating enzyme, USP7, was entirely dispensable. Furthermore, in agreement with EBNA1 inhibiting p65 NF-κB we demonstrate that p65 was exclusively cytoplasmic in 11 out of 11 NPC tumours studied.Inhibition of p65 NF-κB in murine and human epidermis results in tissue hyperplasia and the development of squamous cell carcinoma. In line with this, p65 knockout fibroblasts have a transformed phenotype. Inhibition of p65 NF-κB by EBNA1 may therefore contribute to the development of NPC by inducing tissue hyperplasia. Furthermore, inhibition of NF-κB is employed by viruses as an immune evasion strategy which is also closely linked to oncogenesis during persistent viral infection. Our findings therefore further implicate EBNA1 in playing an important role in the pathogenesis of NPC.Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that is associated with both lymphoid and epithelial tumours [1], including undifferentiated NPC where there is a near 100% association with EBV infection. Whilst the pattern of EBV latent protein expression varies in different tumour types the EBV nuclear antigen, Epstein-Barr nuclear antigen-1 (EBNA1), is expressed in all EBV-associated malignancies due to its indispensable role in the maintenance and replication of the EBV genome via sequence-specific binding to the viral origin of replication, oriP [2]. Furthermore
Translational oncology toward benefiting cancer patients: the Sun Yat-sen University Cancer Center experience
Mathilde Guerin,ChaoNan Qian,Qian Zhong,Qian Cui,YunMiao Guo,JinXin Bei,JianYong Shao,XiaoFeng Zhu,WenLin Huang,JiangXue Wu,RanYi Liu,Qiang Liu,Jing Wang,WeiHua Jia,XiaoHui Zheng,YiXin Zeng
Science China Life Sciences , 2013, DOI: 10.1007/s11427-012-4398-4
Abstract: Sun Yat-sen University Cancer Center (SYSUCC) is currently conducting many translational studies to improve cancer patients’ condition through early diagnosis, discovering new treatments, improving treatment outcomes, and better classification and prognosis of cancer. SYSUCC is a leading institution for treating nasopharyngeal carcinoma (NPC) and carrying out research into the disease. The center has performed several large-scale studies that have produced new insights, such as a genome-wide analysis study, which has allowed researchers to identify new genetic risk factors for NPC; the findings are significant toward building a risk prediction model for NPC. Other researchers are using molecular biological methods to identify new biomarkers, which will allow a better classification and prognosis of this disease. Drug discovery, especially for molecular targeted therapy, is also an active field of research at SYSUCC, not only for NPC treatment, but also for, among others, cancers of the head, neck, and liver. As an alternative to Western medicine, scientists also use derivatives of natural products from Traditional Chinese Medicine to develop new compounds. The tumor biobank at SYSUCC, one of the largest in China, play an essential role in producing clinical applications from research findings. Translational oncology is a promising field, and scientists and clinicians from SYSUCC will continue to work in synergy to develop new anticancer therapies.
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